Interactions on record — worth a quick check against your medications. Based on 7 of 16 ingredients. Check your meds →
Dietary supplement

Complete-GI Unflavored Ingredients & Drug Interactions

by PEScience

Complete-GI Unflavored label
See full label image
Powder Category: Other Combinations
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 23, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Complete-GI Unflavored against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Complete-GI Unflavored is a dietary supplement by PEScience with 16 active ingredients. Its ingredients are commonly taken for muscle recovery and sports performance, gut health and 'leaky gut', recovery from severe illness or injury.Based on those ingredients, 2,088 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Dietary Fiber, LactoSpore, Zinc. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against Complete-GI Unflavored by PEScience

Ask about any prescription or over-the-counter medication and we check it for interactions with Complete-GI Unflavored by PEScience — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of Complete-GI Unflavored by PEScience

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 4 of its 16 active ingredients.
  • “BioCore Optimum Complete” is listed as a grouped ingredient — the label gives one combined amount (110 mg) without saying how much of each component you get.

Complete-GI Unflavored is a digestive enzyme blend with 15 active and inactive ingredients. The main players are L-glutamine (an amino acid that supports gut health), digestive enzymes (protease, lipase, and amylase to break down proteins, fats, and carbs), lactase (for dairy digestion), alpha-galactosidase (for complex carbs and fiber fermentation), LactoSpore (a shelf-stable probiotic strain), zinc, and oat fiber.

The inactive ingredients are silicon dioxide and calcium silicate, which are fillers and flow agents common in powder supplements.

Does it work?

Strong evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Strong

Clinical evidence supports at least one of this product's ingredients for its stated purpose.

Why this rating?
  • The label markets this product for: Gut health support.
  • We looked for evidence on: Antibiotic-associated diarrhea, Constipation, Crohn disease, Diarrhea, Dyspepsia, Flatulence — and 4 related terms.
  • The strongest evidence on file: Black Psyllium is rated "Effective" for Constipation (Natural Medicines).
  • Also on file: Bacillus Coagulans is rated "Possibly Effective" for Constipation.
  • Also on file: Glutamine is rated "Possibly Ineffective" for Crohn disease, Radiation-induced diarrhea.

L-glutamine is effective for sickle cell disease and possibly effective for HIV/AIDS-related wasting, postoperative recovery, and trauma recovery. Lactase is effective for lactose intolerance.

LactoSpore is possibly effective for constipation and irritable bowel syndrome (IBS). Zinc is effective for zinc deficiency and likely effective for Wilson disease; it's possibly effective for acne, age-related macular degeneration, and diabetes.

The evidence for protease, lipase, and several enzymes (invertase, glucoamylase, alpha-galactosidase) is insufficient to rate them for conditions like inflammatory bowel disease or indigestion—we simply don't have enough reliable data on them.

The evidence, ingredient by ingredient Glutamine Black Psyllium Proteolytic Enzymes (proteases) Lipase Lactase Bacillus Coagulans Zinc

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 7 of the 7 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 7 of 7.
  • General safety write-ups exist for 7 of 7.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Most of these ingredients are generally well tolerated in healthy adults. L-glutamine can cause belching, bloating, constipation, diarrhea, flatulence, nausea, and gas—especially at higher doses (10–30 grams daily).

People with kidney or liver disease should use L-glutamine only under medical supervision. Zinc is well tolerated below 40 mg daily but can cause nausea, metallic taste, diarrhea, and cramping at higher doses.

Protease may trigger allergic reactions or digestive upset in sensitive people. LactoSpore is generally well tolerated but comes with a theoretical risk of infection in severely ill or immunocompromised patients (rare).

L-glutamine and lactase are likely safe in pregnancy; lipase and protease have limited safety data, so check with your doctor first. During breastfeeding, avoid L-glutamine and protease supplements unless advised by a clinician, use lipase and lactase only with medical approval, and check with your provider about zinc and LactoSpore.

