Phenylephrine

Name: Phenylephrine Drug Interactions
Creator: Dr. Brian Staiger, PharmD, BCPS

6 interactions

Also sold as: Biorphen Children's Sudafed PE Nasal Decongestant® Immphentiv Little Noses Decongestant Lusonal® Medicone Hemorrhoidal Mydfrin Nasop Neo-Synephrine PediaCare Children's Decongestant® Rhinall Sudafed PE Sudafed PE Congestion® Sudo-Tab Suphedrin PE® Vazculep Wal-Four Wal-Phed PE

About Phenylephrine

Phenylephrine is a nasal decongestant used to relieve nasal congestion from colds, allergies, and hay fever. Read the full Phenylephrine drug information page →

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jun 30, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Dihydroergotamine Injection Dihydroergotamine Nasal Spray Linezolid Injection Fentanyl Transdermal Patch Methylergonovine Olodaterol Oral Inhalation

3 Contraindicated 3 Major

All (6) Contraindicated (3) Major (3)

Contraindicated

Phenylephrine Dihydroergotamine Injection DHE-45® Injection Increased risk of elevation of blood pressure Details Phenylephrine Dihydroergotamine Nasal Spray Migranal Increased risk of elevation of blood pressure Details Phenylephrine Linezolid Injection Zyvox Increased blood pressure Details

Major

Phenylephrine Fentanyl Transdermal Patch Duragesic® Reduced analgesic effect Details Phenylephrine Methylergonovine Methergine Additive hypertensive effects Details Phenylephrine Olodaterol Oral Inhalation Striverdi An increased risk of clinically significant cardiovascular effects and fatalities and an increased/potentiated sympathetic effects... Details

Check another drug

Still have questions about this combination?

Every question gets a real answer from a licensed pharmacist — free, and usually within a day.

Ask the pharmacist

Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.