Major interaction on record — check this product against your medications before combining. Check your meds →
Dietary supplement

CS-W Ingredients & Drug Interactions

by Pure Herbs

CS-W label
See full label image
Liquid Category: Botanical
Most serious interaction: Major
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking CS-W against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Major

CS-W is a dietary supplement by Pure Herbs with 6 active ingredients. Its ingredients are commonly taken for nerve pain (neuropathy), muscle and joint pain (arthritis), back pain.Based on those ingredients, 692 medications have a known interaction with it, the most serious rated major. The ingredients most likely to interact are Motherwort Aerial Parts Extract, Habanero Pepper Fruit Extract, Hawthorn Flower, Fruit, Leaf Extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against CS-W by Pure Herbs

Ask about any prescription or over-the-counter medication and we check it for interactions with CS-W by Pure Herbs — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of CS-W by Pure Herbs

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 12, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 0 of its 6 active ingredients.
  • “Proprietary Blend” is a proprietary blend — the label gives one combined amount (1,969 mg) without saying how much of each component you get.

Pure Herbs CS-W contains six active ingredients in a proprietary blend plus four others individually listed. The habanero pepper fruit extract supplies capsicum, known for pain relief in conditions like shingles nerve pain and diabetic nerve damage.

Blessed thistle, myrrh resin, motherwort, and hawthorn flower/fruit/leaf are traditional botanical extracts added for various purposes — though the evidence supporting most of them is limited or not yet established in our data. Lily-of-the-valley root extract is also included; this ingredient requires particular caution because it contains cardiac glycosides, powerful compounds that affect heart function and carry serious safety concerns.

The product contains no other inactive ingredients.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use.

Why this rating?
  • The label markets this product for: supports circulatory and digestive health.
  • We looked for evidence on: Angina, Arrhythmia, Cardiovascular disease (CVD), Congestive heart failure (CHF), Dyslipidemia, Dyspepsia — and 4 related terms.
  • The closest evidence on file: Blessed Thistle is rated "Insufficient Reliable Evidence To Rate" for Dyspepsia (Natural Medicines).
  • Also on file: Motherwort is rated "Insufficient Reliable Evidence To Rate" for Arrhythmia, Heart failure, Flatulence, Hypertension.
  • Also on file: Lily-of-the-valley is rated "Insufficient Reliable Evidence To Rate" for Arrhythmia, Heart failure.

The evidence for this product's ingredients is mixed. Capsicum is likely effective for shingles nerve pain and diabetic nerve damage, and possibly effective for cluster headaches and back pain.

For the other ingredients — blessed thistle, myrrh, motherwort, hawthorn, and lily-of-the-valley — either the evidence is insufficient to rate their effectiveness or, in some cases, research suggests they may not work for their traditional uses. Before taking this product, understand that most of what's in it lacks solid proof of benefit.

The evidence, ingredient by ingredient Capsicum Blessed Thistle Myrrh Lily-of-the-valley Motherwort Hawthorn

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 6 of the 6 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 6 of 6.
  • General safety write-ups exist for 6 of 6.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Capsicum is generally well tolerated in food amounts, but this concentrated supplement form isn't well studied at higher doses; common side effects from oral use include belching, bloating, burning sensations, diarrhea, nausea, and flushing. Blessed thistle and motherwort are considered likely unsafe in pregnancy because they're traditionally thought to stimulate the uterus, and blessed thistle at high doses can cause nausea or vomiting.

Myrrh and hawthorn also lack safety data in pregnancy and should be avoided. Lily-of-the-valley is particularly concerning — all parts are poisonous and can cause life-threatening heart rhythm problems; it is likely unsafe during pregnancy and lactation.

For nursing mothers, safety of the concentrated supplements hasn't been established for most ingredients.

Side effects, ingredient by ingredient Capsicum Blessed Thistle Myrrh Lily-of-the-valley Motherwort Hawthorn

Meds to double-check

Major interaction found
Known Interaction Concern · database check
Major identified

At least one ingredient has a documented Major-severity interaction. Check your medications for a personalized result.

