Cascara Sagrada Ingredients & Drug Interactions
What is this page for?
First and foremost: checking Cascara Sagrada against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
Cascara Sagrada is a dietary supplement by Herbalist & Alchemist with 1 active ingredient. Its ingredients are commonly taken for constipation, bowel cleansing before procedures, hemorrhoids.Based on those ingredients, 747 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are dried Cascara Sagrada bark extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.
Check Your Meds Against Cascara Sagrada by Herbalist & Alchemist
Ask about any prescription or over-the-counter medication and we check it for interactions with Cascara Sagrada by Herbalist & Alchemist — and tell you which ingredient is responsible.
AI summaries are generated from our interaction database for education only — always confirm with your pharmacist. How we use AI
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HelloPharmacist Scorecard of Cascara Sagrada by Herbalist & Alchemist
Four independent checks of what is known — a summary of the available information, not a grade of the product itself.
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
The stated purpose hasn't been mapped to our evidence data yet.
Why this rating?
- We haven't mapped this product's purpose to our evidence data yet — it'll be graded on the next content refresh.
Every active ingredient lists its own amount on the label.
Why this rating?
- The label discloses an exact amount for 1 of its 1 active ingredient.
- No proprietary blends here — you can verify the dose of every single component.
The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.
Why this rating?
- 1 of the 1 matched ingredient can interact with medications — Cascara Sagrada.
- The most serious interaction on file is rated Moderate.
- Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; heart-rhythm medications.
- For scale: 746 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.
Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.
Why this rating?
- We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
- Pregnancy & breastfeeding safety ratings cover 1 of 1.
- General safety write-ups exist for 1 of 1.
- Remember: this measures how much safety information exists. Thin data is not the same as being safe.
HelloPharmacist summaryFully disclosed formula with no assessable stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.
Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Jul 25, 2016.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about Cascara Sagrada, straight from the product label.
| Brand | Herbalist & Alchemist |
|---|---|
| Barcode (UPC) | 667056105112 |
| Net contents | 2 fl. Oz.; 60 mL |
| Market status | Off market |
| Date entered into DSLD | Jul 25, 2016 |
| DSLD ID | 62673 |
| Product type | Botanical |
| Supplement form | Liquid |
| Dietary claims / uses | All Other, Structure/Function |
| Intended target group(s) | Adult (18 - 50 Years), Kosher |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for Cascara Sagrada by Herbalist & Alchemist, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| dried Cascara Sagrada bark extract | 1.5 mL | -- |
Other ingredients: distilled Water, Ethyl Alcohol
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Seals/Symbols
OK
Formula
OK
Frangula purshiana
Contraindications: Contains Cascara Sagrada.
General Statements
Supports healthy bowel function
H&A
Botanical preparation ratio 1:4
LOT# 16
FDA Statement of Identity
Herbal Supplement
Suggested/Recommended/Usage/Directions
Suggested use: 20-30 drops (1-1.5 mL) in juice or water. Take 3 times per day. Shake well before using.
Precautions
Contraindications: Contains Cascara Sagrada. Do not use if you have or develop diarrhea, loose stools or abdominal pain. Cascara Sagrada may worsen condition.
Consult your physician if you have frequent diarrhea or are pregnant, nursing or taking medication.
Keep out of children's reach
FDA Disclaimer Statement
This statement has not been evaluated by the FDA. This product is not intended to diagnose, treat, cure or prevent any disease.
General
NO. CSG-2 1620FR MFG: 12/14
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
Cascara Sagrada by Herbalist & Alchemist label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in Cascara Sagrada by Herbalist & Alchemist
This is the 1 active ingredient this product is made of. Select it to open its full monograph.
Serving size1 mL Dosage formLiquid Servings per container40 Amounts shown are per serving.
Dried Cascara Sagrada bark extract
Interacts with747 drugs
Cascara sagrada is a stimulant laxative made from the aged bark of a Pacific Northwest tree, used mainly for short-term relief of constipation. Becaus...
