Herb & supplement monograph

Acerola Drug Interactions, Uses, Effectiveness, Safety & More

Medically reviewed by ·Updated July 2026
What is this page for?

First and foremost: how Acerola interacts with medications. The heart of this page is the interaction list — every drug Acerola is known to interact with, and how serious each one is.

But these pages have grown well beyond that into a full monograph — what Acerola is, what people use it for and how strong the evidence is, its safety and side effects, and answers to the questions we’re asked most — written and reviewed by the clinical staff at HelloPharmacist. It’s educational information from our licensed clinical databases, not medical advice, and we don’t sell or endorse products. Our editorial policy

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Acerola Drug Interactions: The Bottom Line

From the HelloPharmacist Editorial Team · Updated July 2026

Based on the available evidence, the overall risk of a clinically significant Acerola drug interaction appears low for most people. None of the listed interactions are rated major, and the great majority are minor, with almost all resting on theoretical or lab-based reasoning rather than human studies.

Interactions deserving the most attention

The concerns that stand out most involve chemotherapy drugs, specifically alkylating agents and antitumor antibiotics. Because acerola is rich in vitamin C, an antioxidant, there is a theory it could blunt chemotherapy drugs that work by generating free radicals, though researchers disagree and some suggest the opposite effect. People taking estrogens, including birth control or hormone therapy, may see somewhat higher estrogen levels when vitamin C is added. Notably, the feared effects on warfarin and aspirin are rated unlikely, since acerola's vitamin C content appears too low to matter.

What the rest of the list means

A long list of interacting medications does not mean each combination is harmful. Nearly all of these entries trace back to acerola's vitamin C content and what high-dose vitamin C might do in theory. In several cases, the predicted effect has been shown not to occur in people at realistic amounts.

Check your medications against Acerola

Based on HelloPharmacist’s Acerola interaction data and reviewed under our editorial standards.

Interaction report

Drugs that interact with Acerola

128 medications have a known interaction with Acerola, graded by severity. Select any drug for the full evidence-based detail.

2,830 drugs
AltretamineHexalen
Moderate Alkylating Agents

Theoretically, the antioxidant effects of acerola might reduce the effectiveness of alkylating agents.

Read the full Acerola + Altretamine interaction
BendamustineBelrapzo, Treanda, Vivimusta
Moderate Alkylating Agents

Theoretically, the antioxidant effects of acerola might reduce the effectiveness of alkylating agents.

Read the full Acerola + Bendamustine interaction Bendamustine drug page: uses, dosage & side effects
Bendamustine HydrochlorideBendeka
Moderate Alkylating Agents

Theoretically, the antioxidant effects of acerola might reduce the effectiveness of alkylating agents.

Read the full Acerola + Bendamustine Hydrochloride interaction Bendamustine Hydrochloride drug page: uses, dosage & side effects
BleomycinBlenoxane
Moderate Antitumor Antibiotics

Theoretically, the antioxidant effects of acerola might reduce the effectiveness of antitumor antibiotics.

Read the full Acerola + Bleomycin interaction Bleomycin drug page: uses, dosage & side effects
BusulfanBusulfex, Myleran
Moderate Alkylating Agents

Theoretically, the antioxidant effects of acerola might reduce the effectiveness of alkylating agents.

Read the full Acerola + Busulfan interaction Busulfan drug page: uses, dosage & side effects
CarboplatinParaplatin
Moderate Alkylating Agents

Theoretically, the antioxidant effects of acerola might reduce the effectiveness of alkylating agents.

Read the full Acerola + Carboplatin interaction Carboplatin drug page: uses, dosage & side effects
CarmustineBiCNU, Gliadel, Gliadel Wafer
Moderate Alkylating Agents

Theoretically, the antioxidant effects of acerola might reduce the effectiveness of alkylating agents.

Read the full Acerola + Carmustine interaction Carmustine drug page: uses, dosage & side effects
ChlorambucilLeukeran
Moderate Alkylating Agents

Theoretically, the antioxidant effects of acerola might reduce the effectiveness of alkylating agents.

Read the full Acerola + Chlorambucil interaction Chlorambucil drug page: uses, dosage & side effects
CisplatinPlatinol-AQ
Moderate Alkylating Agents

Theoretically, the antioxidant effects of acerola might reduce the effectiveness of alkylating agents.

