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Dietary supplement

17 Manganese Copper-Cobalt Ingredients & Drug Interactions

by Somaplex

17 Manganese Copper-Cobalt label
See full label image
Liquid Category: Mineral
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking 17 Manganese Copper-Cobalt against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

17 Manganese Copper-Cobalt is a dietary supplement by Somaplex with 3 active ingredients. Its ingredients are commonly taken for bone health support, antioxidant and enzyme support, filling dietary gaps.Based on those ingredients, 114 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Manganese Sulfate, Cupric Gluconate. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against 17 Manganese Copper-Cobalt by Somaplex

Ask about any prescription or over-the-counter medication and we check it for interactions with 17 Manganese Copper-Cobalt by Somaplex — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of 17 Manganese Copper-Cobalt by Somaplex

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 12, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 3 of its 3 active ingredients.
  • No proprietary blends here — you can verify the dose of every single component.

Somaplex contains 3 active ingredients: manganese sulfate, cupric gluconate, and cobaltous sulfate. Manganese helps your body process amino acids, cholesterol, and carbohydrates, and it's especially important if you're deficient in it.

Copper supports bone strength, immune function, and iron metabolism. Cobalt is included here as an inorganic mineral form, though the product information notes it has no proven benefit and carries toxicity concerns.

The formula also contains water and ethyl alcohol as inactive ingredients.

Does it work?

Strong evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed

This product doesn't appear to be marketed for a specific use, so we graded its ingredients' overall clinical evidence instead.

Strong

Strong clinical evidence supports its ingredients for:

Why this rating?
  • We looked at the product name, claims, and label statements and couldn't find a stated purpose to grade.
  • Since the label doesn't commit to one use, we graded the ingredients' overall clinical evidence instead.
  • On file: Manganese deficiency — rated "Effective" (Manganese) (Natural Medicines).
  • On file: Copper deficiency — rated "Likely Effective" (Copper) (Natural Medicines).

The evidence for these ingredients is mixed. Manganese sulfate is effective for manganese deficiency—if that's your situation, it works.

For other uses like hay fever, osteoporosis, COPD, weight loss, and joint pain, the evidence isn't strong enough to rate it. Cupric gluconate is likely effective for copper deficiency.

However, it's possibly ineffective for Alzheimer disease, and there's insufficient evidence for acne or chemotherapy-related anemia. Cobaltous sulfate has no effectiveness ratings in our data.

The evidence, ingredient by ingredient Manganese Copper Cobalt

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 3 of the 3 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 3 of 3.
  • General safety write-ups exist for 3 of 3.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Manganese and copper are generally well tolerated at normal dietary doses, but high-dose supplements carry real risks. High-dose manganese can cause serious nerve damage resembling Parkinson disease, and one severe case involved irreversible Parkinson disease from taking 100 mg daily for years.

High-dose manganese also risks liver damage. Copper toxicity at high doses is also a concern.

Cobalt is the bigger worry here: inorganic cobalt supplements aren't recommended because they've caused heart damage, hearing loss, and vision loss in some people taking them for anemia. For manganese, amounts in prenatal vitamins are fine, but avoid high-dose supplements in pregnancy.

Copper is needed in pregnancy at recommended amounts—stay within those limits. Cobalt should be avoided in pregnancy and breastfeeding due to toxicity risks and lack of safety data.

Side effects, ingredient by ingredient Manganese Copper Cobalt

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 2 of the 3 matched ingredients can interact with medications — Manganese, Copper.
  • The most serious interaction on file is rated Moderate.
  • For scale: 114 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

If you take an antipsychotic drug like haloperidol, check with your pharmacist before using this product—manganese may increase toxicity risk. Also double-check if you're on quinolone antibiotics (like ciprofloxacin) or tetracycline antibiotics (like doxycycline), since manganese may reduce how well they work.

If you take penicillamine for Wilson disease or rheumatoid arthritis, the copper may interfere—your pharmacist can help you space doses. And if you use oral contraceptives, discuss the copper content with your pharmacist or doctor.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with strong clinical evidence behind its ingredients' uses. Moderate medication interactions have been identified, and safety information is well characterized.

If you're deficient in manganese or copper, this product targets those conditions. You'll want to check your medications—especially antipsychotics, quinolone or tetracycline antibiotics, penicillamine, or oral contraceptives—before starting.