Side effects, ingredient by ingredient Glutamine Black Psyllium Proteolytic Enzymes (proteases) Lipase Lactase Bacillus Coagulans Zinc

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 4 of the 7 matched ingredients can interact with medications — Black Psyllium, Glutamine, Zinc, Bacillus Coagulans.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: seizure medications; heart-rhythm medications; lithium.
  • For scale: 2,089 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Check any anticonvulsant (seizure) medications you take with your pharmacist—L-glutamine's theoretical interaction is Moderate severity. Antibiotics (especially quinolones, tetracyclines, and cephalexin) must be separated from zinc by at least 2–6 hours.

HIV medications (ritonavir and integrase inhibitors) interact with zinc at Moderate severity. Antibiotic drugs may reduce the effectiveness of LactoSpore; space doses apart if possible.

If you take any prescription medication, use the interaction checker below before you start.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with clinical evidence supporting its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

This supplement is aimed at digestive support and may help with lactose intolerance, IBS, and constipation if the probiotics and enzymes are right for you. It's well tolerated by most people but requires careful timing if you take antibiotics, seizure medications, or HIV drugs.

If you have kidney or liver disease, are severely ill, or are pregnant or breastfeeding, talk to your doctor or pharmacist before starting. Run your medications through the interaction checker on this page.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 10 of 16 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Aug 22, 2024.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Complete-GI Unflavored, straight from the product label.

Brand PEScience
Barcode (UPC) 040232618253
Net contents 9.3 Ounce(s); 263 Gram(s)
Market status On market
Date entered into DSLD Aug 22, 2024
DSLD ID 318590
Product type Other Combinations
Supplement form Powder
Dietary claims / uses Nutrient, All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Complete-GI Unflavored by PEScience, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
8.75 Gram(s)
Maximum serving Sizes:
8.75 Gram(s)
Servings per container
30
UPC/BARCODE
040232618253
IngredientAmount% DV
Total Carbohydrates3 Gram(s)3%
L-Glutamine5 Gram(s)--
Amylase0 NP--
Protease0 NP--
Lipase0 NP--
Dietary Fiber3 Gram(s)10%
Lactase0 NP--
Lipase0 NP--
Protease0 NP--
Invertase0 NP--
Glucoamylase0 NP--
Alpha-Galactosidase0 NP--
Glucoamylase0 NP--
Oat Fiber3 Gram(s)--
BioCore Optimum Complete110 mg--
LactoSpore0 NP--
Lipase0 NP--
Zinc16 mg110%

Other ingredients: Silicon Dioxide, Calcium Silicate

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions

Directions: Take 1 scoop daily. Mix into water or your favorite flavored beverage.

Precautions

Warnings: This product is intended to be consumed by healthy individuals. Discontinue use 2 weeks prior to surgery. Discontinue use and immediately consult your health care professional if you experience any adverse reaction to this product. Do not exceed recommended serving. Do not use if safety seal is broken or missing.

Consult with a physician before using this product, especially if you are taking any prescription or over the counter medication, or have any preexisting medical condition. If pregnant or nursing always consult with a physician before starting any new dietary supplement.

Keep out of reach of children.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Formula

3g fiber 2B CFUs probiotics Probiotics, prebiotic fiber, digestive enzymes 5g L-glutamine Natural oat fiber Pepzin-GI gastric aid

Formulation

Gut health support

Lab tested Third party tested for quality and purity

FDA Statement of Identity

Dietary Supplement

Brand IP Statement(s)

BioCore Optimum Complete is a registered trademark of National Enzyme Company.

LactoSpore is a registered trademark of Sabrinsa Corporation.

PepZinGI is a registered trademark of Hamar-iChemicals USA Inc.

General Statements

pescience.com/difference

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Complete-GI Unflavored by PEScience label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Complete-GI Unflavored label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Complete-GI Unflavored by PEScience

These are the 16 active ingredients this product is made of. Select any to open its full monograph.

Serving size8.75 Gram(s) Dosage formPowder Servings per container30 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

L-Glutamine

Interacts with
50 drugs
5 Gram(s) per serving

Glutamine is the most abundant amino acid in the body and is usually made in your muscles. A prescription form is FDA-approved to help reduce sickle c...

L-Glutamine monograph & interactions

Dietary Fiber

Interacts with
2,025 drugs
3 Gram(s) per serving

Black psyllium is a soluble-fiber supplement made from the seeds of a Plantago plant, used mostly to ease constipation and support digestive health. I...