Read the full Acerola + Cisplatin interaction Cisplatin drug page: uses, dosage & side effects
CyclophosphamideCytoxan, Neosar
Moderate Alkylating Agents

Theoretically, the antioxidant effects of acerola might reduce the effectiveness of alkylating agents.

Read the full Acerola + Cyclophosphamide interaction Cyclophosphamide drug page: uses, dosage & side effects
DacarbazineDTIC-Dome
Moderate Alkylating Agents

Theoretically, the antioxidant effects of acerola might reduce the effectiveness of alkylating agents.

Read the full Acerola + Dacarbazine interaction Dacarbazine drug page: uses, dosage & side effects
DactinomycinCosmegan, Cosmegen
Moderate Antitumor Antibiotics

Theoretically, the antioxidant effects of acerola might reduce the effectiveness of antitumor antibiotics.

Read the full Acerola + Dactinomycin interaction Dactinomycin drug page: uses, dosage & side effects
Daunorubicin CitrateDaunoXome
Moderate Antitumor Antibiotics

Theoretically, the antioxidant effects of acerola might reduce the effectiveness of antitumor antibiotics.

Read the full Acerola + Daunorubicin Citrate interaction Daunorubicin Citrate drug page: uses, dosage & side effects
Daunorubicin HydrochlorideCerubidine
Moderate Antitumor Antibiotics

Theoretically, the antioxidant effects of acerola might reduce the effectiveness of antitumor antibiotics.

Read the full Acerola + Daunorubicin Hydrochloride interaction Daunorubicin Hydrochloride drug page: uses, dosage & side effects
Daunorubicin, CytarabineVyxeos
Moderate Antitumor Antibiotics

Theoretically, the antioxidant effects of acerola might reduce the effectiveness of antitumor antibiotics.

Read the full Acerola + Daunorubicin, Cytarabine interaction Daunorubicin, Cytarabine drug page: uses, dosage & side effects
DoripenemDoribax
Moderate Antitumor Antibiotics

Theoretically, the antioxidant effects of acerola might reduce the effectiveness of antitumor antibiotics.

Read the full Acerola + Doripenem interaction Doripenem drug page: uses, dosage & side effects
DoxorubicinAdriamycin, Caelyx, Doxil, Myocet, Rubex
Moderate Antitumor Antibiotics

Theoretically, the antioxidant effects of acerola might reduce the effectiveness of antitumor antibiotics.

Read the full Acerola + Doxorubicin interaction Doxorubicin drug page: uses, dosage & side effects
EpirubicinEllence
Moderate Antitumor Antibiotics

Theoretically, the antioxidant effects of acerola might reduce the effectiveness of antitumor antibiotics.

Read the full Acerola + Epirubicin interaction Epirubicin drug page: uses, dosage & side effects
Estramustine Phosphate SodiumEmcyt
Moderate Alkylating Agents

Theoretically, the antioxidant effects of acerola might reduce the effectiveness of alkylating agents.

Read the full Acerola + Estramustine Phosphate Sodium interaction Estramustine Phosphate Sodium drug page: uses, dosage & side effects
IdarubicinIdamycin
Moderate Antitumor Antibiotics

Theoretically, the antioxidant effects of acerola might reduce the effectiveness of antitumor antibiotics.

Read the full Acerola + Idarubicin interaction Idarubicin drug page: uses, dosage & side effects
IfosfamideIfex
Moderate Alkylating Agents

Theoretically, the antioxidant effects of acerola might reduce the effectiveness of alkylating agents.

Read the full Acerola + Ifosfamide interaction Ifosfamide drug page: uses, dosage & side effects
LomustineCeenu
Moderate Alkylating Agents

Theoretically, the antioxidant effects of acerola might reduce the effectiveness of alkylating agents.

Read the full Acerola + Lomustine interaction Lomustine drug page: uses, dosage & side effects
LurbinectedinZepzelca
Moderate Alkylating Agents

Theoretically, the antioxidant effects of acerola might reduce the effectiveness of alkylating agents.

Read the full Acerola + Lurbinectedin interaction Lurbinectedin drug page: uses, dosage & side effects
Mechlorethamine HydrochlorideValchlor
Moderate Alkylating Agents

Theoretically, the antioxidant effects of acerola might reduce the effectiveness of alkylating agents.

Read the full Acerola + Mechlorethamine Hydrochloride interaction Mechlorethamine Hydrochloride drug page: uses, dosage & side effects
MelphalanAlkeran, Hepzato
Moderate Alkylating Agents

Theoretically, the antioxidant effects of acerola might reduce the effectiveness of alkylating agents.

