Drug & supplement interaction

Vitamin B6 + Lomefloxacin

Lomefloxacin brand name: Maxaquin.

No Known Interaction
The bottom line No known interaction

We found no known interaction between Vitamin B6 and Lomefloxacin in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first.

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Interaction report

Vitamin B6 and Lomefloxacin

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Lomefloxacin and Vitamin B6 in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Vitamin B6 safety at a glance

Vitamin B6 overall Use caution Safe at normal amounts from food and standard supplements, but high doses over time can harm nerves.
Pregnancy Likely Safe When used orally and appropriately. A special sustained-release product providing vitamin B6 (pyridoxine) 75 mg daily is FDA-approved for use in pregnancy. Vita... Read the full pregnancy detail
Breastfeeding Likely Safe When used orally in doses not exceeding the tolerable upper intake level (UL) of vitamin B6 in the form of pyridoxine 80 mg daily for those aged 14-18 years and... Read the full breastfeeding detail

Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center) — the full detail is in the Special populations card below. Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Lomefloxacin and Vitamin B6? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
How we checked

Why No Interaction Is Listed for Lomefloxacin

Interactions in our licensed database are recorded against drug classes, not just single drug names. Lomefloxacin is filed under 8 classifications — including quinolone antibiotics, organic anion-transporting polypeptide substrates (oatp), antibiotic drugs. Vitamin B6 has documented interactions with 5 drug classes — the most serious being amiodarone (cordarone) (moderate), antihypertensive drugs (moderate) and phenobarbital (luminal) (moderate) — and none of Lomefloxacin’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

Vitamin B6 Does Interact With Other Medications

Vitamin B6 has 205 moderate, 5 minor known drug interactions in our database — Lomefloxacin isn’t one of them. If you take anything else, check it against the full list below.

Taking anything else?

Check Another of Your Medications Against Vitamin B6

Covers the 2,830 medications we’ve checked against Vitamin B6. Pick one to open its full report.

What to actually watch for

What Vitamin B6 Itself Has Been Linked To

This is not an interaction — nothing below involves Lomefloxacin. It is the side-effect record for Vitamin B6 on its own, from the licensed Natural Medicines monograph. If something new turns up after you add Vitamin B6, this list is the first place to look. 3 entries are worth acting on rather than waiting out — marked below.

  • Unsteadiness Worth acting on Additional detail

    “Orally or by injection, vitamin B6 (pyridoxine) can cause headache, paresthesia, and somnolence. Vitamin B6 (pyridoxine) can also cause sensory neuropathy, which is related to daily dose and duration of intake. Doses exceeding 1000 mg daily or total doses of 1000 grams or more pose the most risk, although neuropathy can occur with lower daily or total doses as well.”

    Vitamin B6 · Natural Medicines adverse-effect record, reported in cluster headache.

    6 sources cited
    1. 8195. Bendich A, Cohen M. Vitamin B6 safety issues. Ann N Y Acad Sci 1990;585:321-30.
    2. 9479. Kawada A, Kashima A, Shiraishi H, et al. Pyridoxine-induced photosensitivity and hypophosphatasia. Dermatology 2000;201:356-60.. PubMed
    3. 16306. Chittumma P, Kaewkiattikun K, Wiriyasiriwach B. Comparison of the effectiveness of ginger and vitamin B6 for treatment of nausea and vomiting in early pregnancy: a randomized double-blind controlled trial. J Med Assoc Thai 2007;90:15-20.
    4. 8204. Lewis PJ. Pain in the hand and wrist. Pyridoxine supplements may help patients with carpal tunnel syndrome. BMJ 1995;310:1534. PubMed
    5. 8196. Schaumburg H, Kaplan J, Windebank A. Sensory neuropathy from pyridoxine abuse. A new megavitamin syndrome. N Engl J Med 1983;309:445-8. PubMed
    6. 10439. Vasile A, Goldberg R, Kornberg B. Pyridoxine toxicity: report of a case. J Am Osteopath Assoc 1984;83:790-1. DOI
  • Bleeding or bruising Worth acting on Additional detail

    “Orally or by injection, vitamin B6 (pyridoxine) can cause decreased serum folic acid concentrations. One case of persistent bleeding of unknown origin has been reported in a clinical trial for a patient who used vitamin B6 (pyridoxine) 100 mg twice daily on days 16 to 35 of the menstrual cycle. It is unclear if this effect was due to vitamin B6 intake.”

    Vitamin B6 · Natural Medicines adverse-effect record, reported in myasthenia gravis.

