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Dietary supplement

Artichoke Extract Ingredients & Drug Interactions

by Integrative Therapeutics

Artichoke Extract label
See full label image
Tablet Or Pill Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Artichoke Extract against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Artichoke Extract is a dietary supplement by Integrative Therapeutics with 1 active ingredient. Its ingredients are commonly taken for high cholesterol, indigestion and heartburn, constipation and bloating.Based on those ingredients, 363 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Artichoke (Cynara scolymus) (aerial parts) extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Artichoke Extract by Integrative Therapeutics

Ask about any prescription or over-the-counter medication and we check it for interactions with Artichoke Extract by Integrative Therapeutics — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Artichoke Extract by Integrative Therapeutics

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains one active ingredient: artichoke aerial parts extract (from Cynara scolymus). The remaining ingredients are inactive excipients — cellulose, carboxymethyl cellulose, silicon dioxide, magnesium stearate, and others — that make up the tablet structure and don't contribute to the supplement's effects.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: Digestive and liver support.
  • We looked for evidence on: Biliary disorders, Dyspepsia, Hyperlipidemia, Irritable bowel syndrome (IBS), Nonalcoholic fatty liver disease (NAFLD), Cholesterol — and 2 related terms.
  • The strongest evidence on file: Artichoke is rated "Possibly Effective" for Dyspepsia (Natural Medicines).
  • Also on file: Artichoke is rated "Possibly Effective" for Hyperlipidemia.
  • Also on file: Artichoke is rated "Insufficient Reliable Evidence To Rate" for Biliary disorders, Nonalcoholic fatty liver disease (NAFLD), Irritable bowel syndrome (IBS).

Artichoke extract is rated possibly effective for high cholesterol (hyperlipidemia) and indigestion (dyspepsia) based on clinical trial data. For nonalcoholic fatty liver disease, the evidence isn't established enough in the data we hold to rate it.

The evidence, ingredient by ingredient Artichoke

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Artichoke is generally well tolerated when taken short-term, though quality and dosing vary by product. The most common side effects are abdominal pain, diarrhea, gas, hunger, and nausea — most people don't experience them.

A small number of people have reported redness in the face and sweating. Rarely, people allergic to artichoke inulin (a component of the plant) have had severe allergic reactions including anaphylaxis.

If you're sensitive to ragweed, chrysanthemums, daisies, marigolds, or other plants in the Asteraceae family, you have the highest risk of reacting to artichoke. During pregnancy, there isn't enough safety information, so it's best avoided in supplement form.

Safety during breastfeeding hasn't been established either, so it's best avoided then too.

Side effects, ingredient by ingredient Artichoke

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Artichoke.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: diabetes medications.
  • For scale: 363 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking this product, double-check these medication types with your pharmacist: blood pressure drugs (Moderate risk of pressure dropping too low), diabetes medications (Moderate risk of low blood sugar), and medications metabolized by CYP2C19 or CYP2B6 enzyme pathways (Moderate risk of drug levels rising).

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

Artichoke extract may help with high cholesterol or indigestion if you're not on blood pressure or diabetes medications. If you take any prescription drugs — especially for blood pressure, blood sugar, or ones your liver metabolizes — check them against this product's interactions before you start.

Talk to your pharmacist or doctor if you have a family history of plant allergies.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Sep 21, 2017.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Artichoke Extract, straight from the product label.

Brand Integrative Therapeutics
Barcode (UPC) 871791002258
Net contents 45 Tablet(s)
Market status On market
Date entered into DSLD Sep 21, 2017
DSLD ID 78122
Product type Botanical
Supplement form Tablet Or Pill
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Vegetarian, Adult (18 - 50 Years), Gluten Free, Dairy Free, Sugar Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Artichoke Extract by Integrative Therapeutics, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Tablet(s)
Maximum serving Sizes:
1 Tablet(s)
UPC/BARCODE
871791002258
IngredientAmount% DV
Total Carbohydrates1 Gram(s)1%
Artichoke (Cynara scolymus) (aerial parts) extract320 mg--

Other ingredients: Cellulose, Sodium Carboxymethyl Cellulose, Silicon Dioxide, Magnesium Stearate, Hydroxypropyl Methylcellulose, Hydroxypropyl Cellulose, Soy Lecithin, Carnauba wax

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formulation

Contains no sugar, yeast, wheat, gluten, corn, dairy products, artificial colors, flavors, preservatives or ingredients of animal origin.

Brand IP Statement(s)

2016 Integrative Therapeutics, LLC

General

LZ78809.A02 BLK880A

FDA Disclaimer Statement

This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

FDA Statement of Identity

Dietary Supplement

Formula

Contains soy.