Read the full Acerola + Melphalan interaction Melphalan drug page: uses, dosage & side effects
Melphalan FlufenamidePepaxto
Moderate Alkylating Agents

Theoretically, the antioxidant effects of acerola might reduce the effectiveness of alkylating agents.

Read the full Acerola + Melphalan Flufenamide interaction Melphalan Flufenamide drug page: uses, dosage & side effects
Melphalan HydrochlorideEvomela
Moderate Alkylating Agents

Theoretically, the antioxidant effects of acerola might reduce the effectiveness of alkylating agents.

Read the full Acerola + Melphalan Hydrochloride interaction
MitomycinJelmyto, Mitosol, Mutamycin
Moderate Antitumor Antibiotics

Theoretically, the antioxidant effects of acerola might reduce the effectiveness of antitumor antibiotics.

Read the full Acerola + Mitomycin interaction Mitomycin drug page: uses, dosage & side effects
Mitomycin CMitozytrex
Moderate Antitumor Antibiotics

Theoretically, the antioxidant effects of acerola might reduce the effectiveness of antitumor antibiotics.

Read the full Acerola + Mitomycin C interaction
MitoxantroneNovantrone
Moderate Antitumor Antibiotics

Theoretically, the antioxidant effects of acerola might reduce the effectiveness of antitumor antibiotics.

Read the full Acerola + Mitoxantrone interaction Mitoxantrone drug page: uses, dosage & side effects
Read The List Like a Pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

  • Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
  • Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
  • Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
  • No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

  • Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
  • Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
  • Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

  • Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
  • Each drug listed above links to the full report for that exact Acerola combination — clinical detail, likelihood, evidence level, and citations.
  • Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.
The big picture

The kinds of drugs Acerola affects

Every type of medication (drug category) Acerola is known to interact with. Open any category for the detail — or search your exact drug in the checker above.

All 6 drug categories Acerola interacts with
Alkylating AgentsAntitumor AntibioticsAluminumAspirinEstrogensWarfarin (coumadin)
Alkylating Agents

Theoretically, the antioxidant effects of acerola might reduce the effectiveness of alkylating agents.
Acerola contains vitamin C, an antioxidant. There is concern that antioxidants might reduce the activity of chemotherapy drugs that generate free radicals, such as alkylating agents. In contrast, other researchers theorize that antioxidants might make alkylating chemotherapy more effective by reducing oxidative stress that could interfere with apoptosis (cell death) of cancer cells. More evidence is needed to determine what effect, if any, antioxidants such as vitamin C have on chemotherapy.

Likelihood Possible Evidence D
Antitumor Antibiotics

Theoretically, the antioxidant effects of acerola might reduce the effectiveness of antitumor antibiotics.
Acerola contains vitamin C, an antioxidant. There is concern that antioxidants might reduce the activity of chemotherapy drugs that generate free radicals, such as antitumor antibiotics. In contrast, other researchers theorize that antioxidants might make antitumor antibiotic chemotherapy more effective by reducing oxidative stress that could interfere with apoptosis (cell death) of cancer cells. More evidence is needed to determine what effects, if any, antioxidants such as vitamin C have on antitumor antibiotic chemotherapy.

Likelihood Possible Evidence D
Aluminum

Theoretically, concomitant use of acerola with aluminum salts might increase the amount of aluminum absorbed.
Acerola contains vitamin C. It is thought that vitamin C chelates aluminum, keeping it in solution and available for absorption. In people with normal renal function, urinary excretion of aluminum likely increases, making aluminum retention and toxicity unlikely. However, patients with renal failure who take aluminum-containing compounds, such as phosphate binders, should avoid acerola in doses that provide more vitamin C than the recommended dietary allowances.

Likelihood Possible Evidence D
Aspirin

Theoretically, acerola might reduce the clearance of aspirin; however, its vitamin C content is likely too low to produce clinically significant effects.
Acerola contains vitamin C. It has been suggested that acidification of the urine by vitamin C can decrease the urinary excretion of salicylates, increasing plasma salicylate levels. However, short-term use of up to 6 grams daily of vitamin C does not seem to affect urinary pH or salicylate excretion. The vitamin C content of acerola is typically about 2000 mg per 100 grams. Thus, a clinically significant interaction between acerola and aspirin is unlikely.

