Major interaction on record — check this product against your medications before combining. Check your meds →
Dietary supplement

Ai/E 10 Ingredients & Drug Interactions

by Pharmanex

Ai/E 10 label
See full label image
Capsule Category: Amino Acid/protein
Most serious interaction: Major
Clinical methodology reviewed by · Updated Sep 23, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Ai/E 10 against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Major

Ai/E 10 is a dietary supplement by Pharmanex with 1 active ingredient. Its ingredients are commonly taken for muscle building and recovery, increasing daily protein intake, weight management.Based on those ingredients, 53 medications have a known interaction with it, the most serious rated major. The ingredients most likely to interact are Ai/E10(R) Whey extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against Ai/E 10 by Pharmanex

Ask about any prescription or over-the-counter medication and we check it for interactions with Ai/E 10 by Pharmanex — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
Prefer a human? Send your question to our licensed pharmacists — free, answered by email within 24 hours.

HelloPharmacist Scorecard of Ai/E 10 by Pharmanex

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 12, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

Ai/E 10 is a single-ingredient supplement: Ai/E10 whey extract, a concentrated form of whey protein. The capsule also contains microcrystalline cellulose, gelatin, magnesium stearate, and silicon dioxide as inactive ingredients — these are fillers and binders that hold the capsule together.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed

This product doesn't appear to be marketed for a specific use, so we graded Whey Protein's overall clinical evidence instead.

Moderate

Some clinical evidence supports Whey Protein for:

Why this rating?
  • We looked at the product name, claims, and label statements and couldn't find a stated purpose to grade.
  • Since the label doesn't commit to one use, we graded the ingredient's overall clinical evidence instead.
  • On file: Athletic performance — rated "Possibly Effective" (Natural Medicines).

Whey protein is possibly effective for athletic performance — that's the main area where evidence backs it up. For bone health (osteoporosis), the data rates it as possibly ineffective.

There isn't enough reliable evidence to know whether it helps with age-related cognitive decline or with wasting from HIV/AIDS, and for COPD it's rated possibly ineffective.

The evidence, ingredient by ingredient Whey Protein

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Whey protein is generally well tolerated by most healthy adults when used as directed. The most common side effects are acne, bloating, cramps, diarrhea, fatigue, headache, nausea, reflux, reduced appetite, and thirst — most of these are dose-related and improve if you lower the amount.

There's one unusual caution: whey protein has been reported in multiple case reports to trigger or worsen acne, especially in teenagers and young adults. When people stopped taking it, their acne typically cleared.

Because concentrated supplement products aren't as well studied as whey as a food, check with your doctor before starting, particularly if you have any health conditions or take medications.

Side effects, ingredient by ingredient Whey Protein

Meds to double-check

Major interaction found
Known Interaction Concern · database check
Major identified

At least one ingredient has a documented Major-severity interaction. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Whey Protein.
  • The most serious interaction on file is rated Major.
  • Some involve high-stakes drug classes: Parkinson's medications.
  • For scale: 53 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking Ai/E 10, double-check your medications with the search tool on this page if you take levodopa (Major interaction), quinolone or tetracycline antibiotics, or bisphosphonates (all Moderate). Timing your doses apart from this product can prevent most of these interactions.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with some supporting evidence behind its ingredients' uses. Major medication interactions have been identified, and safety information is well characterized.

Ai/E 10 is a whey protein supplement that may help with athletic performance. If you take levodopa for Parkinson disease or any antibiotic or bone medication, you'll need to time your doses carefully — talk to your pharmacist before you start.

It's generally well tolerated, but acne and digestive side effects can happen, especially at higher doses.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Oct 25, 2013.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Ai/E 10, straight from the product label.