Why this rating?
  • 6 of the 6 matched ingredients can interact with medications — Blessed Thistle, Motherwort, Lily-of-the-valley, Hawthorn, Myrrh, among others.
  • The most serious interaction on file is rated Major.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; diabetes medications; heart-rhythm medications; lithium.
  • For scale: 692 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking this product, ask your pharmacist or doctor about any heart medications (especially digoxin or corticosteroids taken long-term), blood pressure drugs (beta-blockers, calcium channel blockers, nitrates, or phosphodiesterase-5 inhibitors like Viagra), blood thinners or antiplatelet drugs (like warfarin or aspirin), diabetes medications, diuretics, lithium, theophylline, certain antibiotics (macrolides or tetracyclines), quinine, and over-the-counter acid reducers or laxatives. Altogether, these interactions span 692 individual medications.

If you take any of these drug types, this supplement is not safe to add without professional guidance.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with no established evidence rating for its marketed use. Major medication interactions have been identified, and safety information is well characterized.

This product is not suitable for anyone with a heart condition, anyone taking digoxin or other cardiac medications, or anyone on blood pressure or blood thinning medications without their doctor's explicit approval first. If you're pregnant or nursing, talk with your pharmacist or doctor before considering it — several ingredients carry safety warnings.

Even if you take no other medications, the presence of lily-of-the-valley (a poisonous plant with cardiac risks) and the limited evidence for most ingredients make this a supplement to discuss carefully with your pharmacist or doctor beforehand.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 6 of 6 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Nov 22, 2022.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about CS-W, straight from the product label.

Brand Pure Herbs
Net contents 1 Fluid Ounce(s); 30 mL
Market status On market
Date entered into DSLD Nov 22, 2022
DSLD ID 280003
Product type Botanical
Supplement form Liquid
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Women (not pregnant or lactating)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for CS-W by Pure Herbs, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
2 mL
Maximum serving Sizes:
2 mL
Servings per container
15
IngredientAmount% DV
Proprietary Blend1969 mg--
Habanero Pepper Fruit Extract0 NP--
Blessed Thistle Aerial Parts Extract0 NP--
Myrrh Resin Extract0 NP--
Lily of the Valley Root Extract0 NP--
Motherwort Aerial Parts Extract0 NP--
Hawthorn Flower, Fruit, Leaf Extract0 NP--

Other ingredients: None

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions

Directions: For adults, mix 2 mL (abt. 1/2 tsp) of extract in 2 fl. oz (60 mL) water one time daily preferably with a meal.

Shake well before use

Formulation

Supports a healthy circulatory system. Supports digestive function.

FDA Disclaimer Statement

This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Precautions

Warning: Not intended for use by pregnant or nursing women. If you have a medical condition or are taking medication, consult your doctor prior to use.

Discontinue use and consult with your doctor if any adverse reactions occur.

Keep out of reach of children

Brand IP Statement(s)

Pure Herbs, Ltd. Natural Herbal Extracts

FDA Statement of Identity

Dietary Supplement

General Statements

"No expense has been spared to provide the finest nature has to offer."

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

CS-W by Pure Herbs label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

CS-W label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in CS-W by Pure Herbs

These are the 6 active ingredients this product is made of. Select any to open its full monograph.

Serving size2 mL Dosage formLiquid Servings per container15 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Other (inactive) ingredients: None. These complete the product’s ingredient list but are not active constituents.

Interaction report

CS-W by Pure Herbs Drug Interactions

Want to check YOUR meds against CS-W?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
692Drugs
40 Major 614 Moderate 38 Minor

Ingredients driving the most interactions

Motherwort Aerial Parts Extract 248
Habanero Pepper Fruit Extract 239
Hawthorn Flower, Fruit, Leaf Extract 191
Lily of the Valley Root Extract 157
Myrrh Resin Extract 88

Individual Drug Interactions

The ingredients in CS-W interact with 692 drugs. Click any drug to see the details.

6 of the 6 ingredients in CS-W interact with drugs. Each result below shows which ingredient is responsible. Motherwort Aerial Parts Extract Habanero Pepper Fruit Extract Hawthorn Flower, Fruit, Leaf Extract Lily of the Valley Root Extract Myrrh Resin Extract Blessed Thistle Aerial Parts Extract

Each ingredient & the kinds of drugs it affects

For each ingredient in CS-W with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Motherwort Aerial Parts Extract1 drug type · 248 drugs

Cns Depressants

Theoretically, taking motherwort concomitantly with other CNS depressants may increase the risk of sedation.
Motherwort has been reported to cause CNS depression and sedation.

