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Dietary supplement

Chelated Manganese 20 mg Ingredients & Drug Interactions

by Carlson

Chelated Manganese 20 mg label
See full label image
Tablet Or Pill Category: Mineral
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Chelated Manganese 20 mg against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Chelated Manganese 20 mg is a dietary supplement by Carlson with 1 active ingredient. Its ingredients are commonly taken for bone health support, antioxidant and enzyme support, filling dietary gaps.Based on those ingredients, 83 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Manganese. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Chelated Manganese 20 mg by Carlson

Ask about any prescription or over-the-counter medication and we check it for interactions with Chelated Manganese 20 mg by Carlson — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Chelated Manganese 20 mg by Carlson

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 12, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains one active ingredient: manganese, in a chelated form (bound to an amino acid for better absorption). You're getting 20 mg per tablet.

The inactive ingredients are microcrystalline cellulose, croscarmellose sodium, stearic acid, silicon dioxide, rice flour, and ethyl cellulose — these are standard tablet binders and fillers.

Does it work?

Strong evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Strong

Clinical evidence supports at least one of this product's ingredients for its stated purpose.

Why this rating?
  • The label markets this product for: healthy metabolism, bone and brain health.
  • We looked for evidence on: Manganese deficiency, Metabolic syndrome, Osteoporosis, Wound healing, bone strength, cognitive function.
  • The strongest evidence on file: Manganese is rated "Effective" for Manganese deficiency (Natural Medicines).
  • Also on file: Manganese is rated "Insufficient Reliable Evidence To Rate" for Osteoporosis, Wound healing, Metabolic syndrome.

Manganese is established as effective for manganese deficiency. For other conditions — hay fever (allergic rhinitis), bone health (osteoporosis), lung disease (COPD), weight management, and joint wear-and-tear (osteoarthritis) — the evidence we hold is insufficient to rate it.

That means the research isn't solid enough to say whether it works for those purposes.

The evidence, ingredient by ingredient Manganese

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Manganese is generally well tolerated at normal dietary doses, but high-dose supplements carry real risks. The main concern is neurotoxicity — at high doses, manganese can cause Parkinson-like symptoms and neurological damage.

One documented case involved someone taking 100 mg daily for 2–4 years who developed irreversible Parkinson disease; another involved a teenager who developed severe neurological symptoms and liver damage from manganese buildup and required intensive treatment including plasma exchange. This 20 mg dose is lower than those extreme cases, but the safety data advises against taking extra high-dose manganese supplements unless a clinician has recommended it.

For pregnancy and breastfeeding: normal dietary amounts and prenatal vitamins are fine, but avoid extra high-dose supplements unless advised by your doctor. The lactation safety data in our files is mixed — talk with your healthcare provider if you're nursing and considering this supplement.

Side effects, ingredient by ingredient Manganese

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Manganese.
  • The most serious interaction on file is rated Moderate.
  • For scale: 83 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before you take this, check with your pharmacist if you're on an antipsychotic drug — there's a Moderate risk that manganese could raise your toxicity risk. Also double-check if you take quinolone antibiotics (like ciprofloxacin) or tetracycline antibiotics — manganese may reduce how well your body absorbs them, making them less effective.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with clinical evidence supporting its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

This product is useful if you have a documented manganese deficiency. If you take antipsychotic medications or antibiotics (especially quinolones like ciprofloxacin or tetracyclines), check with your pharmacist before starting — the interactions are real.

And keep the dose in mind: this 20 mg tablet is modest, but manganese toxicity is a concern at much higher levels, so don't exceed recommended use without medical guidance.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Feb 22, 2024.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Chelated Manganese 20 mg, straight from the product label.

Brand Carlson
Barcode (UPC) 088395056321
Net contents 250 Tablet(s)
Market status On market
Date entered into DSLD Feb 22, 2024
DSLD ID 305305
Product type Mineral
Supplement form Tablet Or Pill
Dietary claims / uses Nutrient, All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Gluten Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Chelated Manganese 20 mg by Carlson, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Tablet(s)
Maximum serving Sizes:
1 Tablet(s)
Servings per container
250
UPC/BARCODE
088395056321
IngredientAmount% DV
Manganese20 mg870%

Other ingredients: Microcrystalline Cellulose, Croscarmellose Sodium, Stearic Acid, Silicon Dioxide, Rice Flour, Ethyl Cellulose

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formulation

Superior absorption Healthy metabolism Bone support Brain health

Potency & quality guaranteed An FDA regulated facility

Gluten-free No artificial preservatives

FDA Statement of Identity

Dietary Supplement

Suggested/Recommended/Usage/Directions

Directions: Adults: Take one tablet every other day at mealtime.

