Drug & supplement interaction

Methylsynephrine + Zuranolone

Zuranolone brand name: Zurzuvae.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 20, 2026
The bottom line No known interaction

We found no known interaction between Methylsynephrine and Zuranolone in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first.

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Interaction report

Methylsynephrine and Zuranolone

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Zuranolone and Methylsynephrine in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Methylsynephrine safety at a glance

Methylsynephrine overall Avoid It is a stimulant drug not approved as a supplement and has been tied to serious cardiovascular events.
Pregnancy Avoid Stimulant with unknown safety; should not be used during pregnancy.
Breastfeeding Avoid No safety data; avoid while breastfeeding.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Zuranolone and Methylsynephrine? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
How we checked

Why No Interaction Is Listed for Zuranolone

Interactions in our licensed database are recorded against drug classes, not just single drug names. Zuranolone is filed under 4 classifications — including antidepressant drugs, cns depressants, cytochrome p450 3a4 (cyp3a4) substrates. Methylsynephrine has documented interactions with 2 drug classes — the most serious being beta-adrenergic agonists (moderate) and stimulant drugs (moderate) — and none of Zuranolone’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

Methylsynephrine Does Interact With Other Medications

Methylsynephrine has 191 moderate known drug interactions in our database — Zuranolone isn’t one of them. If you take anything else, check it against the full list below.

Moderate 191 No known interaction 2,639 (incl. Zuranolone)
Taking anything else?

Check Another of Your Medications Against Methylsynephrine

Covers the 2,830 medications we’ve checked against Methylsynephrine. Pick one to open its full report.

What to actually watch for

What Methylsynephrine Itself Has Been Linked To

This is not an interaction — nothing below involves Zuranolone. It is the side-effect record for Methylsynephrine on its own, from the licensed Natural Medicines monograph. If something new turns up after you add Methylsynephrine, this list is the first place to look. 3 entries are worth acting on rather than waiting out — marked below.

  • An irregular heartbeat Worth acting on Additional detail

    “There is currently a limited amount of information available about the adverse effects of methylsynephrine. Orally, it has been reported to cause increased blood pressure, palpitations, and arrhythmia.”

    Methylsynephrine · Natural Medicines adverse-effect record, reported in arrhythmia.

    2 sources cited
    1. 94386. Pawar RS, Grundel E. Overview of regulation of dietary supplements in the USA and issues of adulteration with phenethylamines (PEAs). Drug Test Anal 2017;9:500-517. PubMed
    2. 99910. Cohen PA, Avula B, Venhuis B, Travis JC, Wang YH, Khan IA. Pharmaceutical doses of the banned stimulant oxilofrine found in dietary supplements sold in the USA. Drug Test Anal. 2017;9(1):135-142. PubMed
  • Chest pain Worth acting on Additional detail

    “Orally, methylsynephrine has been reported to cause increased blood pressure, palpitations, and arrhythmias.

    In the Netherlands, the supplement dexaprine was removed from the market because of reported cases of tachycardia, palpitations, chest pain, and a single report of cardiac arrest. As little as half a tablet was associated with these adverse effects, which occurred within one hour of ingestion.”

    Methylsynephrine · Natural Medicines adverse-effect record, reported in arrhythmia.

    3 sources cited
    1. 94386. Pawar RS, Grundel E. Overview of regulation of dietary supplements in the USA and issues of adulteration with phenethylamines (PEAs). Drug Test Anal 2017;9:500-517. PubMed
    2. 99910. Cohen PA, Avula B, Venhuis B, Travis JC, Wang YH, Khan IA. Pharmaceutical doses of the banned stimulant oxilofrine found in dietary supplements sold in the USA. Drug Test Anal. 2017;9(1):135-142. PubMed
    3. 99913. Venhuis B, Keizers P, van Riel A, de Kaste D. A cocktail of synthetic stimulants found in a dietary supplement associated with serious adverse events. Drug Test Anal. 2014;6(6):578-81. PubMed
  • Raised blood pressure Worth acting on Additional detail

    Recorded for Methylsynephrine in the same Natural Medicines adverse-effect record shown under An irregular heartbeat above.

  • A fast or pounding heartbeat Additional detail

    Recorded for Methylsynephrine in the same Natural Medicines adverse-effect record shown under An irregular heartbeat above.

  • Vomiting / Nausea Additional detail

    “In the Netherlands, the supplement dexaprine was removed from the market following reported cases of nausea and vomiting. As little as half a tablet was associated with these adverse effects, which occurred within one hour of ingestion. Dexaprine was found to contain methylsynephrine, synephrine, deterenol, yohimbine, caffeine, theophylline, and possibly beta-methyl-beta-phenylethylamines.”

    Methylsynephrine · Natural Medicines adverse-effect record, reported in nausea and vomiting.

    1 source cited
    1. 99913. Venhuis B, Keizers P, van Riel A, de Kaste D. A cocktail of synthetic stimulants found in a dietary supplement associated with serious adverse events. Drug Test Anal. 2014;6(6):578-81. PubMed

Everything above comes from the Natural Medicines adverse-effect record for Methylsynephrine — expand a row for the licensed statement it rests on. We haven’t matched Zuranolone to its FDA label in our system yet, so we can’t compare its own side-effect list here — the leaflet that comes with your prescription is the authoritative list for Zuranolone.