Likelihood Possible Evidence D
Motherwort Aerial Parts Extract full monograph & interactions

Habanero Pepper Fruit Extract6 drug types · 239 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, capsicum may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
In vitro research shows that capsicum might increase the effects of antiplatelet drugs. Also, population research shows that capsicum is associated with an increased risk of self-reported bleeding in patients taking warfarin. However, clinical research shows that taking a single dose of capsaicin (Asian Herbex Ltd.), the active ingredient in capsicum, 400-800 mcg orally in combination with aspirin 500 mg does not decrease platelet aggregation when compared with taking aspirin 500 mg alone. Also, there was no notable effect on measures of platelet aggregation with capsaicin. It is unclear whether capsaicin must be used in more than a single dose to affect platelet aggregation.

Likelihood Possible Evidence B
Antidiabetes Drugs

Theoretically, taking capsicum with antidiabetes drugs might increase the risk of hypoglycemia.
Preliminary clinical research shows that consuming capsicum 5 grams along with a glucose drink attenuates the rise in plasma glucose after 30 minutes by 21%, decreases the 2-hour postprandial area under the curve of plasma glucose by 11%, and increases the 2-hour postprandial area under the curve of plasma insulin by 58% in healthy individuals when compared with placebo. Other clinical research shows that taking capsicum 5 mg daily for 28 days significantly reduces postprandial blood glucose and insulin levels, but not fasting blood glucose and insulin levels, in patients with gestational diabetes.

Likelihood Possible Evidence B
Aspirin

Theoretically, taking capsicum with aspirin might reduce the bioavailability of aspirin.
Animal research shows that acute or chronic intake of capsicum pepper reduces oral aspirin bioavailability. This has not been shown in humans.

Likelihood Possible Evidence D
Theophylline

Theoretically, taking capsicum with theophylline might increase the levels and adverse effects of theophylline.
In animal research, oral administration of capsicum reduced excretion of theophylline. However, capsicum does not seem to affect the pharmacokinetics of theophylline when administered intravenously.

Likelihood Possible Evidence D
Ace Inhibitors (Aceis)

Theoretically, using topical capsaicin may increase the risk of ACE inhibitor-induced cough.
There is one case report of a topically applied capsaicin cream contributing to the cough reflex in a patient using an ACEI. However, it is unclear if this interaction is clinically significant.

Likelihood Unlikely Evidence D
Ciprofloxacin (Cipro)

Theoretically, taking capsicum with ciprofloxacin might increase levels and adverse effects of ciprofloxacin.
Animal research shows that concomitant use of capsaicin, the active constituent of capsicum, and ciprofloxacin increases the bioavailability of ciprofloxacin by up to 70%.

Likelihood Possible Evidence D
Habanero Pepper Fruit Extract full monograph & interactions

Hawthorn Flower, Fruit, Leaf Extract6 drug types · 191 drugs

Nitrates

Theoretically, concomitant use might cause additive coronary vasodilatory effects.
Some evidence shows that hawthorn might lower blood pressure due to vasodilatory effects.

Likelihood Probable Evidence D
Phosphodiesterase-5 Inhibitors

Theoretically, concomitant use might result in additive vasodilation and hypotension.
Hawthorn might inhibit PDE-5 and cause vasodilation.

Likelihood Probable Evidence D
Anticoagulant/Antiplatelet Drugs

Theoretically, hawthorn may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
In vitro and animal research shows that hawthorn can inhibit platelet aggregation. However, its effect in humans is unclear. One observational study shows that patients taking hawthorn shortly before undergoing coronary artery bypass graft (CABG) surgery or valve replacement surgery have a 10% incidence of postoperative bleeding, compared with 1% in those who never consumed hawthorn extract. However, clinical research shows that taking a specific preparation of dried hawthorn leaves and flowers (Crataesor, Soria Natural Lab) 800 mg three times daily for 15 days does not affect platelet aggregation or levels of thromboxane B2, the metabolite of thromboxane A2, in healthy humans.

Likelihood Possible Evidence D
Beta-Blockers

Theoretically, concomitant use might cause additive effects on blood pressure and heart rate.
Some evidence shows that hawthorn might lower blood pressure and heart rate.

