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Dietary supplement

TruNeuro+ Ingredients & Drug Interactions

by PEScience

TruNeuro+ label
See full label image
Capsule Category: Fat/fatty Acid
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking TruNeuro+ against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

TruNeuro+ is a dietary supplement by PEScience with 1 active ingredient. Its ingredients are commonly taken for memory and cognitive support, age-related cognitive decline, attention and focus (adhd).Based on those ingredients, 219 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Sharp-PS Green. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against TruNeuro+ by PEScience

Ask about any prescription or over-the-counter medication and we check it for interactions with TruNeuro+ by PEScience — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of TruNeuro+ by PEScience

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

TruNeuro+ contains one active ingredient: Sharp-PS Green, a form of phosphatidylserine (a naturally occurring fat-like compound found in your brain and cell membranes). The capsule also contains gelatin, purified water, glycerin, and sunflower oil as inactive ingredients.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: Memory and cognitive support.
  • We looked for evidence on: Age-related cognitive decline, Cognitive function, Attention deficit-hyperactivity disorder (ADHD), Mental performance, Focus, Brain health.
  • The strongest evidence on file: Phosphatidylserine is rated "Possibly Effective" for Age-related cognitive decline (Natural Medicines).
  • Also on file: Phosphatidylserine is rated "Insufficient Reliable Evidence To Rate" for Attention deficit-hyperactivity disorder (ADHD), Cognitive function.

The evidence for phosphatidylserine is mixed. It's rated Possibly Effective for age-related cognitive decline and Alzheimer disease based on available research.

However, for athletic performance, ADHD, general cognitive function, and dementia, we don't have enough reliable evidence to rate it one way or the other. If you're considering this supplement for a specific concern, talk with your pharmacist about what the current data actually supports.

The evidence, ingredient by ingredient Phosphatidylserine

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Phosphatidylserine is generally well tolerated in studies, though long-term safety isn't fully established. The most common side effects are flatulence, gastrointestinal upset, headache, insomnia, and nausea—especially gastrointestinal upset at lower doses (200–300 mg daily) and insomnia at higher doses (around 600 mg).

The safety data advises against use during pregnancy and breastfeeding because there isn't enough information to know it's safe in those settings.

Side effects, ingredient by ingredient Phosphatidylserine

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Phosphatidylserine.
  • The most serious interaction on file is rated Moderate.
  • For scale: 219 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before you take TruNeuro+, double-check if you're on any anticholinergic drugs (Moderate severity)—these block acetylcholine and might become less effective when combined with phosphatidylserine. Also check for cholinergic drugs (Moderate severity)—these increase acetylcholine and could have stronger effects when combined with this supplement.

Use the medication checker on this page to verify your specific prescriptions.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

TruNeuro+ may be worth considering if you're interested in supporting age-related cognitive decline or Alzheimer disease, though evidence is only "possibly effective." If you take anticholinergic or cholinergic medications—common in allergy, cold, Parkinson's, and bladder treatments—you'll want to check your prescriptions with us first. Talk to your pharmacist before starting, especially if you're pregnant, breastfeeding, or taking any regular medications.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Oct 24, 2024.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about TruNeuro+, straight from the product label.

Brand PEScience
Barcode (UPC) 040232660979
Net contents 90 Capsule(s)
Market status On market
Date entered into DSLD Oct 24, 2024
DSLD ID 318612
Product type Fat/fatty Acid
Supplement form Capsule
Dietary claims / uses Nutrient, All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for TruNeuro+ by PEScience, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Softgel(s)
Maximum serving Sizes:
1 Softgel(s)
Servings per container
90
UPC/BARCODE
040232660979
IngredientAmount% DV
Sharp-PS Green100 mg--

Other ingredients: Gelatin, Water, Purified, Glycerin, Sunflower Oil

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions

Directions: Take 1 softgel 1 to 3 times daily with food.

Precautions

Warnings: This product is intended to be consumed by healthy adults.

Consult with a physician before using this product, especially if you are taking any prescription or over the counter medication, or have any preexisting medical condition. Pregnant or nursing women should not use this product without first consulting with a physician.

Discontinue use 2 weeks prior to surgery. Discontinue use and immediately consult your health care professional if you experience any adverse reaction to this product. Do not exceed recommended serving. Do not use if safety seal is broken or missing.

Keep out of reach of children.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Formula

100mg Sharp-PS 100mg Phosphatidylserine Sharp PS Green

Formulation

Soy Free Non-GMO

Brain support

FDA Statement of Identity

Dietary Supplement

Seals/Symbols

Lab Tested Third Party Tested For Quality and Purity

General Statements

pescience.com/difference

Brand IP Statement(s)

Sharp-PS is a registered trademark of IFF or its affiliates.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

TruNeuro+ by PEScience label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

TruNeuro+ label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in TruNeuro+ by PEScience

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 Softgel(s) Dosage formCapsule Servings per container90 Amounts shown are per serving.

Sharp-PS Green

Interacts with
219 drugs
100 mg per serving Form: Phosphatidylserine

Phosphatidylserine is a natural fat-like compound found in cell membranes, especially in the brain, and it is sold mainly to support memory and thinki...

Sharp-PS Green monograph & interactions

Other (inactive) ingredients: Gelatin, Water, Purified, Glycerin, Sunflower Oil. These complete the product’s ingredient list but are not active constituents.

