Medication interaction hub

What Supplements Interact with Natalizumab?

Natalizumab brand name: Tysabri. Every interaction below applies to the brands too.

70 Interactions 1 Major 59 Moderate 10 Minor
Curated & coded by · Clinical Pharmacist · Updated September 24, 2026

Drug–supplement interaction data sourced from Natural Medicines Pro, the licensed clinical database from TRC Healthcare / Therapeutic Research, with additional analysis by the HelloPharmacist Pharmacist Team. Our sources · Editorial policy

What is this page for?

One answer, for one medication: what supplements and herbal products interact with Natalizumab? Every vitamin, herb, and supplement ingredient we’ve checked against it is on this page, ranked by severity, each linking to the full report for that exact pair.

This page covers supplement interactions only — to check Natalizumab against your other medications, use the drug–drug interaction checker. Educational information from our licensed clinical databases, not medical advice. Our editorial policy

HelloPharmacist Bottom Line
Our Pharmacist Explains
What is this? The interaction data in the HelloPharmacist supplement database is licensed from Natural Medicines Pro by TRC Healthcare (Therapeutic Research). HelloPharmacist pharmacists often add our own analysis and context on top of that licensed data — such as this Bottom Line summary and the notes on individual interaction pages — and any such commentary is noted as ours.

Natalizumab (Tysabri) works by quieting an overactive immune system in multiple sclerosis and Crohn's disease, and that is exactly why this list of 70 supplements deserves real care rather than a shrug. Fifty-three of them, ashwagandha among the familiar names, are believed to stimulate immune function, which could work directly against what the drug is trying to do. The single major-rated entry is activated charcoal, which can lower the body's exposure to many medicines, including some that are not even taken by mouth.

The rest of the entries mostly change how oral medicines are absorbed, bulky fibers like glucomannan and various charcoals that can trap pills in the gut, so keep those well separated from any tablets you take alongside your infusions. Fifty-nine of the 70 rate moderate and ten minor, and much of the evidence is early, from lab or animal work. Even so, for a drug whose entire purpose is dialing immunity down, a daily immune-boosting supplement is the quiet contradiction I would sort out first.

— , Clinical Pharmacist · July 18, 2026

Major 1 Moderate 59 Minor 10 No known interaction 1,382

This box checks one ingredient at a time (like turmeric or magnesium). Taking a supplement product with a whole label of ingredients? Search the product instead — we check every ingredient on it ↓

Top Ingredient Interactions

Natalizumab: Top Interactions at a Glance

The most significant Natalizumab supplement & herbal interactions, colored by severity. Tap any ingredient to open the full report for that pair.

Showing the 12 highest-ranked of 70 interacting ingredients — plus 1,382 more checked with no known interaction. See the complete ranked list.

Start here

The Major Interactions to Know About

The most clinically significant Natalizumab + supplement combinations in our database, best-documented first. Open any card for the full report.

Major Likelihood Probable Activated Charcoal + Natalizumabi

Activated charcoal reduces systemic exposure to many drugs, including those that undergo enterohepatic recirculation, regardless of the route of administration.

Read the full interaction
The complete list

Every Supplement Checked Against Natalizumab

All 1,452 ingredients in our database, ranked by severity — 70 with a Natalizumab interaction on file and 1,382 with none found. Filter by severity or search any ingredient; hover the for what each ingredient is.

Looking for an interaction with a specific supplement product? Search products instead ↓

Straight answers

Can You Take It With Natalizumab?

One-line answers, one card per combination — scroll through today’s 20 and tap any card for the full report. A different set rotates in daily until every combination has had its turn.

Can you take Jiaogulan with Natalizumab?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, jiaogulan might decrease the effectiveness of immunosuppressive therapy.

Full Jiaogulan + Natalizumab answer

Can you take Bupleurum with Natalizumab?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, bupleurum might decrease the effects of immunosuppressants.

