Dew Drops Ingredients & Drug Interactions
by Ron Teeguarden's Dragon Herbs
What is this page for?
First and foremost: checking Dew Drops against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
Dew Drops is a dietary supplement by Ron Teeguarden's Dragon Herbs with 6 active ingredients. Its ingredients are commonly taken for stress and energy support, immune support and colds, blood sugar management.Based on those ingredients, 1,420 medications have a known interaction with it, the most serious rated major. The ingredients most likely to interact are Chinese Licorice root extract, Poria sclerotium extract, American Ginseng root extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.
Check Your Meds Against Dew Drops by Ron Teeguarden's Dragon Herbs
Ask about any prescription or over-the-counter medication and we check it for interactions with Dew Drops by Ron Teeguarden's Dragon Herbs — and tell you which ingredient is responsible.
AI summaries are generated from our interaction database for education only — always confirm with your pharmacist. How we use AI
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HelloPharmacist Scorecard of Dew Drops by Ron Teeguarden's Dragon Herbs
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Low disclosure
Dew Drops contains 6 ingredients, including American Ginseng root extract (traditionally used to support upper respiratory health), Chinese Licorice root extract (used in traditional medicine for skin and digestive support), Poria sclerotium extract (a mushroom used in traditional practice), Chinese Asparagus Root Extract, Pseudostellaria Root Tuber Extract, and Lily Flower extract. The product is delivered as a liquid in a base of water and grain alcohol.
Does it work?
Moderate evidence
American ginseng is rated possibly effective for upper respiratory tract infections. Chinese licorice is possibly effective for canker sores and eczema.
For the other ingredients — Poria mushroom, Chinese Asparagus, Pseudostellaria, and Lily Flower — the evidence we hold is insufficient to rate their effectiveness for any condition listed in our data.
How safe is it?
Well-documented data
American ginseng is generally well tolerated short-term in healthy adults, though long-term safety isn't well studied; headache has been reported. Chinese licorice is generally fine in small food amounts, but high doses or long-term use of products containing glycyrrhizin can cause serious problems including headache, nausea, vomiting, and in rare cases, dangerous electrolyte changes.
Poria mushroom is generally well tolerated in traditional use but has limited human safety data; allergic reactions have been reported rarely. Lily-of-the-valley is toxic and unsafe — all parts can cause life-threatening heart problems including dangerous heart rhythms, headache, and visual disturbances.
For pregnancy and breastfeeding: American ginseng is rated possibly unsafe during pregnancy and should be avoided while breastfeeding. Chinese licorice is unsafe in pregnancy and should be avoided while breastfeeding.
Poria mushroom should be avoided in both pregnancy and breastfeeding due to insufficient safety data. Lily-of-the-valley is likely unsafe in both pregnancy and breastfeeding.
Meds to double-check
Major interaction found
Before taking Dew Drops, check with your doctor or pharmacist if you take blood thinners like warfarin, heart medications including digoxin or corticosteroids, diabetes drugs, antidepressants (especially MAOIs), sedatives, diuretics, lithium, immune-suppressing drugs, stimulant laxatives, or certain antibiotics. The lily flower extract in this product is noted as toxic in our data and poses serious cardiac risks with multiple medication classes.
The bottom line
Scorecard at a glanceFormula with limited ingredient disclosure with some supporting evidence for its stated purpose. Major medication interactions have been identified, and safety information is well characterized.
This product carries major interactions with heart medications, blood thinners, and several other common prescriptions, and contains lily-of-the-valley, which the safety data describes as toxic. If you take any regular medications — especially for the heart, blood clotting, diabetes, or mood — or if you're pregnant or breastfeeding, talk with your doctor or pharmacist before using this product.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 4 of 6 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Dec 13, 2022.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about Dew Drops, straight from the product label.
| Brand | Ron Teeguarden's Dragon Herbs |
|---|---|
| Barcode (UPC) | 679372000255 |
| Net contents | 2 Fluid Ounce(s); 60 mL |
| Market status | On market |
| Date entered into DSLD | Dec 13, 2022 |
| DSLD ID | 278990 |
| Product type | Botanical |
| Supplement form | Liquid |
| Dietary claims / uses | All Other, Structure/Function |
| Intended target group(s) | Adult (18 - 50 Years) |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for Dew Drops by Ron Teeguarden's Dragon Herbs, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| Proprietary Blend Extract | 2.25 mL | -- |
| American Ginseng root extract | 0 NP | -- |
| Chinese Licorice root extract | 0 NP | -- |
| Poria sclerotium extract | 0 NP | -- |
| Chinese Asparagus Root Extract | 0 NP | -- |
| Pseudostellaria Root Tuber Extract | 0 NP | -- |
| Lily Flower Extract | 0 NP | -- |
Other ingredients: Water, Grain Alcohol
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formula
This potent formula is made from the finest Chinese tonic herbs to enhance Yin Jing and to help maintain bodily fluids.
Formulation
It benefits the skin and mucous tissues, helping to maintain moistness and suppleness. Dew Drops supports lung and sinus functions.
Super potency extract
General Statements
Dragon Drops
FDA Statement of Identity
Dietary Supplement
Suggested/Recommended/Usage/Directions
Directions: 3-12 squirts per day as desired or as directed by a health practitioner. Shake well before use. A squirt is a single full squeeze of the rubber bulb.
Precautions
Keep out of the reach of children.
FDA Disclaimer Statement
These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
Dew Drops by Ron Teeguarden's Dragon Herbs label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in Dew Drops by Ron Teeguarden's Dragon Herbs
These are the 6 active ingredients this product is made of. Select any to open its full monograph.
Serving size2.25 mL Dosage formLiquid Servings per container27 Amounts shown are per serving.
Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.
Proprietary Blend Extract
- › American Ginseng root extract
- › Chinese Licorice root extract
- › Poria sclerotium extract
- › Chinese Asparagus Root Extract
- › Pseudostellaria Root Tuber Extract
- › Lily Flower Extract
Other (inactive) ingredients: Water, Grain Alcohol. These complete the product’s ingredient list but are not active constituents.
Dew Drops by Ron Teeguarden's Dragon Herbs Drug Interactions
HelloPharmacist Interaction Report
Dew Drops by Ron Teeguarden's Dragon Herbs carries significant medication interactions through its American Ginseng root extract, Chinese Licorice root extract, Poria sclerotium extract, and Lily Flower extract.
The most serious concern is lily-of-the-valley (the Lily Flower ingredient), which can cause life-threatening cardiac toxicity when combined with heart medications like digoxin, corticosteroids used long-term, or the antimalarial quinine — all rated Major severity.
Read the full breakdown — every affected drug type, severity by severity
American ginseng poses a Major interaction with warfarin (a blood thinner), potentially reducing its effectiveness and raising your clot risk. Both American ginseng and Chinese licorice carry Moderate interactions with blood thinners, diabetes drugs, and several others: ginseng with immune-suppressing medications and MAOIs (a class of older antidepressants); licorice with heart medications, cancer drugs like cisplatin and paclitaxel, and sedatives like midazolam.
