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Dietary supplement

Cissus Ingredients & Drug Interactions

by Absonutrix

Cissus label
See full label image
Capsule Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 30, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Cissus against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Cissus is a dietary supplement by Absonutrix with 1 active ingredient. Its ingredients are commonly taken for bone fracture healing, joint pain and bone health, weight management.Based on those ingredients, 86 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Cissus quadrangularis Stem Extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Cissus by Absonutrix

Ask about any prescription or over-the-counter medication and we check it for interactions with Cissus by Absonutrix — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Cissus by Absonutrix

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

Cissus by Absonutrix is a single-ingredient product: Cissus quadrangularis stem extract. That's the active ingredient doing the work.

The capsule also contains inactive ingredients—cellulose, maltodextrin, gellan gum, and magnesium stearate—which are fillers, binders, and capsule materials that help deliver the extract.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use — see Cissus Quadrangularis's own graded uses on its monograph.

Why this rating?
  • The label markets this product for: Bone and joint health support.
  • We looked for evidence on: Fractures, Joint pain, Osteopenia, Osteoporosis, Rheumatoid arthritis (RA), Bone density — and 1 related terms.
  • The closest evidence on file: Cissus Quadrangularis is rated "Insufficient Reliable Evidence To Rate" for Osteopenia (Natural Medicines).
  • Also on file: Cissus Quadrangularis is rated "Insufficient Reliable Evidence To Rate" for Fractures, Osteoporosis, Joint pain, Rheumatoid arthritis (RA).

Cissus quadrangularis is possibly effective for obesity, based on the evidence we have on file. For other uses—high cholesterol (hyperlipidemia), weak bones (osteopenia), cancer, and epilepsy—the evidence isn't strong enough yet to rate it.

That doesn't mean it doesn't work; it means we don't have reliable data to say one way or the other.

The evidence, ingredient by ingredient Cissus Quadrangularis

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Cissus quadrangularis is generally well tolerated in short-term use. The most common side effects reported in trials—headache, insomnia, flatulence, diarrhea, gastritis, and dry mouth—occurred at rates similar to or lower than placebo, so they're fairly mild and uncommon.

The catch: long-term safety hasn't been well studied, so we don't know what happens if you take it for months or years. If you're pregnant or breastfeeding, the safety data is too thin to know either way.

Talk with your doctor or pharmacist before using this product—they can weigh the pros and cons for your situation.

Side effects, ingredient by ingredient Cissus Quadrangularis

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Cissus Quadrangularis.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: diabetes medications.
  • For scale: 86 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before you start Cissus, double-check if you take any antidiabetes drugs—insulin, metformin, sulfonylureas, or any other medication to lower blood sugar. The extract may increase your risk of low blood sugar when combined with these medications.

Your pharmacist can help you figure out whether it's safe for you or if monitoring is needed.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and safety information is well characterized.

If you're dealing with overweight or obesity and don't take antidiabetes medication, Cissus quadrangularis is worth asking your pharmacist about. If you do take blood sugar medication, check with your pharmacist or doctor first—the interaction is manageable but real.

Long-term safety is still an open question, so this is best thought of as a short-term option for now.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Jan 23, 2025.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Cissus, straight from the product label.

Brand Absonutrix
Barcode (UPC) 661799986724
Net contents 120 Capsule(s)
Market status On market
Date entered into DSLD Jan 23, 2025
DSLD ID 322346
Product type Botanical
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Women (not pregnant or lactating)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Cissus by Absonutrix, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
2 Capsule(s)
Maximum serving Sizes:
2 Capsule(s)
Servings per container
60
UPC/BARCODE
661799986724
IngredientAmount% DV
Cissus quadrangularis Stem Extract1600 mg--

Other ingredients: Cellulose, Maltodextrin, Gellan Gum, Magnesium Stearate

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions

Suggested use: as a dietary supplement, take 2 capsules with breakfast and dinner.

Precautions

Caution: this product is only intended to be consumed by healthy adults 18 years of age or older.

Pregnant women should not use this product. Consult your healthcare provider before using this product, especially if you are taking any prescription, over the counter medication, dietary supplement products or if you have any pre-existing medical condition including but not limited to: high or low blood pressure, cardiac arrhythmia, stroke, heart, liver, kidney or thyroid disease, seizure disorder, psychiatric disease, diabetes, difficulty urinating due to prostate enlargement or if you are taking MAO-B Inhibitor or any other medication.

Discontinue use if you experience any adverse reaction to this product. Do not exceed recommended serving.

Keep out of the reach of children.

Do not use if safety seal is damaged or missing.

Seals/Symbols

Made in USA

General Statements

Please recycle.

Formulation

Maximum strength Highest quality Made in the USA!

Does not contain: shellfish, glucosamine, chondroitin, or MSM.