    3 sources cited
    1. 8195. Bendich A, Cohen M. Vitamin B6 safety issues. Ann N Y Acad Sci 1990;585:321-30.
    2. 9479. Kawada A, Kashima A, Shiraishi H, et al. Pyridoxine-induced photosensitivity and hypophosphatasia. Dermatology 2000;201:356-60.. PubMed
    3. 83103. Lauritzen CH, Reuter HD, Repges R, Bohnert K, and Schmidt U. Treatment of premenstrual tension syndrome with Vitex agnus castus. Controlled, double-blind study versus pyridoxine. Phytomed 1997;4(3):183-189. PubMed
  • An allergic reaction Worth acting on Additional detail

    “Orally, vitamin B6 (pyridoxine) has been linked to reports of skin and other allergic reactions and photosensitivity. High-dose vitamin B6 (80 mg daily as pyridoxine) and vitamin B12 (20 mcg daily) have been associated with cases of rosacea fulminans characterized by intense erythema with nodules, papules, and pustules.”

    Vitamin B6 · Natural Medicines adverse-effect record, reported in erythema.

    4 sources cited
    1. 8195. Bendich A, Cohen M. Vitamin B6 safety issues. Ann N Y Acad Sci 1990;585:321-30.
    2. 9479. Kawada A, Kashima A, Shiraishi H, et al. Pyridoxine-induced photosensitivity and hypophosphatasia. Dermatology 2000;201:356-60.. PubMed
    3. 90375. Fonseca VA, Lavery LA, Thethi TK, et al. Metanx in type 2 diabetes with peripheral neuropathy: A randomized trial. Am J Med 2013;126(2):141-9. PubMed
    4. 10998. Jansen T, Romiti R, Kreuter A, Altmeyer P. Rosacea fulminans triggered by high-dose vitamins B6 and B12. J Eur Acad Dermatol Venereol 2001;15:484-5..
  • Heartburn / Reduced appetite / Stomach pain Additional detail

    “Orally or by injection, vitamin B6 (pyridoxine) can cause nausea, vomiting, heartburn, abdominal pain, mild diarrhea, and loss of appetite. In a clinical trial, one patient experienced infectious gastroenteritis that was deemed possibly related to taking vitamin B6 (pyridoxine) orally up to 20 mg/kg daily.”

    Vitamin B6 · Natural Medicines adverse-effect record, reported in diarrhea.

    6 sources cited
    1. 8195. Bendich A, Cohen M. Vitamin B6 safety issues. Ann N Y Acad Sci 1990;585:321-30.
    2. 9479. Kawada A, Kashima A, Shiraishi H, et al. Pyridoxine-induced photosensitivity and hypophosphatasia. Dermatology 2000;201:356-60.. PubMed
    3. 16306. Chittumma P, Kaewkiattikun K, Wiriyasiriwach B. Comparison of the effectiveness of ginger and vitamin B6 for treatment of nausea and vomiting in early pregnancy: a randomized double-blind controlled trial. J Med Assoc Thai 2007;90:15-20.
    4. 83064. Hagen, I., Nesheim, B. I., and Tuntland, T. No effect of vitamin B-6 against premenstrual tension. A controlled clinical study. Acta Obstet.Gynecol.Scand. 1985;64(8):667-670. PubMed
    5. 83103. Lauritzen CH, Reuter HD, Repges R, Bohnert K, and Schmidt U. Treatment of premenstrual tension syndrome with Vitex agnus castus. Controlled, double-blind study versus pyridoxine. Phytomed 1997;4(3):183-189. PubMed
    6. 107124. Mahmoud A, Tabassum S, Al Enazi S, et al. Amelioration of levetiracetam-induced behavioral side effects by pyridoxine. A randomized double blind controlled study. Pediatr Neurol 2021;119:15-21. PubMed
  • Sun sensitivity Additional detail

    Recorded for Vitamin B6 in the same Natural Medicines adverse-effect record shown under An allergic reaction above.

  • Numbness or tingling Additional detail

    Recorded for Vitamin B6 in the same Natural Medicines adverse-effect record shown under Unsteadiness above.

  • Drowsiness Additional detail

    Recorded for Vitamin B6 in the same Natural Medicines adverse-effect record shown under An allergic reaction above.

  • Diarrhea Additional detail

    Recorded for Vitamin B6 in the same Natural Medicines adverse-effect record shown under Heartburn / Reduced appetite / Stomach pain above.

Showing the 10 most notable of 13 recorded effects — ranked by how unusual each one is across medicines generally, with serious effects weighted up.

