Drug & supplement interaction

Tinospora Cordifolia + Enasidenib

Enasidenib brand name: Idhifa.

Moderate Interaction
Medically reviewed by · Updated October 2026
The bottom line Moderate

Enasidenib falls into 4 drug categories that Tinospora Cordifolia can interact with; the most serious is rated moderate. Theoretically, Tinospora cordifolia might increase levels of drugs metabolized by CYP2D6.

Read the full interaction report
SeverityModerate
LikelihoodPossible
Interactions4
EvidenceD
What do Severity, Likelihood & Evidence mean?
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Interaction report

Tinospora Cordifolia and Enasidenib

These two interact in 4 distinct ways. Each one is explained separately below.

Why Are There 4 Interactions?

Tinospora Cordifolia interacts with whole categories of medication. Enasidenib falls into 4 of those categories, so it can interact with Tinospora Cordifolia in 4 different ways. We’ve listed each one below — your overall risk is driven by the most serious of them (Moderate).

Moderate

CYTOCHROME P450 2D6 (CYP2D6) SUBSTRATES

1 of 4

Why this applies to Enasidenib

Enasidenib falls under CYTOCHROME P450 2D6 (CYP2D6) SUBSTRATES — the group Tinospora Cordifolia interacts with.

Theoretically, Tinospora cordifolia might increase levels of drugs metabolized by CYP2D6.
In vitro research shows that Tinospora cordifolia extract inhibits CYP2D6 at high concentrations. However, this interaction has not been reported in humans.
Severity Moderate Likelihood Possible Evidence D

Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.

Dr. Brian Staiger, PharmD, BCPS
Dr. Brian Staiger explains PharmD, Clinical Pharmacist

Here's the gist with Giloy (Tinospora cordifolia) and your Enasidenib (Idhifa). In lab dishes, this herb can block a liver enzyme called CYP2D6, which is one of the routes your body uses to clear enasidenib. If that pathway slows down, enasidenib could theoretically build up a bit, which might mean more of its known side effects, like nausea, diarrhea, elevated bilirubin, or a serious lung-related reaction called differentiation syndrome.

I want to be straight with you though: this is only a test-tube finding, and it hasn't actually been seen in people. That said, since you're treating leukemia and Giloy has also been tied to liver injury, I'd skip the supplement unless your oncologist or pharmacist clears it first.

Contact Dr. Brian directly if you have additional questions on this interaction
References
  1. Sahu R, Ahmed T, Sangana R, Punde R, Subudhi BB. Effect of Tinospora cordifolia aqua-alcoholic extract on pharmacokinetic of glibenclamide in rat: an herb-drug interaction study. J Pharm Biomed Anal. 2018;151:310-6. doi: 10.1016/j.jpba.2018.01.010. PubMed
Moderate

CYTOCHROME P450 2C19 (CYP2C19) SUBSTRATES

2 of 4

Enasidenib also falls under CYTOCHROME P450 2C19 (CYP2C19) SUBSTRATES.

Theoretically, Tinospora cordifolia might increase levels of drugs metabolized by CYP2C19.
In vitro research shows that Tinospora cordifolia extract inhibits CYP2C19 at high concentrations. However, this interaction has not been reported in humans.
Severity Moderate Likelihood Possible Evidence D

Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.

Dr. Brian Staiger, PharmD, BCPS
Dr. Brian Staiger explains PharmD, Clinical Pharmacist

Here's the gist with Idhifa (enasidenib) and Giloy. Your body partly uses an enzyme called CYP2C19 to clear enasidenib. Lab (test tube) studies hint that Tinospora cordifolia can slow that same enzyme when used in high amounts. If that happened in a person, enasidenib could build up a bit, which might mean more of its known side effects, like nausea, diarrhea, lower appetite, higher bilirubin, or worsening blood counts.

But I want to be honest about the strength of this: it's theoretical and comes only from lab data, never reported in real patients. Since enasidenib treats a serious leukemia and the supplement itself has been linked to liver injury, please don't add Giloy without first checking with your oncology team or pharmacist.

Contact Dr. Brian directly if you have additional questions on this interaction
References
  1. Sahu R, Ahmed T, Sangana R, Punde R, Subudhi BB. Effect of Tinospora cordifolia aqua-alcoholic extract on pharmacokinetic of glibenclamide in rat: an herb-drug interaction study. J Pharm Biomed Anal. 2018;151:310-6. doi: 10.1016/j.jpba.2018.01.010. PubMed
Moderate

CYTOCHROME P450 1A2 (CYP1A2) SUBSTRATES

3 of 4

Enasidenib also falls under CYTOCHROME P450 1A2 (CYP1A2) SUBSTRATES.