Brand Pharmanex
Net contents 30 Capsule(s)
Market status On market
Date entered into DSLD Oct 25, 2013
DSLD ID 27134
Product type Amino Acid/protein
Supplement form Capsule
Dietary claims / uses Nutrient, All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Ai/E 10 by Pharmanex, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Capsule(s)
Maximum serving Sizes:
1 Capsule(s)
IngredientAmount% DV
Ai/E10(R) Whey extract100 mg--

Other ingredients: Microcrystalline Cellulose, Gelatin, Magnesium Stearate, Silicon Dioxide

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Brand IP Statement(s)

Pharmanex(R) Standard: Ai/E10(R) is a highly purified bovine whey extract that utilizes a proprietary application of antigen infusion technology. Commercial application of this technology concentrates the level of low molecular weight molecules that are naturally present in bovine whey (under 100 kDa).

Ai/E10(R) is a registered trademark of Quantum Research, Inc. an Arizona Corporation

(C)2005, 09 NSE Products, Inc.

Precautions

Keep out of reach of children.

Do not use if safety seal is broken or missing.

Warning: Contains: Lactose.

If you are pregnant or lactating, or taking a prescription medication, consult a physician before using this product.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Formula

Purified Whey Extract

Warning: Contains: Lactose.

General Statements

Sold Exclusively by Nu Skin Enterprises Authorized Distributors.

Batch No.: Exp. Date:

Immune Cell Communication

General

01 003721 95300098/2

Suggested/Recommended/Usage/Directions

Directions For Use: Take one(1) capsule with liquid once daily.

Seals/Symbols

QUALITY GUARANTEE

FDA Statement of Identity

DIETARY SUPPLEMENT

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Ai/E 10 by Pharmanex label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Ai/E 10 label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Ai/E 10 by Pharmanex

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 Capsule(s) Dosage formCapsule Amounts shown are per serving.

Ai/E10(R) Whey extract

Interacts with
53 drugs
100 mg per serving

Whey protein is a high-quality, complete protein made from cow's milk that can help people meet protein needs and support muscle growth when combined...

Ai/E10(R) Whey extract monograph & interactions

Other (inactive) ingredients: Microcrystalline Cellulose, Gelatin, Magnesium Stearate, Silicon Dioxide. These complete the product’s ingredient list but are not active constituents.

Interaction report

Ai/E 10 by Pharmanex Drug Interactions

Want to check YOUR meds against Ai/E 10?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
53Drugs
5 Major 48 Moderate

Ingredients driving the most interactions

Ai/E10(R) Whey extract 53

Individual Drug Interactions

The ingredients in Ai/E 10 interact with 53 drugs. Click any drug to see the details.

1 of the 1 ingredient in Ai/E 10 interact with drugs. Each result below shows which ingredient is responsible. Ai/E10(R) Whey extract

Each ingredient & the kinds of drugs it affects

For each ingredient in Ai/E 10 with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Ai/E10(R) Whey extract4 drug types · 53 drugs

Levodopa

Theoretically, whey protein might decrease levodopa absorption.
Small clinical studies show that concomitant ingestion of protein or high doses of leucine or isoleucine (100 mg/kg) and levodopa can exacerbate tremor, rigidity, and the "on-off" syndrome in patients with Parkinson disease.

Likelihood Probable Evidence D
Bisphosphonates

Theoretically, whey protein might reduce the absorption of bisphosphonates.
Whey protein contains minerals such as calcium that bind bisphosphonates in the gut. Advise patients to take bisphosphonates at least 30 minutes before whey protein, but preferably at a different time of day.

Likelihood Probable Evidence D
Quinolone Antibiotics

Theoretically, whey protein might decrease quinolone absorption.
Whey protein contains minerals, such as calcium, that can bind to quinolones in the gut. To avoid this interaction, advise patients to take oral quinolones at least 2 hours before or 4-6 hours after whey protein.

Likelihood Probable Evidence D
Tetracycline Antibiotics

Theoretically, whey protein might decrease tetracycline absorption.
Whey protein contains minerals, such as calcium, that bind to tetracyclines in the gut. To avoid this interaction, advise patients to take oral tetracyclines at least 2 hours before or 4-6 hours after whey protein.

Likelihood Probable Evidence D
Ai/E10(R) Whey extract full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Ai/E 10, from the product label.

