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Dietary supplement

Bacopa 320 mg with Synapsa Ingredients & Drug Interactions

by Doctor's Best

Bacopa 320 mg with Synapsa label
See full label image
Capsule Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Bacopa 320 mg with Synapsa against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Bacopa 320 mg with Synapsa is a dietary supplement by Doctor's Best with 1 active ingredient. Its ingredients are commonly taken for memory and cognitive support, anxiety and stress, adhd symptoms.Based on those ingredients, 930 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Synapsa. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Bacopa 320 mg with Synapsa by Doctor's Best

Ask about any prescription or over-the-counter medication and we check it for interactions with Bacopa 320 mg with Synapsa by Doctor's Best — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Bacopa 320 mg with Synapsa by Doctor's Best

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 16, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains one active ingredient: Synapsa, a standardized extract of bacopa. That's it — no other actives.

The capsule itself is made from hypromellose (a plant-based coating), microcrystalline cellulose, silicon dioxide, and magnesium stearate, which are inactive ingredients that help hold the capsule together and keep it stable on the shelf.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use — see Bacopa's own graded uses on its monograph.

Why this rating?
  • The label markets this product for: memory, learning, cognitive function and mental performance.
  • We looked for evidence on: Cognitive function, Cognitive impairment, Attention deficit-hyperactivity disorder (ADHD), Age-related cognitive decline, Working memory.
  • The closest evidence on file: Bacopa is rated "Insufficient Reliable Evidence To Rate" for Attention deficit-hyperactivity disorder (ADHD) (Natural Medicines).
  • Also on file: Bacopa is rated "Insufficient Reliable Evidence To Rate" for Cognitive function, Cognitive impairment.

The evidence for bacopa isn't established yet. Our data shows insufficient reliable evidence to rate it for Alzheimer disease, cognitive function, cognitive impairment, ADHD, sexual dysfunction, or back pain.

That doesn't mean it doesn't work — it means well-designed human studies haven't proven it does. If you're considering this for any of those reasons, talk with your doctor about whether the current evidence supports trying it.

The evidence, ingredient by ingredient Bacopa

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Bacopa is generally well tolerated in the studies we have, but long-term safety data are limited. The most common side effects are stomach-related: abdominal cramps, diarrhea, nausea, bloating, and indigestion.

Gastrointestinal side effects show up in about 12 to 30 percent of people in studies. Some people also report headache, dry mouth, drowsiness, insomnia, or vivid dreams.

There isn't enough safety information to use bacopa during pregnancy or while breastfeeding — talk with your doctor or pharmacist about whether it's right for you in those situations.

Side effects, ingredient by ingredient Bacopa

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Bacopa.
  • The most serious interaction on file is rated Moderate.
  • For scale: 931 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Check with your doctor or pharmacist before combining this with any medications processed by your liver's cytochrome P450 enzymes (a very common group that includes many heart, blood pressure, and psychiatric drugs), anticholinergic or cholinergic drugs, cevimeline (Evoxac), or thyroid hormone. No interactions are documented for the ingredients we could check beyond these enzyme and nerve-chemical effects, but your pharmacist can run your exact medications through our tool to be sure.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and safety information is well characterized.

Bacopa may be worth considering if you're interested in supporting brain function, though the evidence isn't solid yet. The main caution is with medications your liver processes — and that's a long list.

Before you start, have your doctor or pharmacist check your specific prescriptions against the interaction tool on this page, especially if you take blood thinners, heart medications, or anticholinergic drugs. If you're pregnant, breastfeeding, or taking thyroid medication, bring this product with you when you talk it over with your healthcare provider.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Dec 14, 2023.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Bacopa 320 mg with Synapsa, straight from the product label.

Brand Doctor's Best
Barcode (UPC) 753950004542
Net contents 60 Veggie Cap(s)
Market status On market
Date entered into DSLD Dec 14, 2023
DSLD ID 302639
Product type Botanical
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Vegan, Vegetarian, Adult (18 - 50 Years), Gluten Free, Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Bacopa 320 mg with Synapsa by Doctor's Best, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Veggie Capsule(s)
Maximum serving Sizes:
1 Veggie Capsule(s)
Servings per container
60
UPC/BARCODE
753950004542
IngredientAmount% DV
Synapsa320 mg--

Other ingredients: Hypromellose, Microcrystalline Cellulose, Silicon Dioxide, Magnesium Stearate

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formula

Doctor's Best Bacopa with Synapsa helps support an improvement in visual processing, learning rate, working memory, information retention and mental performance. Synapsa supplementation can help decrease the rate of forgetfulness and improve multitasking accuracy. Clinical studies show that Synapsa helps support mental performance in cognitively demanding environments. Synapsa is a patented standardized form of Bacopa monnieri with more than 30 years of clinical studies.

Bacopa with Synapsa The Future of Memory

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Brand IP Statement(s)

Doctor's Best Science-Based Nutrition

Synapsa is a trademark of Soho Flordis International Pty Ltd., exclusively licensed in the Untied States of PLT Health Solutions, Inc.

Formulation

Helps support cognitive function and performance

Vegan

Non-GMO Gluten Free Soy Free

This product contains natural ingredients that may vary in color.

