Medication interaction hub

What Supplements Interact with Naloxone?

Naloxone brand names: Narcan, Zimhi, Rivive, Evzio, Kloxxado. Every interaction below applies to the brands too.

3 Interactions 3 Moderate
Curated & coded by · Clinical Pharmacist · Updated September 15, 2026

Drug–supplement interaction data sourced from Natural Medicines Pro, the licensed clinical database from TRC Healthcare / Therapeutic Research, with additional analysis by the HelloPharmacist Pharmacist Team. Our sources · Editorial policy

What is this page for?

One answer, for one medication: what supplements and herbal products interact with Naloxone? Every vitamin, herb, and supplement ingredient we’ve checked against it is on this page, ranked by severity, each linking to the full report for that exact pair.

This page covers supplement interactions only — to check Naloxone against your other medications, use the drug–drug interaction checker. Educational information from our licensed clinical databases, not medical advice. Our editorial policy

HelloPharmacist Bottom Line
Our Pharmacist Explains
What is this? The interaction data in the HelloPharmacist supplement database is licensed from Natural Medicines Pro by TRC Healthcare (Therapeutic Research). HelloPharmacist pharmacists often add our own analysis and context on top of that licensed data — such as this Bottom Line summary and the notes on individual interaction pages — and any such commentary is noted as ours.

The list of supplements that interact with naloxone, the emergency spray or injection (Narcan, Zimhi, Rivive) that reverses opioid overdoses, is short and unusual. All three entries are forms of the same substance: gamma-hydroxybutyrate (GHB) and two chemicals the body converts into it, GBL and 1,4-butanediol. For most people this is a watch-and-understand situation rather than a hazard, since the theoretical concern is that naloxone could blunt those substances' effects, not that the pairing itself causes harm.

The practical point cuts the other way, too. Even though naloxone might in theory counteract GHB, real-world reports say it does not reliably reverse GHB poisoning, so nobody should count on Narcan as a rescue for these substances. Worth knowing, given that all three entries carry a moderate rating and the evidence rests on lab work and scattered case reports rather than solid human studies.

— , Clinical Pharmacist · July 18, 2026

Moderate 3 No known interaction 1,449

This box checks one ingredient at a time (like turmeric or magnesium). Taking a supplement product with a whole label of ingredients? Search the product instead — we check every ingredient on it ↓

Top Ingredient Interactions

Naloxone: Top Interactions at a Glance

The most significant Naloxone supplement & herbal interactions, colored by severity. Tap any ingredient to open the full report for that pair.

Showing the 3 highest-ranked of 3 interacting ingredients — plus 1,449 more checked with no known interaction. See the complete ranked list.

Start here

The Moderate Interactions to Know About

The most clinically significant Naloxone + supplement combinations in our database, best-documented first. Open any card for the full report.

Moderate Likelihood Possible 1,4-butanediol + Naloxonei

Theoretically, concomitant use of 1,4-butanediol with naloxone may antagonize the effects of 1,4-butanediol.

Read the full interaction Moderate Likelihood Possible Gamma Butyrolactone (gbl) + Naloxonei

Theoretically, concomitant use of GBL with naloxone may antagonize the effects of GBL.

Read the full interaction Moderate Likelihood Possible Gamma-hydroxybutyrate (ghb) + Naloxonei

Theoretically, naloxone may antagonize the effects of GHB.

Read the full interaction
The complete list

Every Supplement Checked Against Naloxone

All 1,452 ingredients in our database, ranked by severity — 3 with a Naloxone interaction on file and 1,449 with none found. Filter by severity or search any ingredient; hover the for what each ingredient is.

Looking for an interaction with a specific supplement product? Search products instead ↓

Straight answers

Can You Take It With Naloxone?

One-line answers, one card per combination — scroll through today’s 5 and tap any card for the full report. A different set rotates in daily until every combination has had its turn.

Can you take Gamma Butyrolactone (gbl) with Naloxone?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use of GBL with naloxone may antagonize the effects of GBL.

Full Gamma Butyrolactone (gbl) + Naloxone answer

Can you take Gamma-hydroxybutyrate (ghb) with Naloxone?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, naloxone may antagonize the effects of GHB.

Full Gamma-hydroxybutyrate (ghb) + Naloxone answer

Can you take 1,4-butanediol with Naloxone?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use of 1,4-butanediol with naloxone may antagonize the effects of 1,4-butanediol.

Full 1,4-butanediol + Naloxone answer

Can you take Gamma Butyrolactone (gbl) with Naloxone?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use of GBL with naloxone may antagonize the effects of GBL.

Full Gamma Butyrolactone (gbl) + Naloxone answer

Can you take Gamma-hydroxybutyrate (ghb) with Naloxone?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, naloxone may antagonize the effects of GHB.

