Medication interaction hub

What Supplements Interact with Umeclidinium Bromide?

Umeclidinium Bromide brand name: Incruse Ellipta. Every interaction below applies to the brands too.

46 Interactions 3 Major 32 Moderate 11 Minor
Curated & coded by · Clinical Pharmacist · Updated September 30, 2026

Drug–supplement interaction data sourced from Natural Medicines Pro, the licensed clinical database from TRC Healthcare / Therapeutic Research, with additional analysis by the HelloPharmacist Pharmacist Team. Our sources · Editorial policy

What is this page for?

One answer, for one medication: what supplements and herbal products interact with Umeclidinium Bromide? Every vitamin, herb, and supplement ingredient we’ve checked against it is on this page, ranked by severity, each linking to the full report for that exact pair.

This page covers supplement interactions only — to check Umeclidinium Bromide against your other medications, use the drug–drug interaction checker. Educational information from our licensed clinical databases, not medical advice. Our editorial policy

HelloPharmacist Bottom Line
Our Pharmacist Explains
What is this? The interaction data in the HelloPharmacist supplement database is licensed from Natural Medicines Pro by TRC Healthcare (Therapeutic Research). HelloPharmacist pharmacists often add our own analysis and context on top of that licensed data — such as this Bottom Line summary and the notes on individual interaction pages — and any such commentary is noted as ours.

Umeclidinium bromide (Incruse Ellipta) keeps COPD airways open by blocking acetylcholine, and that mechanism is exactly where most of this list presses. Roughly two thirds of the flagged supplements act on the same pathway, either stacking anticholinergic side effects such as dry mouth and constipation, or working against the drug and dulling its effect on your breathing. Henbane and scopolia sit at the serious end of that group, and this is a page that deserves real vigilance rather than a skim.

A second cluster interferes with absorption of oral medicines, fibers and gums mostly, which matters less for an inhaler but can affect anything else you swallow. Activated charcoal is the exception; it can pull down drug levels regardless of how a medicine was taken, and it carries the third major rating. The rest of the 46 ingredients split into 32 moderate and 11 minor, but knowing those three majors comes first.

— , Clinical Pharmacist · July 18, 2026

Major 3 Moderate 32 Minor 11 No known interaction 1,406

This box checks one ingredient at a time (like turmeric or magnesium). Taking a supplement product with a whole label of ingredients? Search the product instead — we check every ingredient on it ↓

Top Ingredient Interactions

Umeclidinium Bromide: Top Interactions at a Glance

The most significant Umeclidinium Bromide supplement & herbal interactions, colored by severity. Tap any ingredient to open the full report for that pair.

Showing the 12 highest-ranked of 46 interacting ingredients — plus 1,406 more checked with no known interaction. See the complete ranked list.

Start here

The Major Interactions to Know About

The most clinically significant Umeclidinium Bromide + supplement combinations in our database, best-documented first. Open any card for the full report.

Major Likelihood Probable Activated Charcoal + Umeclidinium Bromidei

Activated charcoal reduces systemic exposure to many drugs, including those that undergo enterohepatic recirculation, regardless of the route of administration.

Read the full interaction Major Likelihood Probable Henbane + Umeclidinium Bromidei

Concomitant use of henbane can have additive anticholinergic effects and adverse effects with amantadine, antihistamines, atropine, belladonna alkaloids, hyoscy...

Read the full interaction Major Likelihood Probable Scopolia + Umeclidinium Bromidei

The alkaloid constituents of scopolia, including hyoscyamine, scopolamine, and atropine, could potentiate the effects and adverse effects of anticholinergic dru...

Read the full interaction
The complete list

Every Supplement Checked Against Umeclidinium Bromide

All 1,452 ingredients in our database, ranked by severity — 46 with a Umeclidinium Bromide interaction on file and 1,406 with none found. Filter by severity or search any ingredient; hover the for what each ingredient is.

Looking for an interaction with a specific supplement product? Search products instead ↓

Straight answers

Can You Take It With Umeclidinium Bromide?

One-line answers, one card per combination — scroll through today’s 20 and tap any card for the full report. A different set rotates in daily until every combination has had its turn.

Can you take Slippery Elm with Umeclidinium Bromide?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, slippery elm may slow the absorption and reduce serum levels of oral drugs.

