Interactions on record — worth a quick check against your medications. Check your meds →
Dietary supplement

Acidophilus Probiotic Ingredients & Drug Interactions

by Natrol

Acidophilus Probiotic label
See full label image
Capsule Category: Non-nutrient/non-botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 9, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Acidophilus Probiotic against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Acidophilus Probiotic is a dietary supplement by Natrol with 1 active ingredient. Its ingredients are commonly taken for digestive health and balance, diarrhea (including antibiotic-related), vaginal yeast and bacterial infections.Based on those ingredients, 182 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Lactobacillus acidophilus. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against Acidophilus Probiotic by Natrol

Ask about any prescription or over-the-counter medication and we check it for interactions with Acidophilus Probiotic by Natrol — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
Prefer a human? Send your question to our licensed pharmacists — free, answered by email within 24 hours.

HelloPharmacist Scorecard of Acidophilus Probiotic by Natrol

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains one active ingredient: Lactobacillus acidophilus, a beneficial live bacterium that naturally lives in your gut and may help restore balance to your intestinal flora. The inactive ingredients are microcrystalline cellulose, whey powder, gelatin, magnesium stearate, and silicon dioxide — these are fillers and binders that hold the capsule together.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: digestive health and friendly bacteria balance.
  • We looked for evidence on: Antibiotic-associated diarrhea, Bacterial vaginosis, Clostridioides difficile infection, Colic, Constipation, Helicobacter pylori — and 4 related terms.
  • The strongest evidence on file: Lactobacillus Acidophilus is rated "Possibly Effective" for Antibiotic-associated diarrhea (Natural Medicines).
  • Also on file: Lactobacillus Acidophilus is rated "Possibly Effective" for Bacterial vaginosis, Helicobacter pylori, Irritable bowel syndrome (IBS).
  • Also on file: Lactobacillus Acidophilus is rated "Insufficient Reliable Evidence To Rate" for Constipation, Inflammatory bowel disease (IBD), Lactose intolerance.

L. acidophilus shows possibly effective evidence for four uses: irritable bowel syndrome (IBS), Helicobacter pylori (a stomach bacteria linked to ulcers), antibiotic-associated diarrhea, and bacterial vaginosis. The evidence for atopic disease (allergic and inflammatory skin conditions) is possibly ineffective.

For acute respiratory distress syndrome, there isn't enough reliable evidence to rate it either way. If you're considering this for IBS or one of the other possibly effective uses, talk with your doctor about whether it fits your situation.

The evidence, ingredient by ingredient Lactobacillus Acidophilus

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Lactobacillus acidophilus is generally well tolerated in healthy adults and children. That said, because it contains live microorganisms, there is a theoretical concern that in rare cases it could cause infection — cases of bacteremia, sepsis, and other serious infections tied to L. acidophilus have been reported, though most occurred when the bacteria moved from their normal locations in the body.

Oral side effects from L. acidophilus or probiotic combinations are uncommon but can include stomach discomfort, abdominal pain, bloating, gas, diarrhea, or vomiting. In one trial, a multi-ingredient probiotic containing L. acidophilus was linked to two rashes and one case of itching, though it's unclear whether L. acidophilus was the cause.

Check with your doctor before using this product.

Side effects, ingredient by ingredient Lactobacillus Acidophilus

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Lactobacillus Acidophilus.
  • The most serious interaction on file is rated Moderate.
  • For scale: 182 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

If you're on antibiotic drugs, separate your doses from this probiotic — taking them together can reduce the probiotic's effectiveness. Space them out and ask your pharmacist for the right timing.

No other medication interactions are documented for the ingredient we checked.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

This single-ingredient probiotic may be worth trying if you have IBS, antibiotic-related diarrhea, or one of the other possibly effective uses — and the good news is it's generally well tolerated. The main thing to watch: don't take it at the same time as antibiotics, since the antibiotics will kill the live bacteria in the supplement.

Talk to your pharmacist or doctor about spacing, and ask them whether this probiotic makes sense for your situation.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Aug 23, 2019.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Acidophilus Probiotic, straight from the product label.

Brand Natrol
Barcode (UPC) 047469161088
Net contents 150 Capsule(s)
Market status On market
Date entered into DSLD Aug 23, 2019
DSLD ID 203336
Product type Non-nutrient/non-botanical
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Acidophilus Probiotic by Natrol, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Capsule(s)
Maximum serving Sizes:
1 Capsule(s)
Servings per container
150
UPC/BARCODE
047469161088
IngredientAmount% DV
Lactobacillus acidophilus100 mg--

Other ingredients: Microcrystalline Cellulose, Whey powder, Gelatin, Magnesium Stearate, Silicon Dioxide

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements

Natrol Acidophilus Probiotic: Helps maintain a healthy balance of friendly bacteria in the digestive system Strengthens the body's natural immunity Helps ease occasional stomach discomfort Guaranteed 1 billion live cultures At the time of manufacture.