Poria mushroom extract theoretically affects sedatives and drugs that work on nerve signals (anticholinergic and cholinergic drugs) at Moderate severity.
Lily-of-the-valley also interacts with diuretics (water pills), lithium, stimulant laxatives, and certain antibiotics — all Moderate. We could not check Chinese Asparagus Root Extract or Pseudostellaria Root Tuber Extract; no interaction data are on file for those.
Altogether, these interactions span 1,421 individual medications. Before taking this product, search your exact medications on this page or check with your doctor or pharmacist.
Check your own medications below · Editorial policy · How we use AI
Want to check YOUR meds against Dew Drops?
Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.
Go to the checkerIngredients driving the most interactions
Individual Drug Interactions
The ingredients in Dew Drops interact with 1,420 drugs. Click any drug to see the details.
4 of the 6 ingredients in Dew Drops interact with drugs. Each result below shows which ingredient is responsible. Chinese Licorice root extract Poria sclerotium extract American Ginseng root extract Lily Flower Extract
Azelastine Hydrochloride, Fluticasone PropionateDymista
How Azelastine Hydrochloride, Fluticasone Propionate interacts with Dew Drops — through 2 ingredients. Tap an ingredient for the detail:
Lily Flower ExtractCorticosteroids Major
Interaction Summary
Theoretically, using lily-of-the-valley with prolonged corticosteroid therapy can cause cardiac glycoside toxicity.
Read the full Lily Flower Extract + Azelastine Hydrochloride, Fluticasone Propionate interactionChinese Licorice Root ExtractCorticosteroids, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, concomitant use of licorice and corticosteroids might increase the side effects of corticosteroids.
Read the full Chinese Licorice Root Extract + Azelastine Hydrochloride, Fluticasone Propionate interactionBeclometasone DipropionateBecotide
How Beclometasone Dipropionate interacts with Dew Drops — through 3 ingredients. Tap an ingredient for the detail:
Lily Flower ExtractCorticosteroids Major
Interaction Summary
Theoretically, using lily-of-the-valley with prolonged corticosteroid therapy can cause cardiac glycoside toxicity.
Read the full Lily Flower Extract + Beclometasone Dipropionate interactionAmerican Ginseng Root ExtractImmunosuppressants Moderate
Interaction Summary
Theoretically, American ginseng use might interfere with immunosuppressive therapy.
Read the full American Ginseng Root Extract + Beclometasone Dipropionate interactionChinese Licorice Root ExtractCytochrome P450 3a4 (cyp3a4) Substrates, P-glycoprotein Substrates +1 Moderate
Interaction Summary
Theoretically, licorice might increase or decrease levels of drugs metabolized by CYP3A4.
Read the full Chinese Licorice Root Extract + Beclometasone Dipropionate interactionBeclomethasoneBeclovent, Vanceril
How Beclomethasone interacts with Dew Drops — through 3 ingredients. Tap an ingredient for the detail:
Lily Flower ExtractCorticosteroids Major
Interaction Summary
Theoretically, using lily-of-the-valley with prolonged corticosteroid therapy can cause cardiac glycoside toxicity.
Read the full Lily Flower Extract + Beclomethasone interactionChinese Licorice Root ExtractCorticosteroids, Cytochrome P450 3a4 (cyp3a4) Substrates +1 Moderate
Interaction Summary
Theoretically, concomitant use of licorice and corticosteroids might increase the side effects of corticosteroids.
Read the full Chinese Licorice Root Extract + Beclomethasone interactionAmerican Ginseng Root ExtractImmunosuppressants Moderate
Interaction Summary
Theoretically, American ginseng use might interfere with immunosuppressive therapy.
Read the full American Ginseng Root Extract + Beclomethasone interactionBeclomethasone DipropionateQNASL, Qvar
How Beclomethasone Dipropionate interacts with Dew Drops — through 3 ingredients. Tap an ingredient for the detail:
Lily Flower ExtractCorticosteroids Major
Interaction Summary
Theoretically, using lily-of-the-valley with prolonged corticosteroid therapy can cause cardiac glycoside toxicity.
Read the full Lily Flower Extract + Beclomethasone Dipropionate interactionChinese Licorice Root ExtractP-glycoprotein Substrates, Corticosteroids +1 Moderate
Interaction Summary
Theoretically, licorice might decrease the absorption of P-glycoprotein substrates.
Read the full Chinese Licorice Root Extract + Beclomethasone Dipropionate interactionAmerican Ginseng Root ExtractImmunosuppressants Moderate
Interaction Summary
Theoretically, American ginseng use might interfere with immunosuppressive therapy.
Read the full American Ginseng Root Extract + Beclomethasone Dipropionate interactionBetamethasoneCelestone, Diprolene AF, Diprosone
How Betamethasone interacts with Dew Drops — through 3 ingredients. Tap an ingredient for the detail:
Lily Flower ExtractCorticosteroids Major
Interaction Summary
Theoretically, using lily-of-the-valley with prolonged corticosteroid therapy can cause cardiac glycoside toxicity.
Read the full Lily Flower Extract + Betamethasone interactionChinese Licorice Root ExtractCorticosteroids, P-glycoprotein Substrates Moderate
Interaction Summary
Theoretically, concomitant use of licorice and corticosteroids might increase the side effects of corticosteroids.
Read the full Chinese Licorice Root Extract + Betamethasone interactionAmerican Ginseng Root ExtractImmunosuppressants Moderate
Interaction Summary
Theoretically, American ginseng use might interfere with immunosuppressive therapy.
Read the full American Ginseng Root Extract + Betamethasone interactionBetamethasone DipropionateSernivo
How Betamethasone Dipropionate interacts with Dew Drops — through 3 ingredients. Tap an ingredient for the detail:
Lily Flower ExtractCorticosteroids Major
Interaction Summary
Theoretically, using lily-of-the-valley with prolonged corticosteroid therapy can cause cardiac glycoside toxicity.
Read the full Lily Flower Extract + Betamethasone Dipropionate interactionAmerican Ginseng Root ExtractImmunosuppressants Moderate
Interaction Summary
Theoretically, American ginseng use might interfere with immunosuppressive therapy.
Read the full American Ginseng Root Extract + Betamethasone Dipropionate interactionChinese Licorice Root ExtractP-glycoprotein Substrates, Corticosteroids Moderate
Interaction Summary
Theoretically, licorice might decrease the absorption of P-glycoprotein substrates.
Read the full Chinese Licorice Root Extract + Betamethasone Dipropionate interactionBetamethasone Dipropionate, CalcipotrieneEnstilar, Wynzora
How Betamethasone Dipropionate, Calcipotriene interacts with Dew Drops — through 3 ingredients. Tap an ingredient for the detail:
Lily Flower ExtractCorticosteroids Major
Interaction Summary
Theoretically, using lily-of-the-valley with prolonged corticosteroid therapy can cause cardiac glycoside toxicity.