Dried Cascara Sagrada bark extract monograph & interactionsOther (inactive) ingredients: Distilled Water, Ethyl Alcohol. These complete the product’s ingredient list but are not active constituents.
Cascara Sagrada by Herbalist & Alchemist Drug Interactions
Cascara Sagrada contains a single active ingredient, and it has known interactions with 747 medications. Here’s the picture, then you can look up your own drug.
Want to check YOUR meds against Cascara Sagrada?
Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.
Go to the checkerIngredients driving the most interactions
Individual Drug Interactions
The ingredients in Cascara Sagrada interact with 747 drugs. Click any drug to see the details.
1 of the 1 ingredient in Cascara Sagrada interact with drugs. Each result below shows which ingredient is responsible. dried Cascara Sagrada bark extract
EtoposideEtopophos, VePesid, VP16
How Etoposide interacts with Cascara Sagrada — through 1 ingredient. Tap an ingredient for the detail:
Dried Cascara Sagrada Bark ExtractCytochrome P450 3a4 (cyp3a4) Substrates Minor
Interaction Summary
Theoretically, cascara sagrada might decrease the effects of CYP3A4 substrates.
Read the full Dried Cascara Sagrada Bark Extract + Etoposide interactionEtoricoxibArcoxia
How Etoricoxib interacts with Cascara Sagrada — through 1 ingredient. Tap an ingredient for the detail:
Dried Cascara Sagrada Bark ExtractCytochrome P450 3a4 (cyp3a4) Substrates Minor
Interaction Summary
Theoretically, cascara sagrada might decrease the effects of CYP3A4 substrates.
Read the full Dried Cascara Sagrada Bark Extract + Etoricoxib interactionEtrasimodVelsipity
How Etrasimod interacts with Cascara Sagrada — through 1 ingredient. Tap an ingredient for the detail:
Dried Cascara Sagrada Bark ExtractCytochrome P450 3a4 (cyp3a4) Substrates Minor
Interaction Summary
Theoretically, cascara sagrada might decrease the effects of CYP3A4 substrates.
Read the full Dried Cascara Sagrada Bark Extract + Etrasimod interactionEtravirineIntelence
How Etravirine interacts with Cascara Sagrada — through 1 ingredient. Tap an ingredient for the detail:
Dried Cascara Sagrada Bark ExtractCytochrome P450 3a4 (cyp3a4) Substrates Minor
Interaction Summary
Theoretically, cascara sagrada might decrease the effects of CYP3A4 substrates.
Read the full Dried Cascara Sagrada Bark Extract + Etravirine interactionEverolimusAfinitor, Afinitor Disperz, Certican, Zortress
How Everolimus interacts with Cascara Sagrada — through 1 ingredient. Tap an ingredient for the detail:
Dried Cascara Sagrada Bark ExtractCytochrome P450 3a4 (cyp3a4) Substrates Minor
Interaction Summary
Theoretically, cascara sagrada might decrease the effects of CYP3A4 substrates.
Read the full Dried Cascara Sagrada Bark Extract + Everolimus interactionExemestaneAromasin
How Exemestane interacts with Cascara Sagrada — through 1 ingredient. Tap an ingredient for the detail:
Dried Cascara Sagrada Bark ExtractCytochrome P450 3a4 (cyp3a4) Substrates Minor
Interaction Summary
Theoretically, cascara sagrada might decrease the effects of CYP3A4 substrates.
Read the full Dried Cascara Sagrada Bark Extract + Exemestane interactionEzetimibe, AtorvastatinLiptruzet
How Ezetimibe, Atorvastatin interacts with Cascara Sagrada — through 1 ingredient. Tap an ingredient for the detail:
Dried Cascara Sagrada Bark ExtractCytochrome P450 3a4 (cyp3a4) Substrates Minor
Interaction Summary
Theoretically, cascara sagrada might decrease the effects of CYP3A4 substrates.
