Drug & supplement interaction

Rue + Insulin Lispro

Insulin Lispro brand names: Admelog, Admelog Solostar.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 20, 2026
The bottom line No known interaction

We found no known interaction between Rue and Insulin Lispro in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the label for Insulin Lispro states a food rule worth keeping to, and the two are separately associated with some of the same side effects, which would make a new symptom harder to attribute to one or the other.

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Interaction report

Rue and Insulin Lispro

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Insulin Lispro and Rue in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Rue safety at a glance

Rue overall Use caution Rue can be toxic in higher doses and the oil is especially risky, so use it cautiously if at all.
Pregnancy Likely Unsafe When used orally. Rue has uterine stimulant and abortifacient effects; avoid using. Deaths have been reported in women who used rue as an abortifacient. Read the full pregnancy detail
Breastfeeding Avoid Safety is not established and potentially toxic compounds may pass to the baby, so avoid use.

Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center) — the full detail is in the Special populations card below. Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Insulin Lispro and Rue? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
How we checked

Why No Interaction Is Listed for Insulin Lispro

Interactions in our licensed database are recorded against drug classes, not just single drug names. Insulin Lispro is filed under a single classification — antidiabetes drugs. Rue has documented interactions with 1 drug class — the most serious being photosensitizing drugs (moderate) — and none of Insulin Lispro’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

Rue Does Interact With Other Medications

Rue has 335 moderate known drug interactions in our database — Insulin Lispro isn’t one of them. If you take anything else, check it against the full list below.

Moderate 335 No known interaction 2,495 (incl. Insulin Lispro)
Taking anything else?

Check Another of Your Medications Against Rue

Covers the 2,830 medications we’ve checked against Rue. Pick one to open its full report.

What to actually watch for

No Interaction Found — But Data Suggests Rue and Insulin Lispro May Share Several of the Same Side Effects

This is not an interaction. Neither one changes how your body handles the other, and nothing here says they react together. What our sources do show is that each has separately been linked to the effects below — so taking both can make those effects more likely to turn up, and harder to pin on one or the other if they do. One of them is worth acting on rather than waiting out — marked below.

  • Shortness of breath Worth acting on Additional detail

    Rue

    “Orally, high doses of rue can cause respiratory distress (2,12,18).”

    Rue · Natural Medicines adverse-effect record, reported in acute respiratory distress syndrome (ards).

    3 sources cited
    1. 2. Blumenthal M, ed. The Complete German Commission E Monographs: Therapeutic Guide to Herbal Medicines. Trans. S. Klein. Boston, MA: American Botanical Council, 1998.
    2. 12. McGuffin M, Hobbs C, Upton R, Goldberg A, eds. American Herbal Products Association's Botanical Safety Handbook. Boca Raton, FL: CRC Press, LLC 1997.
    3. 18. Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.

    Insulin Lispro

    Listed in the ADVERSE REACTIONS section of the FDA label for Insulin Lispro. Read the label on DailyMed ›

  • Itching Additional detail

    Rue

    “Topically, rue can cause contact dermatitis (2). Exposure to the fresh rue plant followed by sun exposure within 48 hours can lead to severe phototoxic reactions (2,6). Multiple case reports describe patients who developed pruritus, erythema, and severe blistering on the back of the hands and wrists, equivalent to a partial thickness burn, after contact with the fresh plant leaves and exposure to sunlight.”

    Rue · Natural Medicines adverse-effect record, reported in dermatitis.

    4 sources cited
    1. 2. Blumenthal M, ed. The Complete German Commission E Monographs: Therapeutic Guide to Herbal Medicines. Trans. S. Klein. Boston, MA: American Botanical Council, 1998.
    2. 6. The Review of Natural Products by Facts and Comparisons. St. Louis, MO: Wolters Kluwer Co., 1999.
    3. 104119. Radotra I, Gardiner S, Barnes D. A phytophototoxic injury at a burns unit: the ungraceful after-effects of the "common rue" plant. J Burn Care Res. 2018;39(6):1064-6. PubMed
    4. 107948. Avallone G, Mastorino L, Agostini A, et al. Ruta graveolens phytophotodermatitis. Dermatol Online J 2021;27(7). PubMed

    Insulin Lispro

    Listed in the ADVERSE REACTIONS section of the FDA label for Insulin Lispro. Read the label on DailyMed ›

  • A skin rash Additional detail

    Rue

    “Orally, rue is well tolerated when taken in the amounts found in foods. The dried herb seems to be generally well tolerated when taken in medicinal doses; however, a thorough evaluation of safety outcomes has not been conducted.”