The cobalt ingredient here is a significant concern: inorganic cobalt has no proven benefit and carries serious risks of heart, hearing, and vision damage. Talk to your pharmacist about whether this product is right for you and whether a cobalt-free alternative might work better.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 3 of 3 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Sep 25, 2013.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about 17 Manganese Copper-Cobalt, straight from the product label.

Brand Somaplex
Net contents 1 fl. Oz.; 29.5 mL
Market status On market
Date entered into DSLD Sep 25, 2013
DSLD ID 25449
Product type Mineral
Supplement form Liquid
Dietary claims / uses All Other
Intended target group(s) Adult (18 - 50 Years), Children (All)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for 17 Manganese Copper-Cobalt by Somaplex, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
0.3 mL
Maximum serving Sizes:
0.6 mL
Servings per container
49
IngredientAmount% DV
Manganese Sulfate0.195 mcg--
Cupric Gluconate0.195 mcg--
Cobaltous Sulfate0.195 mcg--

Other ingredients: Water, ethyl alcohol

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions

Suggested Use: Adults take 20 drops on the tongue or in 1 oz. water two times daily. Children receive 1/2 or less of the adult amount.

Precautions

Tamper Evident: Use this product only if tamper evident ring has not been broken away from base of cap.

General

2993

General Statements

IONIZED TRACE ELEMENTS

17

>>NESTMANN<<

Made in Germany Nestmann Pharma Zapfendorf/Bamberg

FDA Statement of Identity

SUPPLEMENT

Seals/Symbols

MPI

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

17 Manganese Copper-Cobalt by Somaplex label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

17 Manganese Copper-Cobalt label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in 17 Manganese Copper-Cobalt by Somaplex

These are the 3 active ingredients this product is made of. Select any to open its full monograph.

Serving size0.3 mL Dosage formLiquid Servings per container49 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Manganese Sulfate

Interacts with
83 drugs
0.195 mcg per serving

Manganese is an essential trace mineral your body needs in small amounts for bone formation, metabolism, and antioxidant defense, and most people get...

Manganese Sulfate monograph & interactions

Cupric Gluconate

Interacts with
31 drugs
0.195 mcg per serving

Copper is an essential trace mineral your body needs in small amounts for making red blood cells, supporting nerves and bones, and helping enzymes wor...

Cupric Gluconate monograph & interactions

Cobaltous Sulfate

No known
interactions
0.195 mcg per serving

Cobalt is a trace element that the body only needs as part of vitamin B12 (cobalamin); there is no proven reason to take inorganic cobalt supplements,...

Cobaltous Sulfate monograph & interactions

Other (inactive) ingredients: Water, Ethyl alcohol. These complete the product’s ingredient list but are not active constituents.

Interaction report

17 Manganese Copper-Cobalt by Somaplex Drug Interactions

Want to check YOUR meds against 17 Manganese Copper-Cobalt?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
114Drugs
84 Moderate 30 Minor

Ingredients driving the most interactions

Manganese Sulfate 83
Cupric Gluconate 31

Individual Drug Interactions

The ingredients in 17 Manganese Copper-Cobalt interact with 114 drugs. Click any drug to see the details.

2 of the 3 ingredients in 17 Manganese Copper-Cobalt interact with drugs. Each result below shows which ingredient is responsible. Manganese Sulfate Cupric Gluconate

Each ingredient & the kinds of drugs it affects

For each ingredient in 17 Manganese Copper-Cobalt with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Manganese Sulfate3 drug types · 83 drugs

Antipsychotic Drugs

Theoretically, the risk for manganese toxicity might increase when taken with antipsychotic drugs.
Hallucinations and behavioral changes have been reported in a patient with liver disease who was taking haloperidol and manganese. Researchers speculate that taking manganese along with haloperidol, phenothiazine-derivatives, or other antipsychotic medications might increase the risk of manganese toxicity in some patients.

Likelihood Possible Evidence D
Quinolone Antibiotics

Theoretically, manganese might reduce the absorption of quinolone antibiotics.
Manganese is a multivalent cation. Interactions resulting in reduced quinolone absorption have been reported between quinolones and other multivalent cations, such as calcium and iron.

Likelihood Probable Evidence D
Tetracycline Antibiotics

Theoretically, manganese might reduce the absorption of tetracycline antibiotics.
Manganese is a multivalent cation. Interactions resulting in reduced tetracycline absorption have been reported between tetracyclines and other multivalent cations, such as calcium and iron.

