Drug & supplement interaction

Skullcap + Methazolamide

Methazolamide brand name: Neptazane.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 20, 2026
The bottom line No known interaction

We found no known interaction between Skullcap and Methazolamide in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the two are separately associated with some of the same side effects, which would make a new symptom harder to attribute to one or the other.

Know someone taking this? Share
Facebook Post Reddit Email
On this page
Interaction report

Skullcap and Methazolamide

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Methazolamide and Skullcap in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Skullcap safety at a glance

Skullcap overall Use caution Often used short-term, but evidence is limited and product quality varies, so use with care.
Pregnancy Avoid Not enough safety data, so it is best avoided during pregnancy.
Breastfeeding Avoid Safety is unknown, so avoid while breastfeeding.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Methazolamide and Skullcap? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
How we checked

Why No Interaction Is Listed for Methazolamide

Interactions in our licensed database are recorded against drug classes, not just single drug names. Methazolamide is filed under 5 classifications — including carbonic anhydrase inhibitors, diuretic drugs, antihypertensive drugs. Skullcap has documented interactions with 1 drug class — the most serious being cns depressants (moderate) — and none of Methazolamide’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

Skullcap Does Interact With Other Medications

Skullcap has 248 moderate known drug interactions in our database — Methazolamide isn’t one of them. If you take anything else, check it against the full list below.

Moderate 248 No known interaction 2,582 (incl. Methazolamide)
Taking anything else?

Check Another of Your Medications Against Skullcap

Covers the 2,830 medications we’ve checked against Skullcap. Pick one to open its full report.

What to actually watch for

No Interaction Found — But Data Suggests Skullcap and Methazolamide May Share a Side Effect

This is not an interaction. Neither one changes how your body handles the other, and nothing here says they react together. What our sources do show is that each has separately been linked to the effects below — so taking both can make those effects more likely to turn up, and harder to pin on one or the other if they do.

  • Drowsiness Additional detail

    Skullcap

    “A single skullcap extract dose of 100 mg does not seem to have adverse CNS effects. However, a higher dose of 200 mg might cause sedation and cognitive impairment. One patient taking skullcap 350 mg three times daily for 2 weeks reported vivid dreams. It is unclear if this event was associated with skullcap.”

    Skullcap · Natural Medicines adverse-effect record, reported in cognitive impairment.

    2 sources cited
    1. 12216. Wolfson P, Hoffmann DL. An investigation into the efficacy of Scutellaria lateriflora in healthy volunteers. Altern Ther Health Med 2003;9:74-8.
    2. 91690. Brock C, Whitehouse J, Tewfik I, Towell T. American skullcap (Scutellaria lateriflora): a randomised, double-blind placebo-controlled crossover study of its effects on mood in healthy volunteers. Phytother Res 2014;28(5):692-8.

    Methazolamide

    Listed in the ADVERSE REACTIONS section of the FDA label for Methazolamide. Read the label on DailyMed ›

Reported for Skullcap but not commonly for Methazolamide: memory problems and vivid dreams or nightmares.

Effects for Methazolamide come from the ADVERSE REACTIONS section of its FDA label; effects for Skullcap come from the Natural Medicines adverse-effect record, quoted above. Where a percentage is shown, it is the share of 339 voluntary FDA FAERS reports for Methazolamide that mention that effect — a reporting proportion, not an incidence rate and not evidence the drug caused it. Wording is matched across sources by our own clinical vocabulary, so treat this as a prompt to pay attention, not a diagnosis.

From our Q&A

Questions About Skullcap or Methazolamide

These are real questions from readers, answered by the pharmacists at HelloPharmacist — written by a person, not generated from a database. Each one covers Skullcap or Methazolamide, not necessarily both, but if one is close to what you were about to ask it will usually go further than a database entry can:

Not quite your question? Ask our pharmacists directly — it is free, there is no account required, and answers usually come back within 24 hours.

Everything else you take

See Every Supplement That Interacts With Methazolamide

This page covers Skullcap only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Methazolamide page lists 218 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), American Hellebore (major), American Mistletoe (major), Lithium (major) and Oleander (major).

By severity: 7 major · 187 moderate · 24 minor.

From our pharmacist’s overview on the Methazolamide page

“Methazolamide (Neptazane) treats glaucoma by lowering pressure inside the eye, and because it also has mild water-pill effects it can nudge blood pressure and potassium on its own. That is exactly where most of the 218 supplements on this page press, and the list earns real caution.”

