Drug & supplement interaction

Pregnenolone + Empagliflozin

Empagliflozin brand name: Jardiance.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 20, 2026
The bottom line No known interaction

We found no known interaction between Pregnenolone and Empagliflozin in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first.

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Interaction report

Pregnenolone and Empagliflozin

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Empagliflozin and Pregnenolone in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Pregnenolone safety at a glance

Pregnenolone overall Use caution It is a hormone with limited human safety data, so use only under guidance from a healthcare professional.
Pregnancy Avoid Hormone supplements should be avoided during pregnancy due to unknown risks.
Breastfeeding Avoid Not enough safety information exists, so avoid while breastfeeding.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Empagliflozin and Pregnenolone? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
How we checked

Why No Interaction Is Listed for Empagliflozin

Interactions in our licensed database are recorded against drug classes, not just single drug names. Empagliflozin is filed under 3 classifications — including antidiabetes drugs, oral drugs. Pregnenolone has documented interactions with 5 drug classes — the most serious being benzodiazepines (moderate), estrogens (moderate) and progesterone (moderate) — and none of Empagliflozin’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

Pregnenolone Does Interact With Other Medications

Pregnenolone has 82 moderate known drug interactions in our database — Empagliflozin isn’t one of them. If you take anything else, check it against the full list below.

Moderate 82 No known interaction 2,748 (incl. Empagliflozin)
Taking anything else?

Check Another of Your Medications Against Pregnenolone

Covers the 2,830 medications we’ve checked against Pregnenolone. Pick one to open its full report.

What to actually watch for

What Pregnenolone Itself Has Been Linked To

This is not an interaction — nothing below involves Empagliflozin. It is the side-effect record for Pregnenolone on its own, from the licensed Natural Medicines monograph. If something new turns up after you add Pregnenolone, this list is the first place to look.

  • Increased appetite / Reduced appetite Additional detail

    “Orally, pregnenolone has been reported to cause depressive affect and increased appetite. Increased excitement, agitation, increased motor activity, and anorexia have also been reported; however, it is not certain if these effects were due to pregnenolone.”

    Pregnenolone · Natural Medicines adverse-effect record, reported in anorexia.

    2 sources cited
    1. 94026. Fung LK, Libove RA, Phillips J, Haddad F, Hardan AY.Brief report: an open-label study of the neurosteroid pregnenolone in adults with autism spectrum disorder. J Autism Dev Disord 2014;44(11):2971-7. PubMed
    2. 94031. Meieran SE, Reus VI, Webster R, Shafton R, Wolkowitz OM. Chronic pregnenolone effects in normal humans: attenuation of benzodiazepine-induced sedation. Psychoneuroendocrinology 2004;29(4):486-500. PubMed
  • Acne / Hair loss Additional detail

    “Orally, pregnenolone has been reported to cause skin abscesses, acne, and hair loss. A case of skin rash accompanied by a burning sensation on the back and sides of the hands has also been reported with oral pregnenolone use, possibly related to a photosensitivity reaction. The rash cleared on its own.”

    Pregnenolone · Natural Medicines adverse-effect record, reported in acne.

    2 sources cited
    1. 94027. Brown ES, Park J, Marx CE, et al. A randomized, double-blind, placebo-controlled trial of pregnenolone for bipolar depression. Neuropsychopharmacology 2014;39(12):2867-73. PubMed
    2. 94031. Meieran SE, Reus VI, Webster R, Shafton R, Wolkowitz OM. Chronic pregnenolone effects in normal humans: attenuation of benzodiazepine-induced sedation. Psychoneuroendocrinology 2004;29(4):486-500. PubMed
  • Sun sensitivity Additional detail

    Recorded for Pregnenolone in the same Natural Medicines adverse-effect record shown under Acne / Hair loss above.

  • Tremor or shakiness / Sweating / Drowsiness Additional detail

    “Orally, pregnenolone has been reported to cause restlessness, tiredness, sweating, and a case of cold extremities. Sleep problems, drowsiness, and tremor have also been reported; however, it not certain if these effects were due to pregnenolone.”

    Pregnenolone · Natural Medicines adverse-effect record, reported in common cold.