Likelihood Probable Evidence D
Manganese Sulfate full monograph & interactions

Cupric Gluconate2 drug types · 31 drugs

Penicillamine (Cuprimine, Depen)

Theoretically, taking copper with penicillamine might decrease the absorption of penicillamine; separate dosing by at least 2 hours.
Copper chelates penicillamine, which decreases its absorption and may reduce its clinical effects.

Likelihood Probable Evidence D
Contraceptive Drugs

Theoretically, taking copper with contraceptive drugs might increase the levels and toxic effects of copper.
A meta-analysis of clinical studies suggests that chronic use of oral contraceptives increases serum copper levels by a mean of 57 mcg/dL. In most people, this resulted in levels above the normal reference range for copper.

Likelihood Possible Evidence D
Cupric Gluconate full monograph & interactions
The maker

Brand information

Manufacturer and brand details for 17 Manganese Copper-Cobalt, from the product label.

Somaplex

See all Somaplex products
Name
Marco Pharma Int'l
City
Roseburg
State
OR
ZipCode
97470
Pharmacist Counseling Corner

17 Manganese Copper-Cobalt by Somaplex: Common Questions

Does 17 Manganese Copper-Cobalt by Somaplex interact with any medications?
Yes. Based on its ingredients, 17 Manganese Copper-Cobalt has a known interaction with 114 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
17 Manganese Copper-Cobalt contains 3 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Is this safe during pregnancy?
Manganese and copper at the amounts in prenatal vitamins are appropriate in pregnancy, but avoid high-dose supplements of either unless a doctor advises it. Cobalt should be avoided entirely in pregnancy because of toxicity concerns and lack of safety data. Talk with your doctor or pharmacist before starting.
Can I take this while breastfeeding?
Manganese data shows it's likely safe, possibly unsafe, and likely unsafe at different levels—the facts are mixed, so talk with your pharmacist for personalized advice. Copper is likely safe. Cobalt should be avoided while breastfeeding; rely on vitamin B12 for cobalt needs instead.
What is manganese actually for?
Manganese helps your body break down amino acids, cholesterol, and carbohydrates. It's proven effective if you have a manganese deficiency. For other conditions like osteoarthritis or osteoporosis, there isn't strong enough evidence yet.
Why is cobalt in here if it's not recommended?
Inorganic cobalt supplements have no proven benefit and carry serious risks of heart damage, hearing loss, and vision loss. The safety facts note cobalt is generally not recommended, so this is a red flag for this product.
What happens if I take too much of this product?
High doses of manganese can cause nerve damage resembling Parkinson disease and liver damage. High-dose copper is also toxic. High-dose cobalt can cause heart damage, hearing loss, and vision loss. Stick to the label dose and talk to your pharmacist about what's right for you.
Does copper help with Alzheimer disease?
No—copper is possibly ineffective for Alzheimer disease according to the evidence we hold. Copper is proven effective only for copper deficiency.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

17 Manganese Copper-Cobalt label
Go deeper

The Full Monographs Behind 17 Manganese Copper-Cobalt’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Manganese

Interacts with 83 drugs

Manganese is an essential trace mineral your body needs in small amounts for bone formation, metabolism, and antioxidant defense, and most people get enough from a normal diet. Supplements m...

Read the full Manganese monograph → Herb & supplement monograph

Copper

Interacts with 31 drugs

Copper is an essential trace mineral your body needs in small amounts for making red blood cells, supporting nerves and bones, and helping enzymes work. Most people get enough copper from fo...

Read the full Copper monograph → Herb & supplement monograph

Cobalt

Cobalt is a trace element that the body only needs as part of vitamin B12 (cobalamin); there is no proven reason to take inorganic cobalt supplements, and doing so can be harmful. If you nee...

