Drug & supplement interaction

Rehmannia + Pralsetinib

Pralsetinib brand name: Gavreto.

No Known Interaction
Medically reviewed by · Updated June 2026 · Pair last verified Sep 20, 2026
The bottom line No known interaction

We found no known interaction between Rehmannia and Pralsetinib in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the label for Pralsetinib states a food rule worth keeping to.

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Interaction report

Rehmannia and Pralsetinib

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Pralsetinib and Rehmannia in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Rehmannia safety at a glance

Rehmannia overall Use caution Generally used in traditional medicine, but human safety data are limited and quality varies between products.
Pregnancy Avoid Not enough safety information; best avoided during pregnancy.
Breastfeeding Avoid Not enough safety information; best avoided while breastfeeding.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Pralsetinib and Rehmannia? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
How we checked

Why No Interaction Is Listed for Pralsetinib

Interactions in our licensed database are recorded against drug classes, not just single drug names. Pralsetinib is filed under 5 classifications — including qt interval-prolonging drugs, p-glycoprotein substrates, hepatotoxic drugs. Rehmannia has documented interactions with 2 drug classes — the most serious being antidiabetes drugs (moderate) and antihypertensive drugs (moderate) — and none of Pralsetinib’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

Rehmannia Does Interact With Other Medications

Rehmannia has 258 moderate known drug interactions in our database — Pralsetinib isn’t one of them. If you take anything else, check it against the full list below.

Moderate 258 No known interaction 2,572 (incl. Pralsetinib)
Taking anything else?

Check Another of Your Medications Against Rehmannia

Covers the 2,830 medications we’ve checked against Rehmannia. Pick one to open its full report.

What to actually watch for

What Pralsetinib’s Own FDA Label Lists

This is not an interaction — none of it involves Rehmannia. These are the most notable effects listed in the ADVERSE REACTIONS section of Pralsetinib’s own FDA label, for the medication by itself. Knowing the drug’s own list makes it easier to work out the likely cause if something new turns up while you take both. 10 of them are worth acting on rather than waiting out — marked below.

  • Low sodium Worth acting on
  • Blood clots Worth acting on
  • Yellowing of the skin or eyes Worth acting on
  • Fainting Worth acting on
  • Anemia Worth acting on mentioned in 5.5% of FDA reports for Pralsetinib
  • Raised blood pressure Worth acting on mentioned in 5.6% of FDA reports for Pralsetinib
  • Seizures Worth acting on
  • Chest pain Worth acting on
  • A low platelet count Worth acting on
  • Kidney problems Worth acting on

Showing the 10 most notable of 40 label-listed effects — ranked by how unusual each one is across medicines generally, with serious effects weighted up.

From the ADVERSE REACTIONS section of the FDA label for Pralsetinib. Read the label on DailyMed › Where a percentage is shown, it is the share of 1,699 voluntary FDA FAERS reports for Pralsetinib that mention that effect — a reporting proportion, not an incidence rate and not evidence the drug caused it. Rehmannia’s licensed record lists no adverse effects our clinical vocabulary could match, so there is no Rehmannia side to compare — that is a limit of the record, not a statement that Rehmannia has no side effects.

How to take them

Some Pralsetinib Products Have a Food Rule — Rehmannia Should Not Break It

At least one FDA label for a product containing Pralsetinib says to take it on an empty stomach. Most supplements — Rehmannia included — are taken with a meal, so the easy mistake is swallowing both together at breakfast. Where that rule applies, keep Pralsetinib on its own and move Rehmannia to a meal later in the day.

This may not be true of your version. Food instructions belong to the product, not the ingredient: two Pralsetinib products can carry different directions, and extended-release forms often differ from immediate-release ones. The label we read is quoted below — check the directions on your own box or bottle, or ask your pharmacist, for how to take the exact product you were given.

( 2.1 , 14 ) The recommended dosage in adults and pediatric patients 12 years and older is 400 mg orally once daily on an empty stomach (no food intake for at least 2 hours before and at least 1 hour after taking GAVRETO).

From the Dosage and Administration section of the FDA label we read for Pralsetinib — where that label names a specific product, the instruction is that product's. Read the label on DailyMed ›

A food rule is not an interaction — it is about how much of the medicine you absorb. The directions that came with your own product, and your pharmacist, outrank anything on this page.

Everything else you take

See Every Supplement That Interacts With Pralsetinib

This page covers Rehmannia only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Pralsetinib page lists 181 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), American Hellebore (major), Arsenic (major), Beer (major) and Cesium (major).

By severity: 11 major · 134 moderate · 36 minor.

From our pharmacist’s overview on the Pralsetinib page

“With pralsetinib (Gavreto), a targeted therapy for RET-driven lung and thyroid cancers, I would treat this list as required reading rather than background noise. Most of the interactions change how much of the drug the body actually gets: grapefruit can push its levels higher, while St.”

Reviewed by 2 · Jul 18, 2026

Open the Pralsetinib interaction page

One more smart check

Taking Rehmannia as Part of a Dietary Supplement Product? Check It for Interactions

We hold 861 real supplement products containing Rehmannia, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Rehmannia. Even though Rehmannia itself has no known interaction with Pralsetinib, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Rehmannia and Pralsetinib Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Rehmannia
Top 25%

#257 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Pralsetinib
Steady interest

#2,164 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Rehmannia reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 20, 2026. The Rehmannia and Pralsetinib records this page draws on were last updated June 22, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Rehmannia

What is Rehmannia?