    3 sources cited
    1. 94026. Fung LK, Libove RA, Phillips J, Haddad F, Hardan AY.Brief report: an open-label study of the neurosteroid pregnenolone in adults with autism spectrum disorder. J Autism Dev Disord 2014;44(11):2971-7. PubMed
    2. 94032. Marx CE, Keefe RS, Buchanan RW, et al. Proof-of-concept trial with the neurosteroid pregnenolone targeting cognitive and negative symptoms in schizophrenia. Neuropsychopharmacology 2009;34(8):1885-903. PubMed
    3. 94031. Meieran SE, Reus VI, Webster R, Shafton R, Wolkowitz OM. Chronic pregnenolone effects in normal humans: attenuation of benzodiazepine-induced sedation. Psychoneuroendocrinology 2004;29(4):486-500. PubMed
  • Anxiety or restlessness Additional detail

    Recorded for Pregnenolone in the same Natural Medicines adverse-effect record shown under Acne / Hair loss above.

  • Muscle pain Additional detail

    “A case of muscle pain/stiffness has been reported after oral use of pregnenolone.”

    Pregnenolone · Natural Medicines adverse-effect record, reported in pain.

    1 source cited
    1. 94032. Marx CE, Keefe RS, Buchanan RW, et al. Proof-of-concept trial with the neurosteroid pregnenolone targeting cognitive and negative symptoms in schizophrenia. Neuropsychopharmacology 2009;34(8):1885-903. PubMed

Showing the 10 most notable of 14 recorded effects — ranked by how unusual each one is across medicines generally, with serious effects weighted up.

Everything above comes from the Natural Medicines adverse-effect record for Pregnenolone — expand a row for the licensed statement it rests on. We read the ADVERSE REACTIONS section of Empagliflozin’s FDA label too, and the two lists don’t meaningfully overlap — which is why no Empagliflozin column appears here.

From our Q&A

Questions About Pregnenolone or Empagliflozin

These are real questions from readers, answered by the pharmacists at HelloPharmacist — written by a person, not generated from a database. Each one covers Pregnenolone or Empagliflozin, not necessarily both, but if one is close to what you were about to ask it will usually go further than a database entry can:

Not quite your question? Ask our pharmacists directly — it is free, there is no account required, and answers usually come back within 24 hours.

Everything else you take

See Every Supplement That Interacts With Empagliflozin

This page covers Pregnenolone only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Empagliflozin page lists 257 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Siberian Cocklebur (major), Acai (moderate), African Wild Potato (moderate) and Agaricus Mushroom (moderate).

By severity: 2 major · 216 moderate · 39 minor.

From our pharmacist’s overview on the Empagliflozin page

“Almost everything on this page can nudge blood sugar in someone taking empagliflozin (Jardiance) for type 2 diabetes, heart failure, or kidney protection, and two entries deserve genuine caution before anything else. Siberian cocklebur has caused severe low blood sugar in humans and should not be combined with any glucose-lowering medi…”

Reviewed by 2 · Jul 18, 2026

Open the Empagliflozin interaction page

One more smart check

Taking Pregnenolone as Part of a Dietary Supplement Product? Check It for Interactions

We hold 303 real supplement products containing Pregnenolone, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Pregnenolone. Even though Pregnenolone itself has no known interaction with Empagliflozin, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Pregnenolone and Empagliflozin Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Pregnenolone
Top half

#432 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Empagliflozin
Top 25%

#454 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Pregnenolone reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 20, 2026. The Pregnenolone and Empagliflozin records this page draws on were last updated July 10, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Pregnenolone

What is Pregnenolone?

Pregnenolone
  • Memory and cognitive support
  • Anxiety and stress
  • Anti-aging
  • Fatigue and low energy
  • Mood support

Pregnenolone is a hormone your body makes naturally and a building block for other hormones like cortisol, DHEA, estrogen, and testosterone. It is sold as a supplement for memory, mood, and anti-aging, but solid human evidence for these uses is very limited. Because it is a hormone, talk with your pharmacist or doctor before using it.

Naturally produced in the body; supplements are made synthetically (often from plant sterols like those in soy or wild yam) · Capsules, tablets, sublingual tablets, creams

An interaction check asks whether these two react with each other — it does not ask whether Pregnenolone is a good idea for someone in your situation. Here is what our Pregnenolone record says about it on its own.

Pregnenolone: dosing

There is no well-established or officially recommended dose for pregnenolone. Products vary widely in strength and form, and "more" is not safer with a hormone supplement.If your healthcare provider agrees you should try it, follow the directions on the product label and use the lowest amount that seems reasonable. Do not assume a higher dose works better.

From our Pregnenolone monograph — the full record covers uses, side effects and every documented interaction.