Read the full Lily Flower Extract + Betamethasone Dipropionate, Calcipotriene interactionAmerican Ginseng Root ExtractImmunosuppressants Moderate
Interaction Summary
Theoretically, American ginseng use might interfere with immunosuppressive therapy.
Read the full American Ginseng Root Extract + Betamethasone Dipropionate, Calcipotriene interactionChinese Licorice Root ExtractP-glycoprotein Substrates, Corticosteroids Moderate
Interaction Summary
Theoretically, licorice might decrease the absorption of P-glycoprotein substrates.
Read the full Chinese Licorice Root Extract + Betamethasone Dipropionate, Calcipotriene interactionBetamethasone ValerateLuxiq
How Betamethasone Valerate interacts with Dew Drops — through 3 ingredients. Tap an ingredient for the detail:
Lily Flower ExtractCorticosteroids Major
Interaction Summary
Theoretically, using lily-of-the-valley with prolonged corticosteroid therapy can cause cardiac glycoside toxicity.
Read the full Lily Flower Extract + Betamethasone Valerate interactionChinese Licorice Root ExtractCorticosteroids, P-glycoprotein Substrates Moderate
Interaction Summary
Theoretically, concomitant use of licorice and corticosteroids might increase the side effects of corticosteroids.
Read the full Chinese Licorice Root Extract + Betamethasone Valerate interactionAmerican Ginseng Root ExtractImmunosuppressants Moderate
Interaction Summary
Theoretically, American ginseng use might interfere with immunosuppressive therapy.
Read the full American Ginseng Root Extract + Betamethasone Valerate interactionBudesonideEntocort EC, Eohilia, Pulmicort, Tarpeyo, Uceris
How Budesonide interacts with Dew Drops — through 2 ingredients. Tap an ingredient for the detail:
Lily Flower ExtractCorticosteroids Major
Interaction Summary
Theoretically, using lily-of-the-valley with prolonged corticosteroid therapy can cause cardiac glycoside toxicity.
Read the full Lily Flower Extract + Budesonide interactionChinese Licorice Root ExtractCytochrome P450 3a4 (cyp3a4) Substrates, Corticosteroids Moderate
Interaction Summary
Theoretically, licorice might increase or decrease levels of drugs metabolized by CYP3A4.
Read the full Chinese Licorice Root Extract + Budesonide interactionClobetasolClobex, Temovate
How Clobetasol interacts with Dew Drops — through 2 ingredients. Tap an ingredient for the detail:
Lily Flower ExtractCorticosteroids Major
Interaction Summary
Theoretically, using lily-of-the-valley with prolonged corticosteroid therapy can cause cardiac glycoside toxicity.
Read the full Lily Flower Extract + Clobetasol interactionChinese Licorice Root ExtractCorticosteroids, P-glycoprotein Substrates Moderate
Interaction Summary
Theoretically, concomitant use of licorice and corticosteroids might increase the side effects of corticosteroids.
Read the full Chinese Licorice Root Extract + Clobetasol interactionCortisone AcetateCortisone Tablets, Cortone
How Cortisone Acetate interacts with Dew Drops — through 3 ingredients. Tap an ingredient for the detail:
Lily Flower ExtractCorticosteroids Major
Interaction Summary
Theoretically, using lily-of-the-valley with prolonged corticosteroid therapy can cause cardiac glycoside toxicity.
Read the full Lily Flower Extract + Cortisone Acetate interactionAmerican Ginseng Root ExtractImmunosuppressants Moderate
Interaction Summary
Theoretically, American ginseng use might interfere with immunosuppressive therapy.
Read the full American Ginseng Root Extract + Cortisone Acetate interactionChinese Licorice Root ExtractP-glycoprotein Substrates, Corticosteroids Moderate
Interaction Summary
Theoretically, licorice might decrease the absorption of P-glycoprotein substrates.
Read the full Chinese Licorice Root Extract + Cortisone Acetate interactionDexamethasoneDecadron, Dexone, Dextenza, Dexycu, Hemady, Hexadrol +1 more
How Dexamethasone interacts with Dew Drops — through 3 ingredients. Tap an ingredient for the detail:
Lily Flower ExtractCorticosteroids Major
Interaction Summary
Theoretically, using lily-of-the-valley with prolonged corticosteroid therapy can cause cardiac glycoside toxicity.
Read the full Lily Flower Extract + Dexamethasone interactionAmerican Ginseng Root ExtractImmunosuppressants Moderate
Interaction Summary
Theoretically, American ginseng use might interfere with immunosuppressive therapy.
Read the full American Ginseng Root Extract + Dexamethasone interactionChinese Licorice Root ExtractP-glycoprotein Substrates, Corticosteroids +2 Moderate
Interaction Summary
Theoretically, licorice might decrease the absorption of P-glycoprotein substrates.
Read the full Chinese Licorice Root Extract + Dexamethasone interactionDigoxinDigitek, Lanoxicaps, Lanoxin
How Digoxin interacts with Dew Drops — through 2 ingredients. Tap an ingredient for the detail:
Lily Flower ExtractDigoxin (lanoxin) Major
Interaction Summary
Using lily-of-the-valley with digoxin can cause cardiac glycoside toxicity.
Read the full Lily Flower Extract + Digoxin interactionChinese Licorice Root ExtractP-glycoprotein Substrates, Digoxin (lanoxin) Moderate
Interaction Summary
Theoretically, licorice might decrease the absorption of P-glycoprotein substrates.
Read the full Chinese Licorice Root Extract + Digoxin interactionFludrocortisoneFlorinef Acetate
How Fludrocortisone interacts with Dew Drops — through 3 ingredients. Tap an ingredient for the detail:
Lily Flower ExtractCorticosteroids Major
Interaction Summary
Theoretically, using lily-of-the-valley with prolonged corticosteroid therapy can cause cardiac glycoside toxicity.
Read the full Lily Flower Extract + Fludrocortisone interactionAmerican Ginseng Root ExtractImmunosuppressants Moderate
Interaction Summary
Theoretically, American ginseng use might interfere with immunosuppressive therapy.
Read the full American Ginseng Root Extract + Fludrocortisone interactionChinese Licorice Root ExtractP-glycoprotein Substrates, Corticosteroids Moderate
Interaction Summary
Theoretically, licorice might decrease the absorption of P-glycoprotein substrates.
Read the full Chinese Licorice Root Extract + Fludrocortisone interactionFluticasoneFlixotide, Flonase, Flovent, Seretide, Veramyst
How Fluticasone interacts with Dew Drops — through 2 ingredients. Tap an ingredient for the detail:
Lily Flower ExtractCorticosteroids Major
Interaction Summary
Theoretically, using lily-of-the-valley with prolonged corticosteroid therapy can cause cardiac glycoside toxicity.
Read the full Lily Flower Extract + Fluticasone interactionChinese Licorice Root ExtractCorticosteroids, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, concomitant use of licorice and corticosteroids might increase the side effects of corticosteroids.
