Medication interaction hub

What Supplements Interact with Buprenorphine/Naloxone?

Buprenorphine/Naloxone brand name: Suboxone. Every interaction below applies to the brands too.

199 Interactions 9 Major 151 Moderate 39 Minor
Curated & coded by · Clinical Pharmacist · Updated September 15, 2026

Drug–supplement interaction data sourced from Natural Medicines Pro, the licensed clinical database from TRC Healthcare / Therapeutic Research, with additional analysis by the HelloPharmacist Pharmacist Team. Our sources · Editorial policy

What is this page for?

One answer, for one medication: what supplements and herbal products interact with Buprenorphine/Naloxone? Every vitamin, herb, and supplement ingredient we’ve checked against it is on this page, ranked by severity, each linking to the full report for that exact pair.

This page covers supplement interactions only — to check Buprenorphine/Naloxone against your other medications, use the drug–drug interaction checker. Educational information from our licensed clinical databases, not medical advice. Our editorial policy

HelloPharmacist Bottom Line
Our Pharmacist Explains
What is this? The interaction data in the HelloPharmacist supplement database is licensed from Natural Medicines Pro by TRC Healthcare (Therapeutic Research). HelloPharmacist pharmacists often add our own analysis and context on top of that licensed data — such as this Bottom Line summary and the notes on individual interaction pages — and any such commentary is noted as ours.

If you take buprenorphine/naloxone (Suboxone), give this list real attention, because Suboxone is an opioid and the biggest danger is anything else that slows your breathing. Of the 199 supplements and herbal products on file, most either add sedation on top of the opioid effect or change how your body breaks the drug down. Alcohol and kava sit among the nine major-rated entries for exactly that reason, and St. John's wort is rated major too because it can lower Suboxone levels and blunt the treatment itself.

Most of the 151 moderate entries nudge drug levels up or down by speeding or slowing that same breakdown, and a smaller group of fibers and charcoal products can block absorption if swallowed close to your dose, so keep those well spaced. The 39 minor entries carry far less weight. One rule worth remembering is that anything drowsy on its own hits harder while you are on Suboxone.

— , Clinical Pharmacist · July 18, 2026

Major 9 Moderate 151 Minor 39 No known interaction 1,253

This box checks one ingredient at a time (like turmeric or magnesium). Taking a supplement product with a whole label of ingredients? Search the product instead — we check every ingredient on it ↓

Top Ingredient Interactions

Buprenorphine/Naloxone: Top Interactions at a Glance

The most significant Buprenorphine/Naloxone supplement & herbal interactions, colored by severity. Tap any ingredient to open the full report for that pair.

Showing the 12 highest-ranked of 199 interacting ingredients — plus 1,253 more checked with no known interaction. See the complete ranked list.

Start here

The Major Interactions to Know About

The most clinically significant Buprenorphine/Naloxone + supplement combinations in our database, best-documented first. Open any card for the full report.

Major Likelihood Likely Beer + Buprenorphine/Naloxonei

Concomitant use may increase sedative and other adverse effects.

Read the full interaction Major Likelihood Likely Grapefruit + Buprenorphine/Naloxonei

Grapefruit juice can increase levels of drugs metabolized by CYP3A4.

Read the full interaction Major Likelihood Likely Wine + Buprenorphine/Naloxonei

Concomitant use may increase sedative and other adverse effects.

Read the full interaction Major Likelihood Probable 1,4-butanediol + Buprenorphine/Naloxonei

Theoretically, concomitant use of 1,4-butanediol with CNS depressants may potentiate respiratory and CNS depression.

Read the full interaction Major Likelihood Probable Activated Charcoal + Buprenorphine/Naloxonei

Activated charcoal reduces systemic exposure to many drugs, including those that undergo enterohepatic recirculation, regardless of the route of administration.

Read the full interaction Major Likelihood Probable Gamma-hydroxybutyrate (ghb) + Buprenorphine/Naloxonei

GHB may increase the risk of serious CNS and respiratory depression.

Read the full interaction
The complete list

Every Supplement Checked Against Buprenorphine/Naloxone

All 1,452 ingredients in our database, ranked by severity — 199 with a Buprenorphine/Naloxone interaction on file and 1,253 with none found. Filter by severity or search any ingredient; hover the for what each ingredient is.

Looking for an interaction with a specific supplement product? Search products instead ↓

Straight answers

Can You Take It With Buprenorphine/Naloxone?

One-line answers, one card per combination — scroll through today’s 20 and tap any card for the full report. A different set rotates in daily until every combination has had its turn.

Can you take Cat's Claw with Buprenorphine/Naloxone?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, cat's claw might increase or decrease the levels and effects of drugs metabolized by CYP3A4.

Full Cat's Claw + Buprenorphine/Naloxone answer

Can you take Sweet Annie with Buprenorphine/Naloxone?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Sweet Annie may alter plasma levels and clinical effects of drugs metabolized by CYP3A4.

