Drug & supplement interaction

Pregnenolone + Atovaquone, Proguanil

Atovaquone, Proguanil brand name: Malarone.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 13, 2026
The bottom line No known interaction

We found no known interaction between Pregnenolone and Atovaquone, Proguanil in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the label for Atovaquone, Proguanil states a food rule worth keeping to, and the two are separately associated with some of the same side effects, which would make a new symptom harder to attribute to one or the other.

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Interaction report

Pregnenolone and Atovaquone, Proguanil

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Atovaquone, Proguanil and Pregnenolone in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Pregnenolone safety at a glance

Pregnenolone overall Use caution It is a hormone with limited human safety data, so use only under guidance from a healthcare professional.
Pregnancy Avoid Hormone supplements should be avoided during pregnancy due to unknown risks.
Breastfeeding Avoid Not enough safety information exists, so avoid while breastfeeding.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Atovaquone, Proguanil and Pregnenolone? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
How we checked

Why No Interaction Is Listed for Atovaquone, Proguanil

Interactions in our licensed database are recorded against drug classes, not just single drug names. Atovaquone, Proguanil is filed under 3 classifications — cytochrome p450 2c19 (cyp2c19) substrates, seizure threshold lowering drugs, oral drugs. Pregnenolone has documented interactions with 5 drug classes — the most serious being benzodiazepines (moderate), estrogens (moderate) and progesterone (moderate) — and none of Atovaquone, Proguanil’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

Pregnenolone Does Interact With Other Medications

Pregnenolone has 82 moderate known drug interactions in our database — Atovaquone, Proguanil isn’t one of them. If you take anything else, check it against the full list below.

Moderate 82 No known interaction 2,748 (incl. Atovaquone, Proguanil)
Taking anything else?

Check Another of Your Medications Against Pregnenolone

Covers the 2,830 medications we’ve checked against Pregnenolone. Pick one to open its full report.

What to actually watch for

No Interaction Found — But Data Suggests Pregnenolone and Atovaquone, Proguanil May Share Several of the Same Side Effects

This is not an interaction. Neither one changes how your body handles the other, and nothing here says they react together. What our sources do show is that each has separately been linked to the effects below — so taking both can make those effects more likely to turn up, and harder to pin on one or the other if they do.

  • Reduced appetite Additional detail

    Pregnenolone

    “Orally, pregnenolone has been reported to cause depressive affect and increased appetite. Increased excitement, agitation, increased motor activity, and anorexia have also been reported; however, it is not certain if these effects were due to pregnenolone.”

    Pregnenolone · Natural Medicines adverse-effect record, reported in anorexia.

    2 sources cited
    1. 94026. Fung LK, Libove RA, Phillips J, Haddad F, Hardan AY.Brief report: an open-label study of the neurosteroid pregnenolone in adults with autism spectrum disorder. J Autism Dev Disord 2014;44(11):2971-7. PubMed
    2. 94031. Meieran SE, Reus VI, Webster R, Shafton R, Wolkowitz OM. Chronic pregnenolone effects in normal humans: attenuation of benzodiazepine-induced sedation. Psychoneuroendocrinology 2004;29(4):486-500. PubMed

    Atovaquone, Proguanil

    Listed in the ADVERSE REACTIONS section of the FDA label for Atovaquone, Proguanil. Read the label on DailyMed ›

  • Tiredness Additional detail

    Pregnenolone

    “Orally, pregnenolone has been reported to cause restlessness, tiredness, sweating, and a case of cold extremities. Sleep problems, drowsiness, and tremor have also been reported; however, it not certain if these effects were due to pregnenolone.”

    Pregnenolone · Natural Medicines adverse-effect record, reported in common cold.

    3 sources cited
    1. 94026. Fung LK, Libove RA, Phillips J, Haddad F, Hardan AY.Brief report: an open-label study of the neurosteroid pregnenolone in adults with autism spectrum disorder. J Autism Dev Disord 2014;44(11):2971-7. PubMed
    2. 94032. Marx CE, Keefe RS, Buchanan RW, et al. Proof-of-concept trial with the neurosteroid pregnenolone targeting cognitive and negative symptoms in schizophrenia. Neuropsychopharmacology 2009;34(8):1885-903. PubMed
    3. 94031. Meieran SE, Reus VI, Webster R, Shafton R, Wolkowitz OM. Chronic pregnenolone effects in normal humans: attenuation of benzodiazepine-induced sedation. Psychoneuroendocrinology 2004;29(4):486-500. PubMed

    Atovaquone, Proguanil

    Listed in the ADVERSE REACTIONS section of the FDA label for Atovaquone, Proguanil. Read the label on DailyMed ›

  • Diarrhea Additional detail

    Pregnenolone

    “Orally, pregnenolone may cause diarrhea. Constipation has also been reported after oral use; however, it is not certain if this effect was due to pregnenolone.”