Read the full Chinese Licorice Root Extract + Fluticasone interactionFluticasone Furoate, Umeclidinium, VilanterolTrelegy Ellipta
How Fluticasone Furoate, Umeclidinium, Vilanterol interacts with Dew Drops — through 3 ingredients. Tap an ingredient for the detail:
Lily Flower ExtractCorticosteroids Major
Interaction Summary
Theoretically, using lily-of-the-valley with prolonged corticosteroid therapy can cause cardiac glycoside toxicity.
Read the full Lily Flower Extract + Fluticasone Furoate, Umeclidinium, Vilanterol interactionChinese Licorice Root ExtractCorticosteroids, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, concomitant use of licorice and corticosteroids might increase the side effects of corticosteroids.
Read the full Chinese Licorice Root Extract + Fluticasone Furoate, Umeclidinium, Vilanterol interactionPoria Sclerotium ExtractAnticholinergic Drugs Moderate
Interaction Summary
Theoretically, poria mushroom might decrease the clinical effects of anticholinergic drugs.
Read the full Poria Sclerotium Extract + Fluticasone Furoate, Umeclidinium, Vilanterol interactionFluticasone Furoate, Vilanterol TrifenatateBreo Ellipta
How Fluticasone Furoate, Vilanterol Trifenatate interacts with Dew Drops — through 2 ingredients. Tap an ingredient for the detail:
Lily Flower ExtractCorticosteroids Major
Interaction Summary
Theoretically, using lily-of-the-valley with prolonged corticosteroid therapy can cause cardiac glycoside toxicity.
Read the full Lily Flower Extract + Fluticasone Furoate, Vilanterol Trifenatate interactionChinese Licorice Root ExtractCorticosteroids, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, concomitant use of licorice and corticosteroids might increase the side effects of corticosteroids.
Read the full Chinese Licorice Root Extract + Fluticasone Furoate, Vilanterol Trifenatate interactionHydrocortisoneAlkindi Sprinkle, Alphaderm, Calmurid HC, Carmol HC cream, Cortef, Dioderm +8 more
How Hydrocortisone interacts with Dew Drops — through 3 ingredients. Tap an ingredient for the detail:
Lily Flower ExtractCorticosteroids Major
Interaction Summary
Theoretically, using lily-of-the-valley with prolonged corticosteroid therapy can cause cardiac glycoside toxicity.
Read the full Lily Flower Extract + Hydrocortisone interactionAmerican Ginseng Root ExtractImmunosuppressants Moderate
Interaction Summary
Theoretically, American ginseng use might interfere with immunosuppressive therapy.
Read the full American Ginseng Root Extract + Hydrocortisone interactionChinese Licorice Root ExtractP-glycoprotein Substrates, Corticosteroids +1 Moderate
Interaction Summary
Theoretically, licorice might decrease the absorption of P-glycoprotein substrates.
Read the full Chinese Licorice Root Extract + Hydrocortisone interactionMethylprednisoloneMedrol, Medrol Dosepak
How Methylprednisolone interacts with Dew Drops — through 3 ingredients. Tap an ingredient for the detail:
Lily Flower ExtractCorticosteroids Major
Interaction Summary
Theoretically, using lily-of-the-valley with prolonged corticosteroid therapy can cause cardiac glycoside toxicity.
Read the full Lily Flower Extract + Methylprednisolone interactionChinese Licorice Root ExtractCorticosteroids, P-glycoprotein Substrates +1 Moderate
Interaction Summary
Theoretically, concomitant use of licorice and corticosteroids might increase the side effects of corticosteroids.
Read the full Chinese Licorice Root Extract + Methylprednisolone interactionAmerican Ginseng Root ExtractImmunosuppressants Moderate
Interaction Summary
Theoretically, American ginseng use might interfere with immunosuppressive therapy.
Read the full American Ginseng Root Extract + Methylprednisolone interactionOlopatadine Hydrochloride, Mometasone FuroateRyaltris
How Olopatadine Hydrochloride, Mometasone Furoate interacts with Dew Drops — through 2 ingredients. Tap an ingredient for the detail:
Lily Flower ExtractCorticosteroids Major
Interaction Summary
Theoretically, using lily-of-the-valley with prolonged corticosteroid therapy can cause cardiac glycoside toxicity.
Read the full Lily Flower Extract + Olopatadine Hydrochloride, Mometasone Furoate interactionChinese Licorice Root ExtractCytochrome P450 3a4 (cyp3a4) Substrates, Corticosteroids Moderate
Interaction Summary
Theoretically, licorice might increase or decrease levels of drugs metabolized by CYP3A4.
Read the full Chinese Licorice Root Extract + Olopatadine Hydrochloride, Mometasone Furoate interactionPrednisoloneCortalone, Delta Cortef, Pred Forte, Prednisolone, Solupred, Sterane
How Prednisolone interacts with Dew Drops — through 3 ingredients. Tap an ingredient for the detail:
Lily Flower ExtractCorticosteroids Major
Interaction Summary
Theoretically, using lily-of-the-valley with prolonged corticosteroid therapy can cause cardiac glycoside toxicity.
Read the full Lily Flower Extract + Prednisolone interactionChinese Licorice Root ExtractP-glycoprotein Substrates, Corticosteroids +1 Moderate
Interaction Summary
Theoretically, licorice might decrease the absorption of P-glycoprotein substrates.
Read the full Chinese Licorice Root Extract + Prednisolone interactionAmerican Ginseng Root ExtractImmunosuppressants Moderate
Interaction Summary
Theoretically, American ginseng use might interfere with immunosuppressive therapy.
Read the full American Ginseng Root Extract + Prednisolone interactionPrednisoneCortan, Deltasone, Meticorten, Orasone, Prednicen-M, Prednisone +2 more
How Prednisone interacts with Dew Drops — through 3 ingredients. Tap an ingredient for the detail:
Lily Flower ExtractCorticosteroids Major
Interaction Summary
Theoretically, using lily-of-the-valley with prolonged corticosteroid therapy can cause cardiac glycoside toxicity.
Read the full Lily Flower Extract + Prednisone interactionChinese Licorice Root ExtractP-glycoprotein Substrates, Cytochrome P450 3a4 (cyp3a4) Substrates +1 Moderate
Interaction Summary
Theoretically, licorice might decrease the absorption of P-glycoprotein substrates.
Read the full Chinese Licorice Root Extract + Prednisone interactionAmerican Ginseng Root ExtractImmunosuppressants Moderate
Interaction Summary
Theoretically, American ginseng use might interfere with immunosuppressive therapy.
Read the full American Ginseng Root Extract + Prednisone interactionQuinineQualaquin
How Quinine interacts with Dew Drops — through 2 ingredients. Tap an ingredient for the detail:
Lily Flower ExtractQuinine Major
Interaction Summary
Theoretically, using lily-of-the-valley with quinine can increase the risk of cardiac glycoside toxicity.
