Medication interaction hub

What Supplements Interact with Chlorpheniramine Polistirex, Codeine Polistirex?

Chlorpheniramine Polistirex, Codeine Polistirex brand name: Tuzistra XR. Every interaction below applies to the brands too.

259 Interactions 12 Major 205 Moderate 42 Minor
Curated & coded by · Clinical Pharmacist · Updated September 22, 2026

Drug–supplement interaction data sourced from Natural Medicines Pro, the licensed clinical database from TRC Healthcare / Therapeutic Research, with additional analysis by the HelloPharmacist Pharmacist Team. Our sources · Editorial policy

What is this page for?

One answer, for one medication: what supplements and herbal products interact with Chlorpheniramine Polistirex, Codeine Polistirex? Every vitamin, herb, and supplement ingredient we’ve checked against it is on this page, ranked by severity, each linking to the full report for that exact pair.

This page covers supplement interactions only — to check Chlorpheniramine Polistirex, Codeine Polistirex against your other medications, use the drug–drug interaction checker. Educational information from our licensed clinical databases, not medical advice. Our editorial policy

HelloPharmacist Bottom Line

259 supplements and herbal ingredients have interactions with Chlorpheniramine Polistirex, Codeine Polistirex on file in the HelloPharmacist interaction database — 12 rated major, 205 moderate, and 42 minor. The most serious involve Beer, Grapefruit, Wine, 1,4-butanediol and Activated Charcoal.

Our assessment: with 12 major-rated interactions on the list, this one deserves real attention — know the major entries before combining anything with Chlorpheniramine Polistirex, Codeine Polistirex.

Major 12 Moderate 205 Minor 42 No known interaction 1,193

Ranked by severity below. Every entry links to the full pharmacist-reviewed report for that exact combination — what can happen, how likely it is, and what to do about it.

This box checks one ingredient at a time (like turmeric or magnesium). Taking a supplement product with a whole label of ingredients? Search the product instead — we check every ingredient on it ↓

Most Viewed Ingredient Interactions

Chlorpheniramine Polistirex, Codeine Polistirex: Top Interactions at a Glance

The Chlorpheniramine Polistirex, Codeine Polistirex supplement & herbal interactions people checked most in the last 24 hours, colored by severity. Tap any ingredient to open the full report for that pair.

Showing the 12 highest-ranked of 259 interacting ingredients — plus 1,193 more checked with no known interaction. See the complete ranked list.

Start here

The Most-Checked Chlorpheniramine Polistirex, Codeine Polistirex Combinations Today

The Chlorpheniramine Polistirex, Codeine Polistirex + supplement pages people viewed most in the last 24 hours (resets at midnight). Open any card for the full report.

Major Likelihood Probable Gamma-hydroxybutyrate (ghb) + Chlorpheniramine Polistirex, Codeine Polistirexi

GHB may increase the risk of serious CNS and respiratory depression.

Read the full interaction Moderate Likelihood Possible Black Seed + Chlorpheniramine Polistirex, Codeine Polistirexi

Theoretically, concomitant use with drugs that have sedative properties may cause additive effects.

Read the full interaction Moderate Likelihood Possible Greater Celandine + Chlorpheniramine Polistirex, Codeine Polistirexi

Research in vitro shows that chelidonine, a constituent of greater celandine, inhibits cytochrome P450 2D6 (CYP2D6) enzyme activity.

Read the full interaction Moderate Likelihood Possible Pomegranate + Chlorpheniramine Polistirex, Codeine Polistirexi

Theoretically, pomegranate might increase levels of drugs metabolized by CYP2D6.

Read the full interaction Major Likelihood Probable 1,4-butanediol + Chlorpheniramine Polistirex, Codeine Polistirexi

Theoretically, concomitant use of 1,4-butanediol with CNS depressants may potentiate respiratory and CNS depression.

Read the full interaction Moderate Likelihood Possible Methylene Blue + Chlorpheniramine Polistirex, Codeine Polistirexi

Combining serotonergic drugs with methylene blue can cause additive serotonergic effects, including serotonin syndrome.

Read the full interaction
The complete list

Every Supplement Checked Against Chlorpheniramine Polistirex, Codeine Polistirex

All 1,452 ingredients in our database, ranked by severity — 259 with a Chlorpheniramine Polistirex, Codeine Polistirex interaction on file and 1,193 with none found. Filter by severity or search any ingredient; hover the for what each ingredient is.

Looking for an interaction with a specific supplement product? Search products instead ↓

Straight answers

Can You Take It With Chlorpheniramine Polistirex, Codeine Polistirex?