Likelihood Unlikely Evidence B
Estrogens

Theoretically, concomitant use of acerola with estrogens might increase estrogenic effects.
Acerola contains vitamin C. Increases in plasma estrogen levels of up to 55% have occurred under some circumstances when vitamin C is taken concurrently with oral contraceptives or hormone replacement therapy, including topical products. It is suggested that vitamin C prevents oxidation of estrogen in the tissues, regenerates oxidized estrogen, and reduces sulfate conjugation of estrogen in the gut wall. When tissue levels of vitamin C are high, these processes are already maximized and supplemental vitamin C does not have any effect on estrogen levels. However, increases in plasma estrogen levels may occur when women who are deficient in vitamin C take supplements.

Likelihood Possible Evidence D
Warfarin (Coumadin)

Theoretically, acerola might reduce the effectiveness of warfarin; however, its vitamin C content is likely too low to produce clinically significant effects.
Acerola contains vitamin C. High doses of vitamin C may reduce the response to warfarin, possibly by causing diarrhea and reducing warfarin absorption. This occurred in two people who took up to 16 grams daily of vitamin C, and resulted in decreased prothrombin time. Lower doses of 5-10 grams daily of vitamin C can also reduce warfarin absorption, but this does not seem to be clinically significant. The vitamin C content of acerola is typically about 2000 mg per 100 grams. Thus, a clinically significant interaction between acerola and warfarin is unlikely.

Likelihood Unlikely Evidence D
Monograph

Acerola: Uses, Safety & Side Effects

Medically reviewed by · Reviewed July 2026 ·
The bottom line

Acerola is a small tropical fruit prized for its very high natural vitamin C content, and it is mostly used as a food-based source of vitamin C and antioxidants. While vitamin C itself has well-known roles in the body, strong human studies showing that acerola specifically treats or prevents disease are limited. It is generally considered safe in food amounts, but check with your pharmacist or doctor before using concentrated supplements.

Acerola
Scientific name
Malpighia emarginata
Family
Malpighiaceae
Part used
Fruit (cherry)
Common forms
Capsules, tablets, chewables, powder, juice, gummies
People commonly use it for
  • Vitamin C source
  • Immune support
  • Antioxidant support
  • General wellness
  • Skin health

Popular and traditional uses — not proof it works. See “Uses & effectiveness” below for the evidence.

Safety at a glance
OverallLikely safe

Generally considered safe when used in food amounts or as directed on supplement labels.

PregnancyInsufficient reliable information

Insufficient reliable information available; avoid using in amounts greater than found in foods.

Read the full pregnancy detail
BreastfeedingInsufficient reliable information

Insufficient reliable information available; avoid using in amounts greater than found in foods.

Read the full breastfeeding detail

Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center). Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Jump to a section

Overview

Acerola (Malpighia emarginata) is a small, bright red fruit that looks a bit like a cherry. It grows on shrubs or small trees native to Central America, the Caribbean, and parts of South America. You may also see it called Barbados cherry or West Indian cherry.

The fruit is best known for being one of the richest natural sources of vitamin C. Because of this, acerola is widely used in dietary supplements and is added to juices, jams, gummies, and powders.

People take acerola mainly to boost their vitamin C intake and to get its natural plant antioxidants. It comes in many forms, including capsules, tablets, chewables, and powders.

How it works

The main active ingredient in acerola is vitamin C (ascorbic acid), which it contains in unusually high amounts. Vitamin C is an antioxidant, meaning it can help protect cells from damage caused by unstable molecules called free radicals. It also supports the immune system and helps the body build collagen, a protein important for skin, blood vessels, and connective tissue.

Acerola also contains other plant compounds, such as polyphenols and carotenoids, which may add to its antioxidant activity. Some of these compounds have shown antioxidant effects in laboratory studies.

It is important to know that many of these proposed effects are based on test-tube or animal research. How much benefit a person actually gets from acerola supplements in real life is not fully proven.

Effectiveness

Does Acerola work?

Here’s what the research actually shows for each use — graded by Natural Medicines and reviewed by .

Evidence overview · 4 uses evaluated
1 Possibly effective 3 Insufficient evidence
How to read these evidence grades

Natural Medicines’ 7-point scale. We show each rating’s label word-for-word.