Dietary Fiber monograph & interactions

Oat Fiber

3 Gram(s) per serving

BioCore Optimum Complete

110 mg per serving

LactoSpore

Interacts with
182 drugs
0 NP per serving Form: Bacillus coagulans MTCC-5856

Bacillus coagulans is a spore-forming probiotic that survives stomach acid well and may help with some digestive problems such as IBS, constipation, a...

LactoSpore monograph & interactions

Zinc

Interacts with
67 drugs
16 mg per serving Form: PepZin GI

Zinc is an essential mineral that your body needs for immune function, wound healing, taste, and smell. Most people get enough from food, but suppleme...

Zinc monograph & interactions

Other (inactive) ingredients: Silicon Dioxide, Calcium Silicate. These complete the product’s ingredient list but are not active constituents.

Interaction report

Complete-GI Unflavored by PEScience Drug Interactions

Want to check YOUR meds against Complete-GI Unflavored?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
2,088Drugs
281 Moderate 1,807 Minor

Ingredients driving the most interactions

Dietary Fiber 2,025
LactoSpore 182
Zinc 67
L-Glutamine 50

Individual Drug Interactions

The ingredients in Complete-GI Unflavored interact with 2,088 drugs. Click any drug to see the details.

4 of the 16 ingredients in Complete-GI Unflavored interact with drugs. Each result below shows which ingredient is responsible. Dietary Fiber LactoSpore Zinc L-Glutamine

Each ingredient & the kinds of drugs it affects

For each ingredient in Complete-GI Unflavored with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Dietary Fiber7 drug types · 2,025 drugs

Carbamazepine (Tegretol)

Theoretically, black psyllium might reduce the effects of carbamazepine and increase the risk for convulsions.
Theoretically, black psyllium might reduce carbamazepine absorption. A preliminary study using blond psyllium reported decreased carbamazepine bioavailability due to binding of the drug to psyllium, as well as reduction of available fluid in the gut for dissolution of the drug. This interaction may also occur with black psyllium.

Likelihood Probable Evidence D
Lithium

Theoretically, taking black psyllium at the same time as lithium might reduce lithium absorption.
The fiber in black psyllium might reduce lithium absorption and plasma levels. Some case reports describe a reduction in plasma lithium levels with concomitant administration of blond psyllium. This was reversed when psyllium was stopped. This interaction may also occur with black psyllium.

Likelihood Probable Evidence D
Metformin (Glucophage)

Theoretically, black psyllium might increase the therapeutic and adverse effects of metformin.
Animal research shows that concurrent consumption of blond psyllium with metformin slows and increases the absorption of metformin. This interaction may also occur with black psyllium. To avoid changes in absorption, take psyllium 30-60 minutes after metformin.

Likelihood Possible Evidence D
Olanzapine (Zyprexa)

Theoretically, taking black psyllium at the same time as olanzapine might reduce olanzapine absorption.
The fiber in black psyllium might decrease the absorption of olanzapine. A single case report describes a reduction in the effectiveness of olanzapine when it was concomitantly administered with an unspecified type of psyllium 3 grams orally twice daily. This effect was reversed when psyllium was stopped.

Likelihood Possible Evidence D
Digoxin (Lanoxin)

Theoretically, taking black psyllium at the same time as digoxin might reduce digoxin absorption and decrease digoxin levels.
Psyllium might bind digoxin in the gut. However, some clinical evidence suggests that psyllium does not impact digoxin absorption.

Likelihood Unlikely Evidence B
Ethinyl Estradiol

Theoretically, taking black psyllium at the same time as ethinyl estradiol might alter levels of estradiol.
Concurrent use of blond psyllium with ethinyl estradiol results in a slight increase in the extent of ethinyl estradiol absorption and a slower rate of absorption. This is unlikely to be clinically significant.

