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Dietary supplement

Blessed Thistle Ingredients & Drug Interactions

by Hawaii Pharm

Blessed Thistle label
See full label image
Liquid Category: Botanical
Most serious interaction: Minor
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Blessed Thistle against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Minor

Blessed Thistle is a dietary supplement by Hawaii Pharm with 1 active ingredient. Its ingredients are commonly taken for digestive upset and poor appetite, boosting bile flow, general bitter tonic.Based on those ingredients, 36 medications have a known interaction with it, the most serious rated minor. The ingredients most likely to interact are Blessed Thistle Flower, Leaf, Stem Extract, Dry. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against Blessed Thistle by Hawaii Pharm

Ask about any prescription or over-the-counter medication and we check it for interactions with Blessed Thistle by Hawaii Pharm — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Blessed Thistle by Hawaii Pharm

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 12, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains one active ingredient: blessed thistle flower, leaf, and stem extract. Blessed thistle has been used traditionally to support digestion and appetite, and to promote milk supply in nursing mothers.

The liquid form also includes alcohol, water, and glycerin as inactive ingredients.

Does it work?

Couldn't assess
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not assessable

This is a single-ingredient Blessed Thistle product and its label doesn't state a use — see Blessed Thistle's own graded uses on its monograph.

Why this rating?
  • We looked at the product name, claims, and label statements and couldn't find a stated purpose to grade.

The evidence for blessed thistle in treating dyspepsia (indigestion or upset stomach) is insufficient in our data — there isn't enough reliable research to rate whether it works for that purpose. If you're considering it for digestive support, talk with your pharmacist about what the traditional use suggests versus what science has actually shown.

The evidence, ingredient by ingredient Blessed Thistle

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Blessed thistle is generally well tolerated in small amounts, but human safety data are limited. Doses higher than 5 grams per cup of tea can cause stomach irritation and vomiting.

Topically, it can trigger an allergic reaction (dermatitis) in people sensitive to the ragweed family of plants, which includes daisies, marigolds, and chrysanthemums. Pregnancy safety data advise against it — blessed thistle is traditionally thought to affect the uterus and lacks good safety studies.

For breastfeeding, it's been used traditionally to support milk supply, but safety hasn't been well studied; check with your doctor or pharmacist for personalized advice before taking it while nursing.

Side effects, ingredient by ingredient Blessed Thistle

Meds to double-check

Minor interactions only
Known Interaction Concern · database check
Minor only

Only Minor-severity interactions are documented for these ingredients.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Blessed Thistle.
  • The most serious interaction on file is rated Minor.
  • For scale: 36 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Check your medications if you take H2-blockers (like famotidine for heartburn), antacids, or proton pump inhibitors (PPIs, like omeprazole) before starting this product. All three drug types may be less effective if blessed thistle increases your stomach acid.

Use the interaction checker on this page with your exact medications.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no assessable stated purpose. Only minor medication interactions are documented, and safety information is well characterized.

Blessed thistle may be worth considering if you're interested in traditional digestive support, but the evidence for its effectiveness is thin. If you take acid-reducing medications for heartburn or reflux, check with us first — the plant may interfere with how well they work.

Skip it in pregnancy, and talk to your doctor before using it while breastfeeding.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Dec 14, 2023.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Blessed Thistle, straight from the product label.

Brand Hawaii Pharm
Barcode (UPC) 840253607690
Net contents 4 Fluid Ounce(s); 120 mL
Market status On market
Date entered into DSLD Dec 14, 2023
DSLD ID 301284
Product type Botanical
Supplement form Liquid
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Gluten Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Blessed Thistle by Hawaii Pharm, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
0.7 mL
Maximum serving Sizes:
1 mL
Servings per container
120
UPC/BARCODE
840253607690
IngredientAmount% DV
Blessed Thistle Flower, Leaf, Stem Extract, Dry983 mg--

Other ingredients: Alcohol, Water, Glycerin

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Brand IP Statement(s)

Hawaii Pharm Herbal Extract Highest quality since 2008

Suggested/Recommended/Usage/Directions

Suggested use: Shake well before using. For adults add about 20-30 drops (0.7-1 mL, one full squeeze of the dropper bulb) to some juice or water, up to 4 times a day.

Precautions

Warning: We recommend to seek expert medical advice before taking.

Do not use if you are allergic to any ingredients.

Consult your physician before giving to children under 18, during pregnancy, if nursing or taking medications.

Consult your physician before giving to children under 18, during pregnancy, if nursing or taking medications.

May affect the ability to drive and operate machinery. May have contraindications, can cause side effects and adverse reactions. Do not use if seal is broken or missing.

Keep out of the reach of children!

Storage

Store in a cool dry place.

Seals/Symbols

cGMP Made in compliance with cGMP 21 CFR 111 in an FDA registered and inspected facility.

Organic Alcohol Based USA Made in United States of America

FDA Disclaimer Statement

This product has not been evaluated by the FDA and is not intended to diagnose, treat, cure or prevent any disease.

