Drug & supplement interaction

Picrorhiza + Natalizumab

Natalizumab brand name: Tysabri.

Moderate Interaction
Medically reviewed by · Updated September 2026
The bottom line Moderate

Picrorhiza has a moderate interaction with Natalizumab. Picrorhiza seems to have immunostimulating activity.

Read the full interaction report
SeverityModerate
LikelihoodPossible
EvidenceD
What do Severity, Likelihood & Evidence mean?
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Interaction report

Picrorhiza and Natalizumab

Here is the interaction we found between these two, with the evidence behind it.

Moderate

IMMUNOSUPPRESSANTS

Why this applies to Natalizumab

Natalizumab falls under IMMUNOSUPPRESSANTS — the group Picrorhiza interacts with.

Picrorhiza seems to have immunostimulating activity. Theoretically, picrorhiza may interfere with immunosuppressant therapy. Immunosuppressant drugs include azathioprine (Imuran), basiliximab (Simulect), cyclosporine (Neoral, Sandimmune), daclizumab (Zenapax), muromonab-CD3 (OKT3, Orthoclone OKT3), mycophenolate (CellCept), tacrolimus (FK506, Prograf), sirolimus (Rapamune), prednisone (Deltasone, Orasone), and other corticosteroids (glucocorticoids).
Severity Moderate Likelihood Possible Evidence D

Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.

Dr. Brian Staiger, PharmD, BCPS
Dr. Brian Staiger explains PharmD, Clinical Pharmacist

Here's the concern in plain terms. Natalizumab (Tysabri) works by calming down part of your immune system to keep multiple sclerosis flares in check. Picrorhiza appears to do the opposite, gently revving the immune system up. On paper, that means it could push against what Tysabri is trying to accomplish, possibly making your MS treatment less reliable over time.

I want to be honest about the evidence here. This is a theoretical interaction based only on lab and animal work, not real-world reports in people taking Tysabri. So I'm not raising alarms. Still, because MS treatment is something you don't want to undercut, I'd skip the picrorhiza supplement unless your neurologist or pharmacist gives you the green light. Always loop them in first.

Contact Dr. Brian directly if you have additional questions on this interaction
References
  1. Sharma ML, Rao CS, Duda PL. Immunostimulatory activity of Picrorhiza kurroa leaf extract. J Ethnopharmacol 1994;41:185-92. PubMed
  2. Baruah CC, Gupta PP, Nath A, et al. Anti-allergic and anti-anaphylactic activity of picroliv--a standardised iridoid glycoside fraction of Picrorhiza kurroa. Pharmacol Res 1998;38:487-92.

What These Ratings Mean

Every interaction above is graded three ways — here’s the key to each label.

Severity how clinically significant the interaction is
Major

Clinically significant. Avoid the combination, or use only under close professional supervision.

Moderate

Usually worth avoiding or managing — may need monitoring, a dose change, or timing apart.

Minor

Generally not serious. Be aware of it and mention it to your pharmacist.

Likelihood how strong the evidence is that the interaction actually happens in people
  • LikelyWell-controlled human studies have demonstrated the likely existence of this interaction.
  • ProbableInteraction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • PossibleInteraction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.
  • UnlikelyInteraction has been demonstrated in animal or in lab research but has been shown not to occur in humans.
Evidence the quality of the studies behind the rating (graded A–D)
  • AHigh-quality meta-analysis (quantitative systematic review).
  • BCase-control study.
  • CConsensus.
  • DAnecdotal evidence.

These ratings are for information only. Never start, stop, or otherwise change your therapy before speaking with your provider.

Keep it in perspective

Picrorhiza Also Interacts With Other Medications

Picrorhiza has 206 moderate known drug interactions in our database — the Natalizumab one above is one of them. If you take anything else, check it against the full list below.

Moderate 206 No known interaction 2,624 (incl. Natalizumab)
Taking anything else?

Check Another of Your Medications Against Picrorhiza

Covers the 2,830 medications we’ve checked against Picrorhiza. Pick one to open its full report.

