Interactions on record — worth a quick check against your medications. Based on 1 of 3 ingredients. Check your meds →
Dietary supplement

BCAA Hyperblend Ingredients & Drug Interactions

by Top Secret Nutrition

Capsule Category: Other Combinations
Most serious interaction: Moderate
The interaction bottom line Most serious interaction: Moderate

BCAA Hyperblend is a dietary supplement by Top Secret Nutrition with 3 active ingredients. Its ingredients are commonly taken for morning sickness in pregnancy, premenstrual syndrome (pms), preventing or treating b6 deficiency.Based on those ingredients, 210 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Vitamin B6. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

HelloPharmacist Scorecard of BCAA Hyperblend by Top Secret Nutrition

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 3 of its 3 active ingredients.
  • No proprietary blends here — you can verify the dose of every single component.

BCAA Hyperblend has 3 active ingredients. Vitamin B6 is an essential nutrient your body uses for nerve function, immune health, and metabolism—this product includes it at a dose that could potentially reach higher levels than typical food and supplement amounts.

L-leucine is an amino acid (a building block of protein), and there's also a proprietary blend listed as an anabolic and rapid absorption formula, though the exact contents and amounts aren't specified on the label. The product also contains inactive ingredients: gelatin (the capsule), microcrystalline cellulose, magnesium stearate, and silicon dioxide—these are fillers and binders that hold the capsule together.

Does it work?

Couldn't assess
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not assessable

We hold no graded evidence for this product's ingredients for its stated purpose.

Why this rating?
  • The label markets this product for: Branched-chain amino acids for muscle protein synthesis.
  • We looked for evidence on: Muscle protein synthesis, Muscle anabolism, Muscle recovery, Athletic performance.
  • Our graded evidence for these ingredients doesn't cover that particular purpose.

We hold effectiveness data for vitamin B6 only. It's rated effective for treating sideroblastic anemia and vitamin B6 deficiency, and likely effective for lowering homocysteine levels (a blood marker).

It's possibly effective for pregnancy-related nausea and vomiting. There's no effectiveness data on file for L-leucine or the proprietary blend in this product.

The evidence, ingredient by ingredient Vitamin B6

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Vitamin B6 is generally well tolerated at doses under 100 mg daily. The most common side effects from higher doses include headache, nausea, heartburn, and loss of appetite.

At very high doses (especially over 1,000 mg daily or with very high cumulative intake), it can damage nerves in your hands and feet, causing numbness or tingling sensations that may be slow to reverse. The safety notes caution against high doses over time, though normal dietary amounts and standard supplement doses are considered safe.

For pregnancy, vitamin B6 is rated likely safe, though one rating also indicates possibly unsafe—this mixed picture means you should talk with your doctor or pharmacist before taking it if you're pregnant or planning to become pregnant. It's rated likely safe during breastfeeding.

Side effects, ingredient by ingredient Vitamin B6

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Vitamin B6.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: Parkinson's medications.
  • For scale: 210 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Check your medications if you take antihypertensive drugs (blood pressure medicines), amiodarone for heart rhythm, phenobarbital or phenytoin for seizures, or levodopa for Parkinson's disease—all have documented interactions with vitamin B6 in this product.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no assessable stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

BCAA Hyperblend is worth considering if you're an athlete looking for amino acid support and don't take blood pressure medications, seizure medications, or levodopa. If you take any prescription drugs—especially for blood pressure, heart rhythm, or Parkinson's disease—check with us first using the tool on this page.

Pregnant people should discuss this with their doctor or pharmacist before starting.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 3 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Feb 25, 2013.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about BCAA Hyperblend, straight from the product label.

Brand Top Secret Nutrition
Barcode (UPC) 858311002776
Net contents 120 Capsule(s)
Market status On market
Date entered into DSLD Feb 25, 2013
DSLD ID 17560
Product type Other Combinations
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for BCAA Hyperblend by Top Secret Nutrition, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
4 Capsule(s)
Maximum serving Sizes:
4 Capsule(s)
Servings per container
30
UPC/BARCODE
858311002776
IngredientAmount% DV
Vitamin B65 mg250%
L-Leucine1800 mg--
PROPRIETARY ANABOLIC & RAPID ABSORPTION BLEND1253 mg--

Other ingredients: Gelatin, Microcrystalline Cellulose, Magnesium Stearate, Silicon Dioxide

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements

Branched-Chain Amino Acids Of the 20 amino acids that help build protein, nine of these cannot be synthesized in the human body. These nine compounds are referred to as essential amino acids because they must be consumed through food or supplements. Three of these essential amino acids - leucine, isoleucine, and valine - are branched-chain amino acids, or BCAAs. Unlike the other amino acids, BCAA’s are metabolized in muscle rather than in the liver, which means that they play a critical role in muscle development because they reach muscle tissue faster.