Likelihood Unlikely Evidence D
Oral Drugs

Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.
Psyllium seems to have variable effects on drug absorption. To avoid changes in absorption, take psyllium 30-60 minutes after oral medications. Animal research shows that blond psyllium delays and increases the absorption of metformin and ethinyl estradiol. Case reports and animal research suggest that blond psyllium might reduce absorption of lithium, digoxin, olanzapine, and carbamazepine. Finally, some pharmacokinetic studies show that psyllium does not affect the absorption of levothyroxine or warfarin. Although many of these studies evaluated blond psyllium, the fiber content in black psyllium may have similar effects.

Likelihood Possible Evidence B
Dietary Fiber full monograph & interactions

LactoSpore1 drug type · 182 drugs

Antibiotic Drugs

Theoretically, taking antibiotics with Bacillus coagulans might decrease the effectiveness of B. coagulans.
B. coagulans preparations usually contain live and active organisms. Therefore, simultaneously taking antibiotics might kill a significant number of the organisms. Tell patients to separate administration of antibiotics and B. coagulans preparations by at least two hours.

Likelihood Probable Evidence D
LactoSpore full monograph & interactions

Zinc10 drug types · 67 drugs

Bictegravir/Emtricitabine/Tenofovir Alafenamide (Biktarvy)

Theoretically, zinc might decrease levels of bictegravir/emtricitabine/tenofovir alafenamide by reducing its absorption.
Advise patients that bictegravir/emtricitabine/tenofovir alafenamide should be taken at least 2 hours before or 6 hours after zinc containing products.

Likelihood Probable Evidence D
Cephalexin (Keflex)

Zinc might decrease cephalexin levels by chelating with cephalexin in the gut and preventing its absorption.
A pharmacokinetic study shows that zinc sulfate 250 mg taken concomitantly with cephalexin 500 mg decreases peak levels of cephalexin by 31% and reduces the exposure to cephalexin by 27%. Also, taking zinc sulfate 3 hours before cephalexin decreases peak levels of cephalexin by 11% and reduces the exposure to cephalexin by 18%. By decreasing cephalexin levels, zinc might increase the risk of treatment failure. This effect does not occur when zinc is taken 3 hours after the cephalexin dose. To avoid an interaction, advise patients take zinc sulfate 3 hours after taking cephalexin.

Likelihood Probable Evidence B
Cisplatin (Platinol-Aq)

Theoretically, zinc might interfere with the therapeutic effects of cisplatin.
Animal research suggests that zinc stimulates tumor cell production of the protein metallothionein, which binds and inactivates cisplatin. It is not known whether zinc supplements or high dietary zinc intake can cause clinically significant interference with cisplatin therapy. Cisplatin might also increase zinc excretion.

Likelihood Possible Evidence D
Integrase Inhibitors

Theoretically, taking zinc along with integrase inhibitors might decrease the levels and clinical effects of these drugs.
Zinc is a divalent cation. Pharmacokinetic studies have shown that other divalent cations such as calcium and iron can decrease blood levels of the integrase inhibitor dolutegravir through chelation.

Likelihood Possible Evidence D
Penicillamine (Cuprimine, Depen)

Zinc might reduce the levels and clinical effects of penicillamine.
By forming an insoluble complex with penicillamine, zinc interferes with penicillamine absorption and activity. Zinc supplements reduce the efficacy of low-dose penicillamine (0.5-1 gram/day), but do not seem to affect higher doses (1-2.75 gram/day), provided dosing times are separated. Advise patients to take zinc and penicillamine at least 2 hours apart.

Likelihood Probable Evidence B
Quinolone Antibiotics

Zinc can decrease the levels and clinical effects of quinolones antibiotics.
Quinolones form complexes with zinc in the gastrointestinal tract, reducing absorption of both the quinolone and zinc if taken at the same time. Advise patients to take these drugs at least 2 hours before, or 4-6 hours after, zinc supplements.

Likelihood Probable Evidence B
Ritonavir (Norvir)

Zinc modestly reduces levels of ritonavir.
Clinical research shows that zinc might reduce serum ritonavir levels by chelating with ritonavir in the gut and preventing its absorption. In patients with HIV, ritonavir is taken with atazanavir to prevent the metabolism and increase the effects of atazanavir. A pharmacokinetic study shows that, in patients being treated with atazanavir/ritonavir, co-administration of zinc sulfate (Solvazinc tablets) 125 mg as a single dose or as multiple daily doses for 2 weeks reduces plasma levels of ritonavir by about 16%. However, atazanavir levels still remains high enough to prevent HIV virus replication. Therefore, the decrease in ritonavir levels is not likely to be clinically significant.

