Drug & supplement interaction

Pomegranate + Difluprednate

Difluprednate brand name: Durezol.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 13, 2026
The bottom line No known interaction

We found no known interaction between Pomegranate and Difluprednate in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the two are separately associated with some of the same side effects, which would make a new symptom harder to attribute to one or the other.

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Interaction report

Pomegranate and Difluprednate

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Difluprednate and Pomegranate in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Pomegranate safety at a glance

Pomegranate overall Generally safe Pomegranate fruit and juice are generally safe for most people as food.
Pregnancy Possibly Safe When the fruit or fruit juice is consumed orally and appropriately. There is insufficient reliable information available regarding the safety of using other for... Read the full pregnancy detail
Breastfeeding Possibly Safe When the fruit or fruit juice is consumed orally and appropriately. There is insufficient reliable information available regarding the safety of using other for... Read the full breastfeeding detail

Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center) — the full detail is in the Special populations card below. Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Pharmacist analysis

Pomegranate (and pomegranate extract) has several potential drug interactions that should be taken into consideration.

Primarily, pomegranate can affect drugs metabolized by CYP2C9, CYP2D6, and CYP3A4 enzymes. This accounts for a very large proportion of the drug interactions associated with pomegranate.

Pomegranate also may have mild antihypertensive effects, potentially increasing the risk of adverse effects and hypotension when used with other drugs that lower blood pressure.

Although there is no interaction noted between pomegranate and the drug in question, as always, it is recommended to speak with your doctor before adding on any new medications or supplements so you can be appropraitely monitored.

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Still wondering about combining Difluprednate and Pomegranate? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
Keep it in perspective

Pomegranate Does Interact With Other Medications

Pomegranate has 355 moderate, 567 minor known drug interactions in our database — Difluprednate isn’t one of them. If you take anything else, check it against the full list below.

Moderate 355 Minor 567 No known interaction 1,908 (incl. Difluprednate)
Taking anything else?

Check Another of Your Medications Against Pomegranate

Covers the 2,830 medications we’ve checked against Pomegranate. Pick one to open its full report.

What to actually watch for

No Interaction Found — But Data Suggests Pomegranate and Difluprednate May Share a Side Effect

This is not an interaction. Neither one changes how your body handles the other, and nothing here says they react together. What our sources do show is that each has separately been linked to the effects below — so taking both can make those effects more likely to turn up, and harder to pin on one or the other if they do.

  • Swelling Additional detail

    Pomegranate

    “Orally, pomegranate fruit or seeds may cause allergic reactions. These allergic reactions occur more commonly in people who are allergic to other plants. In rare cases, pomegranate fruit can cause angioedema. Angioedema seems to occur without warning and in people who have eaten pomegranate for many years. Patients should be told to stop eating pomegranate if swelling of the tongue or face develops.”

    Pomegranate · Natural Medicines adverse-effect record, reported in hypotension.

    5 sources cited
    1. 7674. Gaig P, Bartolome B, Lleonart R, et al. Allergy to pomegranate (Punica granatum). Allergy 1999;54:287-8.
    2. 7673. Igea JM, Cuesta J, Cuevas M, et al. Adverse reaction to pomegranate ingestion. Allergy 1991;46:472-4. DOI
    3. 17331. Gangemi S, Mistrello G, Roncarolo D, et al. Pomegranate-dependent exercise-induced anaphylaxis. J Investig Allergol Clin Immunol 2008;18:491-2.
    4. 91692. Enrique E, Utz M, De Mateo JA, et al. Allergy to lipid transfer proteins: cross-reactivity among pomegranate, hazelnut, and peanut. Ann Allergy Asthma Immunol 2006;96(1):122-3. PubMed
    5. 8445. Valsecchi R, Reseghetti A, Leghissa P, et al. Immediate contact hypersensitivity to pomegranate. Contact Dermatitis 1998;38:44-5. PubMed

    Difluprednate

    Listed in the ADVERSE REACTIONS section of the FDA label for Difluprednate. Read the label on DailyMed ›

Reported for Pomegranate but not commonly for Difluprednate: stomach upset, an allergic reaction, stomach pain and constipation.