THIS IS THE FUTURE...

The BCAA Hyperblend team: BCAA Blend - 3:1:1 ratio of leucine (clinically studied 1.8 grams) to isoleucine and valine. Anabolic Power Blend - We have included Ursolic Acid and Brassinolide to enhance the anabolic and muscle protein synthesis stimulating effect of BCAAs. Absorption and Effectiveness Blend - Astravar (TM) and BioPerine(R) help enhance the absorption of the other powerful ingredients. BCAA hyperblend for: • Enhanced muscle protein synthesis • Improved muscle recovery • Reduced muscle soreness • Increased fat oxidation

ANABOLIC BRANCHED CHAIN FORMULA Enhanced Muscle Protein Synthesis Reduced Muscle Soreness Improved Muscle Recovery Increased Fat Oxidation

YOU WORK HARD - TAKE THE BEST

Top Secret Nutrition’s BCAA Hyperblend combines the power of branched-chain amino acids with ingredients designed to promote anabolic activity and enhance absorption to create an incredible one of a kind BCAA supplement.

Storage

Store in a cool, dry place.

Precautions

Consult your physician prior to use if you have any medical condition.

WARNING: KEEP OUT OF REACH OF CHILDREN.

Use this product as a dietary supplement only.

Do not use if you are pregnant or nursing or if you have any medical condition.

Do not use if seal or package is broken.

Brand IP Statement(s)

BioPerine(R) is a trademark of Sabinsa Corporation. AstraGin(TM) is a Trademark of NuLiv Science.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Seals/Symbols

MADE IN USA WITH WORLD-WIDE INGREDIENTS (image)

General

20120725 v1.0

FDA Statement of Identity

DIETARY SUPPLEMENT

Suggested/Recommended/Usage/Directions

DIRECTIONS: For best results take 4 capsules anytime you want to enhance protein synthesis.

See for yourself

BCAA Hyperblend by Top Secret Nutrition label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

What’s inside

The Ingredients in BCAA Hyperblend by Top Secret Nutrition

These are the 3 active ingredients this product is made of. Select any to open its full monograph.

Serving size4 Capsule(s) Dosage formCapsule Servings per container30 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Vitamin B6

Interacts with
210 drugs
5 mg per serving Form: Pyridoxine Hydrochloride

Vitamin B6 (pyridoxine) is an essential water-soluble vitamin that your body needs for metabolism, brain function, and making red blood cells. It is b...

Vitamin B6 monograph & interactions

L-Leucine

1800 mg per serving

PROPRIETARY ANABOLIC & RAPID ABSORPTION BLEND

1253 mg per serving Form: Astravar(TM), L-Isoleucine, L-Valine, Rhodiola rosea, Rosemary

Other (inactive) ingredients: Gelatin, Microcrystalline Cellulose, Magnesium Stearate, Silicon Dioxide. These complete the product’s ingredient list but are not active constituents.

Interaction report

BCAA Hyperblend by Top Secret Nutrition Drug Interactions

Want to check YOUR meds against BCAA Hyperblend?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

Go to the checker
210Drugs
205 Moderate 5 Minor

Ingredients driving the most interactions

Each ingredient & the kinds of drugs it affects

For each ingredient in BCAA Hyperblend with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Vitamin B65 drug types · 210 drugs

Amiodarone (Cordarone)

Theoretically, vitamin B6 might increase the photosensitivity caused by amiodarone.
Despite initial case reports suggesting that pyridoxine may have a protective effect against amiodarone-induced photosensitivity, preliminary clinical research suggests that pyridoxine may actually exacerbate this adverse effect.

Likelihood Possible Evidence B
Antihypertensive Drugs

Theoretically, vitamin B6 may have additive effects when used with antihypertensive drugs.
Research in hypertensive rats shows that vitamin B6 can decrease systolic blood pressure. Similarly, clinical research in patients with hypertension shows that taking high doses of vitamin B6 may reduce systolic and diastolic blood pressure, possibly by reducing plasma levels of epinephrine and norepinephrine.

Likelihood Possible Evidence B
Phenobarbital (Luminal)

High doses of vitamin B6 may reduce the levels and clinical effects of phenobarbital.
Preliminary clinical evidence suggests that vitamin B6 200 mg daily can reduce plasma levels of phenobarbital, possibly by increasing metabolism. It is not known whether lower doses have any effect. Advise people taking phenobarbital to avoid high doses of vitamin B6.

Likelihood Possible Evidence D
Phenytoin (Dilantin)

High doses of vitamin B6 may reduce the levels and clinical effects of phenytoin.
Preliminary clinical evidence suggests that vitamin B6 200 mg daily can reduce plasma levels of phenytoin, possibly by increasing metabolism. It is not known whether lower doses have any effect. Advise people taking phenytoin to avoid high doses of vitamin B6.