Read the full Dried Cascara Sagrada Bark Extract + Ezetimibe, Atorvastatin interactionFedratinib HydrochlorideInrebic
How Fedratinib Hydrochloride interacts with Cascara Sagrada — through 1 ingredient. Tap an ingredient for the detail:
Dried Cascara Sagrada Bark ExtractCytochrome P450 3a4 (cyp3a4) Substrates Minor
Interaction Summary
Theoretically, cascara sagrada might decrease the effects of CYP3A4 substrates.
Read the full Dried Cascara Sagrada Bark Extract + Fedratinib Hydrochloride interactionFelodipinePlendil, Renedil
How Felodipine interacts with Cascara Sagrada — through 1 ingredient. Tap an ingredient for the detail:
Dried Cascara Sagrada Bark ExtractCytochrome P450 3a4 (cyp3a4) Substrates Minor
Interaction Summary
Theoretically, cascara sagrada might decrease the effects of CYP3A4 substrates.
Read the full Dried Cascara Sagrada Bark Extract + Felodipine interactionFentanylAbstral, Duragesic, Fentora, Lazanda, Sublimaze, Subsys
How Fentanyl interacts with Cascara Sagrada — through 1 ingredient. Tap an ingredient for the detail:
Dried Cascara Sagrada Bark ExtractCytochrome P450 3a4 (cyp3a4) Substrates Minor
Interaction Summary
Theoretically, cascara sagrada might decrease the effects of CYP3A4 substrates.
Read the full Dried Cascara Sagrada Bark Extract + Fentanyl interactionFentanyl Citrate, Oral Transmucosal Fentanyl CitrateActiq
How Fentanyl Citrate, Oral Transmucosal Fentanyl Citrate interacts with Cascara Sagrada — through 1 ingredient. Tap an ingredient for the detail:
Dried Cascara Sagrada Bark ExtractCytochrome P450 3a4 (cyp3a4) Substrates Minor
Interaction Summary
Theoretically, cascara sagrada might decrease the effects of CYP3A4 substrates.
Read the full Dried Cascara Sagrada Bark Extract + Fentanyl Citrate, Oral Transmucosal Fentanyl Citrate interactionFentanyl CitrateInnovar
How Fentanyl Citrate interacts with Cascara Sagrada — through 1 ingredient. Tap an ingredient for the detail:
Dried Cascara Sagrada Bark ExtractCytochrome P450 3a4 (cyp3a4) Substrates Minor
Interaction Summary
Theoretically, cascara sagrada might decrease the effects of CYP3A4 substrates.
Read the full Dried Cascara Sagrada Bark Extract + Fentanyl Citrate interactionFesoterodine FumarateToviaz
How Fesoterodine Fumarate interacts with Cascara Sagrada — through 1 ingredient. Tap an ingredient for the detail:
Dried Cascara Sagrada Bark ExtractCytochrome P450 3a4 (cyp3a4) Substrates Minor
Interaction Summary
Theoretically, cascara sagrada might decrease the effects of CYP3A4 substrates.
Read the full Dried Cascara Sagrada Bark Extract + Fesoterodine Fumarate interactionFexofenadineAllegra
How Fexofenadine interacts with Cascara Sagrada — through 1 ingredient. Tap an ingredient for the detail:
Dried Cascara Sagrada Bark ExtractCytochrome P450 3a4 (cyp3a4) Substrates Minor
Interaction Summary
Theoretically, cascara sagrada might decrease the effects of CYP3A4 substrates.
Read the full Dried Cascara Sagrada Bark Extract + Fexofenadine interactionFexofenadine, PseudoephedrineAllegra D
How Fexofenadine, Pseudoephedrine interacts with Cascara Sagrada — through 1 ingredient. Tap an ingredient for the detail:
Dried Cascara Sagrada Bark ExtractCytochrome P450 3a4 (cyp3a4) Substrates Minor
Interaction Summary
Theoretically, cascara sagrada might decrease the effects of CYP3A4 substrates.