Digestive health Helps maintain a healthy digestive tract 1 Billion Live Cultures per capsule Value size

Precautions

Warning: Consult your healthcare professional prior to use if you have or suspect a medical condition, are taking prescription drugs, or are pregnant or lactating.

Keep out of reach of children.

Contains: Milk

Storage

Keep refrigerated after opening.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

General

ITEM: 16108.911 F: 3000325 L: 2008937-17206

FDA Statement of Identity

Dietary Supplement

Suggested/Recommended/Usage/Directions

Directions: Take 1 capsule, three times daily, preferably 30 minutes before a meal.

Formula

Contains: Milk

Formulation

No: Egg, Fish, Crustacean Shellfish, Tree Nuts, Peanuts, Wheat, Soybeans, Yeast, Artificial Colors or Flavors, Added Sugar or Preservatives

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Acidophilus Probiotic by Natrol label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Acidophilus Probiotic label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Acidophilus Probiotic by Natrol

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 Capsule(s) Dosage formCapsule Servings per container150 Amounts shown are per serving.

Lactobacillus acidophilus

Interacts with
182 drugs
100 mg per serving

Lactobacillus acidophilus is a 'friendly' bacterium used as a probiotic to support gut and vaginal health. It is generally well tolerated in healthy p...

Lactobacillus acidophilus monograph & interactions

Other (inactive) ingredients: Microcrystalline Cellulose, Whey powder, Gelatin, Magnesium Stearate, Silicon Dioxide. These complete the product’s ingredient list but are not active constituents.

Interaction report

Acidophilus Probiotic by Natrol Drug Interactions

Want to check YOUR meds against Acidophilus Probiotic?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
182Drugs
182 Moderate

Ingredients driving the most interactions

Lactobacillus acidophilus 182

Individual Drug Interactions

The ingredients in Acidophilus Probiotic interact with 182 drugs. Click any drug to see the details.

1 of the 1 ingredient in Acidophilus Probiotic interact with drugs. Each result below shows which ingredient is responsible. Lactobacillus acidophilus

Each ingredient & the kinds of drugs it affects

For each ingredient in Acidophilus Probiotic with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Lactobacillus acidophilus1 drug type · 182 drugs

Antibiotic Drugs

Theoretically, taking Lactobacillus acidophilus with antibiotic drugs might decrease the effectiveness of L. acidophilus.
L. acidophilus preparations usually contain live and active organisms. Therefore, simultaneously taking antibiotics might kill a significant number of the organisms. Tell patients to separate administration of antibiotics and L. acidophilus preparations by at least two hours.

Likelihood Probable Evidence D
Lactobacillus acidophilus full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Acidophilus Probiotic, from the product label.

Natrol

See all Natrol products
Name
Natrol LLC
City
Chatsworth
State
CA
ZipCode
91311
Phone Number
1-800-262-8765
Web Address
www.natrol.com
Pharmacist Counseling Corner

Acidophilus Probiotic by Natrol: Common Questions

Does Acidophilus Probiotic by Natrol interact with any medications?
Yes. Based on its ingredients, Acidophilus Probiotic has a known interaction with 182 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Acidophilus Probiotic contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this while I'm on antibiotics?
Not at the same time. Antibiotics will kill the live bacteria in this probiotic and make it less effective. Ask your pharmacist how many hours to wait between your antibiotic dose and this supplement — the timing depends on which antibiotic you're taking.
Will this help with my IBS?
The evidence suggests it's possibly effective for irritable bowel syndrome, meaning some people may see benefit. But results vary, and you should talk with your doctor about whether a probiotic like this fits your specific situation and what you're already doing for IBS.
What are the actual side effects I might experience?
Gastrointestinal upset is uncommon but possible — you might notice stomach discomfort, bloating, gas, diarrhea, or nausea. In one trial, a few people experienced rash or itching, though we can't say for certain that L. acidophilus was the cause. Most people tolerate it well.
Is it safe to take while I'm pregnant?
Pregnancy data for L. acidophilus are rated as possibly safe, which means there isn't enough evidence to say no — but there also isn't solid evidence of safety. Talk with your doctor or pharmacist for personalized advice based on your own situation.
What is L. acidophilus, and why is it in this supplement?
It's a live bacterium that naturally lives in your gut and helps maintain healthy intestinal balance. This supplement adds more of it, which may help with conditions like IBS or diarrhea linked to antibiotics.
Does this contain any fillers or other ingredients?
Yes — alongside the live L. acidophilus, the capsule contains microcrystalline cellulose, whey powder, gelatin, magnesium stearate, and silicon dioxide. These are inactive ingredients that help hold the capsule together.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Acidophilus Probiotic is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Acidophilus Probiotic label
Go deeper

The Full Monographs Behind Acidophilus Probiotic’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Lactobacillus Acidophilus

Interacts with 182 drugs

Lactobacillus acidophilus is a 'friendly' bacterium used as a probiotic to support gut and vaginal health. It is generally well tolerated in healthy people, and there is reasonable evidence...