    Rue · Natural Medicines adverse-effect record, reported in depression.

    Insulin Lispro

    Listed in the ADVERSE REACTIONS section of the FDA label for Insulin Lispro. Read the label on DailyMed ›

Reported for Rue but not commonly for Insulin Lispro: trouble sleeping, stomach pain, drowsiness and low mood.

Effects for Insulin Lispro come from the ADVERSE REACTIONS section of its FDA label; effects for Rue come from the Natural Medicines adverse-effect record, quoted above. Wording is matched across sources by our own clinical vocabulary, so treat this as a prompt to pay attention, not a diagnosis.

Special populations

Rue in Pregnancy & Breastfeeding

Pregnancy Likely Unsafe

When used orally. Rue has uterine stimulant and abortifacient effects; avoid using. Deaths have been reported in women who used rue as an abortifacient.

DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.© 2026 Therapeutic Research Center

How to take them

Some Insulin Lispro Products Have a Food Rule — Rue Should Not Break It

At least one FDA label for a product containing Insulin Lispro says to take it with food. If you take Rue on an empty stomach out of habit, keep them separate — and take Insulin Lispro with a meal where the label says to.

This may not be true of your version. Food instructions belong to the product, not the ingredient: two Insulin Lispro products can carry different directions, and extended-release forms often differ from immediate-release ones. The label we read is quoted below — check the directions on your own box or bottle, or ask your pharmacist, for how to take the exact product you were given.

( 2.1 , 2.2 , 2.3 , 2.4 ) Subcutaneous injection ( 2.2 ): Administer HUMALOG ® U-100 or U-200 by subcutaneous injection into the abdominal wall, thigh, upper arm, or buttocks within 15 minutes before a meal or immediately after a meal.

From the Dosage and Administration section of the FDA label we read for Insulin Lispro — where that label names a specific product, the instruction is that product's. Read the label on DailyMed ›

A food rule is not an interaction — it is about how much of the medicine you absorb. The directions that came with your own product, and your pharmacist, outrank anything on this page.

Everything else you take

See Every Supplement That Interacts With Insulin Lispro

This page covers Rue only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Insulin Lispro page lists 239 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Siberian Cocklebur (major), Acai (moderate), African Wild Potato (moderate), Agaricus Mushroom (moderate) and Agmatine (moderate).

By severity: 1 major · 208 moderate · 30 minor.

From our pharmacist’s overview on the Insulin Lispro page

“Blood sugar is the entire subject of this list. Insulin lispro (Admelog) is a rapid mealtime insulin dosed to bring glucose down after eating, and the supplements below can shove that same number around, most of them downward, which risks a genuine low.”

Reviewed by 2 · Jul 18, 2026

Open the Insulin Lispro interaction page

One more smart check

Taking Rue as Part of a Dietary Supplement Product? Check It for Interactions

We hold 47 real supplement products containing Rue, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Rue. Even though Rue itself has no known interaction with Insulin Lispro, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Rue and Insulin Lispro Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Rue
Top half

#652 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Insulin Lispro
Steady interest

#1,802 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Rue reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 20, 2026. The Rue and Insulin Lispro records this page draws on were last updated July 11, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Rue

What is Rue?

Rue
  • Menstrual cramps
  • Digestive upset
  • Muscle spasms and pain
  • Headache
  • Insect repellent (topical)
  • Traditional folk remedy

Rue is a strong-smelling herb from southern Europe with a long history in folk medicine, but there is very little reliable human research to support its health uses. It can be toxic in larger amounts and is considered unsafe during pregnancy, so most people should avoid it or use it only under professional guidance.

Ruta graveolens · Rutaceae · Aerial parts (leaves and flowering tops) and essential oil · Tea, tincture, dried herb, essential oil, topical preparations

An interaction check asks whether these two react with each other — it does not ask whether Rue is a good idea for someone in your situation. Here is what our Rue record says about it on its own.

Rue: dosing

There is no well-established or standardized safe dose of rue. Because the plant can be toxic and the amount of active compounds varies widely between products, it is hard to know what amount is safe.If you choose to use a commercial rue product, follow the directions on the label exactly and do not exceed them. The essential oil should not be taken internally.