Likelihood Possible Evidence D
Calcium Channel Blockers

Theoretically, concomitant use might cause additive coronary vasodilation and hypotensive effects.
Some evidence shows that hawthorn might lower blood pressure due to vasodilatory effects.

Likelihood Possible Evidence D
Digoxin (Lanoxin)

Theoretically, hawthorn might potentiate the effects and adverse effects of digoxin.
Hawthorn appears to improve cardiac output; however, hawthorn does not appear to affect digoxin pharmacokinetics. Case reports suggest that at least one species of hawthorn root extract (Crataegus mexicana) may produce adverse effects similar to digoxin and can cross-react with digoxin assays, leading to falsely elevated plasma digoxin levels.

Likelihood Possible Evidence D
Hawthorn Flower, Fruit, Leaf Extract full monograph & interactions

Lily of the Valley Root Extract8 drug types · 157 drugs

Corticosteroids

Theoretically, using lily-of-the-valley with prolonged corticosteroid therapy can cause cardiac glycoside toxicity.
Lily-of-the-valley contains cardiac glycosides. Concomitant, long-term corticosteroid use can increase the risk of cardiac glycoside toxicity due to potassium depletion and electrolyte imbalance.

Likelihood Probable Evidence D
Digoxin (Lanoxin)

Using lily-of-the-valley with digoxin can cause cardiac glycoside toxicity.
Lily-of-the-valley contains cardiac glycosides. Use of the cardiac glycoside digoxin and lily-of-the-valley concomitantly increases the risk of cardiac glycoside toxicity.

Likelihood Likely Evidence D
Quinine

Theoretically, using lily-of-the-valley with quinine can increase the risk of cardiac glycoside toxicity.
Quinine may reduce the clearance of oral digoxin. Theoretically, concomitant use of quinine with lily-of-the-valley might reduce the clearance of cardiac glycosides found in lily-of-the-valley and increase the risk of toxicity.

Likelihood Probable Evidence D
Diuretic Drugs

Theoretically, using lily-of-the-valley with diuretics can increase the risk of cardiac glycoside toxicity.
Lily-of-the-valley contains cardiac glycosides. Concomitant use of potassium depleting diuretics and lily-of-the-valley can increase the risk of cardiac glycoside toxicity due to potassium depletion and electrolyte imbalance.

Likelihood Possible Evidence D
Lithium

Theoretically, lily-of-the-valley can increase levels of lithium and increase toxicity.
Lily-of-the-valley is thought to have diuretic properties. Theoretically, due to these potential diuretic effects, lily-of-the-valley might reduce excretion and increase levels of lithium. The dose of lithium might need to be decreased.

Likelihood Probable Evidence D
Macrolide Antibiotics

Theoretically, using lily-of-the-valley with macrolide antibiotics can increase the risk of cardiac glycoside toxicity.
Macrolide antibiotics appear to increase the gastrointestinal absorption of oral digoxin. Theoretically, concomitant use of macrolide antibiotics might increase the absorption of the cardiac glycosides found in lily-of-the-valley.

Likelihood Possible Evidence D
Stimulant Laxatives

Theoretically, using lily-of-the-valley with stimulant laxatives can increase the risk of cardiac glycoside toxicity.
Lily-of-the-valley contains cardiac glycosides. The overuse of stimulant laxatives can increase the risk of cardiac glycoside toxicity with lily-of-the-valley due to potassium depletion.

Likelihood Possible Evidence D
Tetracycline Antibiotics

Theoretically, using lily-of-the-valley with tetracycline antibiotics might increase the risk of cardiac glycoside toxicity.
Tetracycline antibiotics appear to increase the gastrointestinal absorption of oral digoxin, a cardiac glycoside. Theoretically, concomitant use of tetracycline antibiotics might increase the absorption of the cardiac glycosides found in lily-of-the-valley.

Likelihood Possible Evidence D
Lily of the Valley Root Extract full monograph & interactions

Myrrh Resin Extract2 drug types · 88 drugs

Antidiabetes Drugs

Theoretically, myrrh might increase the risk of hypoglycemia when taken with antidiabetes drugs.
In vitro and animal research suggests that myrrh has hypoglycemic effects.

