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Dietary supplement

Choline Bitartrate Ingredients & Drug Interactions

by Hard Rhino

Choline Bitartrate label
See full label image
Powder Category: Vitamin
Most serious interaction: Minor
Clinical methodology reviewed by · Updated Sep 9, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Choline Bitartrate against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Minor

Choline Bitartrate is a dietary supplement by Hard Rhino with 1 active ingredient. Its ingredients are commonly taken for liver health and fatty liver, brain and memory support, prenatal nutrition and fetal development.Based on those ingredients, 16 medications have a known interaction with it, the most serious rated minor. The ingredients most likely to interact are Choline Bitartrate. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Choline Bitartrate by Hard Rhino

Ask about any prescription or over-the-counter medication and we check it for interactions with Choline Bitartrate by Hard Rhino — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Choline Bitartrate by Hard Rhino

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 16, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains one active ingredient: choline bitartrate, a form of choline — a nutrient your body uses to support brain function, cell structure, and other processes. The product comes as a powder with no inactive ingredients listed.

Does it work?

Couldn't assess
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not assessable

This is a single-ingredient Choline product and its label doesn't state a use — see Choline's own graded uses on its monograph.

Why this rating?
  • We looked at the product name, claims, and label statements and couldn't find a stated purpose to grade.

The evidence for choline bitartrate is mixed. For athletic performance, it's rated possibly ineffective.

For other uses — Alzheimer disease, age-related cognitive decline, allergic rhinitis, bronchitis, and a liver condition related to nutrition support (TPN-associated hepatic steatosis) — we don't have enough reliable evidence to say whether it works. If you're considering it for a specific purpose, talk with your doctor or pharmacist about what the current data actually shows.

The evidence, ingredient by ingredient Choline

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Choline is generally well tolerated at food-level amounts, but high-dose supplements have limits and can cause side effects. Above the upper safe limit of 3.5 grams daily, it may cause fishy body odor, and at doses of 9 grams or higher, you might experience nausea, vomiting, diarrhea, sweating, or salivation.

Choline is important during pregnancy and while breastfeeding, but you should use supplement doses only as your doctor advises — don't self-dose, since your needs change during these times.

Side effects, ingredient by ingredient Choline

Meds to double-check

Minor interactions only
Known Interaction Concern · database check
Minor only

Only Minor-severity interactions are documented for these ingredients.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Choline.
  • The most serious interaction on file is rated Minor.
  • For scale: 16 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Minor interaction documented with atropine — choline may reduce its brain-level effects. If you take atropine, confirm with your doctor or pharmacist before starting choline.

No other medication interactions are documented in our data for the ingredients we could check.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no assessable stated purpose. Only minor medication interactions are documented, and safety information is well characterized.

Choline bitartrate is a single-ingredient supplement generally well tolerated at moderate doses, though evidence for most claimed benefits is thin or absent. If you take atropine or other medications, double-check before starting.

Pregnant or breastfeeding women should talk with their doctor or pharmacist about the right choline approach for them — don't guess at the dose on your own.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Mar 24, 2017.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Choline Bitartrate, straight from the product label.

Brand Hard Rhino
Barcode (UPC) 798711500222
Net contents 5 kg; 11 lbs
Market status On market
Date entered into DSLD Mar 24, 2017
DSLD ID 71869
Product type Vitamin
Supplement form Powder
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), No Allergies, Gluten Free, Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Choline Bitartrate by Hard Rhino, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
0.55 Gram(s)
Maximum serving Sizes:
0.55 Gram(s)
Servings per container
9090
UPC/BARCODE
798711500222
IngredientAmount% DV
Choline Bitartrate550 mg--

Other ingredients: None

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formulation

-Non-GMO -Gluten free -Allergen free

Allergens: This product contains no soy, dairy, dairy byproducts, eggs, shellfish, wheat, gluten, tree nuts, or sesame seeds.