Precautions

Contains soy.

Caution: Do not use if you are allergic to plants of the Asteraceae/Compositae/Daisy Family, have a bile duct obstruction, or have gallstones.

If pregnant, nursing, or taking prescription drugs, consult your healthcare professional prior to use.

Suggested/Recommended/Usage/Directions

Recommendation: Take 1 tablet three times daily, or as recommended by your healthcare professional.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Artichoke Extract by Integrative Therapeutics label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Artichoke Extract label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Artichoke Extract by Integrative Therapeutics

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 Tablet(s) Dosage formTablet Or Pill Amounts shown are per serving.

Artichoke (Cynara scolymus) (aerial parts) extract

Interacts with
363 drugs
320 mg per serving Form: Caffeoylquinic Acids, Chlorogenic Acid

Artichoke leaf extract is a generally well-tolerated supplement that may have a mild cholesterol-lowering effect and is often used for indigestion, th...

Artichoke (Cynara scolymus) (aerial parts) extract monograph & interactions

Other (inactive) ingredients: Cellulose, Sodium Carboxymethyl Cellulose, Silicon Dioxide, Magnesium Stearate, Hydroxypropyl Methylcellulose, Hydroxypropyl Cellulose, Soy Lecithin, Carnauba wax. These complete the product’s ingredient list but are not active constituents.

Interaction report

Artichoke Extract by Integrative Therapeutics Drug Interactions

Want to check YOUR meds against Artichoke Extract?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
363Drugs
363 Moderate

Ingredients driving the most interactions

Artichoke (Cynara scolymus) (aerial parts) extract 363

Individual Drug Interactions

The ingredients in Artichoke Extract interact with 363 drugs. Click any drug to see the details.

1 of the 1 ingredient in Artichoke Extract interact with drugs. Each result below shows which ingredient is responsible. Artichoke (Cynara scolymus) (aerial parts) extract

Each ingredient & the kinds of drugs it affects

For each ingredient in Artichoke Extract with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Artichoke (Cynara scolymus) (aerial parts) extract4 drug types · 363 drugs

Antidiabetes Drugs

Theoretically, artichoke leaf extract may increase the risk of hypoglycemia when taken with antidiabetes drugs.
A meta-analysis of small clinical studies shows that taking artichoke leaf extract for 8-12 weeks can modestly reduce fasting plasma glucose when compared with placebo.

Likelihood Possible Evidence D
Antihypertensive Drugs

Theoretically, artichoke leaf extract may increase the risk of hypotension when taken with antihypertensive drugs.
A meta-analysis of small clinical studies in patients with hypertension shows that taking artichoke can reduce systolic blood pressure by around 3 mmHg and diastolic blood pressure by around 2 mmHg when compared with placebo.

Likelihood Possible Evidence D
Cytochrome P450 2B6 (Cyp2B6) Substrates

Theoretically, artichoke might increase serum levels of drugs metabolized by CYP2B6.
In vitro research shows that artichoke leaf extract inhibits CYP2B6 activity. However, this interaction has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 2C19 (Cyp2C19) Substrates

Theoretically, artichoke might increase serum levels of drugs metabolized by CYP2C19.
In vitro research shows that artichoke leaf extract inhibits CYP2C19 activity. However, this interaction has not been reported in humans.

Likelihood Possible Evidence D
Artichoke (Cynara scolymus) (aerial parts) extract full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Artichoke Extract, from the product label.

Integrative Therapeutics

See all Integrative Therapeutics products
Name
Integrative Therapeutics, LLC
City
Green Bay
State
WI
ZipCode
54311
Phone Number
800.931.1709
Web Address
integrativepro.com
Pharmacist Counseling Corner

Artichoke Extract by Integrative Therapeutics: Common Questions

Does Artichoke Extract by Integrative Therapeutics interact with any medications?
Yes. Based on its ingredients, Artichoke Extract has a known interaction with 363 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Artichoke Extract contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this if I'm allergic to ragweed?
You're at higher risk of an allergic reaction to artichoke. Ragweed, chrysanthemums, daisies, and marigolds are in the same plant family, so your immune system may react to artichoke too. Talk with your pharmacist before trying it.
What side effects should I watch for?
Most people tolerate it well, but some experience abdominal pain, diarrhea, gas, hunger, or nausea. Rarely, people report redness in the face or sweating. If you're sensitive to artichoke inulin, severe allergic reactions are possible — seek emergency help if you have trouble breathing or chest tightness after taking it.
Can I take this while pregnant or breastfeeding?
No — there isn't enough safety data in either case, so it's best avoided in supplement form during pregnancy and breastfeeding. Talk with your doctor if you're interested in artichoke for a specific reason.
Will this actually help my cholesterol?
The evidence says it's possibly effective for high cholesterol. Clinical trials show it works, but the effect is modest — don't expect it to replace your medication if your doctor prescribed one.
Does this product have any fillers?
Yes — it includes inactive ingredients like cellulose, carboxymethyl cellulose, silicon dioxide, magnesium stearate, and others that make the tablet hold together.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Artichoke Extract is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Artichoke Extract label
Go deeper

The Full Monographs Behind Artichoke Extract’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Artichoke

Interacts with 363 drugs

Artichoke leaf extract is a generally well-tolerated supplement that may have a mild cholesterol-lowering effect and is often used for indigestion, though the evidence is modest. It is not a...

Read the full Artichoke monograph →
Sources

Sources & How We Checked

Artichoke Extract's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 16 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Artichoke 16 references
  1. Leung AY, Foster S. Encyclopedia of Common Natural Ingredients Used in Food, Drugs and Cosmetics. 2nd ed. New York, NY: John Wiley & Sons, 1996.
  2. Walker AF, Middleton RW, Petrowicz O. Artichoke leaf extract reduces symptoms of irritable bowel syndrome in a post-marketing surveillance study. Phytother Res 2001;15:58-61. PubMed
  3. Pittler MH, White AR, Stevinson C, Ernst E. Effectiveness of artichoke extract in preventing alcohol-induced hangovers: a randomized controlled trial. CMAJ 2003;169:1269-73.
  4. Romano, C., Ferrara, A., and Falagiani, P. A case of allergy to globe artichoke and other clinical cases of rare food allergy. J Investig.Allergol.Clin Immunol. 2000;10(2):102-104.
  5. Miralles, J. C., Garcia-Sells, J., Bartolome, B., and Negro, J. M. Occupational rhinitis and bronchial asthma due to artichoke (Cynara scolymus). Ann Allergy Asthma Immunol. 2003;91(1):92-95. PubMed
  6. Franck, P., Moneret-Vautrin, D. A., Morisset, M., Kanny, G., Megret-Gabeaux, M. L., and Olivier, J. L. Anaphylactic reaction to inulin: first identification of specific IgEs to an inulin protein compound. Int Arch Allergy Immunol 2005;136(2):155-158. PubMed
  7. Meding, B. Allergic contact dermatitis from artichoke, Cynara scolymus. Contact Dermatitis 1983;9(4):314.
  8. Quirce, S., Tabar, A. I., Olaguibel, J. M., and Cuevas, M. Occupational contact urticaria syndrome caused by globe artichoke (Cynara scolymus). J Allergy Clin Immunol. 1996;97(2):710-711. PubMed
  9. Held C. Von der 1. Deutsche-Ungarischen Phytopharmakon-Konferenz, Budapest, 20. November 1991. Z Klin Med 1992;47:92-93.
  10. Barrat E, Zaïr Y, Ogier N, et al. A combined natural supplement lowers LDL cholesterol in subjects with moderate untreated hypercholesterolemia: a randomized placebo-controlled trial. Int J Food Sci Nutr. 2013;64(7):882-9. PubMed
  11. Huber R, Müller M, Naumann J, Schenk T, Lüdtke R. Artichoke leave extract for chronic hepatitis C - a pilot study. Phytomedicine. 2009 Sep;16(9):801-4. PubMed
  12. Caputo F, Barranco R, Bonsignore A, Fraternali Orcioni G, Ventura F. A rare case of fatal bowel obstruction secondary to a colonic bezoar. Am J Forensic Med Pathol. 2018;39(1):38-40. PubMed
  13. Elsebai MF, Abass K, Hakkola J, Atawia AR, Farag MA. The wild Egyptian artichoke as a promising functional food for the treatment of hepatitis C virus as revealed via UPLC-MS and clinical trials. Food Funct. 2016;7(7):3006-16. PubMed
  14. Moradi M, Sohrabi G, Golbidi M, et al. Effects of artichoke on blood pressure: a systematic review and meta-analysis. Complement Ther Med 2021;57:102668. PubMed
  15. Jalili C, Moradi S, Babaei A, et al. Effects of Cynara scolymus L. on glycemic indices: a systematic review and meta-analysis of randomized clinical trials. Complement Ther Med 2020;52:102496. PubMed
  16. Gallo R, Oddenino G, Trave I, Gasparini G, Guadagno A, Parodi A. Contact sensitivity to sesquiterpene lactone mix and artichoke in a patient with severe recurrent dermatitis: A puzzling case. Contact Dermatitis 2023;88(2):156-158. PubMed

See these in context on the Artichoke monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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