Storage

Keep bottle tightly closed. Store away from heat and moisture.

Formula

Manganese is an essential trace mineral involved in many body functions, including supporting a healthy metabolism, and promoting bone and brain health. Chelated Manganese contains manganese bound to amino acid glycine for optimal absorption.

FDA Disclaimer Statement

These statements have not been evaluated by the FDA. This product is not intended to diagnose, treat, cure, or prevent any disease.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Chelated Manganese 20 mg by Carlson label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Chelated Manganese 20 mg label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Chelated Manganese 20 mg by Carlson

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 Tablet(s) Dosage formTablet Or Pill Servings per container250 Amounts shown are per serving.

Manganese

Interacts with
83 drugs
20 mg per serving Form: Manganese Glycinate Chelate

Manganese is an essential trace mineral your body needs in small amounts for bone formation, metabolism, and antioxidant defense, and most people get...

Manganese monograph & interactions

Other (inactive) ingredients: Microcrystalline Cellulose, Croscarmellose Sodium, Stearic Acid, Silicon Dioxide, Rice Flour, Ethyl Cellulose. These complete the product’s ingredient list but are not active constituents.

Interaction report

Chelated Manganese 20 mg by Carlson Drug Interactions

Want to check YOUR meds against Chelated Manganese 20 mg?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
83Drugs
83 Moderate

Ingredients driving the most interactions

Manganese 83

Individual Drug Interactions

The ingredients in Chelated Manganese 20 mg interact with 83 drugs. Click any drug to see the details.

1 of the 1 ingredient in Chelated Manganese 20 mg interact with drugs. Each result below shows which ingredient is responsible. Manganese

Each ingredient & the kinds of drugs it affects

For each ingredient in Chelated Manganese 20 mg with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Manganese3 drug types · 83 drugs

Antipsychotic Drugs

Theoretically, the risk for manganese toxicity might increase when taken with antipsychotic drugs.
Hallucinations and behavioral changes have been reported in a patient with liver disease who was taking haloperidol and manganese. Researchers speculate that taking manganese along with haloperidol, phenothiazine-derivatives, or other antipsychotic medications might increase the risk of manganese toxicity in some patients.

Likelihood Possible Evidence D
Quinolone Antibiotics

Theoretically, manganese might reduce the absorption of quinolone antibiotics.
Manganese is a multivalent cation. Interactions resulting in reduced quinolone absorption have been reported between quinolones and other multivalent cations, such as calcium and iron.

Likelihood Probable Evidence D
Tetracycline Antibiotics

Theoretically, manganese might reduce the absorption of tetracycline antibiotics.
Manganese is a multivalent cation. Interactions resulting in reduced tetracycline absorption have been reported between tetracyclines and other multivalent cations, such as calcium and iron.

Likelihood Probable Evidence D
Manganese full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Chelated Manganese 20 mg, from the product label.

Carlson

See all Carlson products
Name
Carlson Division of J.R. Carlson Laboratories, Inc.
City
Arlington Heights
State
IL
ZipCode
60004
Phone Number
888-234-5656
Web Address
carlsonlabs.com
Pharmacist Counseling Corner

Chelated Manganese 20 mg by Carlson: Common Questions

Does Chelated Manganese 20 mg by Carlson interact with any medications?
Yes. Based on its ingredients, Chelated Manganese 20 mg has a known interaction with 83 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Chelated Manganese 20 mg contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
What is manganese, and why would I take it?
Manganese is a mineral your body needs in small amounts. This supplement is proven to treat manganese deficiency. For other uses like bone health or hay fever, the evidence isn't solid enough yet to say whether it helps.
Is 20 mg a lot of manganese?
It's a moderate amount. The safety concern kicks in at much higher doses — cases of serious nerve damage involved 100 mg or more daily — but the data advises against taking extra high-dose supplements unless your doctor recommends it.
Can I take this while breastfeeding?
Normal dietary manganese is fine, but the safety data we have for high-dose supplements while breastfeeding is mixed. Talk with your doctor or pharmacist before taking this if you're nursing — they can give you personalized advice.
What are the side effects of manganese?
At normal supplement doses, manganese is generally well tolerated. At high doses, the main risk is neurotoxicity — nerve damage that can cause Parkinson-like symptoms. This is rare but serious, which is why you shouldn't exceed recommended doses without medical guidance.
What does 'chelated' mean?
Chelated means the manganese is bound to an amino acid, which helps your body absorb it more efficiently than plain manganese would.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Chelated Manganese 20 mg is safe with your meds?

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Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Chelated Manganese 20 mg label
Go deeper

The Full Monographs Behind Chelated Manganese 20 mg’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Manganese

Interacts with 83 drugs

Manganese is an essential trace mineral your body needs in small amounts for bone formation, metabolism, and antioxidant defense, and most people get enough from a normal diet. Supplements m...