1EffectiveStrong, consistent evidence it works.
2Likely EffectiveGood evidence, though not yet conclusive.
3Possibly EffectiveSome evidence suggests a benefit.
4Possibly IneffectiveSome evidence it may not help.
5Likely IneffectiveFairly strong evidence it doesn’t help.
6IneffectiveStrong evidence it doesn’t work.
7Insufficient Reliable Evidence to RateToo little research to say either way.
Possibly Effective Vitamin C deficiency
Rating & evidence shown verbatim from Natural Medicines

Orally, consuming acerola might help to prevent or treat vitamin C deficiency since acerola contains a significant amount of vitamin C.

Also studied for 3 conditions — evidence insufficient to rate
Insufficient Reliable Evidence To Rate Atherosclerosis
Rating & evidence shown verbatim from Natural Medicines

Although there is interest in using oral acerola for atherosclerosis, there is insufficient reliable information about the clinical effects of acerola for this condition.

Insufficient Reliable Evidence To Rate Common cold
Rating & evidence shown verbatim from Natural Medicines

Although there is interest in using oral acerola for the common cold, there is insufficient reliable information about the clinical effects of acerola for this condition.

Insufficient Reliable Evidence To Rate Diarrhea
Rating & evidence shown verbatim from Natural Medicines

Although there is interest in using oral acerola for diarrhea, there is insufficient reliable information about the clinical effects of acerola for this condition.

Source & disclaimer. Effectiveness ratings and evidence summaries are provided by Natural Medicines (Therapeutic Research Center) and shown as licensed. Where Natural Medicines hasn’t rated a use, HelloPharmacist’s pharmacists may add their own reviewed rating and evidence (each such entry is labeled). This is educational information, not medical advice — talk with your pharmacist or doctor before starting, stopping, or changing a supplement.

Safety & precautions

Acerola is a common food and is generally considered safe when eaten or taken as directed. Most concerns relate to its high vitamin C content. Very large amounts of vitamin C can cause stomach upset and, in some people, may increase the risk of kidney stones.

People with a history of kidney stones, kidney disease, or conditions involving iron overload (such as hemochromatosis) should be cautious, since high vitamin C can affect these conditions. If you have these issues, talk to your doctor first.

For pregnancy and breastfeeding, normal food amounts of acerola are likely fine, but the safety of concentrated supplements has not been well studied. To be safe, pregnant or breastfeeding people should check with their doctor before using acerola supplements.

As with any supplement, talk to your pharmacist or doctor before starting acerola, especially if you have a health condition or take medications.

Side effects

Acerola is usually well tolerated. When side effects occur, they are most often linked to its vitamin C content and may include stomach upset, nausea, diarrhea, or cramping, especially with large doses.

Some people may be allergic to acerola. Stop using it and seek medical care if you notice signs of an allergic reaction, such as rash, itching, swelling, or trouble breathing.

Taking very high amounts of vitamin C over time may raise the risk of kidney stones in people who are prone to them.

Acerola: Reported Adverse Effects

Documented safety reports on Acerola from the evidence-graded Natural Medicines (TRC Healthcare) database, shown word-for-word from the licensed record.

Reports by condition
Allergic rhinitis (hay fever) Immunologic

There is a case report of a 37 year old man who developed a pruritic rash, dyspnea, and tachycardia 5 minutes after drinking a mixture of apple and acerola juices. He had a history of hay fever, oral allergy symptoms with avocado, celery, walnut, and curry, and contact urticaria with latex, but tolerated apples and apple juice. IgE antibodies to acerola were identified in the patient's serum. Ultimately, cross-reactivity between a latex protein and acerola was determined.

  1. Raulf-Heimsoth M, Stark R, Sander I, et al. Anaphylactic reaction to apple juice containing acerola: cross-reactivity to latex due to prohevein. J Allergy Clin Immunol 2002;109(4):715-6.
Constipation Gastrointestinal

Osmotic diarrhea and gastrointestinal upset have been reported with doses of vitamin C greater than the tolerable upper intake level (UL) of 2000 mg daily. Theoretically this could occur with large doses of oral acerola. A case report describes rectal obstruction with mass consisting of partially digested acerola fruits in a 5-year-old child who had ingested an unknown quantity of fruits daily for 7 days. The child presented with vomiting, abdominal pain and distension, tenesmus, constipation, and dehydration, and required surgical disimpaction.