Read the full Lily Flower Extract + Quinine interactionChinese Licorice Root ExtractCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, licorice might increase or decrease levels of drugs metabolized by CYP3A4.
Read the full Chinese Licorice Root Extract + Quinine interactionQuinine SulfateQuinamm, Quinine Sulfate
How Quinine Sulfate interacts with Dew Drops — through 2 ingredients. Tap an ingredient for the detail:
Lily Flower ExtractQuinine Major
Interaction Summary
Theoretically, using lily-of-the-valley with quinine can increase the risk of cardiac glycoside toxicity.
Read the full Lily Flower Extract + Quinine Sulfate interactionChinese Licorice Root ExtractCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, licorice might increase or decrease levels of drugs metabolized by CYP3A4.
Read the full Chinese Licorice Root Extract + Quinine Sulfate interactionTriamcinoloneAdcortyl in Orabase, Adcortyl Intra-articular / Intradermal, Aristocort, Kenacort, Kenalog Intra-articular / Intramuscular, Triesence
How Triamcinolone interacts with Dew Drops — through 3 ingredients. Tap an ingredient for the detail:
Lily Flower ExtractCorticosteroids Major
Interaction Summary
Theoretically, using lily-of-the-valley with prolonged corticosteroid therapy can cause cardiac glycoside toxicity.
Read the full Lily Flower Extract + Triamcinolone interactionChinese Licorice Root ExtractCorticosteroids, P-glycoprotein Substrates Moderate
Interaction Summary
Theoretically, concomitant use of licorice and corticosteroids might increase the side effects of corticosteroids.
Read the full Chinese Licorice Root Extract + Triamcinolone interactionAmerican Ginseng Root ExtractImmunosuppressants Moderate
Interaction Summary
Theoretically, American ginseng use might interfere with immunosuppressive therapy.
Read the full American Ginseng Root Extract + Triamcinolone interactionTriamcinolone AcetonideXipere, Zilretta
How Triamcinolone Acetonide interacts with Dew Drops — through 3 ingredients. Tap an ingredient for the detail:
Lily Flower ExtractCorticosteroids Major
Interaction Summary
Theoretically, using lily-of-the-valley with prolonged corticosteroid therapy can cause cardiac glycoside toxicity.
Read the full Lily Flower Extract + Triamcinolone Acetonide interactionChinese Licorice Root ExtractP-glycoprotein Substrates, Corticosteroids Moderate
Interaction Summary
Theoretically, licorice might decrease the absorption of P-glycoprotein substrates.
Read the full Chinese Licorice Root Extract + Triamcinolone Acetonide interactionAmerican Ginseng Root ExtractImmunosuppressants Moderate
Interaction Summary
Theoretically, American ginseng use might interfere with immunosuppressive therapy.
Read the full American Ginseng Root Extract + Triamcinolone Acetonide interactionWarfarinWarfarin
How Warfarin interacts with Dew Drops — through 2 ingredients. Tap an ingredient for the detail:
American Ginseng Root ExtractWarfarin (coumadin) Major
Interaction Summary
American ginseng seems to decrease the effectiveness of warfarin therapy.
Read the full American Ginseng Root Extract + Warfarin interactionChinese Licorice Root ExtractCytochrome P450 2c19 (cyp2c19) Substrates, Warfarin (coumadin) +4 Moderate
Interaction Summary
Theoretically, licorice might increase levels of drugs metabolized by CYP2C19.
Read the full Chinese Licorice Root Extract + Warfarin interactionWarfarin SodiumCoumadin, Panwarfin, Sofarin
How Warfarin Sodium interacts with Dew Drops — through 2 ingredients. Tap an ingredient for the detail:
American Ginseng Root ExtractWarfarin (coumadin) Major
Interaction Summary
American ginseng seems to decrease the effectiveness of warfarin therapy.
Read the full American Ginseng Root Extract + Warfarin Sodium interactionChinese Licorice Root ExtractCytochrome P450 2c8 (cyp2c8) Substrates, Warfarin (coumadin) +4 Moderate
Interaction Summary
Theoretically, licorice might increase levels of drugs metabolized by CYP2C8.
Read the full Chinese Licorice Root Extract + Warfarin Sodium interaction6-mercaptopurinePurinethol
How 6-mercaptopurine interacts with Dew Drops — through 1 ingredient. Tap an ingredient for the detail:
American Ginseng Root ExtractImmunosuppressants Moderate
Interaction Summary
Theoretically, American ginseng use might interfere with immunosuppressive therapy.
Read the full American Ginseng Root Extract + 6-mercaptopurine interactionAdo-trastuzumab EmtansineKadcyla
How Ado-trastuzumab Emtansine interacts with Dew Drops — through 1 ingredient. Tap an ingredient for the detail:
Chinese Licorice Root ExtractCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, licorice might increase or decrease levels of drugs metabolized by CYP3A4.
Read the full Chinese Licorice Root Extract + Ado-trastuzumab Emtansine interactionEach ingredient & the kinds of drugs it affects
For each ingredient in Dew Drops with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.
Chinese Licorice root extract
Antihypertensive Drugs
Theoretically, licorice might reduce the effects of antihypertensive drugs.
In human research, licorice increases blood pressure in a dose-dependent manner.
Cisplatin (Platinol-Aq)
Theoretically, licorice might reduce the effects of cisplatin.
In animal research, licorice diminished the therapeutic efficacy of cisplatin.
Corticosteroids
Theoretically, concomitant use of licorice and corticosteroids might increase the side effects of corticosteroids.
Case reports suggest that concomitant use of licorice and oral corticosteroids, such as hydrocortisone, can potentiate the duration of activity and increase blood levels of corticosteroids. Additionally, in one case report, a patient with neurogenic orthostatic hypertension stabilized on fludrocortisone 0.1 mg twice daily developed pseudohyperaldosteronism after recent consumption of large amounts of black licorice.
Cytochrome P450 2B6 (Cyp2B6) Substrates
Theoretically, licorice might increase levels of drugs metabolized by CYP2B6.
In vitro research shows that licorice extract and glabridin, a licorice constituent, inhibit CYP2B6 isoenzymes. Licorice extract from the species G. uralensis seems to inhibit CYP2B6 isoenzymes to a greater degree than G. glabra extract in vitro. Theoretically, these species of licorice might increase levels of drugs metabolized by CYP2B6; however, these interactions have not yet been reported in humans.
Cytochrome P450 2C19 (Cyp2C19) Substrates
Theoretically, licorice might increase levels of drugs metabolized by CYP2C19.
In vitro, licorice extracts from the species G. glabra and G. uralensis inhibit CYP2C19 isoenzymes in vitro. Theoretically, these species of licorice might increase levels of drugs metabolized by CYP2C19; however, this interaction has not yet been reported in humans.
Cytochrome P450 2C8 (Cyp2C8) Substrates
Theoretically, licorice might increase levels of drugs metabolized by CYP2C8.