Everything above comes from the Natural Medicines adverse-effect record for Vitamin B6 — expand a row for the licensed statement it rests on. We haven’t matched Lomefloxacin to its FDA label in our system yet, so we can’t compare its own side-effect list here — the leaflet that comes with your prescription is the authoritative list for Lomefloxacin.

Special populations

Vitamin B6 in Pregnancy & Breastfeeding

Pregnancy Likely Safe

When used orally and appropriately. A special sustained-release product providing vitamin B6 (pyridoxine) 75 mg daily is FDA-approved for use in pregnancy. Vitamin B6 (pyridoxine) is also considered a first-line treatment for nausea and vomiting in pregnancy by the American College of Obstetrics and Gynecology. However, it should not be used long-term or without medical supervision and close monitoring. The tolerable upper intake level (UL) refers to vitamin B6 in the form of pyridoxine and is 80 mg daily for those aged 14-18 years and 100 mg daily for 19 years and older.

Pregnancy Possibly Unsafe

When used orally in excessive doses. There is some concern that high-dose maternal vitamin B6 (pyridoxine) can cause neonatal seizures.

Lactation Likely Safe

When used orally in doses not exceeding the tolerable upper intake level (UL) of vitamin B6 in the form of pyridoxine 80 mg daily for those aged 14-18 years and 100 mg daily for those 19 years and older. The recommended dietary allowance (RDA) in lactating women is 2 mg daily. There is insufficient reliable information available about the safety of vitamin B6 when used in higher doses in breast-feeding women.

DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.© 2026 Therapeutic Research Center

Worth knowing

No Interaction — But Lomefloxacin May Lower Your Vitamin B6 Levels

These two do not interact. The relationship runs the other way: the licensed record lists Lomefloxacin as associated with lower Vitamin B6 levels — rated “Insignificant Depletion”.

Theoretically, antibiotics might reduce levels of vitamin B6 in the blood. Some sources suggest that destruction of the normal gastrointestinal flora by antibiotics can decrease production and plasma levels of vitamin B6. However, there is no evidence that the gastrointestinal flora is a significant source of vitamin B6 in humans. Supplementation with vitamin B6 is not necessary during antibiotic therapy. For information on foods that are rich in vitamin B6, see our chart.

VITAMIN B6 — Insignificant Depletion

See every medication linked to lower Vitamin B6 levels · See the full Lomefloxacin nutrient report

Disclaimer: This checker finds which nutrients might be depleted by prescription or over-the-counter medications. Each nutrient depletion issue is rated based on clinical significance. Use your own professional judgment prior to making clinical decisions.© 2026 Therapeutic Research Center

Everything else you take

See Every Supplement That Interacts With Lomefloxacin

This page covers Vitamin B6 only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Lomefloxacin page lists 145 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Apple (major), Asarabacca (major), Beer (major) and Grapefruit (major).

By severity: 8 major · 115 moderate · 22 minor.

From our pharmacist’s overview on the Lomefloxacin page

“I would read this page carefully if you take lomefloxacin (Maxaquin), a fluoroquinolone antibiotic. Eight of the 145 interacting ingredients carry a major rating, and several are ordinary drinks.”

Reviewed by 2 · Jul 18, 2026

Open the Lomefloxacin interaction page

One more smart check

Taking Vitamin B6 as Part of a Dietary Supplement Product? Check It for Interactions

We hold 24,838 real supplement products containing Vitamin B6, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Vitamin B6. Even though Vitamin B6 itself has no known interaction with Lomefloxacin, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Vitamin B6 and Lomefloxacin Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Vitamin B6
Top 10

#3 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Lomefloxacin
Steady interest

#2,684 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Vitamin B6 reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 13, 2026. The Vitamin B6 and Lomefloxacin records this page draws on were last updated July 11, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Vitamin B6

What is Vitamin B6?

  • Morning sickness in pregnancy
  • Premenstrual syndrome (PMS)
  • Preventing or treating B6 deficiency
  • Nerve health and metabolism support
  • Nausea

Vitamin B6 (pyridoxine) is an essential water-soluble vitamin that your body needs for metabolism, brain function, and making red blood cells. It is best known for helping with pregnancy-related nausea and may help some people with PMS, but taking very high doses for long periods can cause nerve damage. Get most of your B6 from food, and check with a pharmacist or doctor before taking high-dose supplements.

Tablets, capsules, softgels, liquid drops, part of B-complex and multivitamins

An interaction check asks whether these two react with each other — it does not ask whether Vitamin B6 is a good idea for someone in your situation. Here is what our Vitamin B6 record says about it on its own.