  1. Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Vitamin C, Vitamin E, Selenium, and Carotenoids. Washington, DC: National Academy Press, 2000. Available at: http://www.nap.edu/books/0309069351/html/.
  2. Denadai R, Souza FM, Valle MR. Fecal impaction by rectal acerola bezoar. Indian J Pediatr 2013;80(5):432-3.
DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.

Adverse-effects data: Natural Medicines, Therapeutic Research Center

Dosing

There is no official standardized dose for acerola. Products vary widely in their strength and in how much vitamin C they provide.

The best approach is to follow the directions on the product label and not exceed the recommended amount. Keep in mind that you may also be getting vitamin C from other foods and supplements, so very high combined intakes are best avoided.

If you are unsure how much to take or whether acerola is right for you, ask your pharmacist or doctor for guidance.

Pregnancy & Breastfeeding

Acerola & Pregnancy

Insufficient reliable information

Insufficient reliable information available; avoid using in amounts greater than found in foods.

Acerola & Breastfeeding

Insufficient reliable information

Insufficient reliable information available; avoid using in amounts greater than found in foods.

DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.

© 2026 Therapeutic Research Center

Pregnancy & lactation ratings: Natural Medicines, Therapeutic Research Center

References & further reading

The 20 references that drive our Acerola monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Back DJ, Breckenridge AM, MacIver M, et al. Interaction of ethinyloestradiol with ascorbic acid in man. Br Med J (Clin Res Ed) 1981;282:1516.
  2. Morris JC, Beeley L, Ballantine N. Interaction of ethinyloestradiol with ascorbic acid in man [letter]. Br Med J (Clin Res Ed) 1981;283:503.
  3. Labriola D, Livingston R. Possible interactions between dietary antioxidants and chemotherapy. Oncology 1999;13:1003-8.
  4. Hansten PD, Horn JR. Drug Interactions Analysis and Management. Vancouver, WA: Applied Therapeutics Inc., 1997 and updates.
  5. Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Vitamin C, Vitamin E, Selenium, and Carotenoids. Washington, DC: National Academy Press, 2000. Available at: http://www.nap.edu/books/0309069351/html/.
  6. Rosenthal G. Interaction of ascorbic acid and warfarin. JAMA 1971;215:1671. DOI
  7. Hume R, Johnstone JM, Weyers E. Interaction of ascorbic acid and warfarin. JAMA 1972;219:1479. DOI
  8. Smith EC, Skalski RJ, Johnson GC, Rossi GV. Interaction of ascorbic acid and warfarin. JAMA 1972;221:1166. DOI
  9. Domingo JL, Gomez M, Llobet JM, Richart C. Effect of ascorbic acid on gastrointestinal aluminum absorption (letter). Lancet 1991;338:1467.
  10. Domingo JL, Gomez M, Llobet JM, Corbella J. Influence of some dietary constituents on aluminum absorption and retention in rats. Kidney Int 1991;39:598-601. PubMed
  11. Partridge NA, Regnier FE, White JL, Hem SL. Influence of dietary constituents on intestinal absorption of aluminum. Kidney Int 1989;35:1413-7. PubMed
  12. Mc Leod DC, Nahata MC. Inefficacy of ascorbic acid as a urinary acidifier (letter). N Engl J Med 1977;296:1413. DOI
  13. Hansten PD, Hayton WL. Effect of antacid and ascorbic acid on serum salicylate concentration. J Clin Pharmacol 1980;20:326-31. PubMed
  14. Vihtamaki T, Parantainen J, Koivisto AM, et al. Oral ascorbic acid increases plasma oestradiol during postmenopausal hormone replacement therapy. Maturitas 2002;42:129-35. PubMed
  15. Feetam CL, Leach RH, Meynell MJ. Lack of a clinically important interaction between warfarin and ascorbic acid. Toxicol Appl Pharmacol 1975;31:544-7. PubMed
Keep reading

This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Brand directory

Brands that make products with Acerola

553 brands in our database make a supplement containing Acerola.

Product directory

Supplement products with Acerola

3,133 products in our database contain Acerola. Open any to see its full ingredient list and every drug interaction we check.