One-line answers, one card per combination — scroll through today’s 20 and tap any card for the full report. A different set rotates in daily until every combination has had its turn.

Can you take Gamma-hydroxybutyrate (ghb) with Chlorpheniramine Polistirex, Codeine Polistirex?

Major Use real caution — this is a major-rated interaction, generally best avoided or used only under close supervision. GHB may increase the risk of serious CNS and respiratory depression.

Full Gamma-hydroxybutyrate (ghb) + Chlorpheniramine Polistirex, Codeine Polistirex answer

Can you take Black Seed with Chlorpheniramine Polistirex, Codeine Polistirex?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use with drugs that have sedative properties may cause additive effects.

Full Black Seed + Chlorpheniramine Polistirex, Codeine Polistirex answer

Can you take Greater Celandine with Chlorpheniramine Polistirex, Codeine Polistirex?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Research in vitro shows that chelidonine, a constituent of greater celandine, inhibits cytochrome P450 2D6 (CYP2D6) enzyme activity.

Full Greater Celandine + Chlorpheniramine Polistirex, Codeine Polistirex answer

Can you take Pomegranate with Chlorpheniramine Polistirex, Codeine Polistirex?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, pomegranate might increase levels of drugs metabolized by CYP2D6.

Full Pomegranate + Chlorpheniramine Polistirex, Codeine Polistirex answer

Can you take 1,4-butanediol with Chlorpheniramine Polistirex, Codeine Polistirex?

Major Use real caution — this is a major-rated interaction, generally best avoided or used only under close supervision. Theoretically, concomitant use of 1,4-butanediol with CNS depressants may potentiate respiratory and CNS depression.

Full 1,4-butanediol + Chlorpheniramine Polistirex, Codeine Polistirex answer

Can you take Moringa with Chlorpheniramine Polistirex, Codeine Polistirex?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, moringa might increase or decrease levels of CYP3A4 substrates.

Full Moringa + Chlorpheniramine Polistirex, Codeine Polistirex answer

Can you take Motherwort with Chlorpheniramine Polistirex, Codeine Polistirex?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking motherwort concomitantly with other CNS depressants may increase the risk of sedation.

Full Motherwort + Chlorpheniramine Polistirex, Codeine Polistirex answer

Can you take N,n-dmpea with Chlorpheniramine Polistirex, Codeine Polistirex?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. In vitro research shows that N,N-DMPEA strongly inhibits cytochrome P450 2D6 (CYP2D6).

Full N,n-dmpea + Chlorpheniramine Polistirex, Codeine Polistirex answer

Can you take Neem with Chlorpheniramine Polistirex, Codeine Polistirex?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, neem leaf extract might increase the levels and clinical effects of CYP3A4 substrates.

Full Neem + Chlorpheniramine Polistirex, Codeine Polistirex answer

Can you take Nutmeg with Chlorpheniramine Polistirex, Codeine Polistirex?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, nutmeg might increase the risk of additive sedation when taken with CNS depressants.

Full Nutmeg + Chlorpheniramine Polistirex, Codeine Polistirex answer

Can you take Oregon Grape with Chlorpheniramine Polistirex, Codeine Polistirex?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, Oregon grape might increase the sedative effects of CNS depressants.

Full Oregon Grape + Chlorpheniramine Polistirex, Codeine Polistirex answer

Can you take Padang Cassia with Chlorpheniramine Polistirex, Codeine Polistirex?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. In vitro research shows that a methanol extract of Padang cassia inhibits cytochrome P450 3A4 (CYP3A4) activity.

Full Padang Cassia + Chlorpheniramine Polistirex, Codeine Polistirex answer

Can you take Panax Ginseng with Chlorpheniramine Polistirex, Codeine Polistirex?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, Panax ginseng might increase levels of drugs metabolized by CYP2D6.

Full Panax Ginseng + Chlorpheniramine Polistirex, Codeine Polistirex answer

Can you take Passion Flower with Chlorpheniramine Polistirex, Codeine Polistirex?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Concomitant use of passion flower with sedative drugs might cause additive effects and side effects.

Full Passion Flower + Chlorpheniramine Polistirex, Codeine Polistirex answer

Can you take Peony with Chlorpheniramine Polistirex, Codeine Polistirex?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, use of peony may increase the levels and clinical effects of drugs metabolized by CYP3A4.

Full Peony + Chlorpheniramine Polistirex, Codeine Polistirex answer

Can you take Peppermint with Chlorpheniramine Polistirex, Codeine Polistirex?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, peppermint might increase the levels of CYP3A4 substrates.