Pharmanex

See all Pharmanex products
Name
NSE Products, Inc.
City
Provo
State
UT
ZipCode
84601
Phone Number
1-888-742-7626
Web Address
www.pharmanex.com
Pharmacist Counseling Corner

Ai/E 10 by Pharmanex: Common Questions

Does Ai/E 10 by Pharmanex interact with any medications?
Yes. Based on its ingredients, Ai/E 10 has a known interaction with 53 medications, including 5 rated major. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Ai/E 10 contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this if I'm pregnant or breastfeeding?
The product facts don't include pregnancy and breastfeeding safety data for this ingredient. Talk with your doctor or pharmacist for personalized advice — they can help you weigh what's known about whey protein as a food versus concentrated supplements.
What's Ai/E10 whey extract, and why is it in here?
It's a concentrated form of whey protein. The data shows whey is possibly effective for athletic performance and muscle support — that's what this product is marketed for.
Will this cause acne?
Whey protein has been linked to acne or worsening acne in case reports, mostly in teenagers and young adults. When people stopped taking it, their acne usually cleared. If you're prone to acne, keep an eye out and mention it to your pharmacist if you notice a change.
What are the most common side effects?
Bloating, cramps, diarrhea, nausea, headache, and reduced appetite are the most common — they're usually dose-related. If you drop the dose, they often go away.
Is this safe for everyone?
It's generally well tolerated by healthy adults, but concentrated supplement products aren't as well studied as whey as a food. If you have any health conditions or take medications — especially for Parkinson disease, infections, or bones — check with your doctor first.
Can I take this with my antibiotics?
Yes, but timing matters. Take quinolone or tetracycline antibiotics at least 2 hours before or 4 to 6 hours after this product so the calcium in whey doesn't block antibiotic absorption. Your pharmacist can help you schedule it.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Ai/E 10 is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Ai/E 10 label
Go deeper

The Full Monographs Behind Ai/E 10’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Whey Protein

Interacts with 53 drugs

Whey protein is a high-quality, complete protein made from cow's milk that can help people meet protein needs and support muscle growth when combined with exercise. It is generally safe for...

Read the full Whey Protein monograph →
Sources

Sources & How We Checked

Ai/E 10's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 25 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Whey Protein 25 references
  1. Martindale W. Martindale the Extra Pharmacopoeia. Pharmaceutical Press, 1999.
  2. Maton PN, Burton ME. Antacids revisited: a review of their clinical pharmacology and recommended therapeutic use. Drugs 1999;57:855-70.
  3. Bell SJ. Whey protein concentrates with and without immunoglobulins: a review. J Med Food 2000;3:1-13. PubMed
  4. Nutt JG, Woodward WR, Hammerstad JP, et al. The "on-off" phenomenon in Parkinson's disease. Relation to levodopa absorption and transport. N Engl J Med 1984;310:483-8. PubMed
  5. Baruzzi A, Contin M, Riva R, et al. Influence of meal ingestion time on pharmacokinetics of orally administered levodopa in parkinsonian patients. Clin Neuropharmacol 1987;10:527-37. PubMed
  6. Juncos JL, Fabbrini G, Mouradian MM, et al. Dietary influences on the antiparkinsonian response to levodopa. Arch Neurol 1987;44:1003-5. PubMed
  7. Eriksson T, Granerus AK, Linde A, et al. "On-off" phenomenon in Parkinson's disease: relationship between dopa and other large neutral amino acids in plasma. Neurology 1988;38:1245-8. PubMed
  8. Semla TP, Beizer JL, Higbee MD. Geriatric Dosage Handbook. 4th ed. Hudson, OH: Lexicomp, 1998.
  9. Pletz MW, Petzold P, Allen A, et al. Effect of calcium carbonate on bioavailability of orally administered gemifloxacin. Antimicrob Agents Chemother 2003;47:2158-60.. PubMed
  10. Peters ML, Leonard M, Licata AA. Role of alendronate and risedronate in preventing and treating osteoporosis. Cleve Clin J Med 2001;68:945-51. PubMed
  11. Micke, P., Beeh, K. M., and Buhl, R. Effects of long-term supplementation with whey proteins on plasma glutathione levels of HIV-infected patients. Eur.J Nutr 2002;41(1):12-18. PubMed
  12. Chitapanarux, T., Tienboon, P., Pojchamarnwiputh, S., and Leelarungrayub, D. Open-labeled pilot study of cysteine-rich whey protein isolate supplementation for nonalcoholic steatohepatitis patients. J Gastroenterol.Hepatol. 2009;24(6):1045-1050. PubMed
  13. Sataloff, R. T., Bittermann, T., Marks, L., Lurie, D., and Hawkshaw, M. The effects of glutathione enhancement on sensorineural hearing loss. Ear Nose Throat J 2010;89(9):422-433.
  14. Zhu, K., Meng, X., Kerr, D. A., Devine, A., Solah, V., Binns, C. W., and Prince, R. L. The effects of a two-year randomized, controlled trial of whey protein supplementation on bone structure, IGF-1, and urinary calcium excretion in older postmenopausal
  15. Bjorkman, M. P., Pilvi, T. K., Kekkonen, R. A., Korpela, R., and Tilvis, R. S. Similar effects of leucine rich and regular dairy products on muscle mass and functions of older polymyalgia rheumatica patients: a randomized crossover trial. J Nutr Health A
  16. Brun, A. C., Stordal, K., Johannesdottir, G. B., Bentsen, B. S., and Medhus, A. W. The effect of protein composition in liquid meals on gastric emptying rate in children with cerebral palsy. Clin.Nutr 2012;31(1):108-112. PubMed
  17. Gouni-Berthold, I., Schulte, D. M., Krone, W., Lapointe, J. F., Lemieux, P., Predel, H. G., and Berthold, H. K. The whey fermentation product malleable protein matrix decreases TAG concentrations in patients with the metabolic syndrome: a randomised plac
  18. Errichiello, L., Pezzella, M., Santulli, L., Striano, S., Zara, F., Minetti, C., Mainardi, P., and Striano, P. A proof-of-concept trial of the whey protein alfa-lactalbumin in chronic cortical myoclonus. Mov Disord. 2011;26(14):2573-2575. PubMed
  19. Carcillo, J. A., Dean, J. M., Holubkov, R., Berger, J., Meert, K. L., Anand, K. J., Zimmerman, J., Newth, C. J., Harrison, R., Burr, J., Willson, D. F., and Nicholson, C. The randomized comparative pediatric critical illness stress-induced immune suppres
  20. Chungchunlam, S. M., Moughan, P. J., Henare, S. J., and Ganesh, S. Effect of time of consumption of preloads on measures of satiety in healthy normal weight women. Appetite 2012;59(2):281-288. PubMed
  21. Rencuzogullari I, Börekçi A, Karakoyun S, et al. Coronary thrombosis in three coronary arteries due to whey protein. Am J Emerg Med. 2017;35(4):664.e3-664.e4. PubMed
  22. Silverberg NB. Whey protein precipitating moderate to severe acne flares in 5 teenaged athletes. Case Reports Cutis. 2012;90(2):70-2.
  23. Simonart T. Acne and whey protein supplementation among bodybuilders. Dermatology. 2012;225(3):256-8. PubMed
  24. Pontes TC, Costa Fernandes Filho GM, Pereira Trindade AS, Sobral Filho JF. Incidence of acne vulgaris in young adult users of protein-calorie supplements in the city of João Pessoa-PB. An Bras Dermatol. 2013;88(6):907-12.
  25. Adebamowo CA, Spiegelman D, Berkey CS, et al. Milk consumption and acne in teenaged boys. J Am Acad Dermatol. 2008 May;58(5):787-93. PubMed

See these in context on the Whey Protein monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Keep exploring
Supplement interaction checker › Check any supplement or product against your medications Drug–drug interactions › Check two or more of your medications against each other Browse medications A–Z › Every drug we've checked against herbs & supplements NDC & pricing lookup › Find a drug’s NDCs, packaging and costs Ask a pharmacist › Free, personal answer from our licensed team