From our Rue monograph — the full record covers uses, side effects and every documented interaction.

Read the full Rue monograph & all interactions
Medication

About Insulin Lispro Injection

What Is Insulin Lispro Injection Used For?

Brand names: Admelog, Admelog Solostar

Insulin lispro injection is used to improve glycemic control (blood sugar management) in people with diabetes mellitus. It is a rapid-acting insulin analog approved for use in both type 1 and type 2 diabetes.

Admelog is specifically indicated to improve glycemic control in patients with diabetes mellitus. Humalog Mix75/25 is indicated to improve glycemic control in adults with diabetes mellitus; it is a fixed-ratio mixture of insulin lispro and insulin lispro protamine, and its fixed proportions do not allow for separate adjustment of basal (background) and prandial (mealtime) doses.

See full Insulin Lispro Injection drug information
Keep checking

Other Drugs & Rue

Browse every other medication we’ve checked against Rue — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
335Moderate
0Minor
2,494No known interaction
335 Moderate 2,494 No interaction
Moderate

335 interactions

Showing 60 of 335 moderate interactions — see all 335 on the Rue page.

No interaction 2,494 drugs checked — show the list

We also checked Rue against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,494 medications checked with no known interaction — see the full Rue list.

See the full Rue interactions page
See every supplement checked against Insulin Lispro, ranked by severity
Evidence & sources

Rue References

The 8 references that drive our Rue monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Blumenthal M, ed. The Complete German Commission E Monographs: Therapeutic Guide to Herbal Medicines. Trans. S. Klein. Boston, MA: American Botanical Council, 1998.
  2. The Review of Natural Products by Facts and Comparisons. St. Louis, MO: Wolters Kluwer Co., 1999.
  3. McGuffin M, Hobbs C, Upton R, Goldberg A, eds. American Herbal Products Association's Botanical Safety Handbook. Boca Raton, FL: CRC Press, LLC 1997.
  4. Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.
  5. Brinker F. Herb Contraindications and Drug Interactions. 2nd ed. Sandy, OR: Eclectic Medical Publications, 1998.
  6. Puig L. Pharmacodynamic interaction with phototoxic plants during PUVA therapy. Br J Dermatol 1997;136:973-4. PubMed
  7. Radotra I, Gardiner S, Barnes D. A phytophototoxic injury at a burns unit: the ungraceful after-effects of the "common rue" plant. J Burn Care Res. 2018;39(6):1064-6. PubMed
  8. Avallone G, Mastorino L, Agostini A, et al. Ruta graveolens phytophotodermatitis. Dermatol Online J 2021;27(7). PubMed

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Rue and Insulin Lispro Together: Common Questions

Is it safe to take Rue with Insulin Lispro?
We do not list a known interaction between Rue and Insulin Lispro. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Do Rue and Insulin Lispro have any of the same side effects?
Yes — our sources link each of them separately to 3 of the same effects. That is not an interaction: neither changes how your body handles the other. It does mean that if one of those effects turns up, it can be harder to tell which one is behind it. They are listed on this page with the source behind each.
Should I take Rue and Insulin Lispro at the same time of day?
At least one FDA label for a product containing Insulin Lispro says to take it with food. If you take Rue on an empty stomach out of habit, keep them separate and take Insulin Lispro with a meal where the label says to. Food instructions belong to the product rather than the ingredient — two Insulin Lispro products can differ — so check the directions on your own box. This is about absorption, not an interaction.
How was the Rue and Insulin Lispro combination checked?
Interactions in our licensed database are recorded against drug classes. Insulin Lispro is filed under 1 classification, and Rue has documented interactions with 1 drug class — none of Insulin Lispro's classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.
Does Rue interact with any other medications?
Yes. Rue has 335 documented drug interactions in our database — Insulin Lispro is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.
Does Insulin Lispro interact with any supplements?
Yes. Insulin Lispro has documented interactions with 239 supplements in our database — Rue is not one of them. The Insulin Lispro interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Rue monograph Uses, safety profile, and every drug interaction in one place Insulin Lispro Injection drug information The full plain-English guide to this medication Insulin Lispro supplement interactions Every supplement checked against Insulin Lispro, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 8 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Insulin Lispro and Rue?

Our pharmacists answer your medication & supplement questions — free.

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.