Read the full Manganese monograph →
Sources

Sources & How We Checked

Chelated Manganese 20 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 21 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Manganese 21 references
  1. Hansten PD, Horn JR. Hansten and Horn's Drug Interactions Analysis and Management. Vancouver, CAN:Appl Therapeut, 1999.
  2. Barrington WW, Angle CR, Willcockson NK, et al. Autonomic function in manganese alloy workers. Environ Res 1998;78:50-8. PubMed
  3. Hauser RA, Zesiewicz TA, Martinez C, et al. Blood manganese correlates with brain magnetic resonance imaging changes in patients with liver disease. Can J Neurol Sci 1996;23:95-8. PubMed
  4. Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Vitamin A, Vitamin K, Arsenic, Boron, Chromium, Copper, Iodine, Iron, Manganese, Molybdenum, Nickel, Silicon, Vanadium, and Zinc. Washington, DC: National Academy Press, 2002.
  5. Lee JW. Manganese intoxication. Arch Neurol 2000;57:597-9.. PubMed
  6. Powers KM, Smith-Weller T, Franklin GM, et al. Parkinson's disease risks associated with dietary iron, manganese, and other nutrient intakes. Neurology 2003;60:1761-6.. PubMed
  7. McMillan, D. E. A brief history of the neurobehavioral toxicity of manganese: some unanswered questions. Neurotoxicology 1999;20(2-3):499-507.
  8. Gerber, G. B., Leonard, A., and Hantson, P. Carcinogenicity, mutagenicity and teratogenicity of manganese compounds. Crit Rev Oncol Hematol. 2002;42(1):25-34. PubMed
  9. Jiang, Y. and Zheng, W. Cardiovascular toxicities upon manganese exposure. Cardiovasc.Toxicol 2005;5(4):345-354. PubMed
  10. Mehta, R. and Reilly, J. J. Manganese levels in a jaundiced long-term total parenteral nutrition patient: potentiation of haloperidol toxicity? Case report and literature review. JPEN J Parenter.Enteral Nutr 1990;14(4):428-430. PubMed
  11. Nemery, B. Metal toxicity and the respiratory tract. Eur Respir.J 1990;3(2):202-219. DOI
  12. Vanek VW, Borum P, Buchman A, et al. A.S.P.E.N. position paper: recommendations for changes in commercially available parenteral multivitamin and multi-trace element products. Nutr Clin Pract. 2012;27:440-491.doi: 10.1177/0884533612446706 PubMed
  13. Schuh MJ. Possible Parkinson's disease induced by chronic manganese supplement ingestion. Consult Pharm. 2016;31(12):698-703. doi: 10.4140/TCP.n.2016.698. PubMed
  14. Baker B, Ali A, Isenring L. Recommendations for manganese supplementation to adult patients receiving long-term home parenteral nutrition: an analysis of the supporting evidence. Nutr Clin Pract 2016;31(2):180-5. doi: 10.1177/0884533615591600. PubMed
  15. Ho CSH, Ho RCM, Quek AML. Chronic manganese toxicity associated with voltage-gated potassium channel complex antibodies in a relapsing neuropsychiatric disorder. Int J Environ Res Public Health 2018;15(4). pii: E783. doi: 10.3390/ijerph15040783. PubMed
  16. Yamamoto M, Sakurai K, Eguchi A, et al.; Japan Environment and Children's Study Group: Association between blood manganese level during pregnancy and birth size: the Japan environment and children's study (JECS). Environ Res 2019;172:117-26. PubMed
  17. Li D, Ge X, Liu Z, et al. Association between long-term occupational manganese exposure and bone quality among retired workers. Environ Sci Pollut Res Int 2020;27(1):482-9. PubMed
  18. Martin KV, Sucharew H, Dietrich KN, et al. Co-exposure to manganese and lead and pediatric neurocognition in East Liverpool, Ohio. Environ Res 2021;202:111644. PubMed
  19. Racette BA, Nelson G, Dlamini WW, et al. Depression and anxiety in a manganese-exposed community. Neurotoxicology 2021;85:222-33. PubMed
  20. Ruiz-Azcona L, Fernández-Olmo I, Expósito A, et al. Impact of environmental airborne manganese exposure on cognitive and motor functions in adults: a systematic review and meta-analysis. Int J Environ Res Public Health 2021;18(8):4075. PubMed
  21. Uyar E, Gurkas E, Aksu AU, et al. Can therapeutic plasma exchange be life-saving in life-threatening manganese intoxication?. Transfus Apher Sci 2022;61(4):103417. PubMed

See these in context on the Manganese monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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