General Statements

Bulk pail - Best value - Scoop inside - 9090 servings

Suggested/Recommended/Usage/Directions

Suggested Use: As a dietary supplement, take 1 rounded scoop (~550 mg) with 8-12 ounces of water or suitable beverage. Taken 1-3 times daily or as recommended by your qualified health professional.

Storage: Store in a cool, dry place. Re-seal zipper immediately after use to preserve freshness.

FDA Disclaimer Statement

These statements have not been evaluated by the Food & Drug Administration. This product is not intended to diagnose, treat, cure or prevent any diseases.

Precautions

Warning: Keep out of the reach of children. Do not take this or any other supplement if under the age of 18, pregnant or nursing a baby, or if you have any known or suspected medical conditions and/or taking prescription drug(s) or OTC medication(s).

Do not take this or any other supplement if under the age of 18, pregnant or nursing a baby, or if you have any known or suspected medical conditions and/or taking prescription drug(s) or OTC medication(s).

Always consult with a qualified health physician before taking any new dietary supplement.

Do not use or consume if seal is broken.

FDA Statement of Identity

Dietary Supplement

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Choline Bitartrate by Hard Rhino label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Choline Bitartrate label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Choline Bitartrate by Hard Rhino

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size0.55 Gram(s) Dosage formPowder Servings per container9090 Amounts shown are per serving.

Choline Bitartrate

Interacts with
16 drugs
550 mg per serving

Choline is an essential nutrient your body needs for liver function, brain health, and nerve signaling, and many people get enough from foods like egg...

Choline Bitartrate monograph & interactions

Other (inactive) ingredients: None. These complete the product’s ingredient list but are not active constituents.

Interaction report

Choline Bitartrate by Hard Rhino Drug Interactions

Want to check YOUR meds against Choline Bitartrate?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
16Drugs
16 Minor

Ingredients driving the most interactions

Choline Bitartrate 16

Individual Drug Interactions

The ingredients in Choline Bitartrate interact with 16 drugs. Click any drug to see the details.

1 of the 1 ingredient in Choline Bitartrate interact with drugs. Each result below shows which ingredient is responsible. Choline Bitartrate

Each ingredient & the kinds of drugs it affects

For each ingredient in Choline Bitartrate with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Choline Bitartrate1 drug type · 16 drugs

Atropine

Theoretically, choline might decrease the effects of atropine in the brain.
Animal research shows that administering choline one hour before administering atropine can attenuate atropine-induced decreases in brain levels of acetylcholine. Theoretically, concomitant use of choline and atropine may decrease the effects of atropine.

Likelihood Possible Evidence D
Choline Bitartrate full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Choline Bitartrate, from the product label.

Hard Rhino

See all Hard Rhino products
Name
Guardian Wholesale
City
Phoenix
State
AZ
ZipCode
85085
Phone Number
(866)961-8378
Web Address
HardRhino.com
Pharmacist Counseling Corner

Choline Bitartrate by Hard Rhino: Common Questions

Does Choline Bitartrate by Hard Rhino interact with any medications?
Yes. Based on its ingredients, Choline Bitartrate has a known interaction with 16 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Choline Bitartrate contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Is choline safe to take every day?
At recommended doses, choline is generally well tolerated. However, the upper safe limit is 3.5 grams daily; doses above that carry risk of side effects like nausea, diarrhea, and fishy body odor. Stay within that limit and talk with your pharmacist about what's right for your situation.
Can I take this while pregnant or breastfeeding?
Choline is important during both pregnancy and breastfeeding, but you should use supplements only as your doctor advises rather than picking your own dose. Your nutrient needs change during these times, so get personalized guidance.
Does choline really boost athletic performance?
The evidence we have rates choline as possibly ineffective for athletic performance, so it's not a proven sports supplement. If that's your goal, talk with your doctor or trainer about options with stronger evidence behind them.
What side effects might I get from choline?
At high doses — 9 grams daily or more — choline can cause nausea, vomiting, diarrhea, salivation, and sweating. A common side effect even at lower high doses is a fishy body odor from how your gut metabolizes it. Stick to the 3.5-gram daily upper limit to minimize risk.
Is this the same as lecithin?
No. Choline bitartrate is pure choline, while lecithin is a fat that contains choline. Lecithin also carries choline-related side effects — large lecithin doses have caused diarrhea and fecal incontinence — but they're different products.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Choline Bitartrate label
Go deeper

