Drug & supplement interaction

Rabdosia Rubescens + Linaclotide

Linaclotide brand name: Linzess.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 20, 2026
The bottom line No known interaction

We found no known interaction between Rabdosia Rubescens and Linaclotide in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the label for Linaclotide states a food rule worth keeping to.

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Interaction report

Rabdosia Rubescens and Linaclotide

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Linaclotide and Rabdosia Rubescens in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Rabdosia Rubescens safety at a glance

Rabdosia Rubescens overall Use caution Human safety data are limited, so use carefully and under professional guidance.
Pregnancy Avoid Not enough safety information exists, so it is best avoided during pregnancy.
Breastfeeding Avoid There is no reliable safety data while breastfeeding, so avoid use.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Linaclotide and Rabdosia Rubescens? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
How we checked

Why No Interaction Is Listed for Linaclotide

Interactions in our licensed database are recorded against drug classes, not just single drug names. Linaclotide is filed under a single classification — oral drugs. Rabdosia Rubescens has documented interactions with 3 drug classes — the most serious being cytochrome p450 3a4 (cyp3a4) substrates (moderate), p-glycoprotein substrates (moderate) and cytochrome p450 2c9 (cyp2c9) substrates (minor) — and none of Linaclotide’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

Rabdosia Rubescens Does Interact With Other Medications

Rabdosia Rubescens has 714 moderate, 69 minor known drug interactions in our database — Linaclotide isn’t one of them. If you take anything else, check it against the full list below.

Moderate 714 Minor 69 No known interaction 2,047 (incl. Linaclotide)
Taking anything else?

Check Another of Your Medications Against Rabdosia Rubescens

Covers the 2,830 medications we’ve checked against Rabdosia Rubescens. Pick one to open its full report.

What to actually watch for

What Linaclotide’s Own FDA Label Lists

This is not an interaction — none of it involves Rabdosia Rubescens. These are the most notable effects listed in the ADVERSE REACTIONS section of Linaclotide’s own FDA label, for the medication by itself. Knowing the drug’s own list makes it easier to work out the likely cause if something new turns up while you take both. One of them is worth acting on rather than waiting out — marked below.

  • A higher chance of infection Worth acting on
  • Heartburn
  • Bloating or gas mentioned in 4.4% of FDA reports for Linaclotide
  • Diarrhea mentioned in 17.7% of FDA reports for Linaclotide
  • Constipation mentioned in 7.5% of FDA reports for Linaclotide
  • Stomach pain mentioned in 4.0% of FDA reports for Linaclotide
  • Headache mentioned in 3.9% of FDA reports for Linaclotide
  • Vomiting

From the ADVERSE REACTIONS section of the FDA label for Linaclotide. Read the label on DailyMed › Where a percentage is shown, it is the share of 26,525 voluntary FDA FAERS reports for Linaclotide that mention that effect — a reporting proportion, not an incidence rate and not evidence the drug caused it. Rabdosia Rubescens’s licensed record lists no adverse effects our clinical vocabulary could match, so there is no Rabdosia Rubescens side to compare — that is a limit of the record, not a statement that Rabdosia Rubescens has no side effects.

How to take them

Some Linaclotide Products Have a Food Rule — Rabdosia Rubescens Should Not Break It

At least one FDA label for a product containing Linaclotide says to take it on an empty stomach. Most supplements — Rabdosia Rubescens included — are taken with a meal, so the easy mistake is swallowing both together at breakfast. Where that rule applies, keep Linaclotide on its own and move Rabdosia Rubescens to a meal later in the day.

This may not be true of your version. Food instructions belong to the product, not the ingredient: two Linaclotide products can carry different directions, and extended-release forms often differ from immediate-release ones. The label we read is quoted below — check the directions on your own box or bottle, or ask your pharmacist, for how to take the exact product you were given.

Preparation and Administration Instructions • Take LINZESS on an empty stomach, at least 30 minutes prior to a meal at approximately the same time each day.

From the Dosage and Administration section of the FDA label we read for Linaclotide — where that label names a specific product, the instruction is that product's. Read the label on DailyMed ›

A food rule is not an interaction — it is about how much of the medicine you absorb. The directions that came with your own product, and your pharmacist, outrank anything on this page.

From our Q&A

Questions About Rabdosia Rubescens or Linaclotide

These are real questions from readers, answered by the pharmacists at HelloPharmacist — written by a person, not generated from a database. Each one covers Rabdosia Rubescens or Linaclotide, not necessarily both, but if one is close to what you were about to ask it will usually go further than a database entry can:

Not quite your question? Ask our pharmacists directly — it is free, there is no account required, and answers usually come back within 24 hours.

Everything else you take

See Every Supplement That Interacts With Linaclotide

This page covers Rabdosia Rubescens only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Linaclotide page lists 17 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Coffee Charcoal (moderate), European Mandrake (moderate), Glucomannan (moderate) and Guar Gum (moderate).

By severity: 1 major · 7 moderate · 9 minor.

From our pharmacist’s overview on the Linaclotide page

“Linaclotide (Linzess) treats IBS with constipation by acting inside the intestine itself, so the capsule's contents have to reach the gut unbound to do their job. That is exactly what the 17 supplements on this page can interfere with, and I would read the list with genuine care.”