Read the full Dried Cascara Sagrada Bark Extract + Fexofenadine, Pseudoephedrine interactionFinasteridePropecia, Proscar
How Finasteride interacts with Cascara Sagrada — through 1 ingredient. Tap an ingredient for the detail:
Dried Cascara Sagrada Bark ExtractCytochrome P450 3a4 (cyp3a4) Substrates Minor
Interaction Summary
Theoretically, cascara sagrada might decrease the effects of CYP3A4 substrates.
Read the full Dried Cascara Sagrada Bark Extract + Finasteride interactionFinasteride, TadalafilEntadfi
How Finasteride, Tadalafil interacts with Cascara Sagrada — through 1 ingredient. Tap an ingredient for the detail:
Dried Cascara Sagrada Bark ExtractCytochrome P450 3a4 (cyp3a4) Substrates Minor
Interaction Summary
Theoretically, cascara sagrada might decrease the effects of CYP3A4 substrates.
Read the full Dried Cascara Sagrada Bark Extract + Finasteride, Tadalafil interactionFinerenoneKerendia
How Finerenone interacts with Cascara Sagrada — through 1 ingredient. Tap an ingredient for the detail:
Dried Cascara Sagrada Bark ExtractCytochrome P450 3a4 (cyp3a4) Substrates Minor
Interaction Summary
Theoretically, cascara sagrada might decrease the effects of CYP3A4 substrates.
Read the full Dried Cascara Sagrada Bark Extract + Finerenone interactionFlibanserinAddyi
How Flibanserin interacts with Cascara Sagrada — through 1 ingredient. Tap an ingredient for the detail:
Dried Cascara Sagrada Bark ExtractCytochrome P450 3a4 (cyp3a4) Substrates Minor
Interaction Summary
Theoretically, cascara sagrada might decrease the effects of CYP3A4 substrates.
Read the full Dried Cascara Sagrada Bark Extract + Flibanserin interactionFlutamideEuflex, Eulexin
How Flutamide interacts with Cascara Sagrada — through 1 ingredient. Tap an ingredient for the detail:
Dried Cascara Sagrada Bark ExtractCytochrome P450 3a4 (cyp3a4) Substrates Minor
Interaction Summary
Theoretically, cascara sagrada might decrease the effects of CYP3A4 substrates.
Read the full Dried Cascara Sagrada Bark Extract + Flutamide interactionFluticasone PropionateArmonair Respiclick, Flonase Allergy Relief, Xhance
How Fluticasone Propionate interacts with Cascara Sagrada — through 1 ingredient. Tap an ingredient for the detail:
Dried Cascara Sagrada Bark ExtractCytochrome P450 3a4 (cyp3a4) Substrates Minor
Interaction Summary
Theoretically, cascara sagrada might decrease the effects of CYP3A4 substrates.
Read the full Dried Cascara Sagrada Bark Extract + Fluticasone Propionate interactionFluticasone Proprionate, SalmeterolAirduo Respiclick
How Fluticasone Proprionate, Salmeterol interacts with Cascara Sagrada — through 1 ingredient. Tap an ingredient for the detail:
Dried Cascara Sagrada Bark ExtractCytochrome P450 3a4 (cyp3a4) Substrates Minor
Interaction Summary
Theoretically, cascara sagrada might decrease the effects of CYP3A4 substrates.
Read the full Dried Cascara Sagrada Bark Extract + Fluticasone Proprionate, Salmeterol interactionFluticasone FuroateArnuity Ellipta, Avamys
How Fluticasone Furoate interacts with Cascara Sagrada — through 1 ingredient. Tap an ingredient for the detail:
Dried Cascara Sagrada Bark ExtractCytochrome P450 3a4 (cyp3a4) Substrates Minor
Interaction Summary
Theoretically, cascara sagrada might decrease the effects of CYP3A4 substrates.