Formula

Contains Cissus stem

FDA Statement of Identity

Dietary Supplement

Storage

Store in a cool, dry place, away from direct light.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Cissus by Absonutrix label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Cissus label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Cissus by Absonutrix

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size2 Capsule(s) Dosage formCapsule Servings per container60 Amounts shown are per serving.

Cissus quadrangularis Stem Extract

Interacts with
86 drugs
1600 mg per serving

Cissus quadrangularis is a traditional vine used mainly for bone health, joint pain, and weight management. Most of the supporting evidence comes from...

Cissus quadrangularis Stem Extract monograph & interactions

Other (inactive) ingredients: Cellulose, Maltodextrin, Gellan Gum, Magnesium Stearate. These complete the product’s ingredient list but are not active constituents.

Interaction report

Cissus by Absonutrix Drug Interactions

Want to check YOUR meds against Cissus?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
86Drugs
86 Moderate

Ingredients driving the most interactions

Cissus quadrangularis Stem Extract 86

Individual Drug Interactions

The ingredients in Cissus interact with 86 drugs. Click any drug to see the details.

1 of the 1 ingredient in Cissus interact with drugs. Each result below shows which ingredient is responsible. Cissus quadrangularis Stem Extract

Each ingredient & the kinds of drugs it affects

For each ingredient in Cissus with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Cissus quadrangularis Stem Extract1 drug type · 86 drugs

Antidiabetes Drugs

Theoretically, Cissus quadrangularis might increase the risk of hypoglycemia when taken with antidiabetes drugs.
Small clinical studies suggest that Cissus quadrangularis might reduce fasting blood glucose in individuals with overweight or obesity.

Likelihood Possible Evidence D
Cissus quadrangularis Stem Extract full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Cissus, from the product label.

Absonutrix

See all Absonutrix products
Name
Absonutrix
Street Address
8905 West Market Street
City
Colfax
State
NC
ZipCode
27235
Phone Number
1-855-368-8749
Web Address
www.absonutrix.com
Pharmacist Counseling Corner

Cissus by Absonutrix: Common Questions

Does Cissus by Absonutrix interact with any medications?
Yes. Based on its ingredients, Cissus has a known interaction with 86 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Cissus contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Does Cissus really work for weight loss?
The evidence says it's possibly effective for obesity. Small studies suggest it can help reduce body weight in people who are overweight, but the data isn't huge yet. Talk to your pharmacist about realistic expectations and whether it fits your plan.
What side effects should I watch for?
Headache, insomnia, flatulence, diarrhea, gastritis, and dry mouth have been reported, but they show up about as often as placebo in trials—meaning they're uncommon and usually mild. Most people tolerate it well in the short term.
Is it safe to take long-term?
We don't have good long-term safety data yet. It's been studied mainly in short-term trials, so if you're thinking of taking it for months, talk to your pharmacist about what we do and don't know.
Can I take it if I'm pregnant or breastfeeding?
There isn't enough safety data to say whether it's okay, so it's best avoided during pregnancy and while breastfeeding. Talk with your doctor or pharmacist about what's right for you.
What is Cissus quadrangularis, exactly?
It's a plant extract from the Cissus quadrangularis vine. This product uses the stem extract, which has been used in traditional medicine and studied for effects on weight and metabolism.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Cissus label
Go deeper

The Full Monographs Behind Cissus’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Cissus Quadrangularis

Interacts with 86 drugs

Cissus quadrangularis is a traditional vine used mainly for bone health, joint pain, and weight management. Most of the supporting evidence comes from animal studies and a small number of hu...

Read the full Cissus Quadrangularis monograph →
Sources

Sources & How We Checked

Cissus's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 5 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Cissus Quadrangularis 5 references
  1. Oben J, Kuate D, Agbor G, et al. The use of a Cissus quadrangularis formulation in the management of weight loss and metabolic syndrome. Lipids Health Dis 2006, 5:24.
  2. Oben JE, Ngondi JL, Momo CN, et al. The use of Cissus quadrangularis/Irvingia gabonensis combination in the management of weight loss: a double-blind placebo-controlled study. Lipids Health Dis 2008;7:12.
  3. Panpimanmas, S., Sithipongsri, S., Sukdanon, C., and Manmee, C. Experimental comparative study of the efficacy and side effects of Cissus quadrangularis L. (Vitaceae) to Daflon (Servier) and placebo in the treatment of acute hemorrhoids. J Med Assoc.Thai
  4. Nash R, Azantsa B, Kuate D, Singh H, Oben J. The use of a stem and leaf aqueous extract of Cissus quadrangularis (CQR-300) to reduce body fat and other components of metabolic syndrome in overweight participants. J Altern Complement Med. 2019;25(1):98-106
  5. Benjawan S, Nimitphong H, Tragulpiankit P, Musigavong O, Prathanturarug S, Pathomwichaiwat T. The effect of Cissus quadrangularis L. on delaying bone loss in postmenopausal women with osteopenia: A randomized placebo-controlled trial. Phytomedicine 2022;1 PubMed

See these in context on the Cissus Quadrangularis monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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