Likelihood Possible Evidence D
Warfarin (Coumadin)

Theoretically, myrrh might decrease the effectiveness of warfarin.
In one case, a patient who was previously stable on warfarin had a significant decline in international normalized ratio (INR) following consumption of an aqueous extract of myrrh.

Likelihood Possible Evidence D
Myrrh Resin Extract full monograph & interactions

Blessed Thistle Aerial Parts Extract3 drug types · 36 drugs

Antacids

Theoretically, blessed thistle might decrease the effectiveness of antacids.
There are reports that blessed thistle increases stomach acid.

Likelihood Possible Evidence D
H2-Blockers

Theoretically, blessed thistle might decrease the effectiveness of H2-blockers.
There are reports that blessed thistle increases stomach acid.

Likelihood Possible Evidence D
Proton Pump Inhibitors (Ppis)

Theoretically, blessed thistle might decrease the effectiveness of PPIs.
There are reports that blessed thistle increases stomach acid.

Likelihood Possible Evidence D
Blessed Thistle Aerial Parts Extract full monograph & interactions
The maker

Brand information

Manufacturer and brand details for CS-W, from the product label.

Pure Herbs

See all Pure Herbs products
Name
Pure Herbs, Ltd.
City
Sterling Heights
State
MI
Phone Number
(800) 860-4372
Web Address
www.pureherbs.com
Pharmacist Counseling Corner

CS-W by Pure Herbs: Common Questions

Does CS-W by Pure Herbs interact with any medications?
Yes. Based on its ingredients, CS-W has a known interaction with 692 medications, including 40 rated major. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
CS-W contains 6 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Is lily-of-the-valley really poisonous?
Yes. All parts of lily-of-the-valley contain cardiac glycosides — compounds that can cause serious and even life-threatening heart rhythm problems. The facts show it's likely unsafe for use and can trigger cardiac arrhythmias. It should not be used without strict medical supervision, if at all.
Can I take this if I'm pregnant or breastfeeding?
No. Blessed thistle, motherwort, myrrh, and lily-of-the-valley are all likely unsafe in pregnancy because they're traditionally thought to stimulate the uterus. Hawthorn and the safety of concentrated capsicum during breastfeeding haven't been well studied. Talk with your doctor or pharmacist before considering this product during pregnancy or while nursing.
What does capsicum (habanero pepper) actually do in this product?
Capsicum is likely effective for nerve pain from shingles and diabetes-related nerve damage, and possibly effective for cluster headaches and back pain. However, it's generally well tolerated in food amounts, and common side effects from concentrated supplements include burning sensations, bloating, diarrhea, and nausea.
Why does this product have so many drug interactions?
Mainly because of lily-of-the-valley and hawthorn. Lily-of-the-valley's cardiac glycosides interact with heart medications, blood pressure drugs, diuretics, and certain antibiotics. Hawthorn has vasodilatory effects that can dangerously lower blood pressure when combined with nitrates or ED medications. Both ingredients require extra caution around other cardiac or blood pressure treatments.
Is the evidence good for blessed thistle, myrrh, or motherwort?
Not really. For blessed thistle and motherwort, the evidence is insufficient to rate whether they work. Myrrh research suggests it may be ineffective for some traditional uses. Most of what we know about these ingredients comes from traditional use rather than solid clinical trials.
What are the most common side effects I might notice?
From capsicum, you might experience belching, bloating, burning in the mouth or digestive tract, diarrhea, nausea, or skin flushing. Blessed thistle at high doses can cause nausea and vomiting. Motherwort may cause diarrhea or stomach irritation. Beyond that, side effects depend on individual sensitivity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

CS-W label
Go deeper

The Full Monographs Behind CS-W’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Capsicum

Interacts with 239 drugs

Capsicum (chili pepper) contains capsaicin, which is best known and best studied as a topical treatment for certain types of pain. Topical capsaicin products are supported by reasonable evid...

Read the full Capsicum monograph → Herb & supplement monograph

Blessed Thistle

Interacts with 36 drugs

Blessed thistle is a bitter herb traditionally used to stimulate appetite and ease mild digestive complaints. High-quality human studies are lacking, so its benefits are not well proven. It...