Read the full Cobalt monograph →
Sources

Sources & How We Checked

17 Manganese Copper-Cobalt's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 43 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Manganese 21 references
  1. Hansten PD, Horn JR. Hansten and Horn's Drug Interactions Analysis and Management. Vancouver, CAN:Appl Therapeut, 1999.
  2. Barrington WW, Angle CR, Willcockson NK, et al. Autonomic function in manganese alloy workers. Environ Res 1998;78:50-8. PubMed
  3. Hauser RA, Zesiewicz TA, Martinez C, et al. Blood manganese correlates with brain magnetic resonance imaging changes in patients with liver disease. Can J Neurol Sci 1996;23:95-8. PubMed
  4. Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Vitamin A, Vitamin K, Arsenic, Boron, Chromium, Copper, Iodine, Iron, Manganese, Molybdenum, Nickel, Silicon, Vanadium, and Zinc. Washington, DC: National Academy Press, 2002.
  5. Lee JW. Manganese intoxication. Arch Neurol 2000;57:597-9.. PubMed
  6. Powers KM, Smith-Weller T, Franklin GM, et al. Parkinson's disease risks associated with dietary iron, manganese, and other nutrient intakes. Neurology 2003;60:1761-6.. PubMed
  7. McMillan, D. E. A brief history of the neurobehavioral toxicity of manganese: some unanswered questions. Neurotoxicology 1999;20(2-3):499-507.
  8. Gerber, G. B., Leonard, A., and Hantson, P. Carcinogenicity, mutagenicity and teratogenicity of manganese compounds. Crit Rev Oncol Hematol. 2002;42(1):25-34. PubMed
  9. Jiang, Y. and Zheng, W. Cardiovascular toxicities upon manganese exposure. Cardiovasc.Toxicol 2005;5(4):345-354. PubMed
  10. Mehta, R. and Reilly, J. J. Manganese levels in a jaundiced long-term total parenteral nutrition patient: potentiation of haloperidol toxicity? Case report and literature review. JPEN J Parenter.Enteral Nutr 1990;14(4):428-430. PubMed
  11. Nemery, B. Metal toxicity and the respiratory tract. Eur Respir.J 1990;3(2):202-219. DOI
  12. Vanek VW, Borum P, Buchman A, et al. A.S.P.E.N. position paper: recommendations for changes in commercially available parenteral multivitamin and multi-trace element products. Nutr Clin Pract. 2012;27:440-491.doi: 10.1177/0884533612446706 PubMed
  13. Schuh MJ. Possible Parkinson's disease induced by chronic manganese supplement ingestion. Consult Pharm. 2016;31(12):698-703. doi: 10.4140/TCP.n.2016.698. PubMed
  14. Baker B, Ali A, Isenring L. Recommendations for manganese supplementation to adult patients receiving long-term home parenteral nutrition: an analysis of the supporting evidence. Nutr Clin Pract 2016;31(2):180-5. doi: 10.1177/0884533615591600. PubMed
  15. Ho CSH, Ho RCM, Quek AML. Chronic manganese toxicity associated with voltage-gated potassium channel complex antibodies in a relapsing neuropsychiatric disorder. Int J Environ Res Public Health 2018;15(4). pii: E783. doi: 10.3390/ijerph15040783. PubMed
  16. Yamamoto M, Sakurai K, Eguchi A, et al.; Japan Environment and Children's Study Group: Association between blood manganese level during pregnancy and birth size: the Japan environment and children's study (JECS). Environ Res 2019;172:117-26. PubMed
  17. Li D, Ge X, Liu Z, et al. Association between long-term occupational manganese exposure and bone quality among retired workers. Environ Sci Pollut Res Int 2020;27(1):482-9. PubMed
  18. Martin KV, Sucharew H, Dietrich KN, et al. Co-exposure to manganese and lead and pediatric neurocognition in East Liverpool, Ohio. Environ Res 2021;202:111644. PubMed
  19. Racette BA, Nelson G, Dlamini WW, et al. Depression and anxiety in a manganese-exposed community. Neurotoxicology 2021;85:222-33. PubMed
  20. Ruiz-Azcona L, Fernández-Olmo I, Expósito A, et al. Impact of environmental airborne manganese exposure on cognitive and motor functions in adults: a systematic review and meta-analysis. Int J Environ Res Public Health 2021;18(8):4075. PubMed
  21. Uyar E, Gurkas E, Aksu AU, et al. Can therapeutic plasma exchange be life-saving in life-threatening manganese intoxication?. Transfus Apher Sci 2022;61(4):103417. PubMed