Full Peppermint + Chlorpheniramine Polistirex, Codeine Polistirex answer

Can you take Phellodendron with Chlorpheniramine Polistirex, Codeine Polistirex?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, phellodendron might increase the sedative effects of CNS depressants.

Full Phellodendron + Chlorpheniramine Polistirex, Codeine Polistirex answer

Can you take Phenethylamine (pea) with Chlorpheniramine Polistirex, Codeine Polistirex?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, combining serotonergic drugs with phenethylamine might increase the risk of serotonergic adverse effects.

Full Phenethylamine (pea) + Chlorpheniramine Polistirex, Codeine Polistirex answer

Can you take Phenibut with Chlorpheniramine Polistirex, Codeine Polistirex?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, phenibut might increase the risk of sedation and respiratory depression when taken with CNS depressants.

Full Phenibut + Chlorpheniramine Polistirex, Codeine Polistirex answer

Can you take Phosphatidylserine with Chlorpheniramine Polistirex, Codeine Polistirex?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, phosphatidylserine might decrease the effectiveness anticholinergic drugs.

Full Phosphatidylserine + Chlorpheniramine Polistirex, Codeine Polistirex answer
Read the list like a pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

  • Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
  • Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
  • Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
  • No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

  • Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
  • Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
  • Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

  • Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
  • Each entry links to a full report with the clinical detail, likelihood, evidence level, and citations for that exact combination.
  • Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

How Does Our Interaction Checker Work?

Behind every verdict on this page is a category system. Our source database doesn’t document supplement interactions drug-by-drug — it documents them against groups of medications that behave the same way (for example, “drugs processed by the CYP3A4 liver enzyme” or “blood-thinning medications”).

So the check works in three steps: (1) Chlorpheniramine Polistirex, Codeine Polistirex is classified into the pharmacology categories it belongs to, (2) every supplement interaction documented against any of those categories is inherited by Chlorpheniramine Polistirex, Codeine Polistirex, and (3) each ingredient keeps its own severity, likelihood, and evidence grades from the underlying record. That’s why one supplement can carry several records for one drug — it may interact through more than one category.

Chlorpheniramine Polistirex, Codeine Polistirex sits in 12 interaction categories. Open any one to see what the group means:

Cytochrome P450 3A4 (Cyp3A4) Substrates 121 ingredients

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

121 of the supplement ingredients on this page reach Chlorpheniramine Polistirex, Codeine Polistirex through this category.

Cns Depressants 78 ingredients

Central-nervous-system depressants. Sedating supplements can intensify drowsiness and slowed reactions when combined.

78 of the supplement ingredients on this page reach Chlorpheniramine Polistirex, Codeine Polistirex through this category.

Cytochrome P450 2D6 (Cyp2D6) Substrates 60 ingredients

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

60 of the supplement ingredients on this page reach Chlorpheniramine Polistirex, Codeine Polistirex through this category.

Anticholinergic Drugs 30 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

30 of the supplement ingredients on this page reach Chlorpheniramine Polistirex, Codeine Polistirex through this category.

Photosensitizing Drugs 20 ingredients

Medications that make skin more sun-sensitive. Supplements with the same property can compound it.

20 of the supplement ingredients on this page reach Chlorpheniramine Polistirex, Codeine Polistirex through this category.

Serotonergic Drugs 20 ingredients

Medications that raise serotonin activity. Combining them with serotonin-active supplements can, in rare cases, push serotonin too high.

20 of the supplement ingredients on this page reach Chlorpheniramine Polistirex, Codeine Polistirex through this category.

Oral Drugs 17 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

17 of the supplement ingredients on this page reach Chlorpheniramine Polistirex, Codeine Polistirex through this category.

Seizure Threshold Lowering Drugs 6 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

6 of the supplement ingredients on this page reach Chlorpheniramine Polistirex, Codeine Polistirex through this category.

Narcotic Drugs 5 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

5 of the supplement ingredients on this page reach Chlorpheniramine Polistirex, Codeine Polistirex through this category.

Cytochrome P450 2D6 (Cyp2D6) Inhibitors 3 ingredients

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

3 of the supplement ingredients on this page reach Chlorpheniramine Polistirex, Codeine Polistirex through this category.

Codeine 1 ingredient

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

1 of the supplement ingredient on this page reaches Chlorpheniramine Polistirex, Codeine Polistirex through this category.

Serotonergic Drugs 1 ingredient

Medications that raise serotonin activity. Combining them with serotonin-active supplements can, in rare cases, push serotonin too high.

1 of the supplement ingredient on this page reaches Chlorpheniramine Polistirex, Codeine Polistirex through this category.

