Drug & supplement interaction

Parsnip + Phenylephrine

Phenylephrine brand names: Gilchew, AH Chew D, Gilchew IR, Sudafed PE, Biorphen.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Oct 4, 2026
The bottom line No known interaction

We found no known interaction between Parsnip and Phenylephrine in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first.

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Interaction report

Parsnip and Phenylephrine

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Phenylephrine and Parsnip in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

Worth understanding: our licensed dataset holds no drug-interaction record for Parsnip at all — not against Phenylephrine, and not against any other medication we track. This verdict therefore rests on the absence of any recorded data, not on research that looked at this combination and found nothing. We cannot rule an interaction out.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Parsnip safety at a glance

Parsnip overall Use caution Safe as a food, but its leaves, sap, and seeds contain compounds that can cause skin reactions with sun exposure.
Pregnancy Use caution Fine as a normal food, but avoid concentrated supplement or medicinal amounts due to lack of safety data.
Breastfeeding Use caution Safe as a food, but the safety of medicinal or concentrated amounts is not known.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Phenylephrine and Parsnip? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
What to actually watch for

What Parsnip Itself Has Been Linked To

This is not an interaction — nothing below involves Phenylephrine. It is the side-effect record for Parsnip on its own, from the licensed Natural Medicines monograph. If something new turns up after you add Parsnip, this list is the first place to look.

  • Swelling Additional detail

    “Topically, contact dermatitis and phototoxic reactions, including skin blisters and later hyperpigmentation, have occurred following exposure to parsnip sap or fresh parsnip root and exposure to sunlight or UV-A light from a sunbed. Light-skinned people may be particularly susceptible to these reactions.

    A case report describes a 51-year-old male who developed rashes on his hands after preparing parsnip.”

    Parsnip · Natural Medicines adverse-effect record, reported in dermatitis.

    6 sources cited
    1. 10071. Ivie GW, Holt DL, Ivey MC. Natural toxicants in human foods: psoralens in raw and cooked parsnip root. Science 1981;213:909-10.. PubMed
    2. 68289. Lutchman, L., Inyang, V., and Hodgkinson, D. Phytophotodermatitis associated with parsnip picking. J.Accid.Emerg.Med. 1999;16(6):453-454. PubMed
    3. 68291. Aberer, W. Occupational dermatitis from organically grown parsnip (Pastinaca sativa L.). Contact Dermatitis 1992;26(1):62.
    4. 68295. Bang, Pedersen N. and Pla Arles, U. B. Phototoxic reaction to parsnip and UV-A sunbed. Contact Dermatitis 1998;39(2):97. PubMed
    5. 111192. White JML, Pink AE. English Sunday lunch dermatitis: Allergic contact dermatitis to parsnip, carrot, fennel (and ivy). Contact Dermatitis. 2020 Oct;83(4):317-8. PubMed
    6. 111193. Lafon A, Boulard C. Perioral phytophotodermatitis induced by parsnip mash. Contact Dermatitis. 2020 Oct;83(4):318-9. PubMed
  • A skin rash Additional detail

    “Topically, contact dermatitis and phototoxic reactions (including skin blisters) are possible following exposure to parsnip sap or fresh parsnip root and exposure to sunlight. Allergic contact dermatitis can occur but is rare.”

    Parsnip · Natural Medicines adverse-effect record, reported in dermatitis.

    4 sources cited
    1. 10071. Ivie GW, Holt DL, Ivey MC. Natural toxicants in human foods: psoralens in raw and cooked parsnip root. Science 1981;213:909-10.. PubMed
    2. 68289. Lutchman, L., Inyang, V., and Hodgkinson, D. Phytophotodermatitis associated with parsnip picking. J.Accid.Emerg.Med. 1999;16(6):453-454. PubMed
    3. 68291. Aberer, W. Occupational dermatitis from organically grown parsnip (Pastinaca sativa L.). Contact Dermatitis 1992;26(1):62.
    4. 68295. Bang, Pedersen N. and Pla Arles, U. B. Phototoxic reaction to parsnip and UV-A sunbed. Contact Dermatitis 1998;39(2):97. PubMed

Everything above comes from the Natural Medicines adverse-effect record for Parsnip — expand a row for the licensed statement it rests on. We read the ADVERSE REACTIONS section of Phenylephrine’s FDA label too, and the two lists don’t meaningfully overlap — which is why no Phenylephrine column appears here.

From our Q&A

Questions About Parsnip or Phenylephrine

These are real questions from readers, answered by the pharmacists at HelloPharmacist — written by a person, not generated from a database. Each one covers Parsnip or Phenylephrine, not necessarily both, but if one is close to what you were about to ask it will usually go further than a database entry can:

Not quite your question? Ask our pharmacists directly — it is free, there is no account required, and answers usually come back within 24 hours.

Everything else you take

See Every Supplement That Interacts With Phenylephrine

This page covers Parsnip only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Phenylephrine page lists 81 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Ephedra (major), Lithium (major), Peyote (major) and Rauvolfia Vomitoria (major).

By severity: 6 major · 60 moderate · 15 minor.