Reviewed by 2 · Jul 18, 2026

Open the Linaclotide interaction page

How much people look this up

Where Rabdosia Rubescens and Linaclotide Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Rabdosia Rubescens
Steady interest

#946 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Linaclotide
Steady interest

#1,614 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Rabdosia Rubescens reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 20, 2026. The Rabdosia Rubescens and Linaclotide records this page draws on were last updated July 11, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Rabdosia Rubescens

What is Rabdosia Rubescens?

Rabdosia Rubescens
  • Sore throat and respiratory complaints
  • Inflammation
  • Antimicrobial support
  • Digestive complaints
  • Traditional cancer support

Rabdosia rubescens is a Chinese herb traditionally used for sore throats, inflammation, and infections, and its compound oridonin has drawn lab interest for possible anticancer effects. However, strong human evidence is lacking for any use, and safety has not been well studied, so talk with your pharmacist or doctor before trying it.

Rabdosia rubescens · Lamiaceae · Aerial parts (leaves and stems) · Capsules, tablets, powders, teas, and liquid extracts

An interaction check asks whether these two react with each other — it does not ask whether Rabdosia Rubescens is a good idea for someone in your situation. Here is what our Rabdosia Rubescens record says about it on its own.

Rabdosia Rubescens: dosing

There is no well-established, standardized dose for Rabdosia rubescens. Studies have used different forms and amounts, so there is no agreed-upon safe and effective dose for any condition.If you choose to use it, follow the directions on the product label and do not exceed the recommended amount.

From our Rabdosia Rubescens monograph — the full record covers uses, side effects and every documented interaction.

Read the full Rabdosia Rubescens monograph & all interactions
Medication

About Linaclotide

What Is Linaclotide Used For?

Brand name: Linzess

Linzess (linaclotide) treats three related conditions that cause difficult, infrequent bowel movements. In adults, it is approved for irritable bowel syndrome with constipation (IBS-C) and chronic idiopathic constipation (CIC — ongoing constipation with no identified cause). In children ages 7 and older, Linzess is approved for IBS-C. In children ages 2 and older, Linzess is approved for functional constipation (FC).

Most-Reported Side Effects for Linaclotide

From FAERS, the FDA’s public side-effect reporting system (26,525 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.

Diarrhea 4,703 reports
Constipation 1,998 reports
Nausea 1,476 reports
Fatigue 1,171 reports
Abdominal distension 1,170 reports
See full Linaclotide drug information
Keep checking

Other Drugs & Rabdosia Rubescens

Browse every other medication we’ve checked against Rabdosia Rubescens — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
714Moderate
69Minor
2,046No known interaction
714 Moderate 69 Minor 2,046 No interaction
Moderate

714 interactions

Showing 60 of 714 moderate interactions — see all 714 on the Rabdosia Rubescens page.

Minor

69 interactions

Showing 60 of 69 minor interactions — see all 69 on the Rabdosia Rubescens page.

No interaction 2,046 drugs checked — show the list

We also checked Rabdosia Rubescens against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,046 medications checked with no known interaction — see the full Rabdosia Rubescens list.

See the full Rabdosia Rubescens interactions page
See every supplement checked against Linaclotide, ranked by severity
Evidence & sources

Rabdosia Rubescens References

The 3 references that drive our Rabdosia Rubescens monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Chen S, Liu J, Zhang H. Efficacy of rabdosia rubescens in the treatment of gingivitis. J Huazhong Univ Sci Technolog Med Sci. 2009;29(5):659-63. PubMed
  2. Zhang YW, Zheng XW, Liu YJ, et al. Effect of oridonin on cytochrome P450 expression and activities in HepaRG Cell. Pharmacology. 2018;101(5-6):246-254. PubMed
  3. Li F, Fan J, Wu Z, et al. Reversal effects of Rabdosia rubescens extract on multidrug resistance of MCF-7/Adr cells in vitro. Pharm Biol. 2013;51(9):1196-203.

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Rabdosia Rubescens and Linaclotide Together: Common Questions

Is it safe to take Rabdosia Rubescens with Linaclotide?
We do not list a known interaction between Rabdosia Rubescens and Linaclotide. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Should I take Rabdosia Rubescens and Linaclotide at the same time of day?
At least one FDA label for a product containing Linaclotide says to take it on an empty stomach, and supplements are usually taken with a meal — so taking them together at breakfast is the easy mistake. Where that applies, keep Linaclotide on its own and move Rabdosia Rubescens to a meal later in the day. Food instructions belong to the product rather than the ingredient, so check the directions on your own box. This is about absorption, not an interaction.
How was the Rabdosia Rubescens and Linaclotide combination checked?
Interactions in our licensed database are recorded against drug classes. Linaclotide is filed under 1 classification, and Rabdosia Rubescens has documented interactions with 3 drug classes — none of Linaclotide's classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.
Does Rabdosia Rubescens interact with any other medications?
Yes. Rabdosia Rubescens has 783 documented drug interactions in our database — Linaclotide is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.
Does Linaclotide interact with any supplements?
Yes. Linaclotide has documented interactions with 17 supplements in our database — Rabdosia Rubescens is not one of them. The Linaclotide interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Rabdosia Rubescens monograph Uses, safety profile, and every drug interaction in one place Linaclotide drug information The full plain-English guide to this medication Linaclotide supplement interactions Every supplement checked against Linaclotide, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 3 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Linaclotide and Rabdosia Rubescens?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.