Check a real product

Take a Supplement Product? Check the Whole Bottle Against Chlorpheniramine Polistirex, Codeine Polistirex

Most supplements are combination products — and the interaction may come from an ingredient you didn’t buy it for. Search any product below (or scan its label) and we’ll check every ingredient on it against Chlorpheniramine Polistirex, Codeine Polistirex.

Search a supplement product

Type a product name, brand, or UPC — smart search across our full catalog.

Grounded search over our product catalog — every verdict comes from our interaction database, never AI guesswork. How we use AI

Or scan the bottle

Photograph any Supplement Facts panel — we read the ingredients and check each one against your medications. Free, in seconds.

Open the label scanner

Prefer typing? The interaction checker looks up products by name too.

Products that contain Chlorpheniramine Polistirex, Codeine Polistirex-interacting ingredients

Real supplements from the NIH label database that contain the top interacting ingredients on this page — each one is worth a full label check before combining with Chlorpheniramine Polistirex, Codeine Polistirex.

Yeast-Cleanse by Solaray contains Grapefruit Ultimate GCB by M3 Supplement Company contains Grapefruit Neuro Health by Nature’s Craft contains Grapefruit NDF Happy Peach by Bioray Kids contains Grapefruit
Pharmacist Counseling Corner

Chlorpheniramine Polistirex, Codeine Polistirex & Supplements: Common Questions

What supplements interact with Chlorpheniramine Polistirex, Codeine Polistirex?
More than you might expect — 259 in total, though they are far from equal: 12 are rated major, 205 moderate, and 42 minor. The ranked list on this page puts the ones that genuinely matter first, and every entry opens a full report on that exact pair. The highest-ranked right now: Beer, Grapefruit, Wine.
Which Chlorpheniramine Polistirex, Codeine Polistirex supplement interactions are the most serious?
Focus on the major group: Beer, Grapefruit, Wine, 1,4-butanediol and Activated Charcoal, among others. A major rating means the combination can be clinically significant, not that harm is guaranteed — but it's exactly the kind of thing to run past your pharmacist before your next dose, not after. Jump to the ranked list.
Can I take vitamins or supplements while on Chlorpheniramine Polistirex, Codeine Polistirex?
Usually yes — most people on Chlorpheniramine Polistirex, Codeine Polistirex can take most supplements. The catch is the exceptions, and they aren't always the exotic ones (St. John's Wort trips up more prescriptions than almost anything sold next to it). Look up each ingredient you actually take in the list above, and treat "no known interaction" as a green-ish light, not a guarantee. Try the label scanner or the interaction checker.
Do brands like Tuzistra XR have the same supplement interactions as Chlorpheniramine Polistirex, Codeine Polistirex?
Yes — Tuzistra XR all contain Chlorpheniramine Polistirex, Codeine Polistirex, so everything on this page applies to them equally. Interactions belong to the active drug, never to the brand on the box; the same is true of generics.
Where do these interaction ratings come from?
Every rating comes from the Natural Medicines database — the same evidence-graded reference pharmacists and hospitals use — and each interaction carries three separate grades: severity (how bad it can be), likelihood (how well it's documented in studies and case reports), and an evidence level. Our pharmacists review the content; we never let an AI decide an interaction. See how to read the ratings and our editorial policy.
What about Chlorpheniramine Polistirex, Codeine Polistirex and my other medications?
This page covers Chlorpheniramine Polistirex, Codeine Polistirex against supplements and herbal ingredients. Checking Chlorpheniramine Polistirex, Codeine Polistirex against your other prescription or OTC medications is a different tool — our drug interaction checker covers that side. Head to the drug–drug interaction checker.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Sourcing

Where This Data Comes From — and Why You Can Trust It

🧪 Licensed clinical database

Every interaction verdict on this page comes from Natural Medicines Pro (TRC Healthcare / Therapeutic Research) — the same evidence-graded reference used by pharmacists and hospitals. We license this data directly; we do not scrape it, and no AI invents an interaction.

🧑‍⚕️ Pharmacist review

This page is curated and coded by , Clinical Pharmacist, with additional analysis by the HelloPharmacist Pharmacist Team. Editorial commentary is ours; the licensed interaction records are shown as sourced.

🔄 Kept current

Our interaction database refreshes on a weekly cycle, and this page re-checks the live database every time it’s rebuilt — what you see reflects the database as of September 22, 2026.

🔍 Full transparency

How every dataset on this site is sourced, licensed, and updated is documented publicly: our data sources · editorial policy · how we use AI.

Educational information, not medical advice. An interaction being on file does not mean it will happen to you — and absence of one is not proof of safety. Never start or stop a medication or supplement without talking to your pharmacist or doctor.