Asthma Support Mint Flavor by TerraVita Liquid 1 Fluid Ounce(s) · 30 mL View ingredients & interactions Asthma Support Powder by TerraVita Premium Collection Powder 1 Ounce(s) View ingredients & interactions Asthma Support Powder by TerraVita Premium Collection Powder 4 Ounce(s) View ingredients & interactions Asthma Support Strawberry Flavor by TerraVita Liquid 1 Fluid Ounce(s) · 30 mL View ingredients & interactions Asthma Support Vanilla Flavor by TerraVita Liquid 1 Fluid Ounce(s) · 30 mL View ingredients & interactions Astra C by Health Concerns Tablet Or Pill 90 Tablet(s) View ingredients & interactions Astra C by Health Concerns Capsule 90 Capsule(s) View ingredients & interactions Athletic Greens Ultimate Daily by Athletic Greens Powder 360 Gram(s) · 12.7 Ounce(s) View ingredients & interactions Athletic Nutrients by Pure Encapsulations Capsule 120 Capsule(s) View ingredients & interactions Athletic Nutrients by Pure Encapsulations Capsule 180 Capsule(s) View ingredients & interactions Athletic Nutrients by Pure Encapsulations Capsule 180 Capsule(s) View ingredients & interactions Athletic Pure Pack by Pure Encapsulations Capsule 30 Packet(s) View ingredients & interactions Athletic Pure Pack by Pure Encapsulations Capsule 30 Packet(s) · 270 Capsule(s) View ingredients & interactions Attention by BodSmith Liquid 1 Quart(s) · 32 Fluid Ounce(s) · 946 mL View ingredients & interactions Attention Fruit Flavor by Liquid Health Liquid 32 fl. Oz. · 946 mL View ingredients & interactions B-Complex by Nature's Sunshine Capsule 100 Capsule(s) View ingredients & interactions B-Complex by Nature's Sunshine Capsule 100 VegCap(s) View ingredients & interactions B-Complex by Paradise Earth's Blend Capsule 60 Vegetarian Capsule(s) View ingredients & interactions B-Complex by Paradise Earth's Blend Capsule 60 Vegetarian Capsule(s) View ingredients & interactions B-Complex "100" by Solgar Tablet Or Pill 100 Tablet(s) View ingredients & interactions B-Complex "100" by Solgar Tablet Or Pill 250 Tablet(s) View ingredients & interactions B-Complex "50" by Solgar Capsule 50 Vegetable Capsule(s) View ingredients & interactions B-Complex "50" by Solgar Capsule 100 Vegetable Capsule(s) View ingredients & interactions B-Complex "50" by Solgar Capsule 250 Vegetable Capsule(s) View ingredients & interactions
Pharmacist Counseling Corner

Acerola: Common Questions

What is Acerola used for, and does it work?
People use Acerola for many reasons, but the evidence varies by use. According to the Natural Medicines database, there is at least some clinical evidence supporting Acerola for Vitamin C deficiency. For most other uses it has been studied for, the evidence is currently insufficient to rate. See the graded list on this page, and always confirm with your pharmacist or doctor.
Does Acerola interact with prescription medications?
Yes. We list 128 medications with a known interaction with Acerola. Use the checker above to see how Acerola interacts with a specific drug.
How are Acerola interactions rated?
Each interaction is graded major, moderate, or minor based on how clinically significant it is and the strength of the evidence behind it. Major interactions are the most serious and are best avoided, or used only under close professional supervision.
Is it safe to take Acerola with my medications?
It depends on the specific medication. Some combinations are fine, while others call for monitoring, timing changes, or should be avoided. Check your exact drug above and confirm with your pharmacist or doctor before starting, stopping, or changing anything.
Where does this Acerola interaction information come from?
Our interaction data is built on the Natural Medicines database — an evidence-graded reference for vitamins, herbs, and supplements — and is reviewed by licensed HelloPharmacist pharmacists, who may add clinical context.
What is Acerola used for?
Acerola is mainly used as a natural source of vitamin C and is taken for immune support, antioxidant benefits, and general wellness. It is also added to juices, gummies, and powders.
Is Acerola the same as vitamin C?
Not exactly. Acerola is a fruit that happens to be very rich in vitamin C, but it also contains other natural plant compounds. Many Acerola supplements are used specifically as a food-based vitamin C source.
Is Acerola safe to take every day?
For most healthy people, Acerola is generally considered safe when taken as directed. Very large amounts can cause stomach upset and may raise kidney stone risk in people who are prone to them, so stick to the label amount.
Can I take Acerola while pregnant or breastfeeding?
Food amounts of Acerola are likely fine, but concentrated supplements have not been well studied during pregnancy or breastfeeding. Check with your doctor before using Acerola supplements.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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