Read the full Blessed Thistle monograph → Herb & supplement monograph

Myrrh

Interacts with 88 drugs

Myrrh is a fragrant gum resin from Commiphora trees that has long been used in mouthwashes, throat remedies, and skin care. Modern evidence for most of its uses is limited and comes mostly f...

Read the full Myrrh monograph → Herb & supplement monograph

Lily-of-the-valley

Interacts with 157 drugs

Lily-of-the-valley is a poisonous plant that contains powerful heart-affecting compounds called cardiac glycosides, similar to the drug digoxin. While it was used historically for heart cond...

Read the full Lily-of-the-valley monograph → Herb & supplement monograph

Motherwort

Interacts with 248 drugs

Motherwort is a traditional herb in the mint family long used for anxiety, heart palpitations, and women's reproductive complaints, but solid human evidence is very limited. It should be avo...

Read the full Motherwort monograph → Herb & supplement monograph

Hawthorn

Interacts with 191 drugs

Hawthorn is a plant traditionally used for heart-related complaints, and some studies suggest it may modestly help symptoms of mild heart failure when added to standard care. However, the ev...

Read the full Hawthorn monograph →
Sources

Sources & How We Checked

CS-W's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 137 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Capsicum 89 references
  1. Covington TR, et al. Handbook of Nonprescription Drugs. 11th ed. Washington, DC: American Pharmaceutical Association, 1996.
  2. Cooper RL, Cooper MM. Red pepper-induced dermatitis in breast-fed infants. Dermatol 1996;93:61-2. PubMed
  3. Millqvist E. Cough provocation with capsaicin is an objective way to test sensory hyperreactivity in patients with asthma-like symptoms. Allergy 2000;55:546-50. DOI
  4. Locock RA. Capsicum. Can Pharm J 1985;118:517-9.
  5. Mason L, Moore RA, Derry S, et al. Systematic review of topical capsaicin for the treatment of chronic pain. BMJ 2004;328:991. PubMed
  6. Schmulson MJ, Valdovinos MA, Milke P. Chili pepper and rectal hyperalgesia in irritable bowel syndrome. Am J Gastroenterol 2003;98:1214-5. PubMed
  7. Surh YJ, Lee SS. Capsaicin in hot chili pepper: carcinogen, co-carcinogen or anticarcinogen? Food Chem Toxicol 1996;34:313-6. PubMed
  8. Bouraoui A, Brazier JL, Zouaghi H, Rousseau M. Theophylline pharmacokinetics and metabolism in rabbits following single and repeated administration of Capsicum fruit. Eur J Drug Metab Pharmacokinet 1995;20:173-8.
  9. Hogaboam CM, Wallace JL. Inhibition of platelet aggregation by capsaicin. An effect unrelated to actions on sensory afferent neurons. Eur J Pharmacol 1991;202:129-31. PubMed
  10. Wang JP, Hsu MF, Teng CM. Antiplatelet effect of capsaicin. Thromb Res 1984;36:497-507. PubMed
  11. Williams SR, Clark RF, Dunford JV. Contact dermatitis associated with capsaicin: Hunan hand syndrome. Ann Emerg Med 1995;25:713-5. PubMed
  12. Zollman TM, Bragg RM, Harrison DA. Clinical effects of oleoresin capsicum (pepper spray) on the human cornea and conjunctiva. Ophthalmology 2000;107:2186-9. PubMed
  13. Bortolotti M, Coccia G, Grossi G, Miglioli M. The treatment of functional dyspepsia with red pepper. Aliment Pharmacol Ther 2002;16:1075-82. PubMed
  14. Hakas JF Jr. Topical capsaicin induces cough in patient receiving ACE inhibitor. Ann Allergy 1990;65:322-3.
  15. Rapoport AM, Bigal ME, Tepper SJ, Sheftell FD. Intranasal medications for the treatment of migraine and cluster headache. CNS Drugs 2004;18:671-85. PubMed
  16. Stjarne P, Rinder J, Heden-Blomquist E, et al. Capsaicin desensitization of the nasal mucosa reduces symptoms upon allergen challenge in patients with allergic rhinitis. Acta Otolaryngol 1998;118:235-9. PubMed
  17. Levy RL. Intranasal capsaicin for acute abortive treatment of migraine without aura. Headache 1995;35:277.
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DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

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