Full Gamma-hydroxybutyrate (ghb) + Naloxone answer
Read the list like a pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

  • Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
  • Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
  • Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
  • No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

  • Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
  • Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
  • Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

  • Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
  • Each entry links to a full report with the clinical detail, likelihood, evidence level, and citations for that exact combination.
  • Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

How Does Our Interaction Checker Work?

Behind every verdict on this page is a category system. Our source database doesn’t document supplement interactions drug-by-drug — it documents them against groups of medications that behave the same way (for example, “drugs processed by the CYP3A4 liver enzyme” or “blood-thinning medications”).

So the check works in three steps: (1) Naloxone is classified into the pharmacology categories it belongs to, (2) every supplement interaction documented against any of those categories is inherited by Naloxone, and (3) each ingredient keeps its own severity, likelihood, and evidence grades from the underlying record. That’s why one supplement can carry several records for one drug — it may interact through more than one category.

Naloxone sits in 1 interaction category. Open any one to see what the group means:

Naloxone (Narcan) 3 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

3 of the supplement ingredients on this page reach Naloxone through this category.

About Naloxone

Naloxone injection is an opioid antagonist used to reverse life-threatening opioid overdose and, in specific formulations, to provide temporary protection against opioid exposure in military and chemical incident response settings.

Generic name: Naloxone  ·  Brand names: Narcan, Zimhi, Rivive, Evzio, Kloxxado.

See the full Naloxone Injection drug information
Check a real product

Take a Supplement Product? Check the Whole Bottle Against Naloxone

Most supplements are combination products — and the interaction may come from an ingredient you didn’t buy it for. Search any product below (or scan its label) and we’ll check every ingredient on it against Naloxone.

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Pharmacist Counseling Corner

Naloxone & Supplements: Common Questions

What supplements interact with Naloxone?
More than you might expect — 3 in total, though they are far from equal: 0 are rated major, 3 moderate, and 0 minor. The ranked list on this page puts the ones that genuinely matter first, and every entry opens a full report on that exact pair. The highest-ranked right now: 1,4-butanediol, Gamma Butyrolactone (gbl), Gamma-hydroxybutyrate (ghb).
Which Naloxone supplement interactions are the most serious?
None of the Naloxone supplement interactions on file are currently rated major. The most significant are the 3 moderate-rated ones — combinations that may need monitoring, a dose adjustment, or separated timing. Still worth a quick look through the ranked list for anything you take daily. Jump to the ranked list.
Can I take vitamins or supplements while on Naloxone?
Usually yes — most people on Naloxone can take most supplements. The catch is the exceptions, and they aren't always the exotic ones (St. John's Wort trips up more prescriptions than almost anything sold next to it). Look up each ingredient you actually take in the list above, and treat "no known interaction" as a green-ish light, not a guarantee. Try the label scanner or the interaction checker.
Do brands like Narcan have the same supplement interactions as Naloxone?
Yes — Narcan, Zimhi, Rivive, Evzio, Kloxxado all contain Naloxone, so everything on this page applies to them equally. Interactions belong to the active drug, never to the brand on the box; the same is true of generics.
Where do these interaction ratings come from?
Every rating comes from the Natural Medicines database — the same evidence-graded reference pharmacists and hospitals use — and each interaction carries three separate grades: severity (how bad it can be), likelihood (how well it's documented in studies and case reports), and an evidence level. Our pharmacists review the content; we never let an AI decide an interaction. See how to read the ratings and our editorial policy.
What about Naloxone and my other medications?
This page covers Naloxone against supplements and herbal ingredients. Checking Naloxone against your other prescription or OTC medications is a different tool — our drug interaction checker covers that side. Head to the drug–drug interaction checker, or read the full Naloxone Injection drug information.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

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Sourcing

Where This Data Comes From — and Why You Can Trust It

🧪 Licensed clinical database

Every interaction verdict on this page comes from Natural Medicines Pro (TRC Healthcare / Therapeutic Research) — the same evidence-graded reference used by pharmacists and hospitals. We license this data directly; we do not scrape it, and no AI invents an interaction.

🧑‍⚕️ Pharmacist review

This page is curated and coded by , Clinical Pharmacist, with additional analysis by the HelloPharmacist Pharmacist Team. Editorial commentary is ours; the licensed interaction records are shown as sourced.

🔄 Kept current

Our interaction database refreshes on a weekly cycle, and this page re-checks the live database every time it’s rebuilt — what you see reflects the database as of September 15, 2026.

🔍 Full transparency

How every dataset on this site is sourced, licensed, and updated is documented publicly: our data sources · editorial policy · how we use AI.

Educational information, not medical advice. An interaction being on file does not mean it will happen to you — and absence of one is not proof of safety. Never start or stop a medication or supplement without talking to your pharmacist or doctor.