Full Bupleurum + Natalizumab answer

Can you take Cat's Claw with Natalizumab?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, cat's claw might interfere with immunosuppressive therapy.

Full Cat's Claw + Natalizumab answer

Can you take Catechu with Natalizumab?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, catechu might interfere with immunosuppressant therapy.

Full Catechu + Natalizumab answer

Can you take Ceylon Leadwort with Natalizumab?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Plumbagin, a constituent of Ceylon leadwort, has demonstrated immunosuppressant activity in animal research.

Full Ceylon Leadwort + Natalizumab answer

Can you take Chaga with Natalizumab?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, chaga might interfere with immunosuppressive therapy.

Full Chaga + Natalizumab answer

Can you take Cordyceps with Natalizumab?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concurrent use of cordyceps might interfere with immunosuppressive therapy.

Full Cordyceps + Natalizumab answer

Can you take Echinacea with Natalizumab?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Echinacea has immunostimulant activity which may interfere with immunosuppressant therapy.

Full Echinacea + Natalizumab answer

Can you take Elderberry with Natalizumab?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, elderberry might interfere with immunosuppressant therapy due to its immunostimulant activity.

Full Elderberry + Natalizumab answer

Can you take Eleuthero with Natalizumab?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, eleuthero might interfere with immunosuppressive drugs because of its immunostimulant activity.

Full Eleuthero + Natalizumab answer

Can you take European Mistletoe with Natalizumab?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, European mistletoe might decrease the effectiveness of immunosuppressants.

Full European Mistletoe + Natalizumab answer

Can you take Fermented Milk with Natalizumab?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, fermented milk might decrease the effects of immunosuppressants.

Full Fermented Milk + Natalizumab answer

Can you take Fermented Wheat Germ Extract with Natalizumab?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, fermented wheat germ extract might decrease the effects of immunosuppressants.

Full Fermented Wheat Germ Extract + Natalizumab answer

Can you take Fulvic Acid with Natalizumab?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking fulvic acid might decrease the effects of immunosuppressive therapy.

Full Fulvic Acid + Natalizumab answer

Can you take Galacto-oligosaccharides (gos) with Natalizumab?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, GOS might reduce the effects of immunosuppressants.

Full Galacto-oligosaccharides (gos) + Natalizumab answer

Can you take Glyconutrients with Natalizumab?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Evidence from in vitro research suggests that glyconutrients stimulate certain immune responses.

Full Glyconutrients + Natalizumab answer

Can you take Greater Celandine with Natalizumab?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Preliminary clinical research suggests that taking a specific semi-synthetic derivative of the greater celandine constituent chelidonine (Uk...

Full Greater Celandine + Natalizumab answer

Can you take Guar Gum with Natalizumab?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Guar gum might reduce the absorption of some oral drugs, potentially decreasing their effectiveness.

Full Guar Gum + Natalizumab answer

Can you take Gum Arabic with Natalizumab?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, gum arabic can alter the absorption of oral drugs due to its fiber content.

Full Gum Arabic + Natalizumab answer

Can you take Ipriflavone with Natalizumab?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Concurrent use of ipriflavone and immunosuppressant drugs might have additive effects on inhibiting immune function.

Full Ipriflavone + Natalizumab answer
Read the list like a pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

  • Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
  • Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
  • Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
  • No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

  • Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
  • Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
  • Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

  • Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
  • Each entry links to a full report with the clinical detail, likelihood, evidence level, and citations for that exact combination.
  • Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

How Does Our Interaction Checker Work?

Behind every verdict on this page is a category system. Our source database doesn’t document supplement interactions drug-by-drug — it documents them against groups of medications that behave the same way (for example, “drugs processed by the CYP3A4 liver enzyme” or “blood-thinning medications”).

So the check works in three steps: (1) Natalizumab is classified into the pharmacology categories it belongs to, (2) every supplement interaction documented against any of those categories is inherited by Natalizumab, and (3) each ingredient keeps its own severity, likelihood, and evidence grades from the underlying record. That’s why one supplement can carry several records for one drug — it may interact through more than one category.