Read the full Dried Cascara Sagrada Bark Extract + Fluticasone Furoate interactionFluticasone, SalmeterolAdvair Diskus
How Fluticasone, Salmeterol interacts with Cascara Sagrada — through 1 ingredient. Tap an ingredient for the detail:
Dried Cascara Sagrada Bark ExtractCytochrome P450 3a4 (cyp3a4) Substrates Minor
Interaction Summary
Theoretically, cascara sagrada might decrease the effects of CYP3A4 substrates.
Read the full Dried Cascara Sagrada Bark Extract + Fluticasone, Salmeterol interactionFosamprenavirLexiva, Telzir
How Fosamprenavir interacts with Cascara Sagrada — through 1 ingredient. Tap an ingredient for the detail:
Dried Cascara Sagrada Bark ExtractCytochrome P450 3a4 (cyp3a4) Substrates Minor
Interaction Summary
Theoretically, cascara sagrada might decrease the effects of CYP3A4 substrates.
Read the full Dried Cascara Sagrada Bark Extract + Fosamprenavir interactionFosaprepitantEmend Injection, Focinvez
How Fosaprepitant interacts with Cascara Sagrada — through 1 ingredient. Tap an ingredient for the detail:
Dried Cascara Sagrada Bark ExtractCytochrome P450 3a4 (cyp3a4) Substrates Minor
Interaction Summary
Theoretically, cascara sagrada might decrease the effects of CYP3A4 substrates.
Read the full Dried Cascara Sagrada Bark Extract + Fosaprepitant interactionFosnetupitant, Palonosetron (iv)Akynzeo
How Fosnetupitant, Palonosetron (iv) interacts with Cascara Sagrada — through 1 ingredient. Tap an ingredient for the detail:
Dried Cascara Sagrada Bark ExtractCytochrome P450 3a4 (cyp3a4) Substrates Minor
Interaction Summary
Theoretically, cascara sagrada might decrease the effects of CYP3A4 substrates.
Read the full Dried Cascara Sagrada Bark Extract + Fosnetupitant, Palonosetron (iv) interactionFostamatinibTavalisse
How Fostamatinib interacts with Cascara Sagrada — through 1 ingredient. Tap an ingredient for the detail:
Dried Cascara Sagrada Bark ExtractCytochrome P450 3a4 (cyp3a4) Substrates Minor
Interaction Summary
Theoretically, cascara sagrada might decrease the effects of CYP3A4 substrates.
Read the full Dried Cascara Sagrada Bark Extract + Fostamatinib interactionFostemsavir TromethamineRukobia
How Fostemsavir Tromethamine interacts with Cascara Sagrada — through 1 ingredient. Tap an ingredient for the detail:
Dried Cascara Sagrada Bark ExtractCytochrome P450 3a4 (cyp3a4) Substrates Minor
Interaction Summary
Theoretically, cascara sagrada might decrease the effects of CYP3A4 substrates.
Read the full Dried Cascara Sagrada Bark Extract + Fostemsavir Tromethamine interactionFruquintinibFruzaqla
How Fruquintinib interacts with Cascara Sagrada — through 1 ingredient. Tap an ingredient for the detail:
Dried Cascara Sagrada Bark ExtractCytochrome P450 3a4 (cyp3a4) Substrates Minor
Interaction Summary
Theoretically, cascara sagrada might decrease the effects of CYP3A4 substrates.
Read the full Dried Cascara Sagrada Bark Extract + Fruquintinib interactionEach ingredient & the kinds of drugs it affects
For each ingredient in Cascara Sagrada with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.
dried Cascara Sagrada bark extract
Corticosteroids
Theoretically, cascara sagrada might increase the risk of hypokalemia when taken with corticosteroids.
Cascara sagrada has stimulant laxative effects, and long-term use has been associated with hypokalemia.
