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What Supplements Interact with Guaifenesin, Phenylpropanolamine?

Guaifenesin, Phenylpropanolamine brand names: Entex LA, Miraphen PE, Dura-Vent, Guaifed, Guaifed-PD, and others. Every interaction below applies to the brands too.

62 Interactions 5 Major 44 Moderate 13 Minor
Curated & coded by · Clinical Pharmacist · Updated September 23, 2026

Drug–supplement interaction data sourced from Natural Medicines Pro, the licensed clinical database from TRC Healthcare / Therapeutic Research, with additional analysis by the HelloPharmacist Pharmacist Team. Our sources · Editorial policy

What is this page for?

One answer, for one medication: what supplements and herbal products interact with Guaifenesin, Phenylpropanolamine? Every vitamin, herb, and supplement ingredient we’ve checked against it is on this page, ranked by severity, each linking to the full report for that exact pair.

This page covers supplement interactions only — to check Guaifenesin, Phenylpropanolamine against your other medications, use the drug–drug interaction checker. Educational information from our licensed clinical databases, not medical advice. Our editorial policy

HelloPharmacist Bottom Line
Our Pharmacist Explains
What is this? The interaction data in the HelloPharmacist supplement database is licensed from Natural Medicines Pro by TRC Healthcare (Therapeutic Research). HelloPharmacist pharmacists often add our own analysis and context on top of that licensed data — such as this Bottom Line summary and the notes on individual interaction pages — and any such commentary is noted as ours.

Ephedra is the entry I'd want anyone taking guaifenesin with phenylpropanolamine (Entex LA, Guaifed, Dura-Vent) to understand first. Phenylpropanolamine is a stimulant decongestant that can raise blood pressure on its own, and ephedra, along with three other stimulant herbs rated major, can stack on that effect and strain the heart. Across the 62 supplements and herbs on file, five are major and 44 moderate, enough that this list deserves genuine care rather than a quick glance.

Most of the moderate entries repeat the same theme in gentler form. Caffeine drives many of them; whatever the source, coffee, tea, or an herbal energy blend, it adds to the stimulant load, and phenylpropanolamine may even raise caffeine levels while the two push blood pressure up together. The fifth major item, activated charcoal, works differently, soaking up medicines in the gut so less reaches you. Space it well away from your dose, and treat the 13 minor entries as background reading.

— , Clinical Pharmacist · July 18, 2026

Major 5 Moderate 44 Minor 13 No known interaction 1,390

This box checks one ingredient at a time (like turmeric or magnesium). Taking a supplement product with a whole label of ingredients? Search the product instead — we check every ingredient on it ↓

Most Viewed Ingredient Interactions

Guaifenesin, Phenylpropanolamine: Top Interactions at a Glance

The Guaifenesin, Phenylpropanolamine supplement & herbal interactions people checked most in the last 24 hours, colored by severity. Tap any ingredient to open the full report for that pair.

Showing the 12 highest-ranked of 62 interacting ingredients — plus 1,390 more checked with no known interaction. See the complete ranked list.

Start here

The Most-Checked Guaifenesin, Phenylpropanolamine Combinations Today

The Guaifenesin, Phenylpropanolamine + supplement pages people viewed most in the last 24 hours (resets at midnight). Open any card for the full report.

Moderate Likelihood Probable Caffeine + Guaifenesin, Phenylpropanolaminei

Theoretically, concomitant use might increase stimulant adverse effects.

Read the full interaction Major Likelihood Probable Peyote + Guaifenesin, Phenylpropanolaminei

Concomitant use of peyote with stimulant drugs may increase the risk of adverse CNS effects.

Read the full interaction Major Likelihood Probable Activated Charcoal + Guaifenesin, Phenylpropanolaminei

Activated charcoal reduces systemic exposure to many drugs, including those that undergo enterohepatic recirculation, regardless of the route of administration.

Read the full interaction Moderate Likelihood Possible Securinega Suffruticosa + Guaifenesin, Phenylpropanolaminei

Theoretically, taking Securinega suffruticosa with stimulant drugs might increase the risk of serious adverse effects.

Read the full interaction Major Likelihood Probable Ephedra + Guaifenesin, Phenylpropanolaminei

Theoretically, concomitant use might increase the risk for serious adverse effects.

Read the full interaction Major Likelihood Probable Rauvolfia Vomitoria + Guaifenesin, Phenylpropanolaminei

Theoretically, concomitant use might cause additive effects.

Read the full interaction
The complete list

Every Supplement Checked Against Guaifenesin, Phenylpropanolamine

All 1,452 ingredients in our database, ranked by severity — 62 with a Guaifenesin, Phenylpropanolamine interaction on file and 1,390 with none found. Filter by severity or search any ingredient; hover the for what each ingredient is.

Looking for an interaction with a specific supplement product? Search products instead ↓

Straight answers

Can You Take It With Guaifenesin, Phenylpropanolamine?

One-line answers, one card per combination — scroll through today’s 20 and tap any card for the full report. A different set rotates in daily until every combination has had its turn.

Can you take Caffeine with Guaifenesin, Phenylpropanolamine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use might increase stimulant adverse effects.

Full Caffeine + Guaifenesin, Phenylpropanolamine answer

Can you take Peyote with Guaifenesin, Phenylpropanolamine?

Major Use real caution — this is a major-rated interaction, generally best avoided or used only under close supervision. Concomitant use of peyote with stimulant drugs may increase the risk of adverse CNS effects.

Full Peyote + Guaifenesin, Phenylpropanolamine answer

Can you take Activated Charcoal with Guaifenesin, Phenylpropanolamine?

Major Use real caution — this is a major-rated interaction, generally best avoided or used only under close supervision. Activated charcoal reduces systemic exposure to many drugs, including those that undergo enterohepatic recirculation, regardless of the rout...

Full Activated Charcoal + Guaifenesin, Phenylpropanolamine answer

Can you take Securinega Suffruticosa with Guaifenesin, Phenylpropanolamine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking Securinega suffruticosa with stimulant drugs might increase the risk of serious adverse effects.

Full Securinega Suffruticosa + Guaifenesin, Phenylpropanolamine answer

Can you take Coffee Charcoal with Guaifenesin, Phenylpropanolamine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Coffee charcoal can reduce the absorption of orally administered drugs and should be separated from oral drug administration by at least two...

Full Coffee Charcoal + Guaifenesin, Phenylpropanolamine answer

Can you take Cola Nut with Guaifenesin, Phenylpropanolamine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use might increase stimulant adverse effects.

Full Cola Nut + Guaifenesin, Phenylpropanolamine answer

Can you take European Mandrake with Guaifenesin, Phenylpropanolamine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concurrent use might increase absorption of some drugs because of inhibited gastrointestinal (GI) motility caused by European...

Full European Mandrake + Guaifenesin, Phenylpropanolamine answer

Can you take Fever Bark with Guaifenesin, Phenylpropanolamine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, fever bark might increase or decrease the effects of stimulant drugs.

Full Fever Bark + Guaifenesin, Phenylpropanolamine answer

Can you take Glucomannan with Guaifenesin, Phenylpropanolamine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, glucomannan may decrease absorption of drugs taken orally.

Full Glucomannan + Guaifenesin, Phenylpropanolamine answer

Can you take Green Coffee with Guaifenesin, Phenylpropanolamine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use might increase stimulant adverse effects.

Full Green Coffee + Guaifenesin, Phenylpropanolamine answer

Can you take Green Tea with Guaifenesin, Phenylpropanolamine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use might increase stimulant adverse effects.

Full Green Tea + Guaifenesin, Phenylpropanolamine answer

Can you take Guarana with Guaifenesin, Phenylpropanolamine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, phenylpropanolamine might increase the risk of hypertension, as well as the levels and adverse effects of caffeine.

Full Guarana + Guaifenesin, Phenylpropanolamine answer

Can you take Ilex Guayusa with Guaifenesin, Phenylpropanolamine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use might increase stimulant adverse effects.

Full Ilex Guayusa + Guaifenesin, Phenylpropanolamine answer

Can you take Oolong Tea with Guaifenesin, Phenylpropanolamine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use might increase stimulant adverse effects.

Full Oolong Tea + Guaifenesin, Phenylpropanolamine answer

Can you take Psilocybin with Guaifenesin, Phenylpropanolamine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use of psilocybin with stimulant drugs might increase stimulant adverse effects.

Full Psilocybin + Guaifenesin, Phenylpropanolamine answer

Can you take Pu-erh Tea with Guaifenesin, Phenylpropanolamine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use might increase stimulant adverse effects.

Full Pu-erh Tea + Guaifenesin, Phenylpropanolamine answer

Can you take Yerba Mate with Guaifenesin, Phenylpropanolamine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use of stimulant drugs and yerba mate might increase stimulant adverse effects.

Full Yerba Mate + Guaifenesin, Phenylpropanolamine answer

Can you take 1,3-dmaa with Guaifenesin, Phenylpropanolamine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. 1,3-DMAA is thought to have stimulant effects.

Full 1,3-dmaa + Guaifenesin, Phenylpropanolamine answer

Can you take 1,3-dmba with Guaifenesin, Phenylpropanolamine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, combining 1,3-DMBA with other stimulant drugs might increase the risk of cardiovascular toxicity.

Full 1,3-dmba + Guaifenesin, Phenylpropanolamine answer

Can you take 1,4-dmaa with Guaifenesin, Phenylpropanolamine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. 1,4-DMAA is thought to have stimulant and vasoconstrictive effects, which have been demonstrated in animal studies.

Full 1,4-dmaa + Guaifenesin, Phenylpropanolamine answer
Read the list like a pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

  • Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
  • Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
  • Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
  • No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

  • Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
  • Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
  • Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

  • Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
  • Each entry links to a full report with the clinical detail, likelihood, evidence level, and citations for that exact combination.
  • Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

How Does Our Interaction Checker Work?

Behind every verdict on this page is a category system. Our source database doesn’t document supplement interactions drug-by-drug — it documents them against groups of medications that behave the same way (for example, “drugs processed by the CYP3A4 liver enzyme” or “blood-thinning medications”).

So the check works in three steps: (1) Guaifenesin, Phenylpropanolamine is classified into the pharmacology categories it belongs to, (2) every supplement interaction documented against any of those categories is inherited by Guaifenesin, Phenylpropanolamine, and (3) each ingredient keeps its own severity, likelihood, and evidence grades from the underlying record. That’s why one supplement can carry several records for one drug — it may interact through more than one category.

Guaifenesin, Phenylpropanolamine sits in 4 interaction categories. Open any one to see what the group means:

Stimulant Drugs 44 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

44 of the supplement ingredients on this page reach Guaifenesin, Phenylpropanolamine through this category.

Oral Drugs 17 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

17 of the supplement ingredients on this page reach Guaifenesin, Phenylpropanolamine through this category.

Phenylpropanolamine 12 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

12 of the supplement ingredients on this page reach Guaifenesin, Phenylpropanolamine through this category.

Alpha-Adrenergic Agonists 1 ingredient

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

1 of the supplement ingredient on this page reaches Guaifenesin, Phenylpropanolamine through this category.

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Take a Supplement Product? Check the Whole Bottle Against Guaifenesin, Phenylpropanolamine

Most supplements are combination products — and the interaction may come from an ingredient you didn’t buy it for. Search any product below (or scan its label) and we’ll check every ingredient on it against Guaifenesin, Phenylpropanolamine.

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Pharmacist Counseling Corner

Guaifenesin, Phenylpropanolamine & Supplements: Common Questions

What supplements interact with Guaifenesin, Phenylpropanolamine?
In our interaction database, 62 supplement and herbal ingredients have an interaction with Guaifenesin, Phenylpropanolamine on file — 5 rated major, 44 moderate, and 13 minor. That number sounds scarier than it is: severity matters far more than the count, which is why the list on this page is ranked instead of alphabetical. Start at the top. The highest-ranked right now: Activated Charcoal, Ephedra, Peyote.
Which Guaifenesin, Phenylpropanolamine supplement interactions are the most serious?
Focus on the major group: Activated Charcoal, Ephedra, Peyote, Rauvolfia Vomitoria and Sida Cordifolia. A major rating means the combination can be clinically significant, not that harm is guaranteed — but it's exactly the kind of thing to run past your pharmacist before your next dose, not after. Jump to the ranked list.
Can I take vitamins or supplements while on Guaifenesin, Phenylpropanolamine?
That depends entirely on which supplement. The honest answer for Guaifenesin, Phenylpropanolamine is in the ranked list above — and if what you take is a combination product with a dozen ingredients, don't check them one by one: photograph the label with our scanner and we'll check the whole thing at once. Try the label scanner or the interaction checker.
Do brands like Entex LA have the same supplement interactions as Guaifenesin, Phenylpropanolamine?
Yes — Entex LA, Miraphen PE, Dura-Vent, Guaifed, Guaifed-PD and other brands all contain Guaifenesin, Phenylpropanolamine, so everything on this page applies to them equally. Interactions belong to the active drug, never to the brand on the box; the same is true of generics.
Where do these interaction ratings come from?
Every rating comes from the Natural Medicines database — the same evidence-graded reference pharmacists and hospitals use — and each interaction carries three separate grades: severity (how bad it can be), likelihood (how well it's documented in studies and case reports), and an evidence level. Our pharmacists review the content; we never let an AI decide an interaction. See how to read the ratings and our editorial policy.
What about Guaifenesin, Phenylpropanolamine and my other medications?
This page covers Guaifenesin, Phenylpropanolamine against supplements and herbal ingredients. Checking Guaifenesin, Phenylpropanolamine against your other prescription or OTC medications is a different tool — our drug interaction checker covers that side. Head to the drug–drug interaction checker.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Sourcing

Where This Data Comes From — and Why You Can Trust It

🧪 Licensed clinical database

Every interaction verdict on this page comes from Natural Medicines Pro (TRC Healthcare / Therapeutic Research) — the same evidence-graded reference used by pharmacists and hospitals. We license this data directly; we do not scrape it, and no AI invents an interaction.

🧑‍⚕️ Pharmacist review

This page is curated and coded by , Clinical Pharmacist, with additional analysis by the HelloPharmacist Pharmacist Team. Editorial commentary is ours; the licensed interaction records are shown as sourced.

🔄 Kept current

Our interaction database refreshes on a weekly cycle, and this page re-checks the live database every time it’s rebuilt — what you see reflects the database as of September 23, 2026.

🔍 Full transparency

How every dataset on this site is sourced, licensed, and updated is documented publicly: our data sources · editorial policy · how we use AI.

Educational information, not medical advice. An interaction being on file does not mean it will happen to you — and absence of one is not proof of safety. Never start or stop a medication or supplement without talking to your pharmacist or doctor.