Reviewed by 2 · Jul 18, 2026

Open the Methazolamide interaction page

One more smart check

Taking Skullcap as Part of a Dietary Supplement Product? Check It for Interactions

We hold 926 real supplement products containing Skullcap, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Skullcap. Even though Skullcap itself has no known interaction with Methazolamide, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Skullcap and Methazolamide Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Skullcap
Top 25%

#199 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Methazolamide
Steady interest

#1,883 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Skullcap reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 20, 2026. The Skullcap and Methazolamide records this page draws on were last updated July 10, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Skullcap

What is Skullcap?

Skullcap
  • Anxiety and stress
  • Trouble sleeping
  • Nervous tension
  • Muscle spasms
  • General relaxation

American skullcap is an herb traditionally used to calm anxiety and promote relaxation, but solid human evidence is very limited. It is generally considered relatively safe for short-term use in healthy adults, though it should be avoided in pregnancy and breastfeeding and used cautiously because of possible liver concerns and product mislabeling.

Scutellaria lateriflora · Lamiaceae · Above-ground parts (leaves, stems, and flowers) · Tea, capsules, tinctures, liquid extracts, dried herb

An interaction check asks whether these two react with each other — it does not ask whether Skullcap is a good idea for someone in your situation. Here is what our Skullcap record says about it on its own.

Skullcap: dosing

There is no official, standardized dose for American skullcap. The right amount can vary depending on the product and the form (tea, capsule, or tincture).The safest approach is to follow the directions on the product label and not take more than recommended.

From our Skullcap monograph — the full record covers uses, side effects and every documented interaction.

Read the full Skullcap monograph & all interactions
Medication

About Methazolamide

What Is Methazolamide Used For?

Brand name: Neptazane

Methazolamide tablets are used to treat eye conditions where lowering intraocular pressure (pressure inside the eye) is expected to help. These include chronic open-angle glaucoma and secondary glaucoma.

Methazolamide tablets are also used before surgery in acute angle-closure glaucoma, when reducing eye pressure ahead of the procedure is needed. Note that long-term use in angle-closure glaucoma is not appropriate.

Most-Reported Side Effects for Methazolamide

From FAERS, the FDA’s public side-effect reporting system (339 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.

Fatigue 41 reports
Dizziness 29 reports
Dyspnea 28 reports
Headache 28 reports
Blood pressure increased 22 reports
See full Methazolamide drug information
Keep checking

Other Drugs & Skullcap

Browse every other medication we’ve checked against Skullcap — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
248Moderate
0Minor
2,581No known interaction
248 Moderate 2,581 No interaction
Moderate

248 interactions

Showing 60 of 248 moderate interactions — see all 248 on the Skullcap page.

No interaction 2,581 drugs checked — show the list

We also checked Skullcap against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,581 medications checked with no known interaction — see the full Skullcap list.

See the full Skullcap interactions page
See every supplement checked against Methazolamide, ranked by severity
Evidence & sources

Skullcap References

The 3 references that drive our Skullcap monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Wolfson P, Hoffmann DL. An investigation into the efficacy of Scutellaria lateriflora in healthy volunteers. Altern Ther Health Med 2003;9:74-8.
  2. Awad, R., Arnason, J. T., Trudeau, V., Bergeron, C., Budzinski, J. W., Foster, B. C., and Merali, Z. Phytochemical and biological analysis of skullcap (Scutellaria lateriflora L.): a medicinal plant with anxiolytic properties. Phytomedicine. 2003;10(8):6 PubMed
  3. Brock C, Whitehouse J, Tewfik I, Towell T. American skullcap (Scutellaria lateriflora): a randomised, double-blind placebo-controlled crossover study of its effects on mood in healthy volunteers. Phytother Res 2014;28(5):692-8.

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Skullcap and Methazolamide Together: Common Questions

Is it safe to take Skullcap with Methazolamide?
We do not list a known interaction between Skullcap and Methazolamide. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Do Skullcap and Methazolamide have any of the same side effects?
Yes — our sources link each of them separately to one of the same effects. That is not an interaction: neither changes how your body handles the other. It does mean that if one of those effects turns up, it can be harder to tell which one is behind it. They are listed on this page with the source behind each.
How was the Skullcap and Methazolamide combination checked?
Interactions in our licensed database are recorded against drug classes. Methazolamide is filed under 5 classifications, and Skullcap has documented interactions with 1 drug class — none of Methazolamide's classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.
Does Skullcap interact with any other medications?
Yes. Skullcap has 248 documented drug interactions in our database — Methazolamide is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.
Does Methazolamide interact with any supplements?
Yes. Methazolamide has documented interactions with 218 supplements in our database — Skullcap is not one of them. The Methazolamide interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Skullcap monograph Uses, safety profile, and every drug interaction in one place Methazolamide drug information The full plain-English guide to this medication Methazolamide supplement interactions Every supplement checked against Methazolamide, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 3 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Methazolamide and Skullcap?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.