Everything else you take

See Every Supplement That Interacts With Natalizumab

This page covers Picrorhiza only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Natalizumab page lists 70 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Active Hexose Correlated Compound (ahcc) (moderate), Alfalfa (moderate), American Ginseng (moderate) and Andrographis (moderate).

By severity: 1 major · 59 moderate · 10 minor.

From our pharmacist’s overview on the Natalizumab page

“Natalizumab (Tysabri) works by quieting an overactive immune system in multiple sclerosis and Crohn's disease, and that is exactly why this list of 70 supplements deserves real care rather than a shrug. Fifty-three of them, ashwagandha among the familiar names, are believed to stimulate immune function, which could work directly agains…”

Reviewed by 2 · Jul 18, 2026

Open the Natalizumab interaction page

One more smart check

Taking Picrorhiza as Part of a Dietary Supplement Product? Check It for Interactions

We hold 177 real supplement products containing Picrorhiza, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Picrorhiza. Your product may carry other ingredients that interact with Natalizumab too, on top of Picrorhiza — and those would not show on this page. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Picrorhiza and Natalizumab Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Picrorhiza
Top 25%

#302 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Natalizumab
Steady interest

#1,518 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Supplement

About Picrorhiza

What is Picrorhiza?

  • Liver support
  • Digestive complaints
  • Asthma and breathing problems
  • Skin conditions
  • Fever
  • Immune support

Picrorhiza (Picrorhiza kurroa) is a bitter Himalayan herb used in Ayurvedic medicine, mainly for liver and digestive complaints. Early lab and small human studies suggest possible liver-protective and anti-inflammatory effects, but high-quality evidence is limited. Talk with your pharmacist or doctor before using it, and avoid it during pregnancy and breastfeeding.

Read the full Picrorhiza monograph & all interactions
Medication

About Natalizumab Injection

What Is Natalizumab Injection Used For?

Brand name: Tysabri

Tysabri is approved for adults with relapsing forms of multiple sclerosis — including clinically isolated syndrome, relapsing-remitting disease, and active secondary progressive disease. It is used as a solo therapy (monotherapy) for MS, not combined with other disease-modifying drugs.

Tysabri is also approved to induce and maintain remission in adults with moderately to severely active Crohn's disease when standard treatments and TNF-alpha inhibitors have not worked or cannot be tolerated. In Crohn's disease, it must not be combined with immunosuppressants or TNF-alpha inhibitors.

See full Natalizumab Injection drug information
Keep checking

Other Drugs & Picrorhiza

Browse every other medication we’ve checked against Picrorhiza — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
206Moderate
0Minor
2,623No known interaction
206 Moderate 2,623 No interaction
Moderate

206 interactions

Showing 60 of 206 moderate interactions — see all 206 on the Picrorhiza page.

No interaction 2,623 drugs checked — show the list

We also checked Picrorhiza against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,623 medications checked with no known interaction — see the full Picrorhiza list.

See the full Picrorhiza interactions page
See every supplement checked against Natalizumab, ranked by severity
Sources

Sources & How We Checked

Interaction details are evidence-graded and sourced from the Natural Medicines database. The medication overview comes from MedlinePlus.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Keep exploring
Picrorhiza monograph › Uses, safety, and every drug interaction in one place Natalizumab supplement interactions › Every supplement checked against Natalizumab, ranked by severity Natalizumab Injection drug information › The full plain-English guide to this medication Supplement interaction checker › Check any supplement or product against your medications Browse medications A–Z › Every drug we've checked against herbs & supplements Ask a pharmacist › Free, personal answer from our licensed team
Pharmacist Counseling Corner

Taking Picrorhiza and Natalizumab Together: Common Questions

Can you take Picrorhiza with Natalizumab?
There is a moderate interaction, so it may be acceptable with monitoring or timing changes — but check with your pharmacist first. Read the full details on this page and confirm with your pharmacist before combining them.
How serious is the Picrorhiza and Natalizumab interaction?
We rate it Moderate. This combination may require monitoring, a dose adjustment, or separating the times you take each one. Consult your pharmacist before using them together.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Still Have a Question About Natalizumab and Picrorhiza?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.