Likelihood Possible Evidence D
Levodopa

Vitamin B6 may increase the metabolism of levodopa when taken alone, but not when taken in conjunction with carbidopa.
Vitamin B6 (pyridoxine) enhances the metabolism of levodopa, reducing its clinical effects. However, this interaction does not occur when carbidopa is used concurrently with levodopa (Sinemet). Therefore, it is not likely to be a problem in most people.

Likelihood Unlikely Evidence D
The maker

Brand information

Manufacturer and brand details for BCAA Hyperblend, from the product label.

Top Secret Nutrition

See all Top Secret Nutrition products
Name
Top Secret Nutrition
Street Address
11341 Interchange Circle South
City
Miramar
State
Florida
ZipCode
33025
Phone Number
(877)-633-3830
Web Address
www.topsecretnutrition.com
Pharmacist Counseling Corner

BCAA Hyperblend by Top Secret Nutrition: Common Questions

Does BCAA Hyperblend by Top Secret Nutrition interact with any medications?
Yes. Based on its ingredients, BCAA Hyperblend has a known interaction with 210 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
BCAA Hyperblend contains 3 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this if I'm pregnant?
The data on file shows mixed ratings for vitamin B6 in pregnancy—one says likely safe and another says possibly unsafe. That means there isn't enough certainty to say yes or no. Talk with your doctor or pharmacist about whether this is right for you during pregnancy.
What is L-leucine and what does it do?
L-leucine is an amino acid, one of the building blocks your body uses to make and repair muscle. We couldn't find interaction data for it in our database.
Is vitamin B6 safe at the dose in this product?
Vitamin B6 is well tolerated under 100 mg daily. If this product contains high doses, be aware that very high intake over time—especially over 1,000 mg daily—can damage nerves in your feet and hands. Check the label for the amount per serving and talk with your pharmacist about whether it's right for you.
What is the proprietary anabolic and rapid absorption blend?
The label doesn't specify what's in this proprietary blend or how much of each ingredient it contains, so we can't check it for interactions. You'd need to contact the manufacturer for the full ingredient list.
What are the inactive ingredients, and do they matter?
The inactive ingredients are gelatin, microcrystalline cellulose, magnesium stearate, and silicon dioxide—these are the capsule material and fillers that help hold the product together. They're not active and shouldn't affect how the supplement works.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if BCAA Hyperblend is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