Theoretically, Tinospora cordifolia might increase levels of drugs metabolized by CYP1A2.
In vitro research shows that Tinospora cordifolia extract inhibits CYP1A2 at high concentrations. However, this interaction has not been reported in humans.
Severity Moderate Likelihood Possible Evidence D

Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.

Dr. Brian Staiger, PharmD, BCPS
Dr. Brian Staiger explains PharmD, Clinical Pharmacist

Here's the gist for Idhifa (enasidenib). Giloy (Tinospora cordifolia) has shown in lab dishes that it can block a liver enzyme called CYP1A2, which is one pathway your body uses to clear enasidenib. If that enzyme slows down, enasidenib could in theory build up a bit, which might mean more side effects like nausea, low appetite, or changes in your blood counts and liver tests.

I want to be honest about how soft this signal is. It comes only from test-tube research at high concentrations and has never actually been seen in people, so the real-world risk is unclear. There's also a separate concern: Giloy itself has been tied to liver injury, and enasidenib already stresses the liver. Please don't start or stop anything on your own. Loop in your oncology team or pharmacist first.

Contact Dr. Brian directly if you have additional questions on this interaction
References
  1. Sahu R, Ahmed T, Sangana R, Punde R, Subudhi BB. Effect of Tinospora cordifolia aqua-alcoholic extract on pharmacokinetic of glibenclamide in rat: an herb-drug interaction study. J Pharm Biomed Anal. 2018;151:310-6. doi: 10.1016/j.jpba.2018.01.010. PubMed
Moderate

CYTOCHROME P450 2C9 (CYP2C9) SUBSTRATES

4 of 4

Enasidenib also falls under CYTOCHROME P450 2C9 (CYP2C9) SUBSTRATES.

Theoretically, Tinospora cordifolia might increase levels of drugs metabolized by CYP2C9.
In vitro research shows that Tinospora cordifolia extract inhibits CYP2C9. Animal research shows that Tinospora cordifolia extract 400 mg/kg twice daily for 14 days reduces the clearance and increases plasma levels of glyburide, a CYP2C9 substrate. However, this interaction has not been reported in humans.
Severity Moderate Likelihood Possible Evidence D

Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.

Dr. Brian Staiger, PharmD, BCPS
Dr. Brian Staiger explains PharmD, Clinical Pharmacist

Here's the gist: your body uses an enzyme called CYP2C9 to help clear certain medicines, and lab studies suggest Tinospora cordifolia (Giloy) may slow that enzyme down. Since enasidenib is partly handled by CYP2C9, the theory is that this herb could let more of it build up in your blood. That might mean stronger effects, including a higher chance of side effects like nausea, low appetite, or rising bilirubin (which can show as yellowing of the skin or eyes).

I want to be honest about the evidence here: this comes only from test tube and animal work, not from people taking these two together, so it's a possible concern rather than a proven one. Enasidenib is a serious cancer drug, so please don't add Giloy without first running it by your oncologist or pharmacist.

Contact Dr. Brian directly if you have additional questions on this interaction
References
  1. Sahu R, Ahmed T, Sangana R, Punde R, Subudhi BB. Effect of Tinospora cordifolia aqua-alcoholic extract on pharmacokinetic of glibenclamide in rat: an herb-drug interaction study. J Pharm Biomed Anal. 2018;151:310-6. doi: 10.1016/j.jpba.2018.01.010. PubMed

What These Ratings Mean

Every interaction above is graded three ways — here’s the key to each label.

Severity how clinically significant the interaction is
Major

Clinically significant. Avoid the combination, or use only under close professional supervision.

Moderate

Usually worth avoiding or managing — may need monitoring, a dose change, or timing apart.

Minor

Generally not serious. Be aware of it and mention it to your pharmacist.

Likelihood how strong the evidence is that the interaction actually happens in people
  • LikelyWell-controlled human studies have demonstrated the likely existence of this interaction.
  • ProbableInteraction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • PossibleInteraction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.
  • UnlikelyInteraction has been demonstrated in animal or in lab research but has been shown not to occur in humans.
Evidence the quality of the studies behind the rating (graded A–D)
  • AHigh-quality meta-analysis (quantitative systematic review).
  • BCase-control study.
  • CConsensus.
  • DAnecdotal evidence.

These ratings are for information only. Never start, stop, or otherwise change your therapy before speaking with your provider.

Keep it in perspective

Tinospora Cordifolia Also Interacts With Other Medications

Tinospora Cordifolia has 613 moderate known drug interactions in our database — the Enasidenib one above is among them. If you take anything else, check it against the full list below.