Supports Cognitive function and working memory Information processing and retention Antioxidant activity in the brain

FDA Statement of Identity

Dietary Supplement

Suggested/Recommended/Usage/Directions

Suggested Adult Use: Take 1 capsule daily with or without food, or as recommended by a nutritionally informed physician.

Storage

Store in a cool dry place.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Bacopa 320 mg with Synapsa by Doctor's Best label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Bacopa 320 mg with Synapsa label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Bacopa 320 mg with Synapsa by Doctor's Best

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 Veggie Capsule(s) Dosage formCapsule Servings per container60 Amounts shown are per serving.

Synapsa

Interacts with
930 drugs
320 mg per serving Form: Bacopa monnieri Whole Plant Extract

Bacopa is an Ayurvedic herb most often used for memory and thinking. Some small studies suggest it may modestly help memory when taken regularly for s...

Synapsa monograph & interactions

Other (inactive) ingredients: Hypromellose, Microcrystalline Cellulose, Silicon Dioxide, Magnesium Stearate. These complete the product’s ingredient list but are not active constituents.

Interaction report

Bacopa 320 mg with Synapsa by Doctor's Best Drug Interactions

Want to check YOUR meds against Bacopa 320 mg with Synapsa?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
930Drugs
917 Moderate 13 Minor

Ingredients driving the most interactions

Synapsa 930

Individual Drug Interactions

The ingredients in Bacopa 320 mg with Synapsa interact with 930 drugs. Click any drug to see the details.

1 of the 1 ingredient in Bacopa 320 mg with Synapsa interact with drugs. Each result below shows which ingredient is responsible. Synapsa

Each ingredient & the kinds of drugs it affects

For each ingredient in Bacopa 320 mg with Synapsa with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Synapsa8 drug types · 930 drugs

Anticholinergic Drugs

Theoretically, concurrent use might decrease the effectiveness of both agents.
Bacopa seems to inhibit acetylcholinesterase and might increase acetylcholine levels, which could counteract the effects of anticholinergic drugs. Similarly, anticholinergic drugs might counteract the cholinergic effects of bacopa.

Likelihood Possible Evidence D
Cevimeline (Evoxac)

Theoretically, bacopa might increase the effects and adverse effects of cevimeline.
In one case, a 58-year-old female taking cevimeline long-term for Sjogren syndrome experienced hyperhidrosis, malaise, nausea, and tachycardia shortly after taking a single dose of bacopa. Symptoms resolved after two days. Cevimeline is metabolized by cytochrome P450 (CYP) 2D6 and CYP3A4, and researchers theorize that bacopa may have inhibited these isoenzymes. However, it is unclear if bacopa causes clinically significant inhibition of either CYP2D6 or CYP3A4.

Likelihood Possible Evidence D
Cholinergic Drugs

Theoretically, concurrent use of bacopa with other cholinergic drugs might have additive effects.
Bacopa seems to inhibit acetylcholinesterase and might increase acetylcholine levels. Theoretically, this could result in additive cholinergic effects when used with cholinergic drugs.

Likelihood Possible Evidence D
Cytochrome P450 1A2 (Cyp1A2) Substrates

Theoretically, bacopa might increase the levels and adverse effects of CYP1A2 substrates.
Research on the effects of bacopa extracts on CYP1A2 enzymes is conflicting. Some in vitro evidence shows that bacopa extract can moderately and non-competitively inhibit CYP1A2, while other in vitro evidence suggests that any effect is unlikely to be clinically significant.

Likelihood Possible Evidence D
Cytochrome P450 2C19 (Cyp2C19) Substrates

Theoretically, bacopa might increase the levels and adverse effects of CYP2C19 substrates.
In vitro evidence suggests that bacopa extract can moderately and non-competitively inhibit CYP2C19 enzymes. It is not known whether this is clinically significant.

Likelihood Possible Evidence D
Cytochrome P450 2C9 (Cyp2C9) Substrates

Theoretically, bacopa might increase the levels and adverse effects of CYP2C9 substrates.
Research on the effect of bacopa extracts on CYP2C9 enzymes is conflicting. Some in vitro evidence suggests that bacopa extract can moderately and non-competitively inhibit CYP2C9, while other in vitro evidence suggests that any effect is unlikely to be clinically significant.

Likelihood Possible Evidence D
Cytochrome P450 3A4 (Cyp3A4) Substrates

Theoretically, bacopa might increase the levels and adverse effects of CYP3A4 substrates.
Research on the effects of bacopa extracts on CYP3A4 enzymes is conflicting. Some in vitro evidence suggests that bacopa extract can moderately and competitively inhibit CYP3A4, while other in vitro evidence suggests that any effect is unlikely to be clinically significant.

Likelihood Possible Evidence D
Thyroid Hormone

Theoretically, bacopa might have additive effects when used with thyroid hormone.
Animal research suggests that bacopa increases thyroxine (T4) levels in mice by about 40%.

Likelihood Possible Evidence D
Synapsa full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Bacopa 320 mg with Synapsa, from the product label.