BCAA Hyperblend label
Sources

Sources & How We Checked

BCAA Hyperblend's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 32 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Vitamin B6 32 references
  1. Hansten PD, Horn JR. Drug Interactions Analysis and Management. Vancouver, WA: Applied Therapeutics Inc., 1997 and updates.
  2. Yates AA, Schlicker SA, Suitor CW. Dietary reference intakes: The new basis for recommendations for calcium and related nutrients, B vitamins, and choline. J Am Diet Assoc 1998;98:699-706. PubMed
  3. Geerling BJ, Dagnelie PC, Badart-Smook A, et al. Diet as a risk factor for the development of ulcerative colitis. Am J Gastroenterol 2000;95:1008-13. PubMed
  4. South M. Neonatal seizures after pyridoxine use -- reply. Lancet 1999;354:2083. PubMed
  5. Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Thiamin, Riboflavin, Niacin, Vitamin B6, Folate, Vitamin B12, Pantothenic Acid, Biotin, and Choline (2000). Washington, DC: National Academy Press, 2000. Available at: http://b
  6. Baxter P, Aicardi J. Neonatal seizures after pyridoxine use. Lancet 1999;354:2082-3. PubMed
  7. Bendich A, Cohen M. Vitamin B6 safety issues. Ann N Y Acad Sci 1990;585:321-30.
  8. Schaumburg H, Kaplan J, Windebank A. Sensory neuropathy from pyridoxine abuse. A new megavitamin syndrome. N Engl J Med 1983;309:445-8. PubMed
  9. Gordon N. Pyridoxine dependency: an update. Dev Med Child Neurol 1997;39:63-5. PubMed
  10. Lewis PJ. Pain in the hand and wrist. Pyridoxine supplements may help patients with carpal tunnel syndrome. BMJ 1995;310:1534. PubMed
  11. Kaufman G. Pyridoxine against amiodarone-induced photosensitivity (letter). Lancet 1984;1:51-2. PubMed
  12. Mulrow JP, Mulrow CD, McKenna WJ. Pyridoxine and amiodarone-induced photosensitivity. Ann Intern Med 1985;103:68-9. PubMed
  13. Kawada A, Kashima A, Shiraishi H, et al. Pyridoxine-induced photosensitivity and hypophosphatasia. Dermatology 2000;201:356-60.. PubMed
  14. Vasile A, Goldberg R, Kornberg B. Pyridoxine toxicity: report of a case. J Am Osteopath Assoc 1984;83:790-1. DOI
  15. Hansson O, Sillanpaa M. Pyridoxine and serum concentration of phenytoin and phenobarbitone. Lancet 1976;1:256. DOI
  16. Jansen T, Romiti R, Kreuter A, Altmeyer P. Rosacea fulminans triggered by high-dose vitamins B6 and B12. J Eur Acad Dermatol Venereol 2001;15:484-5..
  17. Chittumma P, Kaewkiattikun K, Wiriyasiriwach B. Comparison of the effectiveness of ginger and vitamin B6 for treatment of nausea and vomiting in early pregnancy: a randomized double-blind controlled trial. J Med Assoc Thai 2007;90:15-20.
  18. Hatzitolios, A., Iliadis, F., Katsiki, N., and Baltatzi, M. Is the anti-hypertensive effect of dietary supplements via aldehydes reduction evidence based? A systematic review. Clin Exp.Hypertens. 2008;30(7):628-639. PubMed
  19. Vasdev, S., Ford, C. A., Parai, S., Longerich, L., and Gadag, V. Dietary vitamin B6 supplementation attenuates hypertension in spontaneously hypertensive rats. Mol.Cell Biochem. 1999;200(1-2):155-162.
  20. de, Vogel S., Dindore, V., van, Engeland M., Goldbohm, R. A., van den Brandt, P. A., and Weijenberg, M. P. Dietary folate, methionine, riboflavin, and vitamin B-6 and risk of sporadic colorectal cancer. J Nutr 2008;138(12):2372-2378. PubMed
  21. Hagen, I., Nesheim, B. I., and Tuntland, T. No effect of vitamin B-6 against premenstrual tension. A controlled clinical study. Acta Obstet.Gynecol.Scand. 1985;64(8):667-670. PubMed
  22. Aybak, M., Sermet, A., Ayyildiz, M. O., and Karakilcik, A. Z. Effect of oral pyridoxine hydrochloride supplementation on arterial blood pressure in patients with essential hypertension. Arzneimittelforschung. 1995;45(12):1271-1273.
  23. Lal, K. J., Dakshinamurti, K., and Thliveris, J. The effect of vitamin B6 on the systolic blood pressure of rats in various animal models of hypertension. J Hypertens. 1996;14(3):355-363. PubMed
  24. Lauritzen CH, Reuter HD, Repges R, Bohnert K, and Schmidt U. Treatment of premenstrual tension syndrome with Vitex agnus castus. Controlled, double-blind study versus pyridoxine. Phytomed 1997;4(3):183-189. PubMed
  25. Fonseca VA, Lavery LA, Thethi TK, et al. Metanx in type 2 diabetes with peripheral neuropathy: A randomized trial. Am J Med 2013;126(2):141-9. PubMed
  26. Hankey GJ, Eikelboom JW, Yi Q, et al. Treatment with B vitamins and incidence of cancer in patients with previous stroke or transient ischemic attack: Results of a randomized placebo-controlled trial. Stroke 2012;43(6):1572-7. PubMed
  27. Hoyer-Kuhn H, Kohbrok S, Volland R, Franklin J, Hero B, Beck BB, Hoppe B. Vitamin B6 in primary hyperoxaluria I: first prospective trial after 40 years of practice. Clin J Am Soc Nephrol. 2014 Mar;9(3):468-77. PubMed
  28. Mahmoud A, Tabassum S, Al Enazi S, et al. Amelioration of levetiracetam-induced behavioral side effects by pyridoxine. A randomized double blind controlled study. Pediatr Neurol 2021;119:15-21. PubMed
  29. Gupta M, Gallante B, Bamberger JN, et al. Prospective randomized evaluation of idiopathic hyperoxaluria treatments. J Endourol 2021;35(12):1844-1851. PubMed
  30. Li H, Chen M, Liang S, et al. Excessive vitamin B6 during treatment is related to poor prognosis of patients with nasopharyngeal carcinoma: A U-shaped distribution suggests low dose supplement. Clin Nutr 2021;40(4):2293-2300. PubMed
  31. Tanigawa J, Nabatame S, Tominaga K, et al. High-dose pyridoxine treatment for inherited glycosylphosphatidylinositol deficiency. Brain Dev 2021;43(6):680-687. PubMed
  32. Committee on Practice Bulletins-Obstetrics. ACOG Practice Bulletin No. 189: Nausea And Vomiting Of Pregnancy. Obstet Gynecol. 2018;131(1):e15-e30. PubMed

See these in context on the Vitamin B6 monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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