    Pregnenolone · Natural Medicines adverse-effect record, reported in constipation.

    1 source cited
    1. 94026. Fung LK, Libove RA, Phillips J, Haddad F, Hardan AY.Brief report: an open-label study of the neurosteroid pregnenolone in adults with autism spectrum disorder. J Autism Dev Disord 2014;44(11):2971-7. PubMed

    Atovaquone, Proguanil

    Listed in the ADVERSE REACTIONS section of the FDA label for Atovaquone, Proguanil. Read the label on DailyMed ›

Reported for Pregnenolone but not commonly for Atovaquone, Proguanil: sun sensitivity, increased appetite, constipation and anxiety or restlessness.

Effects for Atovaquone, Proguanil come from the ADVERSE REACTIONS section of its FDA label; effects for Pregnenolone come from the Natural Medicines adverse-effect record, quoted above. Wording is matched across sources by our own clinical vocabulary, so treat this as a prompt to pay attention, not a diagnosis.

How to take them

Some Atovaquone, Proguanil Products Have a Food Rule — Pregnenolone Should Not Break It

At least one FDA label for a product containing Atovaquone, Proguanil says to take it with food. If you take Pregnenolone on an empty stomach out of habit, keep them separate — and take Atovaquone, Proguanil with a meal where the label says to.

This may not be true of your version. Food instructions belong to the product, not the ingredient: two Atovaquone, Proguanil products can carry different directions, and extended-release forms often differ from immediate-release ones. The label we read is quoted below — check the directions on your own box or bottle, or ask your pharmacist, for how to take the exact product you were given.

2 DOSAGE AND ADMINISTRATION The daily dose should be taken at the same time each day with food or a milky drink.

From the Dosage and Administration section of the FDA label we read for Atovaquone, Proguanil — where that label names a specific product, the instruction is that product's. Read the label on DailyMed ›

A food rule is not an interaction — it is about how much of the medicine you absorb. The directions that came with your own product, and your pharmacist, outrank anything on this page.

Everything else you take

See Every Supplement That Interacts With Atovaquone, Proguanil

This page covers Pregnenolone only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Atovaquone, Proguanil page lists 54 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Adrafinil (moderate), Artichoke (moderate), Bacopa (moderate) and Baikal Skullcap (moderate).

By severity: 1 major · 40 moderate · 13 minor.

From our pharmacist’s overview on the Atovaquone, Proguanil page

“Most people taking atovaquone-proguanil (Malarone) are travelers trying to prevent malaria, so this list of 54 interacting supplements deserves real attention, since anything that weakens the drug can leave you exposed to the disease itself. The single major-rated entry is activated charcoal, a common travel remedy for stomach upset, w…”

Reviewed by 2 · Jul 18, 2026

Open the Atovaquone, Proguanil interaction page

One more smart check

Taking Pregnenolone as Part of a Dietary Supplement Product? Check It for Interactions

We hold 303 real supplement products containing Pregnenolone, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Pregnenolone. Even though Pregnenolone itself has no known interaction with Atovaquone, Proguanil, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Pregnenolone and Atovaquone, Proguanil Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Pregnenolone
Top half

#403 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Atovaquone, Proguanil
Steady interest

#2,030 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Pregnenolone reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 13, 2026. The Pregnenolone and Atovaquone, Proguanil records this page draws on were last updated July 10, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Pregnenolone

What is Pregnenolone?

Pregnenolone
  • Memory and cognitive support
  • Anxiety and stress
  • Anti-aging
  • Fatigue and low energy
  • Mood support

Pregnenolone is a hormone your body makes naturally and a building block for other hormones like cortisol, DHEA, estrogen, and testosterone. It is sold as a supplement for memory, mood, and anti-aging, but solid human evidence for these uses is very limited. Because it is a hormone, talk with your pharmacist or doctor before using it.

Naturally produced in the body; supplements are made synthetically (often from plant sterols like those in soy or wild yam) · Capsules, tablets, sublingual tablets, creams

An interaction check asks whether these two react with each other — it does not ask whether Pregnenolone is a good idea for someone in your situation. Here is what our Pregnenolone record says about it on its own.

Pregnenolone: dosing

There is no well-established or officially recommended dose for pregnenolone. Products vary widely in strength and form, and "more" is not safer with a hormone supplement.If your healthcare provider agrees you should try it, follow the directions on the product label and use the lowest amount that seems reasonable. Do not assume a higher dose works better.

From our Pregnenolone monograph — the full record covers uses, side effects and every documented interaction.