Full Slippery Elm + Umeclidinium Bromide answer

Can you take Glucomannan with Umeclidinium Bromide?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, glucomannan may decrease absorption of drugs taken orally.

Full Glucomannan + Umeclidinium Bromide answer

Can you take Clubmoss with Umeclidinium Bromide?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Evidence from in vitro research suggests that clubmoss extract can inhibit acetylcholinesterase activity.

Full Clubmoss + Umeclidinium Bromide answer

Can you take Corkwood Tree with Umeclidinium Bromide?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, corkwood tree might increase the risk of adverse anticholinergic effects when taken with anticholinergic drugs.

Full Corkwood Tree + Umeclidinium Bromide answer

Can you take European Barberry with Umeclidinium Bromide?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking European barberry with anticholinergic drugs might cause additive effects.

Full European Barberry + Umeclidinium Bromide answer

Can you take Guar Gum with Umeclidinium Bromide?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Guar gum might reduce the absorption of some oral drugs, potentially decreasing their effectiveness.

Full Guar Gum + Umeclidinium Bromide answer

Can you take Gum Arabic with Umeclidinium Bromide?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, gum arabic can alter the absorption of oral drugs due to its fiber content.

Full Gum Arabic + Umeclidinium Bromide answer

Can you take Huperzine A with Umeclidinium Bromide?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, huperzine A might decrease the effects of anticholinergic drugs.

Full Huperzine A + Umeclidinium Bromide answer

Can you take Iboga with Umeclidinium Bromide?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, iboga might decrease the effectiveness of anticholinergic drugs.

Full Iboga + Umeclidinium Bromide answer

Can you take Jimson Weed with Umeclidinium Bromide?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, jimson weed may increase anticholinergic effects and adverse effects.

Full Jimson Weed + Umeclidinium Bromide answer

Can you take Marjoram with Umeclidinium Bromide?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. In vitro research suggests that marjoram extract can inhibit acetylcholinesterase activity.

Full Marjoram + Umeclidinium Bromide answer

Can you take Methylene Blue with Umeclidinium Bromide?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Concomitant use may increase anticholinergic effects and adverse effects.

Full Methylene Blue + Umeclidinium Bromide answer

Can you take Nutmeg with Umeclidinium Bromide?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use of nutmeg and anticholinergic drugs might decrease the effectiveness of either agent.

Full Nutmeg + Umeclidinium Bromide answer

Can you take Phosphatidylserine with Umeclidinium Bromide?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, phosphatidylserine might decrease the effectiveness anticholinergic drugs.

Full Phosphatidylserine + Umeclidinium Bromide answer

Can you take Poria Mushroom with Umeclidinium Bromide?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, poria mushroom might decrease the clinical effects of anticholinergic drugs.

Full Poria Mushroom + Umeclidinium Bromide answer

Can you take Purple Nut Sedge with Umeclidinium Bromide?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. In vitro, purple nut sedge dose-dependently inhibits acetylcholinesterase (AChE).

Full Purple Nut Sedge + Umeclidinium Bromide answer

Can you take Sage with Umeclidinium Bromide?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, sage might decrease the clinical effects of anticholinergic drugs.

Full Sage + Umeclidinium Bromide answer

Can you take Syrian Rue with Umeclidinium Bromide?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, Syrian rue might decrease the effects of anticholinergic drugs.

Full Syrian Rue + Umeclidinium Bromide answer

Can you take Teazle with Umeclidinium Bromide?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. In vitro research suggests that teazle extract can inhibit acetylcholinesterase activity.

Full Teazle + Umeclidinium Bromide answer

Can you take Thyme with Umeclidinium Bromide?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concurrent use of anticholinergic drugs and thyme essential oil might reduce the effects of anticholinergic drugs.

Full Thyme + Umeclidinium Bromide answer
Read the list like a pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

  • Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
  • Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
  • Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
  • No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

  • Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
  • Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
  • Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

  • Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
  • Each entry links to a full report with the clinical detail, likelihood, evidence level, and citations for that exact combination.
  • Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

How Does Our Interaction Checker Work?

Behind every verdict on this page is a category system. Our source database doesn’t document supplement interactions drug-by-drug — it documents them against groups of medications that behave the same way (for example, “drugs processed by the CYP3A4 liver enzyme” or “blood-thinning medications”).