The Full Monographs Behind Choline Bitartrate’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Choline

Interacts with 16 drugs

Choline is an essential nutrient your body needs for liver function, brain health, and nerve signaling, and many people get enough from foods like eggs, meat, and fish. Supplements may help...

Read the full Choline monograph →
Sources

Sources & How We Checked

Choline Bitartrate's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 14 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Choline 14 references
  1. Yates AA, Schlicker SA, Suitor CW. Dietary reference intakes: The new basis for recommendations for calcium and related nutrients, B vitamins, and choline. J Am Diet Assoc 1998;98:699-706. PubMed
  2. Cho E, Willett WC, Colditz GA, et al. Dietary choline and betaine and the risk of distal colorectal adenoma in women. J Natl Cancer Inst 2007;99:1224-31. PubMed
  3. Schmidt, C., Abicht, A., Krampfl, K., Voss, W., Stucka, R., Mildner, G., Petrova, S., Schara, U., Mortier, W., Bufler, J., Huebner, A., and Lochmuller, H. Congenital myasthenic syndrome due to a novel missense mutation in the gene encoding choline acetyl
  4. Tamminga, C., Smith, R. C., Chang, S., Haraszti, J. S., and Davis, J. M. Depression associated with oral choline. Lancet 10-23-1976;2(7991):905. PubMed
  5. Wood, J. L. and Allison, R. G. Effects of consumption of choline and lecithin on neurological and cardiovascular systems. Fed.Proc. 1982;41(14):3015-3021.
  6. Growdon, J. H. and Gelenberg, A. J. Choline and lecithin administration to patients with tardive dyskinesia. Trans.Am.Neurol.Assoc. 1978;103:95-99.
  7. Smith, C. M., Swash, M., Exton-Smith, A. N., Phillips, M. J., Overstall, P. W., Piper, M. E., and Bailey, M. R. Choline therapy in Alzheimer's disease. Lancet 8-5-1978;2(8084):318. PubMed
  8. Morrison, L. M. and W. F. Gonzales. Choline in coronary atherosclerosis. Amer.Heart J. 1950;39:729.
  9. Christie, J. G. Blackburn 1. M. Glen A. I. M. Zeisel S. Shering A. & Yates C. M. Effects of choline and lecithin on CSF choline levels and on cognitive functioning in patients with presenile dementia of the Alzheimer type. Nutrition and the brain 1979;5
  10. Sidhu N, Davies S, Nadarajah A, et al. Oral choline supplementation for postoperative pain. Br J Anaesth 2013;111(2):249-55. PubMed
  11. Wozniak JR, Fuglestad AJ, Eckerle JK, et al. Choline supplementation in children with fetal alcohol spectrum disorders has high feasibility and tolerability. Nutr Res. 2013;33(11):897-904. PubMed
  12. Wozniak JR, Fuglestad AJ, Eckerle JK, et al. Choline supplementation in children with fetal alcohol disorders: a randomized, double-blind, placebo-controlled trial. Am J Clin Nutr. 2015;102(5): 1113-25.
  13. Ross RG, Hunter SK, McCarthy L, et al. Perinatal choline effects on neonatal pathophysiology related to later schizophrenia risk. Am J Psychiatry. 2013;170(3):290-8. PubMed
  14. Food and Nutrition Board, Institute of Medicine. Choline. Dietary Reference Intakes: Thiamin, Riboflavin, Niacin, Vitamin B-6, Vitamin B-12, Pantothenic Acid, Biotin, and Choline. Washington D.C.: National Academy Press; 1998:390-422.

See these in context on the Choline monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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