Read the full Pregnenolone monograph & all interactions
Medication

About Atovaquone and Proguanil

What Is Atovaquone and Proguanil Used For?

Brand name: Malarone

Atovaquone and proguanil is used for two purposes: preventing P. falciparum malaria before and during travel to areas where malaria is common, and treating an active, uncomplicated P. falciparum malaria infection. This includes regions where other antimalarials — such as chloroquine, mefloquine, halofantrine, and amodiaquine — may no longer be effective due to drug resistance.

Both the adult-strength and pediatric-strength tablet formulations share these same two approved uses. The brand Malarone is approved for both prevention and treatment of P. falciparum malaria in adults and in pediatric patients, with dosing based on body weight for children.

See full Atovaquone and Proguanil drug information
Keep checking

Other Drugs & Pregnenolone

Browse every other medication we’ve checked against Pregnenolone — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
82Moderate
0Minor
2,747No known interaction
82 Moderate 2,747 No interaction
Moderate

82 interactions

Showing 60 of 82 moderate interactions — see all 82 on the Pregnenolone page.

No interaction 2,747 drugs checked — show the list

We also checked Pregnenolone against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,747 medications checked with no known interaction — see the full Pregnenolone list.

See the full Pregnenolone interactions page
See every supplement checked against Atovaquone, Proguanil, ranked by severity
Evidence & sources

Pregnenolone References

The 6 references that drive our Pregnenolone monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Devlin TM, ed. Textbook of Biochemistry With Clinical Correlations. third ed. New York: Wiley-Liss Inc., 1992.
  2. Fung LK, Libove RA, Phillips J, Haddad F, Hardan AY.Brief report: an open-label study of the neurosteroid pregnenolone in adults with autism spectrum disorder. J Autism Dev Disord 2014;44(11):2971-7. PubMed
  3. Brown ES, Park J, Marx CE, et al. A randomized, double-blind, placebo-controlled trial of pregnenolone for bipolar depression. Neuropsychopharmacology 2014;39(12):2867-73. PubMed
  4. Ritsner MS, Gibel A, Shleifer T, et al. Pregnenolone and dehydroepiandrosterone as an adjunctive treatment in schizophrenia and schizoaffective disorder: an 8-week, double-blind, randomized, controlled, 2-center, parallel-group trial. J Clin Psychiatry 20 PubMed
  5. Meieran SE, Reus VI, Webster R, Shafton R, Wolkowitz OM. Chronic pregnenolone effects in normal humans: attenuation of benzodiazepine-induced sedation. Psychoneuroendocrinology 2004;29(4):486-500. PubMed
  6. Marx CE, Keefe RS, Buchanan RW, et al. Proof-of-concept trial with the neurosteroid pregnenolone targeting cognitive and negative symptoms in schizophrenia. Neuropsychopharmacology 2009;34(8):1885-903. PubMed

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Pregnenolone and Atovaquone, Proguanil Together: Common Questions

Is it safe to take Pregnenolone with Atovaquone, Proguanil?
We do not list a known interaction between Pregnenolone and Atovaquone, Proguanil. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Do Pregnenolone and Atovaquone, Proguanil have any of the same side effects?
Yes — our sources link each of them separately to 3 of the same effects. That is not an interaction: neither changes how your body handles the other. It does mean that if one of those effects turns up, it can be harder to tell which one is behind it. They are listed on this page with the source behind each.
Should I take Pregnenolone and Atovaquone, Proguanil at the same time of day?
At least one FDA label for a product containing Atovaquone, Proguanil says to take it with food. If you take Pregnenolone on an empty stomach out of habit, keep them separate and take Atovaquone, Proguanil with a meal where the label says to. Food instructions belong to the product rather than the ingredient — two Atovaquone, Proguanil products can differ — so check the directions on your own box. This is about absorption, not an interaction.
How was the Pregnenolone and Atovaquone, Proguanil combination checked?
Interactions in our licensed database are recorded against drug classes. Atovaquone, Proguanil is filed under 3 classifications, and Pregnenolone has documented interactions with 5 drug classes — none of Atovaquone, Proguanil's classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.
Does Pregnenolone interact with any other medications?
Yes. Pregnenolone has 82 documented drug interactions in our database — Atovaquone, Proguanil is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.
Does Atovaquone, Proguanil interact with any supplements?
Yes. Atovaquone, Proguanil has documented interactions with 54 supplements in our database — Pregnenolone is not one of them. The Atovaquone, Proguanil interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Pregnenolone monograph Uses, safety profile, and every drug interaction in one place Atovaquone and Proguanil drug information The full plain-English guide to this medication Atovaquone, Proguanil supplement interactions Every supplement checked against Atovaquone, Proguanil, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 6 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.