Doctor's Best

See all Doctor's Best products
Name
Doctor's Best, Inc.
City
Tustin
State
California
ZipCode
92780
Phone Number
(800) 777-2474
Web Address
www.drbvitamins.com
Pharmacist Counseling Corner

Bacopa 320 mg with Synapsa by Doctor's Best: Common Questions

Does Bacopa 320 mg with Synapsa by Doctor's Best interact with any medications?
Yes. Based on its ingredients, Bacopa 320 mg with Synapsa has a known interaction with 930 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Bacopa 320 mg with Synapsa contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
What is Synapsa bacopa, and why is it in this product?
Synapsa is a standardized extract of the bacopa plant. It's included because some research suggests bacopa may support memory and brain function, though we don't yet have strong enough evidence to confirm that.
Can I take this if I'm pregnant or breastfeeding?
There isn't enough safety information to know whether bacopa is safe in pregnancy or while breastfeeding. The data advises against it in both cases. Talk with your doctor or pharmacist about what's right for you.
What side effects might I experience?
The most common are stomach issues — nausea, diarrhea, cramps, bloating, and indigestion — which show up in about 12 to 30 percent of people. Some also report headache, dry mouth, drowsiness, insomnia, or vivid dreams. Most people tolerate it without problems.
Does bacopa interact with a lot of medications?
Bacopa affects several broad groups of drugs: those processed by your liver's cytochrome P450 enzymes (a very common pathway), anticholinergic and cholinergic drugs, and possibly thyroid hormone. That's why it's important to check your exact medications before you start — your pharmacist or doctor can do that for you.
Is bacopa proven to work for memory or ADHD?
We don't have enough reliable evidence yet to say whether it works for memory, ADHD, or cognitive problems. The research isn't conclusive, so talk with your doctor about whether trying it makes sense for your situation.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Bacopa 320 mg with Synapsa is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Bacopa 320 mg with Synapsa label
Go deeper

The Full Monographs Behind Bacopa 320 mg with Synapsa’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Bacopa

Interacts with 930 drugs

Bacopa is an Ayurvedic herb most often used for memory and thinking. Some small studies suggest it may modestly help memory when taken regularly for several weeks, but the evidence is limite...

Read the full Bacopa monograph →
Sources

Sources & How We Checked

Bacopa 320 mg with Synapsa's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 12 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Bacopa 12 references
  1. Stough C, Lloyd J, Clarke J, et al. The chronic effects of an extract of Bacopa monniera (Brahmi) on cognitive function in healthy human subjects. Psychopharmacology 2001;156:481-4..
  2. Yadav SK, Jain AK, Tripathi SN, Gupta JP. Irritable bowel syndrome: therapeutic evaluation of indigenous drugs. Indian J Med Res 1989;90:496-503..
  3. Morgan A, Stevens J. Does Bacopa monnieri improve memory performance in older persons? Results of a randomized, placebo-controlled, double-blind trial. J Altern Complement Med 2010;16:753-9.
  4. Kar, A., Panda, S., and Bharti, S. Relative efficacy of three medicinal plant extracts in the alteration of thyroid hormone concentrations in male mice. J Ethnopharmacol. 2002;81(2):281-285. PubMed
  5. Mukherjee, G. D. and Dey, C. D. Clinical trial on Brahmi. I. J.Exp.Med.Sci. 1966;10(1):5-11.
  6. Kar A, Pandit S, Mukherjee K, Bahadur S, Mukherjee PK. Safety assessment of selected medicinal food plants used in Ayurveda through CYP450 enzyme inhibition study. J Sci Food Agric 2017;97(1):333-40. doi: 10.1002/jsfa.7739. PubMed
  7. Kongkeaw C, Dilokthornsakul P, Thanarangsarit P, et al. Meta-analysis of randomized controlled trials on cognitive effects of Bacopa monnieri extract. J Ethnopharmacol 2014;151(1):528-35. PubMed
  8. Ramasamy S, Kiew LV, Chung LY. Inhibition of human cytochrome P450 enzymes by Bacopa monnieri standardized extract and constituents. Molecules 2014;19(2):2588-601. PubMed
  9. Prabhakar S, Vishnu VY, Modi M, et al. Efficacy of Bacopa monnieri (Brahmi) and donepezil in Alzheimer's disease and mild cognitive impairment: a randomized double-blind parallel phase 2b study. Ann Indian Acad Neurol 2020;23(6):767-73. PubMed
  10. Acquarulo B, Tandon P, Macica CM. Suspected cholinergic toxicity due to cevimeline hydrochloride and Bacopa monnieri interaction: a case report. J Med Case Rep 2022;16(1):253. PubMed
  11. Keegan AP, Stough C, Paris D, et al. Bacopa monnieri supplementation has no effect on serum brain-derived neurotrophic factor levels but beneficially modulates nuclear factor kappa B and cyclic AMP response element-binding protein levels in healthy elderl
  12. Yaworski AM, Blyumin M, Chang T, Mammen AL, Greene M. Necrotizing myopathy with elevated anti-HMGCR antibodies following exposure to the supplement Bacopa. Muscle Nerve 2023;67(2):E1-E3.

See these in context on the Bacopa monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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