Effects for Difluprednate come from the ADVERSE REACTIONS section of its FDA label; effects for Pomegranate come from the Natural Medicines adverse-effect record, quoted above. Where a percentage is shown, it is the share of 830 voluntary FDA FAERS reports for Difluprednate that mention that effect — a reporting proportion, not an incidence rate and not evidence the drug caused it. Wording is matched across sources by our own clinical vocabulary, so treat this as a prompt to pay attention, not a diagnosis.

Special populations

Pomegranate in Pregnancy & Breastfeeding

Pregnancy And Lactation Possibly Safe

When the fruit or fruit juice is consumed orally and appropriately. There is insufficient reliable information available regarding the safety of using other forms of pomegranate or other parts of the plant during pregnancy or lactation; avoid using.

DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.© 2026 Therapeutic Research Center

From our Q&A

Questions About Pomegranate or Difluprednate

These are real questions from readers, answered by the pharmacists at HelloPharmacist — written by a person, not generated from a database. Each one covers Pomegranate or Difluprednate, not necessarily both, but if one is close to what you were about to ask it will usually go further than a database entry can:

Not quite your question? Ask our pharmacists directly — it is free, there is no account required, and answers usually come back within 24 hours.

One more smart check

Taking Pomegranate as Part of a Dietary Supplement Product? Check It for Interactions

We hold 4,607 real supplement products containing Pomegranate, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Pomegranate. Even though Pomegranate itself has no known interaction with Difluprednate, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Pomegranate and Difluprednate Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Pomegranate
Top 5%

#56 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Difluprednate
Top half

#1,106 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Pomegranate reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 13, 2026. The Pomegranate and Difluprednate records this page draws on were last updated July 10, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Pomegranate

What is Pomegranate?

Pomegranate
  • Heart and blood vessel health
  • Antioxidant support
  • High blood pressure
  • Inflammation
  • Digestive upset
  • Skin health

Pomegranate is a nutrient-rich fruit that is high in antioxidants and is widely enjoyed as food and juice. Early research suggests it may support heart health and blood pressure, but the evidence is still limited and not strong enough to call it a proven treatment. As a food it is generally safe, but talk to your pharmacist or doctor before using concentrated extracts, especially if you are pregnant, breastfeeding, or take medications.

Punica granatum · Lythraceae · Fruit, juice, seeds (arils), peel/rind, flower, and leaf · Fresh fruit, juice, extract capsules, powder, tea, and topical products

An interaction check asks whether these two react with each other — it does not ask whether Pomegranate is a good idea for someone in your situation. Here is what our Pomegranate record says about it on its own.

Pomegranate: dosing

There is no single established standard dose for pomegranate. In studies, amounts have varied widely depending on whether the fruit, juice, or extract was used.If you use a pomegranate supplement, follow the directions on the product label and do not exceed the recommended amount.

From our Pomegranate monograph — the full record covers uses, side effects and every documented interaction.

Read the full Pomegranate monograph & all interactions
Medication

About Difluprednate Ophthalmic

What Is Difluprednate Ophthalmic Used For?

Brand name: Durezol

Difluprednate ophthalmic emulsion is used for two main purposes. First, it treats inflammation and pain that occur after ocular (eye) surgery. Second, it treats endogenous anterior uveitis — inflammation of the front part of the inside of the eye that originates from within the body rather than from an outside infection.

Most-Reported Side Effects for Difluprednate

From FAERS, the FDA’s public side-effect reporting system (830 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.

Eye pain 40 reports
Fatigue 31 reports
Diarrhea 30 reports
Headache 30 reports
Eye irritation 29 reports
See full Difluprednate Ophthalmic drug information
Keep checking

Other Drugs & Pomegranate

Browse every other medication we’ve checked against Pomegranate — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
355Moderate
567Minor
1,907No known interaction
355 Moderate 567 Minor 1,907 No interaction
Moderate

355 interactions

Showing 60 of 355 moderate interactions — see all 355 on the Pomegranate page.

Minor

567 interactions

Showing 60 of 567 minor interactions — see all 567 on the Pomegranate page.

No interaction 1,907 drugs checked — show the list

We also checked Pomegranate against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 1,907 medications checked with no known interaction — see the full Pomegranate list.