Likelihood Probable Evidence B
Tetracycline Antibiotics

Zinc might reduce levels of tetracycline antibiotics.
Tetracyclines form complexes with zinc in the gastrointestinal tract, which can reduce absorption of both the tetracycline and zinc when taken at the same time. Taking zinc sulfate 200 mg with tetracycline reduces absorption of the antibiotic by 30% to 40%. Demeclocycline and minocycline cause a similar interaction. However, doxycycline does not seem to interact significantly with zinc. Advise patients to take tetracyclines at least 2 hours before, or 4-6 hours after, zinc supplements to avoid any interactions.

Likelihood Probable Evidence B
Amiloride (Midamor)

Amiloride can modestly reduce zinc excretion and increase zinc levels.
Clinical research shows that amiloride can reduce urinary zinc excretion, especially at doses of 10 mg per day or more. This zinc-sparing effect can help to counteract zinc losses caused by thiazide diuretics, but it is unlikely to cause zinc toxicity at usual amiloride doses. The other potassium-sparing diuretics, spironolactone (Aldactone) and triamterene (Dyrenium), do not seem to have a zinc-sparing effect.

Likelihood Probable Evidence B
Atazanavir (Reyataz)

Zinc modestly reduces levels of atazanavir, although this effect does not seem to be clinically significant.
Clinical research shows that zinc might decrease serum atazanavir levels by chelating with atazanavir in the gut and preventing its absorption. Although a single dose of zinc sulfate (Solvazinc tablets) 125 mg orally does not affect atazanavir concentrations in patients being treated with atazanavir/ritonavir, co-administration of zinc sulfate 125 mg daily for 2 weeks reduces plasma levels of atazanavir by about 22% in these patients. However, despite this decrease, atazanavir levels still remain at high enough concentrations for the prevention of HIV virus replication.

Likelihood Probable Evidence B
Zinc full monograph & interactions

L-Glutamine1 drug type · 50 drugs

Anticonvulsants

Theoretically, glutamine might antagonize the effects of anticonvulsant medications.
Glutamine is metabolized to the excitatory neurotransmitter glutamate. Glutamate might have antagonistic effects with anticonvulsant drugs. However, this interaction has not yet been reported in humans.

Likelihood Possible Evidence D
L-Glutamine full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Complete-GI Unflavored, from the product label.

PEScience

See all PEScience products
Name
PEScience LLC
Street Address
3665 East Bay Dr #155-204
City
Largo
State
FL
ZipCode
33771
Phone Number
888-885-0195
Web Address
PESCIENCE.com
Pharmacist Counseling Corner

Complete-GI Unflavored by PEScience: Common Questions

Does Complete-GI Unflavored by PEScience interact with any medications?
Yes. Based on its ingredients, Complete-GI Unflavored has a known interaction with 2,088 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Complete-GI Unflavored contains 16 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Does this help with IBS or constipation?
LactoSpore in the blend is possibly effective for both IBS and constipation. The digestive enzymes and fiber may help too, though the evidence for enzymes alone is insufficient. It's worth a try, but if you don't see results in a few weeks, talk to your doctor about other options.
Can I take this with antibiotics?
Not at the same time. The zinc and LactoSpore both interact with antibiotics. Space your antibiotic dose at least 2–6 hours apart from this supplement—your pharmacist can help you work out the timing. Otherwise the antibiotic may not work as well, and the probiotic may be killed off.
What's in this that actually does something?
L-glutamine supports gut healing, lactase breaks down milk sugar, digestive enzymes help you break down fats and proteins, LactoSpore adds beneficial bacteria, zinc supports immune and digestive health, and oat fiber feeds your gut bacteria. Several enzymes (amylase, invertase) don't have strong evidence behind them yet.
Is it safe while pregnant or breastfeeding?
L-glutamine is likely safe in pregnancy, but avoid high-dose supplements unless your doctor recommends them. Protease should be avoided in pregnancy unless prescribed. During breastfeeding, don't use L-glutamine or protease without medical advice; lipase and lactase need clearance from your provider first. Ask your doctor or pharmacist about the other ingredients.
What side effects might I see?
Gas, bloating, flatulence, nausea, diarrhea, and constipation are the most common, especially when you first start. These usually settle down. If you take high doses of L-glutamine (10+ grams daily), watch for more nausea and GI upset. Rare allergic reactions to protease are possible.
Do I need to take this with food?
The product facts don't say, so ask your pharmacist—timing with food can affect how well digestive enzymes work.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Complete-GI Unflavored label
Go deeper