Vitamin B6: dosing

There is no single "best" supplement dose for everyone, and the right amount depends on your age, health, and the reason you are taking it. Health authorities set recommended daily intakes and an upper limit to help avoid nerve-related side effects from too much.The safest approach is to follow the directions on the product label and not exceed the upper limit unless a healthcare provider tells you to. Avoid taking high-dose B6 for long periods on your own.If you take a B-complex or multivitamin, check how much B6 it already contains so you do not accidentally take too much from multiple products.

From our Vitamin B6 monograph — the full record covers uses, side effects and every documented interaction.

Read the full Vitamin B6 monograph & all interactions
Keep checking

Other Drugs & Vitamin B6

Browse every other medication we’ve checked against Vitamin B6 — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
205Moderate
5Minor
2,619No known interaction
Moderate

205 interactions

Showing 60 of 205 moderate interactions — see all 205 on the Vitamin B6 page.

Minor

5 interactions

No interaction 2,619 drugs checked — show the list
Evidence & sources

Vitamin B6 References

The 32 references that drive our Vitamin B6 monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Hansten PD, Horn JR. Drug Interactions Analysis and Management. Vancouver, WA: Applied Therapeutics Inc., 1997 and updates.
  2. Yates AA, Schlicker SA, Suitor CW. Dietary reference intakes: The new basis for recommendations for calcium and related nutrients, B vitamins, and choline. J Am Diet Assoc 1998;98:699-706. PubMed
  3. Geerling BJ, Dagnelie PC, Badart-Smook A, et al. Diet as a risk factor for the development of ulcerative colitis. Am J Gastroenterol 2000;95:1008-13. PubMed
  4. South M. Neonatal seizures after pyridoxine use -- reply. Lancet 1999;354:2083. PubMed
  5. Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Thiamin, Riboflavin, Niacin, Vitamin B6, Folate, Vitamin B12, Pantothenic Acid, Biotin, and Choline (2000). Washington, DC: National Academy Press, 2000. Available at: http://b
  6. Baxter P, Aicardi J. Neonatal seizures after pyridoxine use. Lancet 1999;354:2082-3. PubMed
  7. Bendich A, Cohen M. Vitamin B6 safety issues. Ann N Y Acad Sci 1990;585:321-30.
  8. Schaumburg H, Kaplan J, Windebank A. Sensory neuropathy from pyridoxine abuse. A new megavitamin syndrome. N Engl J Med 1983;309:445-8. PubMed
  9. Gordon N. Pyridoxine dependency: an update. Dev Med Child Neurol 1997;39:63-5. PubMed
  10. Lewis PJ. Pain in the hand and wrist. Pyridoxine supplements may help patients with carpal tunnel syndrome. BMJ 1995;310:1534. PubMed
  11. Kaufman G. Pyridoxine against amiodarone-induced photosensitivity (letter). Lancet 1984;1:51-2. PubMed
  12. Mulrow JP, Mulrow CD, McKenna WJ. Pyridoxine and amiodarone-induced photosensitivity. Ann Intern Med 1985;103:68-9. PubMed
  13. Kawada A, Kashima A, Shiraishi H, et al. Pyridoxine-induced photosensitivity and hypophosphatasia. Dermatology 2000;201:356-60.. PubMed
  14. Vasile A, Goldberg R, Kornberg B. Pyridoxine toxicity: report of a case. J Am Osteopath Assoc 1984;83:790-1. DOI
  15. Hansson O, Sillanpaa M. Pyridoxine and serum concentration of phenytoin and phenobarbitone. Lancet 1976;1:256. DOI

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Vitamin B6 and Lomefloxacin Together: Common Questions

Is it safe to take Vitamin B6 with Lomefloxacin?
We do not list a known interaction between Vitamin B6 and Lomefloxacin. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Can Lomefloxacin lower my Vitamin B6 levels?
Natural Medicines records Lomefloxacin as a medicine that can deplete Vitamin B6. That is the opposite direction to an interaction — it is a reason some people are told to take a supplement, not a reason to avoid one. Do not start one on the strength of this page; ask your pharmacist or doctor whether it applies to you.
How was the Vitamin B6 and Lomefloxacin combination checked?
Interactions in our licensed database are recorded against drug classes. Lomefloxacin is filed under 8 classifications, and Vitamin B6 has documented interactions with 5 drug classes — none of Lomefloxacin's classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.
Does Vitamin B6 interact with any other medications?
Yes. Vitamin B6 has 210 documented drug interactions in our database — Lomefloxacin is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.
Does Lomefloxacin interact with any supplements?
Yes. Lomefloxacin has documented interactions with 145 supplements in our database — Vitamin B6 is not one of them. The Lomefloxacin interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Still Have a Question About Lomefloxacin and Vitamin B6?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.