  • Kidney and adrenal support
  • Anemia and blood building (traditional)
  • Inflammatory conditions
  • Allergies
  • Fatigue and aging-related complaints

Rehmannia is a root used for centuries in Traditional Chinese Medicine, often to 'tonify' the kidneys and support energy or blood health. Human evidence for most modern uses is limited, so it should be viewed as unproven rather than reliable. Talk with a pharmacist or doctor before trying it, especially if you are pregnant, breastfeeding, or take other medicines.

Rehmannia glutinosa · Orobanchaceae · Root (raw or steam-prepared) · Dried root, decoctions/teas, capsules, tinctures, and ingredient in multi-herb formulas

An interaction check asks whether these two react with each other — it does not ask whether Rehmannia is a good idea for someone in your situation. Here is what our Rehmannia record says about it on its own.

Rehmannia: dosing

There is no official, well-established standardized dose for Rehmannia. Traditional use varies widely depending on the form (raw versus prepared root), whether it is a tea, capsule, or tincture, and whether it is part of a larger herbal formula.The safest approach is to follow the directions on the product label and not exceed them.

From our Rehmannia monograph — the full record covers uses, side effects and every documented interaction.

Read the full Rehmannia monograph & all interactions
Medication

About Pralsetinib

What Is Pralsetinib Used For?

Brand name: Gavreto

Gavreto (pralsetinib) is used to treat adults with metastatic RET fusion-positive non-small cell lung cancer (NSCLC) — a type of lung cancer that has spread and carries a specific genetic alteration detected by an FDA-approved test.

Gavreto is also approved for adults and children aged 12 and older with advanced or metastatic RET fusion-positive thyroid cancer who need systemic (whole-body) treatment and whose cancer no longer responds to radioactive iodine (when radioactive iodine is an appropriate option). This thyroid cancer use is under accelerated approval, meaning continued approval depends on results from confirmatory clinical trials.

Most-Reported Side Effects for Pralsetinib

From FAERS, the FDA’s public side-effect reporting system (1,788 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.

Product prescribing issue 181 reports
Fatigue 126 reports
Asthenia 116 reports
Anemia 98 reports
Hypertension 96 reports
See full Pralsetinib drug information
Keep checking

Other Drugs & Rehmannia

Browse every other medication we’ve checked against Rehmannia — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
258Moderate
0Minor
2,571No known interaction
258 Moderate 2,571 No interaction
Moderate

258 interactions

Showing 60 of 258 moderate interactions — see all 258 on the Rehmannia page.

No interaction 2,571 drugs checked — show the list

We also checked Rehmannia against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,571 medications checked with no known interaction — see the full Rehmannia list.

See the full Rehmannia interactions page
See every supplement checked against Pralsetinib, ranked by severity
Evidence & sources

Rehmannia References

The 3 references that drive our Rehmannia monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Zhang R, Zhou J, Jia Z, et al. Hypoglycemic effect of Rehmannia glutinosa oligosaccharide in hyperglycemic and alloxan-induced diabetic rats and its mechanism. J Ethnopharmacol 2004;90:39-43. PubMed
  2. Zhang RX, Li MX, Jia ZP. Rehmannia glutinosa: review of botany, chemistry and pharmacology. J Ethnopharmacol 2008;117(2):199-214. PubMed
  3. Chao CH, Hsu JL, Chen MF, et al. Anti-hypertensive effects of Radix Rehmanniae and its active ingredients. Nat Prod Res. 2020;34(11):1547-1552.

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Rehmannia and Pralsetinib Together: Common Questions

Is it safe to take Rehmannia with Pralsetinib?
We do not list a known interaction between Rehmannia and Pralsetinib. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Should I take Rehmannia and Pralsetinib at the same time of day?
At least one FDA label for a product containing Pralsetinib says to take it on an empty stomach, and supplements are usually taken with a meal — so taking them together at breakfast is the easy mistake. Where that applies, keep Pralsetinib on its own and move Rehmannia to a meal later in the day. Food instructions belong to the product rather than the ingredient, so check the directions on your own box. This is about absorption, not an interaction.
How was the Rehmannia and Pralsetinib combination checked?
Interactions in our licensed database are recorded against drug classes. Pralsetinib is filed under 5 classifications, and Rehmannia has documented interactions with 2 drug classes — none of Pralsetinib's classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.
Does Rehmannia interact with any other medications?
Yes. Rehmannia has 258 documented drug interactions in our database — Pralsetinib is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.
Does Pralsetinib interact with any supplements?
Yes. Pralsetinib has documented interactions with 181 supplements in our database — Rehmannia is not one of them. The Pralsetinib interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Rehmannia monograph Uses, safety profile, and every drug interaction in one place Pralsetinib drug information The full plain-English guide to this medication Pralsetinib supplement interactions Every supplement checked against Pralsetinib, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 3 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Pralsetinib and Rehmannia?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.