General Statements

Scan this QR-code to get 15% discount on your next purchase. Limited time deal.

Formula

Cnicus benedictus

Organic Alcohol Based

Formulation

Only natural ingredients Purity is laboratory tested and verified

All the raw materials are gluten-free by their nature No artificial colors, flavors, or preservatives

Not tested on animals

Organic Alcohol Based

Made in USA, Hawaii

FDA Statement of Identity

Herbal Supplement

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Blessed Thistle by Hawaii Pharm label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Blessed Thistle label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Blessed Thistle by Hawaii Pharm

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size0.7 mL Dosage formLiquid Servings per container120 Amounts shown are per serving.

Blessed Thistle Flower, Leaf, Stem Extract, Dry

Interacts with
36 drugs
983 mg per serving Form: Blessed Thistle Flower Extract, Dry, Blessed Thistle Leaf Extract, Dry, Blessed Thistle Stem Extract, Dry

Blessed thistle is a bitter herb traditionally used to stimulate appetite and ease mild digestive complaints. High-quality human studies are lacking,...

Blessed Thistle Flower, Leaf, Stem Extract, Dry monograph & interactions

Other (inactive) ingredients: Alcohol, Water, Glycerin. These complete the product’s ingredient list but are not active constituents.

Interaction report

Blessed Thistle by Hawaii Pharm Drug Interactions

Want to check YOUR meds against Blessed Thistle?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
36Drugs
36 Minor

Ingredients driving the most interactions

Blessed Thistle Flower, Leaf, Stem Extract, Dry 36

Individual Drug Interactions

The ingredients in Blessed Thistle interact with 36 drugs. Click any drug to see the details.

1 of the 1 ingredient in Blessed Thistle interact with drugs. Each result below shows which ingredient is responsible. Blessed Thistle Flower, Leaf, Stem Extract, Dry

Each ingredient & the kinds of drugs it affects

For each ingredient in Blessed Thistle with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Blessed Thistle Flower, Leaf, Stem Extract, Dry3 drug types · 36 drugs

Antacids

Theoretically, blessed thistle might decrease the effectiveness of antacids.
There are reports that blessed thistle increases stomach acid.

Likelihood Possible Evidence D
H2-Blockers

Theoretically, blessed thistle might decrease the effectiveness of H2-blockers.
There are reports that blessed thistle increases stomach acid.

Likelihood Possible Evidence D
Proton Pump Inhibitors (Ppis)

Theoretically, blessed thistle might decrease the effectiveness of PPIs.
There are reports that blessed thistle increases stomach acid.

Likelihood Possible Evidence D
Blessed Thistle Flower, Leaf, Stem Extract, Dry full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Blessed Thistle, from the product label.

Hawaii Pharm

See all Hawaii Pharm products
Name
Hawaii Pharm LLC
Street Address
510 Sumner St. Ste. 613
City
Honolulu
State
HI
ZipCode
96817
Phone Number
888-854-2924
Web Address
www.hawaiipharm.com
Pharmacist Counseling Corner

Blessed Thistle by Hawaii Pharm: Common Questions

Does Blessed Thistle by Hawaii Pharm interact with any medications?
Yes. Based on its ingredients, Blessed Thistle has a known interaction with 36 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Blessed Thistle contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this if I'm pregnant?
No — blessed thistle is traditionally thought to affect the uterus and safety data are lacking, so it's best avoided during pregnancy. Talk to your doctor if you're thinking about it.
Can I use it while breastfeeding?
Blessed thistle has been used traditionally to support milk supply, but safety hasn't been well studied. You'll want to check with your doctor or pharmacist first for personalized advice.
What dose is safe?
Doses higher than 5 grams per cup of tea can cause stomach irritation and vomiting. The product label should tell you the dose per serving — check with your pharmacist if you're unsure.
Does blessed thistle actually help with digestion?
There isn't enough reliable evidence in our data to say whether it works for indigestion. It's been used traditionally for that purpose, but we can't rate its effectiveness based on current research.
Can it cause an allergic reaction?
If you're sensitive to ragweed, daisies, marigolds, or other plants in that family, blessed thistle can cause allergic skin reactions like dermatitis when applied topically.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Blessed Thistle is safe with your meds?

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Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Blessed Thistle label
Go deeper

The Full Monographs Behind Blessed Thistle’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Blessed Thistle

Interacts with 36 drugs

Blessed thistle is a bitter herb traditionally used to stimulate appetite and ease mild digestive complaints. High-quality human studies are lacking, so its benefits are not well proven. It...

Read the full Blessed Thistle monograph →
Sources

Sources & How We Checked

Blessed Thistle's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 2 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Blessed Thistle 2 references
  1. McGuffin M, Hobbs C, Upton R, Goldberg A, eds. American Herbal Products Association's Botanical Safety Handbook. Boca Raton, FL: CRC Press, LLC 1997.
  2. Brinker F. Herb Contraindications and Drug Interactions. 2nd ed. Sandy, OR: Eclectic Medical Publications, 1998.

See these in context on the Blessed Thistle monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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