Read the full Pregnenolone monograph & all interactions
Medication

About Empagliflozin

What Is Empagliflozin Used For?

Brand name: Jardiance

Jardiance (empagliflozin) tablets are approved for several important uses in adults. It reduces the risk of cardiovascular death and hospitalization in adults with heart failure. It also slows the progression of chronic kidney disease by reducing the risk of serious kidney decline, end-stage kidney disease, cardiovascular death, and hospitalization. In adults with type 2 diabetes and established cardiovascular disease, Jardiance reduces the risk of cardiovascular death.

Jardiance is also used — alongside diet and exercise — to improve blood sugar control in type 2 diabetes in adults and children aged 10 and older. It is not recommended for blood sugar control in type 1 diabetes (it may raise the risk of a dangerous condition called diabetic ketoacidosis) or in type 2 diabetes patients with severely reduced kidney function.

Most-Reported Side Effects for Empagliflozin

From FAERS, the FDA’s public side-effect reporting system (71,563 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.

Diabetic ketoacidosis 4,153 reports
Nausea 3,866 reports
Blood glucose increased 3,534 reports
Diarrhea 3,424 reports
Weight decreased 3,137 reports
See full Empagliflozin drug information
Keep checking

Other Drugs & Pregnenolone

Browse every other medication we’ve checked against Pregnenolone — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
82Moderate
0Minor
2,747No known interaction
82 Moderate 2,747 No interaction
Moderate

82 interactions

Showing 60 of 82 moderate interactions — see all 82 on the Pregnenolone page.

No interaction 2,747 drugs checked — show the list

We also checked Pregnenolone against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,747 medications checked with no known interaction — see the full Pregnenolone list.

See the full Pregnenolone interactions page
See every supplement checked against Empagliflozin, ranked by severity
Evidence & sources

Pregnenolone References

The 6 references that drive our Pregnenolone monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Devlin TM, ed. Textbook of Biochemistry With Clinical Correlations. third ed. New York: Wiley-Liss Inc., 1992.
  2. Fung LK, Libove RA, Phillips J, Haddad F, Hardan AY.Brief report: an open-label study of the neurosteroid pregnenolone in adults with autism spectrum disorder. J Autism Dev Disord 2014;44(11):2971-7. PubMed
  3. Brown ES, Park J, Marx CE, et al. A randomized, double-blind, placebo-controlled trial of pregnenolone for bipolar depression. Neuropsychopharmacology 2014;39(12):2867-73. PubMed
  4. Ritsner MS, Gibel A, Shleifer T, et al. Pregnenolone and dehydroepiandrosterone as an adjunctive treatment in schizophrenia and schizoaffective disorder: an 8-week, double-blind, randomized, controlled, 2-center, parallel-group trial. J Clin Psychiatry 20 PubMed
  5. Meieran SE, Reus VI, Webster R, Shafton R, Wolkowitz OM. Chronic pregnenolone effects in normal humans: attenuation of benzodiazepine-induced sedation. Psychoneuroendocrinology 2004;29(4):486-500. PubMed
  6. Marx CE, Keefe RS, Buchanan RW, et al. Proof-of-concept trial with the neurosteroid pregnenolone targeting cognitive and negative symptoms in schizophrenia. Neuropsychopharmacology 2009;34(8):1885-903. PubMed

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Pregnenolone and Empagliflozin Together: Common Questions

Is it safe to take Pregnenolone with Empagliflozin?
We do not list a known interaction between Pregnenolone and Empagliflozin. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
How was the Pregnenolone and Empagliflozin combination checked?
Interactions in our licensed database are recorded against drug classes. Empagliflozin is filed under 3 classifications, and Pregnenolone has documented interactions with 5 drug classes — none of Empagliflozin's classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.
Does Pregnenolone interact with any other medications?
Yes. Pregnenolone has 82 documented drug interactions in our database — Empagliflozin is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.
Does Empagliflozin interact with any supplements?
Yes. Empagliflozin has documented interactions with 257 supplements in our database — Pregnenolone is not one of them. The Empagliflozin interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Pregnenolone monograph Uses, safety profile, and every drug interaction in one place Empagliflozin drug information The full plain-English guide to this medication Empagliflozin supplement interactions Every supplement checked against Empagliflozin, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 6 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Empagliflozin and Pregnenolone?

Our pharmacists answer your medication & supplement questions — free.

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.