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Dietary supplement

Cissus quadrangularis 1000 mg Capsules Ingredients & Drug Interactions

by BulkSupplements.com

Cissus quadrangularis 1000 mg Capsules label
See full label image
Capsule Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Cissus quadrangularis 1000 mg Capsules against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Cissus quadrangularis 1000 mg Capsules is a dietary supplement by BulkSupplements.com with 1 active ingredient. Its ingredients are commonly taken for bone fracture healing, joint pain and bone health, weight management.Based on those ingredients, 86 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Cissus quadrangularis Aerial Parts Extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Cissus quadrangularis 1000 mg Capsules by BulkSupplements.com

Ask about any prescription or over-the-counter medication and we check it for interactions with Cissus quadrangularis 1000 mg Capsules by BulkSupplements.com — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Cissus quadrangularis 1000 mg Capsules by BulkSupplements.com

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 16, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains one active ingredient: Cissus quadrangularis Aerial Parts Extract at 1000 mg per capsule. The capsule itself is made from bovine gelatin (a binder and capsule material).

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed

This product doesn't appear to be marketed for a specific use, so we graded Cissus Quadrangularis's overall clinical evidence instead.

Moderate

Some clinical evidence supports Cissus Quadrangularis for:

Why this rating?
  • We looked at the product name, claims, and label statements and couldn't find a stated purpose to grade.
  • Since the label doesn't commit to one use, we graded the ingredient's overall clinical evidence instead.
  • On file: Obesity — rated "Possibly Effective" (Natural Medicines).

The extract is possibly effective for obesity — small studies suggest it may help reduce fasting blood glucose in people who are overweight or obese. For high cholesterol (hyperlipidemia), bone density loss (osteopenia), cancer, and epilepsy, the evidence we have is insufficient to rate whether it works.

You'd want to talk with your doctor about whether it's a good fit for your specific situation.

The evidence, ingredient by ingredient Cissus Quadrangularis

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Cissus quadrangularis is generally well tolerated in short-term use, though long-term safety hasn't been well studied. In clinical trials, some people reported headache, insomnia, flatulence, diarrhea, gastritis, and dry mouth — but these occurred at rates similar to or lower than placebo, so they're not a major concern.

The safety data advises against use during pregnancy and breastfeeding because there isn't enough information to know either way. If you're pregnant, nursing, or planning to become pregnant, talk with your doctor or pharmacist before starting.

Side effects, ingredient by ingredient Cissus Quadrangularis

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Cissus Quadrangularis.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: diabetes medications.
  • For scale: 86 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

If you take antidiabetes drugs, check your exact medications with the tool on this page before starting — Cissus quadrangularis may increase the risk of low blood sugar when combined with them.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with some supporting evidence behind its ingredients' uses. Moderate medication interactions have been identified, and safety information is well characterized.

Cissus quadrangularis may help with weight management and blood glucose, but it can interact with diabetes medications. If you take a diabetes drug, check your specific medications before starting and discuss it with your doctor or pharmacist.

It's generally well tolerated short-term, but isn't recommended in pregnancy or breastfeeding.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Apr 23, 2024.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Cissus quadrangularis 1000 mg Capsules, straight from the product label.

Brand BulkSupplements.com
Barcode (UPC) X003CQYOPH
Net contents 120 Capsule(s)
Market status On market
Date entered into DSLD Apr 23, 2024
DSLD ID 312874
Product type Botanical
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Gluten Free, Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Cissus quadrangularis 1000 mg Capsules by BulkSupplements.com, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
2 Capsule(s)
Maximum serving Sizes:
2 Capsule(s)
Servings per container
60
UPC/BARCODE
X003CQYOPH
IngredientAmount% DV
Cissus quadrangularis Aerial Parts Extract1000 mg--

Other ingredients: Bovine Gelatin

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formula

Cissus quadrangularis 1000 mg per serving

Suggested/Recommended/Usage/Directions

Suggested use: As a dietary supplement, take 2 capsules once daily, or as directed by a physician.

FDA Disclaimer Statement

Warning: This product is not intended to diagnose, treat, cure, or prevent any disease.

Precautions

Always consult a physician before taking any dietary supplement.

Keep out of reach of children.

Formulation

Free of: Added sugar, soy, dairy, gluten, additives

Storage

Store in a dry, cool place

General Statements

New Scan me

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Cissus quadrangularis 1000 mg Capsules by BulkSupplements.com label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Cissus quadrangularis 1000 mg Capsules label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Cissus quadrangularis 1000 mg Capsules by BulkSupplements.com

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size2 Capsule(s) Dosage formCapsule Servings per container60 Amounts shown are per serving.

Cissus quadrangularis Aerial Parts Extract

Interacts with
86 drugs
1000 mg per serving

Cissus quadrangularis is a traditional vine used mainly for bone health, joint pain, and weight management. Most of the supporting evidence comes from...

Cissus quadrangularis Aerial Parts Extract monograph & interactions

Other (inactive) ingredients: Bovine Gelatin. These complete the product’s ingredient list but are not active constituents.