From our pharmacist’s overview on the Phenylephrine page

“If you take phenylephrine (Sudafed PE, Biorphen) for congestion, treat this list as one that needs real attention, since six of its 81 entries carry a major rating. Phenylephrine tightens blood vessels to clear your nose, and more than half of the interactions here come from stimulant ingredients, ephedra above all, that can push blood…”

Reviewed by 2 · Jul 18, 2026

Open the Phenylephrine interaction page

One more smart check

Taking Parsnip as Part of a Dietary Supplement Product? Check It for Interactions

We hold 38 real supplement products containing Parsnip, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Parsnip. Even though Parsnip itself has no known interaction with Phenylephrine, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Parsnip and Phenylephrine Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Parsnip
Steady interest

#1,173 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Phenylephrine
Top 25%

#668 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Parsnip reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified October 4, 2026. The Parsnip and Phenylephrine records this page draws on were last updated July 10, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Parsnip

What is Parsnip?

  • Digestive support
  • Mild diuretic ('water pill') effect
  • Nutritional/dietary fiber source
  • Traditional kidney and urinary support
  • General wellness

Parsnip is mainly a nutritious root vegetable that is safe and healthy as part of a normal diet. Its use as a concentrated supplement or herbal remedy is not well studied, and certain parts of the plant can make skin very sensitive to sunlight. Talk to your pharmacist or doctor before using parsnip in any medicinal or high-dose form.

Pastinaca sativa · Apiaceae · Root, leaves, seeds, and essential oil · Whole root (food), cooked vegetable, juice, dried seeds, and rarely supplements or essential oil

An interaction check asks whether these two react with each other — it does not ask whether Parsnip is a good idea for someone in your situation. Here is what our Parsnip record says about it on its own.

Parsnip: dosing

There is no established medicinal dose for parsnip. As a food, it is simply eaten as a vegetable in normal serving amounts.If you choose to use a parsnip supplement, juice, or extract, there is no standardized dose backed by research.

From our Parsnip monograph — the full record covers uses, side effects and every documented interaction.

Read the full Parsnip monograph & all interactions
Medication

About Phenylephrine

What Is Phenylephrine Used For?

Brand names: Gilchew, AH Chew D, Gilchew IR, Sudafed PE, Biorphen

Phenylephrine is used in several different products, and each one has its own use.

Injection (IV): raises blood pressure in adults with clinically important hypotension (low blood pressure) caused mainly by widened blood vessels. Some injections are labeled for anesthesia only. Others are labeled for anesthesia and septic shock.

Eye drops: Phenylephrine Hydrochloride Ophthalmic Solution is used to dilate the pupil.

Nasal products: temporarily relieve nasal and sinus congestion from the common cold, hay fever or other upper respiratory allergies.

Rectal suppositories: relieve itching, burning and discomfort from hemorrhoids and temporarily shrink hemorrhoidal tissue.

Most-Reported Side Effects for Phenylephrine

From FAERS, the FDA’s public side-effect reporting system (221,388 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.

Fatigue 20,609 reports
Headache 17,301 reports
Nausea 16,925 reports
Diarrhea 14,221 reports
Dyspnea 13,719 reports
See full Phenylephrine drug information
Keep checking

Other Drugs & Parsnip

Browse every other medication we’ve checked against Parsnip — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
0Moderate
0Minor
2,829No known interaction
2,829 No interaction
No interaction 2,829 drugs checked — show the list

We also checked Parsnip against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,829 medications checked with no known interaction — see the full Parsnip list.

See the full Parsnip interactions page
See every supplement checked against Phenylephrine, ranked by severity
Evidence & sources

Parsnip References

The 6 references that drive our Parsnip monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Ivie GW, Holt DL, Ivey MC. Natural toxicants in human foods: psoralens in raw and cooked parsnip root. Science 1981;213:909-10.. PubMed
  2. Lutchman, L., Inyang, V., and Hodgkinson, D. Phytophotodermatitis associated with parsnip picking. J.Accid.Emerg.Med. 1999;16(6):453-454. PubMed
  3. Aberer, W. Occupational dermatitis from organically grown parsnip (Pastinaca sativa L.). Contact Dermatitis 1992;26(1):62.
  4. Bang, Pedersen N. and Pla Arles, U. B. Phototoxic reaction to parsnip and UV-A sunbed. Contact Dermatitis 1998;39(2):97. PubMed
  5. White JML, Pink AE. English Sunday lunch dermatitis: Allergic contact dermatitis to parsnip, carrot, fennel (and ivy). Contact Dermatitis. 2020 Oct;83(4):317-8. PubMed
  6. Lafon A, Boulard C. Perioral phytophotodermatitis induced by parsnip mash. Contact Dermatitis. 2020 Oct;83(4):318-9. PubMed

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Parsnip and Phenylephrine Together: Common Questions

Is it safe to take Parsnip with Phenylephrine?
We do not list a known interaction between Parsnip and Phenylephrine. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Does Phenylephrine interact with any supplements?
Yes. Phenylephrine has documented interactions with 81 supplements in our database — Parsnip is not one of them. The Phenylephrine interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Parsnip monograph Uses, safety profile, and every drug interaction in one place Phenylephrine drug information The full plain-English guide to this medication Phenylephrine supplement interactions Every supplement checked against Phenylephrine, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 6 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Phenylephrine and Parsnip?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.