Moderate 613 No known interaction 2,217 (incl. Enasidenib)
Taking anything else?

Check Another of Your Medications Against Tinospora Cordifolia

Covers the 2,830 medications we’ve checked against Tinospora Cordifolia. Pick one to open its full report.

Everything else you take

See Every Supplement That Interacts With Enasidenib

This page covers Tinospora Cordifolia only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Enasidenib page lists 203 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Grapefruit (major), St. John's Wort (major), 1,3-dmaa (moderate) and Acacia Rigidula (moderate).

By severity: 3 major · 156 moderate · 44 minor.

From our pharmacist’s overview on the Enasidenib page

“Anyone taking enasidenib (Idhifa) for acute myeloid leukemia should treat this supplement list with genuine care, beginning with the major-rated entries: grapefruit, St. John's wort, and activated charcoal.”

Reviewed by 2 · Jul 18, 2026

Open the Enasidenib interaction page

One more smart check

Taking Tinospora Cordifolia as Part of a Dietary Supplement Product? Check It for Interactions

We hold 393 real supplement products containing Tinospora Cordifolia, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Tinospora Cordifolia. Your product may carry other ingredients that interact with Enasidenib too, on top of Tinospora Cordifolia — and those would not show on this page. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Tinospora Cordifolia and Enasidenib Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Tinospora Cordifolia
Top 25%

#316 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Enasidenib
Steady interest

#1,850 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Supplement

About Tinospora Cordifolia

What is Tinospora Cordifolia?

  • Immune support
  • Fever
  • Blood sugar support
  • General wellness and 'rejuvenation'
  • Allergic rhinitis
  • Inflammation

Tinospora cordifolia, known as Guduchi or Giloy in Ayurvedic medicine, is a climbing plant traditionally used to support immunity and treat fevers. Early laboratory and small human studies suggest possible immune and blood sugar effects, but high-quality evidence is limited, and there have been reports of liver injury. Talk with your pharmacist or doctor before using it.

Read the full Tinospora Cordifolia monograph & all interactions
Medication

About Enasidenib

What Is Enasidenib Used For?

Brand name: Idhifa

Enasidenib (brand name Idhifa) treats adults with acute myeloid leukemia (AML) that has come back (relapsed) or has not responded to other treatment (refractory).

It is only for AML with an IDH2 mutation, confirmed by an FDA-approved test on blood or bone marrow.

See full Enasidenib drug information Enasidenib Mesylate NDC codes and packages
Keep checking

Other Drugs & Tinospora Cordifolia

Browse every other medication we’ve checked against Tinospora Cordifolia — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
613Moderate
0Minor
2,216No known interaction
613 Moderate 2,216 No interaction
Moderate

613 interactions

Showing 60 of 613 moderate interactions — see all 613 on the Tinospora Cordifolia page.

No interaction 2,216 drugs checked — show the list

We also checked Tinospora Cordifolia against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,216 medications checked with no known interaction — see the full Tinospora Cordifolia list.

See the full Tinospora Cordifolia interactions page
See every supplement checked against Enasidenib, ranked by severity
Sources

Sources & How We Checked

Interaction details are evidence-graded and sourced from the Natural Medicines database. The medication overview comes from MedlinePlus.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Keep exploring
Tinospora Cordifolia monograph › Uses, safety, and every drug interaction in one place Enasidenib supplement interactions › Every supplement checked against Enasidenib, ranked by severity Enasidenib drug information › The full plain-English guide to this medication Enasidenib Mesylate NDC codes and packages › Every package, labeler and price in the FDA directory Supplement interaction checker › Check any supplement or product against your medications Browse medications A–Z › Every drug we've checked against herbs & supplements Ask a pharmacist › Free, personal answer from our licensed team
Pharmacist Counseling Corner

Taking Tinospora Cordifolia and Enasidenib Together: Common Questions

Can you take Tinospora Cordifolia with Enasidenib?
There is a moderate interaction, so it may be acceptable with monitoring or timing changes — but check with your pharmacist first. Read the full details on this page and confirm with your pharmacist before combining them.
Why are there 4 interactions listed for Tinospora Cordifolia and Enasidenib?
Enasidenib belongs to more than one drug category, and Tinospora Cordifolia interacts with each of those categories a little differently. We list every one so nothing is missed — your overall risk is driven by the most serious of them.
How serious is the Tinospora Cordifolia and Enasidenib interaction?
We rate it Moderate. This combination may require monitoring, a dose adjustment, or separating the times you take each one. Consult your pharmacist before using them together.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Still Have a Question About Enasidenib and Tinospora Cordifolia?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.