So the check works in three steps: (1) Umeclidinium Bromide is classified into the pharmacology categories it belongs to, (2) every supplement interaction documented against any of those categories is inherited by Umeclidinium Bromide, and (3) each ingredient keeps its own severity, likelihood, and evidence grades from the underlying record. That’s why one supplement can carry several records for one drug — it may interact through more than one category.

Umeclidinium Bromide sits in 2 interaction categories. Open any one to see what the group means:

Anticholinergic Drugs 30 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

30 of the supplement ingredients on this page reach Umeclidinium Bromide through this category.

Oral Drugs 17 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

17 of the supplement ingredients on this page reach Umeclidinium Bromide through this category.

About Umeclidinium Bromide

Umeclidinium is a long-acting anticholinergic bronchodilator inhaled once daily for the maintenance treatment of chronic obstructive pulmonary disease (COPD).

Generic name: Umeclidinium Bromide  ·  Brand name: Incruse Ellipta.

See the full Umeclidinium Oral Inhalation drug information
Check a real product

Take a Supplement Product? Check the Whole Bottle Against Umeclidinium Bromide

Most supplements are combination products — and the interaction may come from an ingredient you didn’t buy it for. Search any product below (or scan its label) and we’ll check every ingredient on it against Umeclidinium Bromide.

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Pharmacist Counseling Corner

Umeclidinium Bromide & Supplements: Common Questions

What supplements interact with Umeclidinium Bromide?
Our database currently documents 46 ingredients with a known Umeclidinium Bromide interaction (3 major, 32 moderate, 11 minor). The practical move: scan the major group first, then look up the exact supplements you take rather than reading all 46. The highest-ranked right now: Activated Charcoal, Henbane, Scopolia.
Which Umeclidinium Bromide supplement interactions are the most serious?
Focus on the major group: Activated Charcoal, Henbane and Scopolia. A major rating means the combination can be clinically significant, not that harm is guaranteed — but it's exactly the kind of thing to run past your pharmacist before your next dose, not after. Jump to the ranked list.
Can I take vitamins or supplements while on Umeclidinium Bromide?
Plenty of supplements coexist fine with Umeclidinium Bromide; a shorter list does not. Rather than memorizing it, check the specific ingredients on your labels — the ranked list above covers every one we've checked, and multi-ingredient products can be checked label-by-label with our scanner. Try the label scanner or the interaction checker.
Do brands like Incruse Ellipta have the same supplement interactions as Umeclidinium Bromide?
Yes — Incruse Ellipta all contain Umeclidinium Bromide, so everything on this page applies to them equally. Interactions belong to the active drug, never to the brand on the box; the same is true of generics.
Where do these interaction ratings come from?
Every rating comes from the Natural Medicines database — the same evidence-graded reference pharmacists and hospitals use — and each interaction carries three separate grades: severity (how bad it can be), likelihood (how well it's documented in studies and case reports), and an evidence level. Our pharmacists review the content; we never let an AI decide an interaction. See how to read the ratings and our editorial policy.
What about Umeclidinium Bromide and my other medications?
This page covers Umeclidinium Bromide against supplements and herbal ingredients. Checking Umeclidinium Bromide against your other prescription or OTC medications is a different tool — our drug interaction checker covers that side. Head to the drug–drug interaction checker, or read the full Umeclidinium Oral Inhalation drug information.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Sourcing

Where This Data Comes From — and Why You Can Trust It

🧪 Licensed clinical database

Every interaction verdict on this page comes from Natural Medicines Pro (TRC Healthcare / Therapeutic Research) — the same evidence-graded reference used by pharmacists and hospitals. We license this data directly; we do not scrape it, and no AI invents an interaction.

🧑‍⚕️ Pharmacist review

This page is curated and coded by , Clinical Pharmacist, with additional analysis by the HelloPharmacist Pharmacist Team. Editorial commentary is ours; the licensed interaction records are shown as sourced.

🔄 Kept current

Our interaction database refreshes on a weekly cycle, and this page re-checks the live database every time it’s rebuilt — what you see reflects the database as of September 30, 2026.

🔍 Full transparency

How every dataset on this site is sourced, licensed, and updated is documented publicly: our data sources · editorial policy · how we use AI.

Educational information, not medical advice. An interaction being on file does not mean it will happen to you — and absence of one is not proof of safety. Never start or stop a medication or supplement without talking to your pharmacist or doctor.