See these in context on the Manganese monograph →

Copper 11 references
  1. Murry JJ, Healy MD. Drug-mineral interactions: a new responsibility for the hospital dietician. J Am Diet Assoc 1991;91:66-73.
  2. Campbell IA, Elmes PC. Ethambutol and the eye: zinc and copper (letter). Lancet 1975;2:711. DOI
  3. Segal S, Kaminski S. Drug-nutrient interactions. American Druggist 1996 Jul;42-8.
  4. Kozak SF, Inderlied CB, Hsu HY, et al. The role of copper on ethambutol's antimicrobial action and implications for ethambutol-induced optic neuropathy. Diag Microbiol Infect Dis 1998;30:83-7. PubMed
  5. Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Vitamin A, Vitamin K, Arsenic, Boron, Chromium, Copper, Iodine, Iron, Manganese, Molybdenum, Nickel, Silicon, Vanadium, and Zinc. Washington, DC: National Academy Press, 2002.
  6. Cantilena LR, Klaassen CD. The effect of chelating agents on the excretion of endogenous metals. Toxicol Appl Pharmacol 1982;63:344-50.
  7. Babic Z, Tariba B, Kovacic J, Pizent A, Varnai VM, Macan J. Relevance of serum copper elevation induced by oral contraceptives: a meta-analysis. Contraception. 2013 Jun;87(6):790-800. PubMed
  8. Qui Q, Zhang F, Zhu W, Wu J, Liang M. Copper in diabetes mellitus: a meta-analysis and systematic review of plasma and serum studies. Biol Trace Elem Res 2017;177(1):53-63.
  9. Walker-Smith PK, Keith DJ, Kennedy CT, Sansom JE. Allergic contact dermatitis caused by copper. Contact Dermatitis 2016;75(3):186-7. PubMed
  10. Gallentine A. Third-degree burn on the neuropathic lower extremity in a patient with diabetes while wearing a copper-containing compression sock: a case report. Wound Manag Prev 2021;67(12):26-29. DOI
  11. Chung KJ, Chin YM, Wong MS, Sanmugam A, Singaravel S, Nah SA. Effectiveness of table salt versus copper sulphate in treating umbilical granuloma: A pilot randomized controlled trial. J Pediatr Surg 2022;57(2):261-265. PubMed

See these in context on the Copper monograph →

Cobalt 11 references
  1. Packer M. Cobalt cardiomyopathy: a critical reappraisal in light of a recent resurgence. Circ Heart Fail 2016;9(12). pii: e003604. PubMed
  2. Adams TN, Butt YM, Batra K, Glazer CS. Cobalt related interstitial lung disease. Respir Med 2017;129:91-7. PubMed
  3. Lim CA, Khan J, Chelva E, Khan R, Unsworth-Smith T. The effect of cobalt on the human eye. Doc Ophthalmol 2015;130(1):43-8. PubMed
  4. Guarneri F, Guarneri C, Cannavò SP. Nail-art and cobalt allergy. Contact Dermatitis 2010;62(5):320-1. PubMed
  5. Fowler JF Jr. Cobalt. Dermatitis 2016;27(1):3-8.
  6. Zajdel NJ, Smith WA, Taintor AR, Jacob SE, Olasz EB. Chemical tattoo treatment leading to systemic cobalt hypersensitivity. Skinmed 2017;15(3):221-2.
  7. Bregnbak D, Opstrup MS, Jellesen MS, Johansen JD, Thyssen JP. Allergic contact dermatitis caused by cobalt in leather - clinical cases. Contact Dermatitis 2017;76(6):366-8. PubMed
  8. Simonsen AB, Friis UF, Johansen JD, Zachariae C, Sloth JJ, Thyssen JP. Occupational allergic contact dermatitis caused by cobalt in machine oil. Contact Dermatitis 2019;80(1):59-61. PubMed
  9. Paustenbach DJ, Galbraith DA, Finley BL. Interpreting cobalt blood concentrations in hip implant patients. Clin Toxicol (Phila) 2014;52(2):98-112. PubMed
  10. Zywiel MG, Cherian JJ, Banerjee S, et al. Systemic cobalt toxicity from total hip arthroplasties: review of a rare condition Part 2. measurement, risk factors, and step-wise approach to treatment. Bone Joint J 2016;98-B(1):14-20. PubMed
  11. Catalani S, Rizzetti MC, Padovani A, Apostoli P. Neurotoxicity of cobalt. Hum Exp Toxicol 2012;31(5):421-37. PubMed

See these in context on the Cobalt monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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