Interaction report

Cissus quadrangularis 1000 mg Capsules by BulkSupplements.com Drug Interactions

Want to check YOUR meds against Cissus quadrangularis 1000 mg Capsules?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
86Drugs
86 Moderate

Ingredients driving the most interactions

Cissus quadrangularis Aerial Parts Extract 86

Individual Drug Interactions

The ingredients in Cissus quadrangularis 1000 mg Capsules interact with 86 drugs. Click any drug to see the details.

1 of the 1 ingredient in Cissus quadrangularis 1000 mg Capsules interact with drugs. Each result below shows which ingredient is responsible. Cissus quadrangularis Aerial Parts Extract

Each ingredient & the kinds of drugs it affects

For each ingredient in Cissus quadrangularis 1000 mg Capsules with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Cissus quadrangularis Aerial Parts Extract1 drug type · 86 drugs

Antidiabetes Drugs

Theoretically, Cissus quadrangularis might increase the risk of hypoglycemia when taken with antidiabetes drugs.
Small clinical studies suggest that Cissus quadrangularis might reduce fasting blood glucose in individuals with overweight or obesity.

Likelihood Possible Evidence D
Cissus quadrangularis Aerial Parts Extract full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Cissus quadrangularis 1000 mg Capsules, from the product label.

BulkSupplements.com

See all BulkSupplements.com products
Name
BulkSupplements.com
Street Address
7511 Eastgate Rd
City
Henderson
State
NV
ZipCode
89011
Web Address
BulkSupplements.com
Pharmacist Counseling Corner

Cissus quadrangularis 1000 mg Capsules by BulkSupplements.com: Common Questions

Does Cissus quadrangularis 1000 mg Capsules by BulkSupplements.com interact with any medications?
Yes. Based on its ingredients, Cissus quadrangularis 1000 mg Capsules has a known interaction with 86 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Cissus quadrangularis 1000 mg Capsules contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this if I have diabetes?
Not without talking to your doctor first. This supplement may lower blood glucose on its own, and when combined with diabetes medications, it could raise the risk of low blood sugar (hypoglycemia). Your doctor or pharmacist needs to review your specific diabetes drug before you start.
Is it safe during pregnancy?
The safety data advises against it — there isn't enough information to know whether it's safe for you or the baby. Talk with your doctor or pharmacist if you're pregnant or planning to become pregnant.
Is it safe while breastfeeding?
The safety data advises against it because there isn't enough information to know if it passes into milk or how it might affect an infant. Talk with your doctor or pharmacist if you're nursing.
What side effects might I notice?
In clinical trials, headache, insomnia, flatulence, diarrhea, gastritis, and dry mouth were reported, but at rates no higher than placebo. They're not expected to be a major concern in short-term use.
Does it really work for weight loss?
For obesity it's rated possibly effective — small studies suggest it may help lower fasting blood glucose in people who are overweight or obese. But the evidence is modest, and long-term effects aren't well studied.
How long can I safely take this?
Short-term use appears generally well tolerated, but long-term safety hasn't been well studied. Talk with your doctor about how long it's appropriate for you to use it.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Cissus quadrangularis 1000 mg Capsules is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Cissus quadrangularis 1000 mg Capsules label
Go deeper

The Full Monographs Behind Cissus quadrangularis 1000 mg Capsules’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Cissus Quadrangularis

Interacts with 86 drugs

Cissus quadrangularis is a traditional vine used mainly for bone health, joint pain, and weight management. Most of the supporting evidence comes from animal studies and a small number of hu...

Read the full Cissus Quadrangularis monograph →
Sources

Sources & How We Checked

Cissus quadrangularis 1000 mg Capsules's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 5 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Cissus Quadrangularis 5 references
  1. Oben J, Kuate D, Agbor G, et al. The use of a Cissus quadrangularis formulation in the management of weight loss and metabolic syndrome. Lipids Health Dis 2006, 5:24.
  2. Oben JE, Ngondi JL, Momo CN, et al. The use of Cissus quadrangularis/Irvingia gabonensis combination in the management of weight loss: a double-blind placebo-controlled study. Lipids Health Dis 2008;7:12.
  3. Panpimanmas, S., Sithipongsri, S., Sukdanon, C., and Manmee, C. Experimental comparative study of the efficacy and side effects of Cissus quadrangularis L. (Vitaceae) to Daflon (Servier) and placebo in the treatment of acute hemorrhoids. J Med Assoc.Thai
  4. Nash R, Azantsa B, Kuate D, Singh H, Oben J. The use of a stem and leaf aqueous extract of Cissus quadrangularis (CQR-300) to reduce body fat and other components of metabolic syndrome in overweight participants. J Altern Complement Med. 2019;25(1):98-106
  5. Benjawan S, Nimitphong H, Tragulpiankit P, Musigavong O, Prathanturarug S, Pathomwichaiwat T. The effect of Cissus quadrangularis L. on delaying bone loss in postmenopausal women with osteopenia: A randomized placebo-controlled trial. Phytomedicine 2022;1 PubMed

See these in context on the Cissus Quadrangularis monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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