In vitro, licorice extract from the species G. glabra and G. uralensis inhibits CYP2C8 isoenzymes. Theoretically, these species of licorice might increase levels of drugs metabolized by CYP2C8; however, this interaction has not yet been reported in humans.
Cytochrome P450 2C9 (Cyp2C9) Substrates
Theoretically, licorice might increase or decrease levels of drugs metabolized by CYP2C9.
There is conflicting evidence about the effect of licorice on CYP2C9 enzyme activity. In vitro research shows that extracts from the licorice species G. glabra and G. uralensis moderately inhibit CYP2C9 isoenzymes. However, evidence from an animal model shows that licorice extract from the species G. uralensis can induce hepatic CYP2C9 activity. Until more is known, licorice should be used cautiously in people taking CYP2C9 substrates.
Cytochrome P450 3A4 (Cyp3A4) Substrates
Theoretically, licorice might increase or decrease levels of drugs metabolized by CYP3A4.
Pharmacokinetic research shows that the licorice constituent glycyrrhizin, taken in a dosage of 150 mg orally twice daily for 14 days, modestly decreases the area under the concentration-time curve of midazolam by about 20%. Midazolam is a substrate of CYP3A4, suggesting that glycyrrhizin modestly induces CYP3A4 activity. Animal research also shows that licorice extract from the species G. uralensis induces CYP3A4 activity. However, licorice extract from G. glabra species appear to inhibit CYP3A4-induced metabolism of testosterone in vitro. It is thought that the G. glabra inhibits CYP3A4 due to its constituent glabridin, which is a moderate CYP3A4 inhibitor in vitro and not present in other licorice species. Until more is known, licorice should be used cautiously in people taking CYP3A4 substrates.
Digoxin (Lanoxin)
Theoretically, concomitant use of licorice with digoxin might increase the risk of cardiac toxicity.
Overuse or misuse of licorice with cardiac glycoside therapy might increase the risk of cardiac toxicity due to potassium loss.
Diuretic Drugs
Theoretically, concomitant use of licorice with diuretic drugs might increase the risk of hypokalemia.
Overuse of licorice might compound diuretic-induced potassium loss. In one case report, a 72-year-old male with a past medical history of hypertension, type 2 diabetes, hyperlipidemia, arrhythmia, stroke, and hepatic dysfunction was hospitalized with severe hypokalemia and uncontrolled hypertension due to pseudohyperaldosteronism. This was thought to be provoked by concomitant daily consumption of a product containing 225 mg of glycyrrhizin, a constituent of licorice, and hydrochlorothiazide 12.5 mg for 1 month.
Estrogens
Theoretically, licorice might increase or decrease the effects of estrogen therapy.
Theoretically, licorice might interfere with estrogen therapy due to estrogenic and anti-estrogenic effects.
Loop Diuretics
Theoretically, loop diuretics might increase the mineralocorticoid effects of licorice.
Theoretically, loop diuretics might enhance the mineralocorticoid effects of licorice by inhibiting the enzyme that converts cortisol to cortisone; however, bumetanide (Bumex) does not appear to have this effect.
Midazolam (Versed)
Theoretically, licorice might decrease levels of midazolam.
In humans, the licorice constituent glycyrrhizin appears to moderately induce the metabolism of midazolam. This is likely due to induction of cytochrome P450 3A4 by licorice. Until more is known, licorice should be used cautiously in people taking midazolam.
P-Glycoprotein Substrates
Theoretically, licorice might decrease the absorption of P-glycoprotein substrates.
In vitro research shows that licorice can increase P-glycoprotein activity.
Paclitaxel (Abraxane, Onxol)
Theoretically, licorice might decrease plasma levels and clinical effects of paclitaxel.
Multiple doses of licorice taken concomitantly with paclitaxel might reduce the effectiveness of paclitaxel. Animal research shows that licorice 3 grams/kg given orally for 14 days before intravenous administration of paclitaxel decreases the exposure to paclitaxel and increases its clearance. Theoretically, this occurs because licorice induces cytochrome P450 3A4 enzymes, which metabolize paclitaxel. Notably, a single dose of licorice did not affect exposure or clearance of paclitaxel.
Warfarin (Coumadin)
Theoretically, licorice might decrease plasma levels and clinical effects of warfarin.
Licorice seems to increase metabolism and decrease levels of warfarin in animal models. This is likely due to induction of cytochrome P450 2C9 (CYP2C9) metabolism by licorice. Advise patients taking warfarin to avoid taking licorice.
Cytochrome P450 1A2 (Cyp1A2) Substrates
Theoretically, licorice might decrease the levels and clinical effects of CYP1A2 substrates.
In vitro research shows that licorice induces CYP1A2 enzymes.
Methotrexate (Trexall, Others)
Theoretically, licorice might increase levels of methotrexate.
Animal research suggests that intravenous administration of glycyrrhizin, a licorice constituent, and high-dose methotrexate may delay methotrexate excretion and increase systemic exposure, leading to transient elevations in liver enzymes and total bilirubin. This interaction has not yet been reported in humans.
Poria sclerotium extract
Anticholinergic Drugs
Theoretically, poria mushroom might decrease the clinical effects of anticholinergic drugs.
In animal research, poria mushroom essential oil reduces acetylcholinesterase activity. This interaction has not been shown in humans.
Cholinergic Drugs
Theoretically, poria mushroom might have additive effects when used with cholinergic drugs.
In animal research, poria mushroom essential oil reduces acetylcholinesterase activity. This interaction has not been shown in humans.
Cns Depressants
Theoretically, taking poria mushroom extract may enhance the therapeutic and adverse effects of sedatives.
Animal research shows that poria mushroom extract has sedative properties. This interaction has not been shown in humans.
American Ginseng root extract
Warfarin (Coumadin)
American ginseng seems to decrease the effectiveness of warfarin therapy.
Healthy patients receiving warfarin 5 mg daily, who also take American ginseng 1 gram twice daily, seem to have a significantly reduced international normalized ratio (INR).
Antidiabetes Drugs
Theoretically, taking American ginseng with antidiabetes drugs might increase the risk of hypoglycemia.
American ginseng seems to lower postprandial blood glucose. Theoretically, concomitant use with antidiabetes drugs might enhance blood glucose lowering effects and possibly cause hypoglycemia.
Immunosuppressants
Theoretically, American ginseng use might interfere with immunosuppressive therapy.
American ginseng seems to stimulate immune function. Theoretically, American ginseng might decrease the effectiveness of immunosuppressant drugs.
Monoamine Oxidase Inhibitors (Maois)
Theoretically, American ginseng can interfere with MAOI therapy.
There is one case report of insomnia, headache, and tremors when an unspecified ginseng product was used with phenelzine (Nardil), an MAOI. There is also one case report of hypomania when an unspecified ginseng product was used with phenelzine. Theoretically, American ginseng may interfere with MAOI therapy.
Lily Flower Extract
Corticosteroids
Theoretically, using lily-of-the-valley with prolonged corticosteroid therapy can cause cardiac glycoside toxicity.