See the full Pomegranate interactions page
See every supplement checked against Difluprednate, ranked by severity
Evidence & sources

Pomegranate References

The 27 references that drive our Pomegranate monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Igea JM, Cuesta J, Cuevas M, et al. Adverse reaction to pomegranate ingestion. Allergy 1991;46:472-4. DOI
  2. Gaig P, Bartolome B, Lleonart R, et al. Allergy to pomegranate (Punica granatum). Allergy 1999;54:287-8.
  3. Aviram M, Dornfeld L. Pomegranate juice consumption inhibits serum angiotensin converting enzyme activity and reduces systolic blood pressure. Atherosclerosis 2001;158:195-8. PubMed
  4. Valsecchi R, Reseghetti A, Leghissa P, et al. Immediate contact hypersensitivity to pomegranate. Contact Dermatitis 1998;38:44-5. PubMed
  5. Esmaillzadeh A, Tahbaz F, Gaieni I, et al. Concentrated pomegranate juice improves lipid profiles in diabetic patients with hyperlipidemia. J Med Food 2004;7:305-8. PubMed
  6. Aviram M, Rosenblat M, Gaitini D, et al. Pomegranate juice consumption for 3 years by patients with carotid artery stenosis reduces common carotid intima-media thickness, blood pressure and LDL oxidation. Clin Nutr 2004;23:423-33. DOI
  7. Hidaka M, Okumura M, Fujita K, et al. Effects of pomegranate juice on human cytochrome p450 3A (CYP3A) and carbamazepine pharmacokinetics in rats. Drug Metab Dispos 2005;33:644-8. PubMed
  8. Loren DJ, Seeram NP, Schulman RN, Holtzman DM. Maternal dietary supplementation with pomegranate juice is neuroprotective in an animal model of neonatal hypoxic-ischemic brain injury. Pediatr Res 2005;57:858-64. PubMed
  9. Kim ND, Mehta R, Yu W, et al. Chemopreventive and adjuvant therapeutic potential of pomegranate (Punica granatum) for human breast cancer. Breast Cancer Res Treat 2002;71:203-17. PubMed
  10. Sorokin AV, Duncan B, Panetta R, Thompson PD. Rhabdomyolysis associated with pomegranate juice consumption. Am J Cardiol 2006;98:705-6. PubMed
  11. Farkas D, Oleson LE, Zhao Y, et al. Pomegranate juice does not impair clearance of oral or intravenous midazolam, a probe for cytochrome P450-3A activity: comparison with grapefruit juice. J Clin Pharmacol 2007;47:286-94. PubMed
  12. Yeo C, Shon J, Liu K, et al. The effects of pomegranate juice on the pharmacokinetics of simvastatin in healthy Korean subjects (PI-63). Clin Pharmacol Ther 2006;79:23.
  13. Farkas D, Greenblatt DJ. Influence of fruit juices on drug disposition: discrepancies between in vitro and clinical studies. Expert Opin Drug Metab Toxicol 2008;4:381-93.
  14. Nagata M, Hidaka M, Sekiya H, et al. Effects of pomegranate juice on human cytochrome P450 2C9 and tolbutamide pharmacokinetics in rats. Drug Metab Dispos 2007;35:302-5. PubMed
  15. Komperda KE. Potential interaction between pomegranate juice and warfarin. Pharmacotherapy 2009;29:1002-6. PubMed

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Pomegranate and Difluprednate Together: Common Questions

Is it safe to take Pomegranate with Difluprednate?
We do not list a known interaction between Pomegranate and Difluprednate. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Do Pomegranate and Difluprednate have any of the same side effects?
Yes — our sources link each of them separately to one of the same effects. That is not an interaction: neither changes how your body handles the other. It does mean that if one of those effects turns up, it can be harder to tell which one is behind it. They are listed on this page with the source behind each.
Does Pomegranate interact with any other medications?
Yes. Pomegranate has 922 documented drug interactions in our database — Difluprednate is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Pomegranate monograph Uses, safety profile, and every drug interaction in one place Difluprednate Ophthalmic drug information The full plain-English guide to this medication Difluprednate supplement interactions Every supplement checked against Difluprednate, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 27 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Difluprednate and Pomegranate?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.