Interaction report

TruNeuro+ by PEScience Drug Interactions

Want to check YOUR meds against TruNeuro+?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
219Drugs
219 Moderate

Ingredients driving the most interactions

Sharp-PS Green 219

Individual Drug Interactions

The ingredients in TruNeuro+ interact with 219 drugs. Click any drug to see the details.

1 of the 1 ingredient in TruNeuro+ interact with drugs. Each result below shows which ingredient is responsible. Sharp-PS Green

Each ingredient & the kinds of drugs it affects

For each ingredient in TruNeuro+ with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Sharp-PS Green2 drug types · 219 drugs

Anticholinergic Drugs

Theoretically, phosphatidylserine might decrease the effectiveness anticholinergic drugs.
Phosphatidylserine is thought to increase acetylcholine levels, which could theoretically interfere with the activity of anticholinergic agents.

Likelihood Possible Evidence B
Cholinergic Drugs

Theoretically, phosphatidylserine might have additive effects with cholinergic drugs.
Phosphatidylserine is thought to increase acetylcholine levels, which could theoretically lead to additive cholinergic effects when used with cholinergic drugs.

Likelihood Possible Evidence B
Sharp-PS Green full monograph & interactions
The maker

Brand information

Manufacturer and brand details for TruNeuro+, from the product label.

PEScience

See all PEScience products
Name
PEScience LLC
Street Address
3665 East Bay Dr #204-155
City
Largo
State
FL
Phone Number
888-885-0195
Web Address
pescience.com
Pharmacist Counseling Corner

TruNeuro+ by PEScience: Common Questions

Does TruNeuro+ by PEScience interact with any medications?
Yes. Based on its ingredients, TruNeuro+ has a known interaction with 219 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
TruNeuro+ contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Is phosphatidylserine safe to take if I'm pregnant or breastfeeding?
No. The safety data advises against use during pregnancy because there isn't enough information to know it's safe. The same applies to breastfeeding. If you're pregnant, planning to become pregnant, or breastfeeding, talk with your doctor or pharmacist before considering this supplement.
What are the most common side effects?
Most often, people report flatulence, gastrointestinal upset like nausea, headache, and insomnia. Gastrointestinal upset is more likely at doses of 200–300 mg daily, and insomnia becomes more likely at higher doses around 600 mg.
Does phosphatidylserine actually work for memory or brain function?
It's rated Possibly Effective for age-related cognitive decline and Alzheimer disease based on research. For other uses like ADHD, athletic performance, or general cognitive function, we don't have enough reliable evidence to say whether it works or not.
What is phosphatidylserine?
It's a naturally occurring fat-like compound found in your brain and cell membranes. The form in this product is called Sharp-PS Green, and it's thought to increase levels of acetylcholine, a brain chemical involved in memory and cognition.
How long is it safe to take TruNeuro+?
While phosphatidylserine is generally well tolerated in studies, we don't have complete data on long-term safety. It's a good idea to discuss how long you plan to take it with your pharmacist or doctor.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if TruNeuro+ is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

TruNeuro+ label
Go deeper

The Full Monographs Behind TruNeuro+’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Phosphatidylserine

Interacts with 219 drugs

Phosphatidylserine is a natural fat-like compound found in cell membranes, especially in the brain, and it is sold mainly to support memory and thinking. Some research suggests possible bene...

Read the full Phosphatidylserine monograph →
Sources

Sources & How We Checked

TruNeuro+'s label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 9 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Phosphatidylserine 9 references
  1. Crook T, Petrie W, Wells C, Massari DC. Effects of phosphatidylserine in Alzheimer's disease. Psychopharmacol Bull 1992;28:61-6.
  2. Pepping J. Phosphatidylserine. Am J Health-Syst Pharm 1999;56:2038,2043-4.
  3. Kidd PM. Phosphatidylserine; Membrane nutrient for memory. A clinical and mechanistic assessment. Altern Med Rev 1996;1:70-84.
  4. Kim HY, Akbar M, Lau A, et al. Inhibition of neuronal apoptosis by docosahexaenoic acid (22:6n-3). Role of phosphatidylserine in antiapoptotic effect. J Biol Chem 2000;275:35215-23.. PubMed
  5. Zanotti A, Valzelli L, Toffano G. Chronic phosphatidylserine treatment improves spatial memory and passive avoidance in aged rats. Psychopharmacology (Berl) 1989;99:316-21.. PubMed
  6. Schreiber S, Kampf-Sherf O, Gorfine M, et al. An open trial of plant-source derived phosphatydilserine for treatment of age-related cognitive decline. Isr J Psychiatry Relat Sci 2000;37:302-7.
  7. Pepping, J. Phosphatidylserine. Am J Health Syst.Pharm. 10-15-1999;56(20):2038, 2043-2038, 2044.
  8. Monteverde, A., Gnemmi, P., Rossi, F., Monteverde, A., and Finali, G. C. Selegiline in the treatment of mild to moderate Alzheimer-type dementia. Clin.Ther 1990;12(4):315-322.
  9. Vakhapova V, Cohen T, Richter Y, Herzog Y, Kam Y, Korczyn AD. Phosphatidylserine containing omega-3 Fatty acids may improve memory abilities in nondemented elderly individuals with memory complaints: results from an open-label extension study. Dement Geri PubMed

See these in context on the Phosphatidylserine monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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