Lily-of-the-valley contains cardiac glycosides. Concomitant, long-term corticosteroid use can increase the risk of cardiac glycoside toxicity due to potassium depletion and electrolyte imbalance.
Digoxin (Lanoxin)
Using lily-of-the-valley with digoxin can cause cardiac glycoside toxicity.
Lily-of-the-valley contains cardiac glycosides. Use of the cardiac glycoside digoxin and lily-of-the-valley concomitantly increases the risk of cardiac glycoside toxicity.
Quinine
Theoretically, using lily-of-the-valley with quinine can increase the risk of cardiac glycoside toxicity.
Quinine may reduce the clearance of oral digoxin. Theoretically, concomitant use of quinine with lily-of-the-valley might reduce the clearance of cardiac glycosides found in lily-of-the-valley and increase the risk of toxicity.
Diuretic Drugs
Theoretically, using lily-of-the-valley with diuretics can increase the risk of cardiac glycoside toxicity.
Lily-of-the-valley contains cardiac glycosides. Concomitant use of potassium depleting diuretics and lily-of-the-valley can increase the risk of cardiac glycoside toxicity due to potassium depletion and electrolyte imbalance.
Lithium
Theoretically, lily-of-the-valley can increase levels of lithium and increase toxicity.
Lily-of-the-valley is thought to have diuretic properties. Theoretically, due to these potential diuretic effects, lily-of-the-valley might reduce excretion and increase levels of lithium. The dose of lithium might need to be decreased.
Macrolide Antibiotics
Theoretically, using lily-of-the-valley with macrolide antibiotics can increase the risk of cardiac glycoside toxicity.
Macrolide antibiotics appear to increase the gastrointestinal absorption of oral digoxin. Theoretically, concomitant use of macrolide antibiotics might increase the absorption of the cardiac glycosides found in lily-of-the-valley.
Stimulant Laxatives
Theoretically, using lily-of-the-valley with stimulant laxatives can increase the risk of cardiac glycoside toxicity.
Lily-of-the-valley contains cardiac glycosides. The overuse of stimulant laxatives can increase the risk of cardiac glycoside toxicity with lily-of-the-valley due to potassium depletion.
Tetracycline Antibiotics
Theoretically, using lily-of-the-valley with tetracycline antibiotics might increase the risk of cardiac glycoside toxicity.
Tetracycline antibiotics appear to increase the gastrointestinal absorption of oral digoxin, a cardiac glycoside. Theoretically, concomitant use of tetracycline antibiotics might increase the absorption of the cardiac glycosides found in lily-of-the-valley.
Brand information
Manufacturer and brand details for Dew Drops, from the product label.
Ron Teeguarden's Dragon Herbs
See all Ron Teeguarden's Dragon Herbs products- Name
- Ron Teeguarden's Dragon Herbs
- Street Address
- P.O. Box 361459
- City
- Los Angeles
- State
- CA
- ZipCode
- 90036
- Phone Number
- (888) 558-6642
- Web Address
- www.dragonherbs.com
Dew Drops by Ron Teeguarden's Dragon Herbs: Common Questions
Does Dew Drops by Ron Teeguarden's Dragon Herbs interact with any medications?
How can one product interact with so many drugs?
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Does American ginseng really help with colds?
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Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Not sure if Dew Drops is safe with your meds?
Our pharmacists answer your medication & supplement questions — free.
Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.
The Full Monographs Behind Dew Drops’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
American Ginseng
Interacts with 217 drugsAmerican ginseng is an herbal root used as an 'adaptogen' to support energy, stress, immune function, and blood sugar. Some uses—such as reducing the chance or length of colds and modestly l...
Read the full American Ginseng monograph → Herb & supplement monographLicorice
Interacts with 1,040 drugsLicorice root is a traditional remedy used for sore throats, coughs, and digestive complaints, but solid human evidence is limited for most uses. Regular licorice contains glycyrrhizin, whic...
Read the full Licorice monograph → Herb & supplement monographPoria Mushroom
Interacts with 417 drugsPoria mushroom (Fu Ling) is a fungus long used in Traditional Chinese Medicine, mainly as a mild diuretic and digestive and calming aid. Modern scientific evidence in humans is very limited,...
Read the full Poria Mushroom monograph → Herb & supplement monographLily-of-the-valley
Interacts with 157 drugsLily-of-the-valley is a poisonous plant that contains powerful heart-affecting compounds called cardiac glycosides, similar to the drug digoxin. While it was used historically for heart cond...
Read the full Lily-of-the-valley monograph →Sources & How We Checked
Dew Drops's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 114 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
American Ginseng 12 references
- Shader RI, Greenblatt DJ. Phenelzine and the dream machine-ramblings and reflections. J Clin Psychopharmacol 1985;5:65. PubMed
- Jones BD, Runikis AM. Interaction of ginseng with phenelzine. J Clin Psychopharmacol 1987;7:201-2. PubMed
- Janetzky K, Morreale AP. Probable interaction between warfarin and ginseng. Am J Health Syst Pharm 1997;54:692-3. PubMed
- Vuksan V, Sievenpiper JL, Koo VY, et al. American ginseng (Panax quinquefolius L) reduces postprandial glycemia in nondiabetic subjects and subjects with type 2 diabetes mellitus. Arch Intern Med 2000;160:1009-13. PubMed
- Vuksan V, Stavro MP, Sievenpiper JL, et al. Similar postprandial glycemic reductions with escalation of dose and administration time of American ginseng in type 2 diabetes. Diabetes Care 2000;23:1221-6. PubMed
- Chan LY, Chiu PY, Lau TK. An in-vitro study of ginsenoside Rb(1)-induced teratogenicity using a whole rat embryo culture model. Hum Reprod 2003;18:2166-8..
- McElhaney JE, Gravenstein S, Cole SK, et al. A Placebo-Controlled Trial of a Proprietary Extract of North American Ginseng (CVT-E002) to Prevent Acute Respiratory Illness in Institutionalized Older Adults. J Am Geriatr Soc 2004;52:13-9. PubMed
- Yuan CS, Wei G, Dey L, et al. American ginseng reduces warfarin's effect in healthy patients: a randomized, controlled trial. Ann Intern Med 2004;141:23-7.
- Predy GN, Goel V, Lovlin R, et al. Efficacy of an extract of North American ginseng containing poly-furanosyl-pyranosyl-saccharides for preventing upper respiratory tract infections: a randomized controlled trial. CMAJ 2005;173:1043-8.. PubMed
- McElhaney JE, Goel V, Toane B, et al. Efficacy of COLD-fX in the prevention of respiratory symptoms in community-dwelling adults: a randomized, double-blinded, placebo controlled trial. J Altern Complement Med 2006;12:153-7. PubMed
- Predy GN, Goel V, Lovlin RE, et al. Immune modulating effects of daily supplementation of COLD-fX (a proprietary extract of North American ginseng) in healthy adults. J Clin Biochem Nutr 2006;39:162-167. DOI
- Stavro PM, Woo M, Leiter LA, et al. Long-term intake of North American ginseng has no effect on 24-hour blood pressure and renal function. Hypertension 2006;47(4):791-6. PubMed
Licorice 92 references
- Farese RV Jr, Biglieri EG, Shackleton CH, et al. Licorice-induced hypermineralocorticoidism. N Engl J Med 1991;325:1223-7. PubMed
- Sigurjonsdottir HA, Ragnarsson J, Franzson L, Sigurdsson G. Is blood pressure commonly raised by moderate consumption of liquorice? J Hum Hypertens 1995;9:345-8.