The Full Monographs Behind Complete-GI Unflavored’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Glutamine

Interacts with 50 drugs

Glutamine is the most abundant amino acid in the body and is usually made in your muscles. A prescription form is FDA-approved to help reduce sickle cell disease complications, but for most...

Read the full Glutamine monograph → Herb & supplement monograph

Black Psyllium

Interacts with 2,025 drugs

Black psyllium is a soluble-fiber supplement made from the seeds of a Plantago plant, used mostly to ease constipation and support digestive health. It is best known and most studied for rel...

Read the full Black Psyllium monograph → Herb & supplement monograph

Proteolytic Enzymes (proteases)

Proteolytic enzymes are proteins that help break down other proteins, and common examples include bromelain (from pineapple), papain (from papaya), trypsin, chymotrypsin, and pancreatin. Peo...

Read the full Proteolytic Enzymes (proteases) monograph → Herb & supplement monograph

Lipase

Lipase is a digestive enzyme that helps your body break down dietary fats. It is well established as part of prescription pancreatic enzyme therapy for people who cannot make enough of their...

Read the full Lipase monograph → Herb & supplement monograph

Lactase

Lactase is a digestive enzyme supplement that helps people who lack enough natural lactase break down lactose, the sugar in milk and dairy. It can reduce gas, bloating, cramping, and diarrhe...

Read the full Lactase monograph → Herb & supplement monograph

Bacillus Coagulans

Interacts with 182 drugs

Bacillus coagulans is a spore-forming probiotic that survives stomach acid well and may help with some digestive problems such as IBS, constipation, and certain types of diarrhea. The eviden...

Read the full Bacillus Coagulans monograph → Herb & supplement monograph

Zinc

Interacts with 67 drugs

Zinc is an essential mineral that your body needs for immune function, wound healing, taste, and smell. Most people get enough from food, but supplements can help correct or prevent a defici...

Read the full Zinc monograph →
Sources

Sources & How We Checked

Complete-GI Unflavored's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 142 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Glutamine 11 references
  1. Miller AL. Therapeutic considerations of L-glutamine: a review of the literature. Altern Med Rev 1999;4:239-48..
  2. Bozzetti F, Biganzoli L, Gavazzi C, et al. Glutamine supplementation in cancer patients receiving chemotherapy: a double-blind randomized study. Nutrition 1997;13:748-51.. PubMed
  3. Mebane AH. L-Glutamine and mania. Am J Psychiatry 984;141:1302-3.
  4. Meldrum BS. Glutamate as a neurotransmitter in the brain: review of physiology and pathology. J Nutr 2000;130:1007S-15S.. PubMed
  5. Garlick PJ. Assessment of the safety of glutamine and other amino acids. J Nutr 2001;131:2556S-61S.. PubMed
  6. Chapman AG. Glutamate and epilepsy. J Nutr 2000;130:1043S-5S.. PubMed
  7. Ziegler TR. Glutamine supplementation in cancer patients receiving bone marrow transplantation and high dose chemotherapy. J Nutr 2001;131:2578S-84S.. PubMed
  8. Laviano A, Molfino A, Lacaria MT, Canelli A, De Leo S, Preziosa I, Rossi Fanelli F. Glutamine supplementation favors weight loss in nondieting obese female patients. A pilot study. Eur J Clin Nutr. 2014 Nov;68(11):1264-6. PubMed
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Proteolytic Enzymes (proteases) 3 references
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Lactase 1 reference
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