Full Sweet Annie + Buprenorphine/Naloxone answer

Can you take Bishop's Weed with Buprenorphine/Naloxone?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Bergapten, a constituent of bishop's weed, has been shown to inhibit cytochrome P450 3A4 (CYP3A4) in vitro.

Full Bishop's Weed + Buprenorphine/Naloxone answer

Can you take Danshen with Buprenorphine/Naloxone?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Danshen might alter the levels and clinical effects of drugs metabolized by CYP3A4.

Full Danshen + Buprenorphine/Naloxone answer

Can you take Delta-9-tetrahydrocannabinol (thc) with Buprenorphine/Naloxone?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, THC might have additive effects if used with other CNS depressants.

Full Delta-9-tetrahydrocannabinol (thc) + Buprenorphine/Naloxone answer

Can you take Dendrobium with Buprenorphine/Naloxone?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. The dendrobium constituent dendrobine is reported to have convulsant effects.

Full Dendrobium + Buprenorphine/Naloxone answer

Can you take Devil's Claw with Buprenorphine/Naloxone?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, devil's claw might increase levels of drugs metabolized by CYP3A4.

Full Devil's Claw + Buprenorphine/Naloxone answer

Can you take Dhea with Buprenorphine/Naloxone?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, DHEA might increase the levels of drugs metabolized by CYP3A4.

Full Dhea + Buprenorphine/Naloxone answer

Can you take Diosmin with Buprenorphine/Naloxone?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, diosmin might inhibit the metabolism of CYP3A4 substrates.

Full Diosmin + Buprenorphine/Naloxone answer

Can you take Echinacea with Buprenorphine/Naloxone?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Echinacea may induce hepatic CYP3A4 and inhibit intestinal CYP3A4.

Full Echinacea + Buprenorphine/Naloxone answer

Can you take Elecampane with Buprenorphine/Naloxone?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, elecampane may cause additive sedative effects when taken with CNS depressants.

Full Elecampane + Buprenorphine/Naloxone answer

Can you take Eucalyptus with Buprenorphine/Naloxone?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, eucalyptus might increase the levels of CYP3A4 substrates.

Full Eucalyptus + Buprenorphine/Naloxone answer

Can you take European Barberry with Buprenorphine/Naloxone?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use with drugs that have sedative properties may cause additive effects.

Full European Barberry + Buprenorphine/Naloxone answer

Can you take Evodia with Buprenorphine/Naloxone?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, evodia might increase the levels and clinical effects of CYP3A4 substrates.

Full Evodia + Buprenorphine/Naloxone answer

Can you take False Unicorn with Buprenorphine/Naloxone?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. In vitro, false unicorn extract inhibits cytochrome P450 3A4 (CYP3A4) activity.

Full False Unicorn + Buprenorphine/Naloxone answer

Can you take Fennel with Buprenorphine/Naloxone?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, fennel might increase levels of drugs metabolized by CYP3A4.

Full Fennel + Buprenorphine/Naloxone answer

Can you take Feverfew with Buprenorphine/Naloxone?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, feverfew might increase levels of drugs metabolized by CYP3A4.

Full Feverfew + Buprenorphine/Naloxone answer

Can you take Fo-ti with Buprenorphine/Naloxone?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, fo-ti might increase the levels and clinical effects of drugs metabolized by CYP3A4.

Full Fo-ti + Buprenorphine/Naloxone answer

Can you take Galphimia Glauca with Buprenorphine/Naloxone?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking Galphimia glauca with CNS depressants may increase the risk of sedation.

Full Galphimia Glauca + Buprenorphine/Naloxone answer

Can you take Gamma Butyrolactone (gbl) with Buprenorphine/Naloxone?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use of GBL with CNS depressants may potentiate respiratory and CNS depression.

Full Gamma Butyrolactone (gbl) + Buprenorphine/Naloxone answer
Read the list like a pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

  • Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
  • Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
  • Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
  • No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

  • Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
  • Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
  • Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

  • Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
  • Each entry links to a full report with the clinical detail, likelihood, evidence level, and citations for that exact combination.
  • Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

How Does Our Interaction Checker Work?

Behind every verdict on this page is a category system. Our source database doesn’t document supplement interactions drug-by-drug — it documents them against groups of medications that behave the same way (for example, “drugs processed by the CYP3A4 liver enzyme” or “blood-thinning medications”).

So the check works in three steps: (1) Buprenorphine/Naloxone is classified into the pharmacology categories it belongs to, (2) every supplement interaction documented against any of those categories is inherited by Buprenorphine/Naloxone, and (3) each ingredient keeps its own severity, likelihood, and evidence grades from the underlying record. That’s why one supplement can carry several records for one drug — it may interact through more than one category.

Buprenorphine/Naloxone sits in 6 interaction categories. Open any one to see what the group means:

Cytochrome P450 3A4 (Cyp3A4) Substrates 121 ingredients

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

121 of the supplement ingredients on this page reach Buprenorphine/Naloxone through this category.