Digoxin (Lanoxin)
Theoretically, cascara sagrada might cause hypokalemia, potentially increasing the risk of digoxin toxicity.
Cascara sagrada has stimulant laxative effects, and long-term use has been associated with hypokalemia.
Diuretic Drugs
Theoretically, cascara sagrada might increase the risk of hypokalemia when taken with diuretic drugs.
Cascara sagrada has stimulant laxative effects, and long-term use has been associated with hypokalemia.
Stimulant Laxatives
Theoretically, cascara sagrada might have additive adverse effects when taken with stimulant laxatives.
Cascara sagrada has stimulant laxative effects and might compound fluid and electrolyte losses when taken with stimulant laxatives.
Warfarin (Coumadin)
Theoretically, cascara sagrada might increase the risk of bleeding when taken with warfarin.
Cascara sagrada has stimulant laxative effects. In some people, cascara sagrada can cause diarrhea. Diarrhea can increase the effects of warfarin, increase international normalized ratio (INR), and increase the risk of bleeding.
Cytochrome P450 3A4 (Cyp3A4) Substrates
Theoretically, cascara sagrada might decrease the effects of CYP3A4 substrates.
In vitro research suggests that cascara sagrada can induce CYP3A4 enzymes, albeit to a much lower degree than rifampin, a known CYP3A4 inducer.
Brand information
Manufacturer and brand details for Cascara Sagrada, from the product label.
Herbalist & Alchemist
See all Herbalist & Alchemist products- Name
- Herbalist & Alchemist, Inc.
- City
- Washington
- State
- NJ
- ZipCode
- 07882
- Phone Number
- 800-611-8235
- Web Address
- www.herbalist-alchemist.com
Cascara Sagrada by Herbalist & Alchemist: Common Questions
Does Cascara Sagrada by Herbalist & Alchemist interact with any medications?
How can one product interact with so many drugs?
Where does this information come from?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Not sure if Cascara Sagrada is safe with your meds?
Our pharmacists answer your medication & supplement questions — free.
Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.
The Full Monographs Behind Cascara Sagrada’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Sources & How We Checked
Cascara Sagrada's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 9 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Cascara Sagrada 9 references
- Blumenthal M, ed. The Complete German Commission E Monographs: Therapeutic Guide to Herbal Medicines. Trans. S. Klein. Boston, MA: American Botanical Council, 1998.
- Newall CA, Anderson LA, Philpson JD. Herbal Medicine: A Guide for Healthcare Professionals. London, UK: The Pharmaceutical Press, 1996.
- Brinker F. Herb Contraindications and Drug Interactions. 2nd ed. Sandy, OR: Eclectic Medical Publications, 1998.
- Covington TR, et al. Handbook of Nonprescription Drugs. 11th ed. Washington, DC: American Pharmaceutical Association, 1996.
- Nusko G, Schneider B, Schneider I, et al. Anthranoid laxative use is not a risk factor for colorectal neoplasia: results of a prospective case control study. Gut 2000;46:651-5. PubMed
- Nadir A, Reddy D, Van Thiel DH. Cascara-sagrada induced intrahepatic cholestasis causing portal hypertension: case report and review of herbal hepatotoxicity. Am J Gastroenterol 2000;95:3634-7. PubMed
- Nakasone ES, Tokeshi J. A serendipitous find: a case of cholangiocarcinoma identified incidentally after acute liver injury due to cascara sagrada ingestion. Hawaii J Med Public Health 2015;74(6):200-2.
- Cirillo C, Capasso R. Constipation and botanical medicines: an overview. Phytother Res 2015;29(10):1488-93. PubMed
- Mazzari ALDA, Lacerda MG, Milton FA, et al. In vitro effects of European and Latin-American medicinal plants in CYP3A4 gene expression, glutathione levels, and P-glycoprotein activity. Front Pharmacol 2022;13:826395. PubMed
Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC