Medication interaction hub

What Supplements Interact with Naloxone, Pentazocine?

Naloxone, Pentazocine brand name: Talwin Nx. Every interaction below applies to the brands too.

167 Interactions 7 Major 126 Moderate 34 Minor
Curated & coded by · Clinical Pharmacist · Updated September 22, 2026

Drug–supplement interaction data sourced from Natural Medicines Pro, the licensed clinical database from TRC Healthcare / Therapeutic Research, with additional analysis by the HelloPharmacist Pharmacist Team. Our sources · Editorial policy

What is this page for?

One answer, for one medication: what supplements and herbal products interact with Naloxone, Pentazocine? Every vitamin, herb, and supplement ingredient we’ve checked against it is on this page, ranked by severity, each linking to the full report for that exact pair.

This page covers supplement interactions only — to check Naloxone, Pentazocine against your other medications, use the drug–drug interaction checker. Educational information from our licensed clinical databases, not medical advice. Our editorial policy

HelloPharmacist Bottom Line
Our Pharmacist Explains
What is this? The interaction data in the HelloPharmacist supplement database is licensed from Natural Medicines Pro by TRC Healthcare (Therapeutic Research). HelloPharmacist pharmacists often add our own analysis and context on top of that licensed data — such as this Bottom Line summary and the notes on individual interaction pages — and any such commentary is noted as ours.

If you take pentazocine with naloxone (Talwin Nx) for pain, this is a list to handle with real care. Seven of its 167 entries rate major, and almost all of that serious risk comes from supplements that also sedate. Nearly 80 calming ingredients, kava among them, can deepen drowsiness and at worst slow breathing, and alcohol, whether beer or wine, is the best documented of the group.

Most of the rest runs quieter. Roughly 80 moderate entries share the liver enzyme that clears this drug and can nudge its level up or down, while 17 others, mostly charcoals and bulky fibers, blunt absorption of anything swallowed. Activated charcoal is rated major for that reason and belongs well apart from your dose. A few more can make seizures likelier, but the sedating pairings deserve your attention first, because sleepiness stacked on an opioid is how this list turns dangerous.

— , Clinical Pharmacist · July 18, 2026

Major 7 Moderate 126 Minor 34 No known interaction 1,285

This box checks one ingredient at a time (like turmeric or magnesium). Taking a supplement product with a whole label of ingredients? Search the product instead — we check every ingredient on it ↓

Top Ingredient Interactions

Naloxone, Pentazocine: Top Interactions at a Glance

The most significant Naloxone, Pentazocine supplement & herbal interactions, colored by severity. Tap any ingredient to open the full report for that pair.

Showing the 12 highest-ranked of 167 interacting ingredients — plus 1,285 more checked with no known interaction. See the complete ranked list.

Start here

The Major Interactions to Know About

The most clinically significant Naloxone, Pentazocine + supplement combinations in our database, best-documented first. Open any card for the full report.

Major Likelihood Likely Beer + Naloxone, Pentazocinei

Concomitant use may increase sedative and other adverse effects.

Read the full interaction Major Likelihood Likely Wine + Naloxone, Pentazocinei

Concomitant use may increase sedative and other adverse effects.

Read the full interaction Major Likelihood Probable 1,4-butanediol + Naloxone, Pentazocinei

Theoretically, concomitant use of 1,4-butanediol with CNS depressants may potentiate respiratory and CNS depression.

Read the full interaction Major Likelihood Probable Activated Charcoal + Naloxone, Pentazocinei

Activated charcoal reduces systemic exposure to many drugs, including those that undergo enterohepatic recirculation, regardless of the route of administration.

Read the full interaction Major Likelihood Probable Gamma-hydroxybutyrate (ghb) + Naloxone, Pentazocinei

GHB may increase the risk of serious CNS and respiratory depression.

Read the full interaction Major Likelihood Probable Kava + Naloxone, Pentazocinei

Combining kava with CNS depressants can have additive sedative effects.

Read the full interaction
The complete list

Every Supplement Checked Against Naloxone, Pentazocine

All 1,452 ingredients in our database, ranked by severity — 167 with a Naloxone, Pentazocine interaction on file and 1,285 with none found. Filter by severity or search any ingredient; hover the for what each ingredient is.

Looking for an interaction with a specific supplement product? Search products instead ↓

Straight answers

Can You Take It With Naloxone, Pentazocine?

One-line answers, one card per combination — scroll through today’s 20 and tap any card for the full report. A different set rotates in daily until every combination has had its turn.

Can you take Propolis with Naloxone, Pentazocine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, high doses of propolis might increase blood levels of drugs metabolized by CYP1A2.

Full Propolis + Naloxone, Pentazocine answer

Can you take Rauvolfia Vomitoria with Naloxone, Pentazocine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking Rauvolfia vomitoria might cause additive sedative effects.

Full Rauvolfia Vomitoria + Naloxone, Pentazocine answer

Can you take Rauwolscine with Naloxone, Pentazocine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking rauwolscine with seizure threshold lowering drugs might increase the risk of adverse convulsant effects.

Full Rauwolscine + Naloxone, Pentazocine answer

Can you take Resveratrol with Naloxone, Pentazocine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, resveratrol might increase levels of drugs metabolized by CYP1A2.

Full Resveratrol + Naloxone, Pentazocine answer

Can you take Rooibos with Naloxone, Pentazocine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking rooibos with CYP1A2 substrates may increase the effects of CYP1A2 substrates.

Full Rooibos + Naloxone, Pentazocine answer

Can you take Saffron with Naloxone, Pentazocine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use of saffron and CNS depressants might have additive sedative effects.

Full Saffron + Naloxone, Pentazocine answer

Can you take Sage with Naloxone, Pentazocine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking sage might increase the sedative and adverse effects of CNS depressants.

Full Sage + Naloxone, Pentazocine answer

Can you take Sassafras with Naloxone, Pentazocine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use of sassafras with drugs with sedative properties may cause additive sedative effects.

Full Sassafras + Naloxone, Pentazocine answer

Can you take Sceletium with Naloxone, Pentazocine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use of sceletium and CNS depressants might result in additive sedative effects.

Full Sceletium + Naloxone, Pentazocine answer

Can you take Schizonepeta with Naloxone, Pentazocine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Animal research suggests that schizonepetin, a monoterpene constituent of schizonepeta, inhibits cytochrome P450 (CYP) 1A2.

Full Schizonepeta + Naloxone, Pentazocine answer

Can you take Shepherd's Purse with Naloxone, Pentazocine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use with drugs with sedative properties may cause additive effects and side effects.

Full Shepherd's Purse + Naloxone, Pentazocine answer

Can you take Skullcap with Naloxone, Pentazocine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, skullcap can have additive effects when used with other CNS depressants.

Full Skullcap + Naloxone, Pentazocine answer

Can you take Slippery Elm with Naloxone, Pentazocine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, slippery elm may slow the absorption and reduce serum levels of oral drugs.

Full Slippery Elm + Naloxone, Pentazocine answer

Can you take Spearmint with Naloxone, Pentazocine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, spearmint might alter the sedative effects of CNS depressants.

Full Spearmint + Naloxone, Pentazocine answer

Can you take St. John's Wort with Naloxone, Pentazocine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. St.

Full St. John's Wort + Naloxone, Pentazocine answer

Can you take Sulforaphane with Naloxone, Pentazocine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, sulforaphane might alter the levels and clinical effects of CYP1A2 substrates.

Full Sulforaphane + Naloxone, Pentazocine answer

Can you take Tarragon with Naloxone, Pentazocine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Evidence from animal research suggests that tarragon essential oil can cause sedation and motor impairment when administered intraperitoneal...

Full Tarragon + Naloxone, Pentazocine answer

Can you take Theacrine with Naloxone, Pentazocine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, theacrine might alter the effects of CNS depressants.

Full Theacrine + Naloxone, Pentazocine answer

Can you take Thuja with Naloxone, Pentazocine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Thuja products can contains significant amounts of thujone, a neurotoxin.

Full Thuja + Naloxone, Pentazocine answer

Can you take Thunder God Vine with Naloxone, Pentazocine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, thunder god vine might increase the levels and clinical effects of CYP1A2 substrates.

Full Thunder God Vine + Naloxone, Pentazocine answer
Read the list like a pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

  • Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
  • Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
  • Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
  • No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

  • Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
  • Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
  • Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

  • Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
  • Each entry links to a full report with the clinical detail, likelihood, evidence level, and citations for that exact combination.
  • Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

How Does Our Interaction Checker Work?

Behind every verdict on this page is a category system. Our source database doesn’t document supplement interactions drug-by-drug — it documents them against groups of medications that behave the same way (for example, “drugs processed by the CYP3A4 liver enzyme” or “blood-thinning medications”).

So the check works in three steps: (1) Naloxone, Pentazocine is classified into the pharmacology categories it belongs to, (2) every supplement interaction documented against any of those categories is inherited by Naloxone, Pentazocine, and (3) each ingredient keeps its own severity, likelihood, and evidence grades from the underlying record. That’s why one supplement can carry several records for one drug — it may interact through more than one category.

Naloxone, Pentazocine sits in 8 interaction categories. Open any one to see what the group means:

Cytochrome P450 1A2 (Cyp1A2) Substrates 79 ingredients

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

79 of the supplement ingredients on this page reach Naloxone, Pentazocine through this category.

Cns Depressants 78 ingredients

Central-nervous-system depressants. Sedating supplements can intensify drowsiness and slowed reactions when combined.

78 of the supplement ingredients on this page reach Naloxone, Pentazocine through this category.

Oral Drugs 17 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

17 of the supplement ingredients on this page reach Naloxone, Pentazocine through this category.

Seizure Threshold Lowering Drugs 6 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

6 of the supplement ingredients on this page reach Naloxone, Pentazocine through this category.

Narcotic Drugs 5 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

5 of the supplement ingredients on this page reach Naloxone, Pentazocine through this category.

Naloxone (Narcan) 3 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

3 of the supplement ingredients on this page reach Naloxone, Pentazocine through this category.

Cytochrome P450 1A2 (Cyp1A2) Substrates 1 ingredient

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

1 of the supplement ingredient on this page reaches Naloxone, Pentazocine through this category.

Pentazocine (Talwin) 1 ingredient

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

1 of the supplement ingredient on this page reaches Naloxone, Pentazocine through this category.

Check a real product

Take a Supplement Product? Check the Whole Bottle Against Naloxone, Pentazocine

Most supplements are combination products — and the interaction may come from an ingredient you didn’t buy it for. Search any product below (or scan its label) and we’ll check every ingredient on it against Naloxone, Pentazocine.

Search a supplement product

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Grounded search over our product catalog — every verdict comes from our interaction database, never AI guesswork. How we use AI

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Pharmacist Counseling Corner

Naloxone, Pentazocine & Supplements: Common Questions

What supplements interact with Naloxone, Pentazocine?
Our database currently documents 167 ingredients with a known Naloxone, Pentazocine interaction (7 major, 126 moderate, 34 minor). The practical move: scan the major group first, then look up the exact supplements you take rather than reading all 167. The highest-ranked right now: Beer, Wine, 1,4-butanediol.
Which Naloxone, Pentazocine supplement interactions are the most serious?
Focus on the major group: Beer, Wine, 1,4-butanediol, Activated Charcoal and Gamma-hydroxybutyrate (ghb), among others. A major rating means the combination can be clinically significant, not that harm is guaranteed — but it's exactly the kind of thing to run past your pharmacist before your next dose, not after. Jump to the ranked list.
Can I take vitamins or supplements while on Naloxone, Pentazocine?
Plenty of supplements coexist fine with Naloxone, Pentazocine; a shorter list does not. Rather than memorizing it, check the specific ingredients on your labels — the ranked list above covers every one we've checked, and multi-ingredient products can be checked label-by-label with our scanner. Try the label scanner or the interaction checker.
Do brands like Talwin Nx have the same supplement interactions as Naloxone, Pentazocine?
Yes — Talwin Nx all contain Naloxone, Pentazocine, so everything on this page applies to them equally. Interactions belong to the active drug, never to the brand on the box; the same is true of generics.
Where do these interaction ratings come from?
Every rating comes from the Natural Medicines database — the same evidence-graded reference pharmacists and hospitals use — and each interaction carries three separate grades: severity (how bad it can be), likelihood (how well it's documented in studies and case reports), and an evidence level. Our pharmacists review the content; we never let an AI decide an interaction. See how to read the ratings and our editorial policy.
What about Naloxone, Pentazocine and my other medications?
This page covers Naloxone, Pentazocine against supplements and herbal ingredients. Checking Naloxone, Pentazocine against your other prescription or OTC medications is a different tool — our drug interaction checker covers that side. Head to the drug–drug interaction checker.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

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Sourcing

Where This Data Comes From — and Why You Can Trust It

🧪 Licensed clinical database

Every interaction verdict on this page comes from Natural Medicines Pro (TRC Healthcare / Therapeutic Research) — the same evidence-graded reference used by pharmacists and hospitals. We license this data directly; we do not scrape it, and no AI invents an interaction.

🧑‍⚕️ Pharmacist review

This page is curated and coded by , Clinical Pharmacist, with additional analysis by the HelloPharmacist Pharmacist Team. Editorial commentary is ours; the licensed interaction records are shown as sourced.

🔄 Kept current

Our interaction database refreshes on a weekly cycle, and this page re-checks the live database every time it’s rebuilt — what you see reflects the database as of September 22, 2026.

🔍 Full transparency

How every dataset on this site is sourced, licensed, and updated is documented publicly: our data sources · editorial policy · how we use AI.

Educational information, not medical advice. An interaction being on file does not mean it will happen to you — and absence of one is not proof of safety. Never start or stop a medication or supplement without talking to your pharmacist or doctor.