Read the full Lactobacillus Acidophilus monograph →
Sources

Sources & How We Checked

Acidophilus Probiotic's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 15 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Lactobacillus Acidophilus 15 references
  1. Pierce A. The American Pharmaceutical Association Practical Guide to Natural Medicines. New York: The Stonesong Press, 1999:19.
  2. Begtrup LM, de Muckadell OB, Kjeldsen J, Christensen RD, Jarbøl DE. Long-term treatment with probiotics in primary care patients with irritable bowel syndrome--a randomised, double-blind, placebo controlled trial. Scand J Gastroenterol 2013;48(10):1127-35 PubMed
  3. Chatterjee S, Kar P, Das T, Ray S, Gangulyt S, Rajendiran C, Mitra M. Randomised placebo-controlled double blind multicentric trial on efficacy and safety of Lactobacillus acidophilus LA-5 and Bifidobacterium BB-12 for prevention of antibiotic-associated
  4. Shavakhi A, Tabesh E, Yaghoutkar A, Hashemi H, Tabesh F, Khodadoostan M,Minakari M, Shavakhi S, Gholamrezaei A. The effects of multistrain probiotic compound on bismuth-containing quadruple therapy for Helicobacter pylori infection: a randomized placebo-c
  5. Karamali M, Dadkhah F, Sadrkhanlou M, et al. Effects of probiotic supplementation on glycaemic control and lipid profiles in gestational diabetes: a randomized, double-blind, placebo-controlled trial. Diabetes Metab 2016;42(4):234-41. PubMed
  6. Badehnoosh B, Karamali M, Zarrati M, et al. The effects of probiotic supplementation on biomarkers of inflammation, oxidative stress and pregnancy outcomes in gestational diabetes. J Matern Fetal Neonatal Med. 2018 May;31(9):1128-1136.
  7. Kumar S, Kumar R, Rohilla L, Jacob N, Yadav J, Sachdeva N. A high potency multi-strain probiotic improves glycemic control in children with new-onset type 1 diabetes mellitus: A randomized, double-blind, and placebo-controlled pilot study. Pediatr Diabete
  8. Shahriari A, Karimi E, Shahriari M, Aslani N, Khooshideh M, Arab A. The effect of probiotic supplementation on the risk of gestational diabetes mellitus among high-risk pregnant women: A parallel double-blind, randomized, placebo-controlled clinical trial PubMed
  9. Xiao SD, Zhang DZ, Lu H, et al. Multicenter, randomized, controlled trial of heat-killed Lactobacillus acidophilus LB in patients with chronic diarrhea. Adv Ther. 2003;20(5):253-60.
  10. Rossi F, Amadoro C, Gasperi M, Colavita G. Lactobacilli infection case reports in the last three years and safety implications. Nutrients. 2022;14(6):1178. PubMed
  11. Ozer M, Goksu SY, Shahverdiani A, Mustafa M. Lactobacillus acidophilus-induced endocarditis and associated splenic abscess. Case Rep Infect Dis 2020;2020:1382709.
  12. Sadrin S, Sennoune S, Gout B, et al. A 2-strain mixture of Lactobacillus acidophilus in the treatment of irritable bowel syndrome: A placebo-controlled randomized clinical trial. Dig Liver Dis 2020;52(5):534-540. PubMed
  13. Stoffer JN, Slingsby TJ, Giuliari GP. Lactobacillus acidophilus endophthalmitis after intravitreal bevacizumab injection requiring intraocular lens explantation. Can J Ophthalmol 2022;57(1):e21-e22. PubMed
  14. Cukovic-Cavka S, Likic R, Francetic I, Rustemovic N, Opacic M, Vucelic B. Lactobacillus acidophilus as a cause of liver abscess in a NOD2/CARD15-positive patient with Crohn's disease. Digestion 2006;73(2-3):107-10.
  15. Hui J, Ren Y, Wang Y, Han Q. Lactobacillus acidophilus endophthalmitis postcataract operation: A case report with a literature review. Ocul Immunol Inflamm 2023.

See these in context on the Lactobacillus Acidophilus monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Keep exploring
Supplement interaction checker › Check any supplement or product against your medications Drug–drug interactions › Check two or more of your medications against each other Browse medications A–Z › Every drug we've checked against herbs & supplements NDC & pricing lookup › Find a drug’s NDCs, packaging and costs Ask a pharmacist › Free, personal answer from our licensed team