Everything else you take

See Every Supplement That Interacts With Zuranolone

This page covers Methylsynephrine only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Zuranolone page lists 195 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: 1,4-butanediol (major), Activated Charcoal (major), Beer (major), Gamma-hydroxybutyrate (ghb) (major) and Grapefruit (major).

By severity: 9 major · 147 moderate · 39 minor.

From our pharmacist’s overview on the Zuranolone page

“Zuranolone (Zurzuvae) is a two-week pill for postpartum depression that works by quieting brain activity, and it already makes many people drowsy on its own. That is why I would treat this page with genuine care rather than a shrug.”

Reviewed by 2 · Jul 18, 2026

Open the Zuranolone interaction page

One more smart check

Taking Methylsynephrine as Part of a Dietary Supplement Product? Check It for Interactions

We hold 55 real supplement products containing Methylsynephrine, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Methylsynephrine. Even though Methylsynephrine itself has no known interaction with Zuranolone, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Methylsynephrine and Zuranolone Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Methylsynephrine
Top half

#656 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Zuranolone
Steady interest

#2,064 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Methylsynephrine reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 20, 2026. The Methylsynephrine and Zuranolone records this page draws on were last updated July 10, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Methylsynephrine

What is Methylsynephrine?

  • Weight loss and fat burning
  • Boosting energy
  • Athletic and workout performance
  • Appetite control

Methylsynephrine (also called oxilofrine) is a synthetic stimulant sometimes added to weight-loss and pre-workout products, but it is not a legal or approved dietary ingredient in the United States. It has been linked to serious heart and blood pressure problems, and there is no good evidence it is safe or effective for these uses, so it is best avoided.

Synthetic compound (also reported in some Citrus species) · Capsules, tablets, powders (mostly in weight-loss and pre-workout supplements)

An interaction check asks whether these two react with each other — it does not ask whether Methylsynephrine is a good idea for someone in your situation. Here is what our Methylsynephrine record says about it on its own.

Methylsynephrine: dosing

There is no established safe or approved dose of methylsynephrine for use as a dietary supplement, and we will not suggest one. It is not a legal supplement ingredient in the United States.Supplement labels may list it under different names (such as oxilofrine or methylsynephrine) and amounts can be inconsistent or unreliable. The safest choice is to avoid products that contain it.

From our Methylsynephrine monograph — the full record covers uses, side effects and every documented interaction.

Read the full Methylsynephrine monograph & all interactions
Medication

About Zuranolone

Most-Reported Side Effects for Zuranolone

From FAERS, the FDA’s public side-effect reporting system (1,579 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.

Somnolence 519 reports
Dizziness 304 reports
Fatigue 241 reports
Anxiety 126 reports
Sedation 118 reports
Keep checking

Other Drugs & Methylsynephrine

Browse every other medication we’ve checked against Methylsynephrine — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
191Moderate
0Minor
2,638No known interaction
191 Moderate 2,638 No interaction
Moderate

191 interactions

Showing 60 of 191 moderate interactions — see all 191 on the Methylsynephrine page.

No interaction 2,638 drugs checked — show the list

We also checked Methylsynephrine against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,638 medications checked with no known interaction — see the full Methylsynephrine list.

See the full Methylsynephrine interactions page
See every supplement checked against Zuranolone, ranked by severity
Evidence & sources

Methylsynephrine References

The 3 references that drive our Methylsynephrine monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Pawar RS, Grundel E. Overview of regulation of dietary supplements in the USA and issues of adulteration with phenethylamines (PEAs). Drug Test Anal 2017;9:500-517. PubMed
  2. Cohen PA, Avula B, Venhuis B, Travis JC, Wang YH, Khan IA. Pharmaceutical doses of the banned stimulant oxilofrine found in dietary supplements sold in the USA. Drug Test Anal. 2017;9(1):135-142. PubMed
  3. Venhuis B, Keizers P, van Riel A, de Kaste D. A cocktail of synthetic stimulants found in a dietary supplement associated with serious adverse events. Drug Test Anal. 2014;6(6):578-81. PubMed

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Methylsynephrine and Zuranolone Together: Common Questions

Is it safe to take Methylsynephrine with Zuranolone?
We do not list a known interaction between Methylsynephrine and Zuranolone. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
How was the Methylsynephrine and Zuranolone combination checked?
Interactions in our licensed database are recorded against drug classes. Zuranolone is filed under 4 classifications, and Methylsynephrine has documented interactions with 2 drug classes — none of Zuranolone's classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.
Does Methylsynephrine interact with any other medications?
Yes. Methylsynephrine has 191 documented drug interactions in our database — Zuranolone is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.
Does Zuranolone interact with any supplements?
Yes. Zuranolone has documented interactions with 195 supplements in our database — Methylsynephrine is not one of them. The Zuranolone interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Methylsynephrine monograph Uses, safety profile, and every drug interaction in one place Zuranolone supplement interactions Every supplement checked against Zuranolone, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 3 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Zuranolone and Methylsynephrine?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.