Cns Depressants 78 ingredients

Central-nervous-system depressants. Sedating supplements can intensify drowsiness and slowed reactions when combined.

78 of the supplement ingredients on this page reach Buprenorphine/Naloxone through this category.

Oral Drugs 17 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

17 of the supplement ingredients on this page reach Buprenorphine/Naloxone through this category.

Seizure Threshold Lowering Drugs 6 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

6 of the supplement ingredients on this page reach Buprenorphine/Naloxone through this category.

Narcotic Drugs 5 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

5 of the supplement ingredients on this page reach Buprenorphine/Naloxone through this category.

Naloxone (Narcan) 3 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

3 of the supplement ingredients on this page reach Buprenorphine/Naloxone through this category.

Check a real product

Take a Supplement Product? Check the Whole Bottle Against Buprenorphine/Naloxone

Most supplements are combination products — and the interaction may come from an ingredient you didn’t buy it for. Search any product below (or scan its label) and we’ll check every ingredient on it against Buprenorphine/Naloxone.

Search a supplement product

Type a product name, brand, or UPC — smart search across our full catalog.

Grounded search over our product catalog — every verdict comes from our interaction database, never AI guesswork. How we use AI

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Photograph any Supplement Facts panel — we read the ingredients and check each one against your medications. Free, in seconds.

Open the label scanner

Prefer typing? The interaction checker looks up products by name too.

Products that contain Buprenorphine/Naloxone-interacting ingredients

Real supplements from the NIH label database that contain the top interacting ingredients on this page — each one is worth a full label check before combining with Buprenorphine/Naloxone.

Yeast-Cleanse by Solaray contains Grapefruit Ultimate GCB by M3 Supplement Company contains Grapefruit Neuro Health by Nature’s Craft contains Grapefruit NDF Happy Peach by Bioray Kids contains Grapefruit
Pharmacist Counseling Corner

Buprenorphine/Naloxone & Supplements: Common Questions

What supplements interact with Buprenorphine/Naloxone?
Our database currently documents 199 ingredients with a known Buprenorphine/Naloxone interaction (9 major, 151 moderate, 39 minor). The practical move: scan the major group first, then look up the exact supplements you take rather than reading all 199. The highest-ranked right now: Beer, Grapefruit, Wine.
Which Buprenorphine/Naloxone supplement interactions are the most serious?
The 9 major-rated combinations — led by Beer, Grapefruit, Wine, 1,4-butanediol and Activated Charcoal — deserve real caution: these are the ones generally best avoided, or used only with your prescriber watching. If you take any of them today, don't panic and don't stop anything abruptly — call your pharmacist first. Jump to the ranked list.
Can I take vitamins or supplements while on Buprenorphine/Naloxone?
Plenty of supplements coexist fine with Buprenorphine/Naloxone; a shorter list does not. Rather than memorizing it, check the specific ingredients on your labels — the ranked list above covers every one we've checked, and multi-ingredient products can be checked label-by-label with our scanner. Try the label scanner or the interaction checker.
Do brands like Suboxone have the same supplement interactions as Buprenorphine/Naloxone?
Yes — Suboxone all contain Buprenorphine/Naloxone, so everything on this page applies to them equally. Interactions belong to the active drug, never to the brand on the box; the same is true of generics.
Where do these interaction ratings come from?
Every rating comes from the Natural Medicines database — the same evidence-graded reference pharmacists and hospitals use — and each interaction carries three separate grades: severity (how bad it can be), likelihood (how well it's documented in studies and case reports), and an evidence level. Our pharmacists review the content; we never let an AI decide an interaction. See how to read the ratings and our editorial policy.
What about Buprenorphine/Naloxone and my other medications?
This page covers Buprenorphine/Naloxone against supplements and herbal ingredients. Checking Buprenorphine/Naloxone against your other prescription or OTC medications is a different tool — our drug interaction checker covers that side. Head to the drug–drug interaction checker.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

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Sourcing

Where This Data Comes From — and Why You Can Trust It

🧪 Licensed clinical database

Every interaction verdict on this page comes from Natural Medicines Pro (TRC Healthcare / Therapeutic Research) — the same evidence-graded reference used by pharmacists and hospitals. We license this data directly; we do not scrape it, and no AI invents an interaction.

🧑‍⚕️ Pharmacist review

This page is curated and coded by , Clinical Pharmacist, with additional analysis by the HelloPharmacist Pharmacist Team. Editorial commentary is ours; the licensed interaction records are shown as sourced.

🔄 Kept current

Our interaction database refreshes on a weekly cycle, and this page re-checks the live database every time it’s rebuilt — what you see reflects the database as of September 15, 2026.

🔍 Full transparency

How every dataset on this site is sourced, licensed, and updated is documented publicly: our data sources · editorial policy · how we use AI.

Educational information, not medical advice. An interaction being on file does not mean it will happen to you — and absence of one is not proof of safety. Never start or stop a medication or supplement without talking to your pharmacist or doctor.