Natalizumab sits in 2 interaction categories. Open any one to see what the group means:

Immunosuppressants 53 ingredients

Medications that damp down the immune system. Supplements that stimulate immunity can work against them.

53 of the supplement ingredients on this page reach Natalizumab through this category.

Oral Drugs 17 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

17 of the supplement ingredients on this page reach Natalizumab through this category.

About Natalizumab

Natalizumab injection (Tysabri) is used to treat relapsing forms of multiple sclerosis and moderately to severely active Crohn's disease.

Generic name: Natalizumab  ·  Brand name: Tysabri.

See the full Natalizumab Injection drug information
Check a real product

Take a Supplement Product? Check the Whole Bottle Against Natalizumab

Most supplements are combination products — and the interaction may come from an ingredient you didn’t buy it for. Search any product below (or scan its label) and we’ll check every ingredient on it against Natalizumab.

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Pharmacist Counseling Corner

Natalizumab & Supplements: Common Questions

What supplements interact with Natalizumab?
In our interaction database, 70 supplement and herbal ingredients have an interaction with Natalizumab on file — 1 rated major, 59 moderate, and 10 minor. That number sounds scarier than it is: severity matters far more than the count, which is why the list on this page is ranked instead of alphabetical. Start at the top. The highest-ranked right now: Activated Charcoal, Coffee Charcoal, European Mandrake.
Which Natalizumab supplement interactions are the most serious?
The 1 major-rated combination — led by Activated Charcoal — deserve real caution: these are the ones generally best avoided, or used only with your prescriber watching. If you take any of them today, don't panic and don't stop anything abruptly — call your pharmacist first. Jump to the ranked list.
Can I take vitamins or supplements while on Natalizumab?
That depends entirely on which supplement. The honest answer for Natalizumab is in the ranked list above — and if what you take is a combination product with a dozen ingredients, don't check them one by one: photograph the label with our scanner and we'll check the whole thing at once. Try the label scanner or the interaction checker.
Do brands like Tysabri have the same supplement interactions as Natalizumab?
Yes — Tysabri all contain Natalizumab, so everything on this page applies to them equally. Interactions belong to the active drug, never to the brand on the box; the same is true of generics.
Where do these interaction ratings come from?
Every rating comes from the Natural Medicines database — the same evidence-graded reference pharmacists and hospitals use — and each interaction carries three separate grades: severity (how bad it can be), likelihood (how well it's documented in studies and case reports), and an evidence level. Our pharmacists review the content; we never let an AI decide an interaction. See how to read the ratings and our editorial policy.
What about Natalizumab and my other medications?
This page covers Natalizumab against supplements and herbal ingredients. Checking Natalizumab against your other prescription or OTC medications is a different tool — our drug interaction checker covers that side. Head to the drug–drug interaction checker, or read the full Natalizumab Injection drug information.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

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Sourcing

Where This Data Comes From — and Why You Can Trust It

🧪 Licensed clinical database

Every interaction verdict on this page comes from Natural Medicines Pro (TRC Healthcare / Therapeutic Research) — the same evidence-graded reference used by pharmacists and hospitals. We license this data directly; we do not scrape it, and no AI invents an interaction.

🧑‍⚕️ Pharmacist review

This page is curated and coded by , Clinical Pharmacist, with additional analysis by the HelloPharmacist Pharmacist Team. Editorial commentary is ours; the licensed interaction records are shown as sourced.

🔄 Kept current

Our interaction database refreshes on a weekly cycle, and this page re-checks the live database every time it’s rebuilt — what you see reflects the database as of September 24, 2026.

🔍 Full transparency

How every dataset on this site is sourced, licensed, and updated is documented publicly: our data sources · editorial policy · how we use AI.

Educational information, not medical advice. An interaction being on file does not mean it will happen to you — and absence of one is not proof of safety. Never start or stop a medication or supplement without talking to your pharmacist or doctor.