- Armanini D, Lewicka S, Pratesi C, et al. Further studies on the mechanism of the mineralocorticoid action of licorice in humans. J Endocrinol Invest 1996;19:624-9. PubMed
- Zhang YD, Lorenzo B, Reidenberg MM. Inhibition of 11 beta hydroxysteroid dehydrogenase obtained from guinea pig kidney by furosemide, naringenin and some other compounds. J Steroid Biochem Mol Biol 1994;49:81-5.
- Strandberg TE, Jarvenpaa AL, Vanhanen H, McKeigue PM. Birth outcome in relation to licorice consumption during pregnancy. Am J Epidemiol 2001;153:1085-8. PubMed
- Sigurjonsdottir HA, Franzson L, Manhem K, et al. Liquorice-induced rise in blood pressure: a linear dose-response relationship. J Hum Hypertens 2001;15:549-52. PubMed
- Amato P, Christophe S, Mellon PL. Estrogenic activity of herbs commonly used as remedies for menopausal symptoms. Menopause 2002;9:145-50. PubMed
- Kent UM, Aviram M, Rosenblat M, Hollenberg PF. The licorice root derived isoflavan glabridin inhibits the activities of human cytochrome P450S 3A4, 2B6, and 2C9. Drug Metab Dispos 2002;30:709-15.. PubMed
- Yoshida S, Takayama Y. Licorice-induced hypokalemia as a treatable cause of dropped head syndrome. Clin Neurol Neurosurg 2003;105:286-7.. PubMed
- Strandberg TE, Andersson S, Jarvenpaa AL, et al. Preterm birth and licorice consumption during pregnancy. Am J Epidemiol 2002;156:803-5.. PubMed
- Hussain RM. The sweet cake that reaches parts other cakes can't! Postgrad Med J 2003;79:115-6.. PubMed
- Morris DJ, Davis E, Latif SA. Licorice, tobacco chewing, and hypertension. N Engl J Med 1990;322:849-50. PubMed
- Quinkler M, Stewart PM. Hypertension and the cortisol-cortisone shuttle. J Clin Endocrinol Metab 2003;88:2384-92. PubMed
- Westman EC, Guthrie GP. Licorice, tobacco chewing, and hypertension. N Engl J Med 1990;322:850. PubMed
- Mu Y, Zhang J, Zhang S, et al. Traditional Chinese medicines Wu Wei Zi (Schisandra chinensis Baill) and Gan Cao (Glycyrrhiza uralensis Fisch) activate pregnane X receptor and increase warfarin clearance in rats. J Pharmacol Exp Ther 2006;316:1369-77. PubMed
- Yasue H, Itoh T, Mizuno Y, Harada E. Severe hypokalemia, rhabdomyolysis, muscle paralysis, and respiratory impairment in a hypertensive patient taking herbal medicines containing licorice. Intern Med 2007;46:575-8. PubMed
- Brayley J, Jones J. Life-threatening hypokalemia associated with excessive licorice ingestion (letter). Am J Psychiatry 1994;151:617-8. PubMed
- de Klerk GJ, Nieuwenhuis G, Beutler JJ. Hypokalaemia and hypertension associated with use of liquorice flavoured chewing gum. BMJ 1997;314:731-2.
- Dellow EL, Unwin RJ, Honour JW. Pontefract cakes can be bad for you: refractory hypertension and liquorice excess. Nephol Dial Transplant 1999;14:218-20. PubMed
- Elinav E, Chajek-Shaul T. Licorice consumption causing severe hypokalemic paralysis. Mayo Clin Proc 2003;78:767-8. PubMed
- Eriksson JW, Carlberg B, Hillom V. Life-threatening ventricular tachycardia due to liquorice-induced hypokalemia. J Intern Med 1999;245:307-10.
- Janse A, van Iersel M, Hoefnagels WH, Olde Rikker MG. The old lady who liked liquorice: hypertension due to chronic intoxication in a memory-impaired patient. Neth J Med 2005;63:149-50.
- Lin SH, Yang SS, Chau T, Halperin ML. An unusual cause of hypokalemic paralysis: chronic licorice ingestion. Am J Med Sci 2003;325:153-6. PubMed
- van den Bosch AE, van der Klooster JM, Zuidgeest DM, et al. Severe hypokalemic paralysis and rhabdomyolysis due to ingestion of liquorice. Neth J Med 2005;63:146-8.
- van Uum SH. Liquorice and hypertension. Neth J Med 2005;63:119-20.
- Russo S, Mastropasqua M, Mosetti MA, et al. Low doses of liquorice can induce hypertension encephalopathy. Am J Nephrol 2000;20:145-8. PubMed
- Stormer FC, Reistad R, Alexander J. Glycyrrhizic acid in liquorice - evaluation of health hazard. Food Chem Toxicol 1993;31:303-12. PubMed
- Sontia B, Mooney J, Gaudet L, Touyz RM. Pseudohyperaldosteronism, liquorice, and hypertension. J Clin Hypertens (Greenwich) 2008;10:153-7. PubMed
- Francini-Pesenti F, Puato M, Piccoli A, Brocadello F. Liquorice-induced hypokalaemia and water retention in the absence of hypertension. Phytother Res 2008;22:563-5. PubMed
- Lapi F, Gallo E, Bernasconi S, et al. Myopathies associated with red yeast rice and liquorice: spontaneous reports from the Italian Surveillance System of Natural Health Products. Br J Clin Pharmacol 2008;66:572-4. PubMed
- Chen MF, Shimada F, Kato H, Yano S, Kanaoka M. Effect of glycyrrhizin on the pharmacokinetics of prednisolone following low dosage of prednisolone hemisuccinate. Endocrinol Jpn 1990;37:331-41. PubMed
- Teelucksingh S, Mackie AD, Burt D, McIntyre MA, Brett L, Edwards CR. Potentiation of hydrocortisone activity in skin by glycyrrhetinic acid. Lancet 1990;335(8697):1060-3. PubMed
- Heidemann HT, Kreuzfelder E. Hypokalemic rhabdomyolysis with myoglobinuria due to licorice ingestion and diuretic treatment. Klin Wochenschr 1983;61:303-5. PubMed
- Hukkanen J, Ukkola O, Savolainen MJ. Effects of low-dose liquorice alone or in combination with hydrochlorothiazide on the plasma potassium in healthy volunteers. Blood Press 2009;18:192-5. PubMed
- Bisogni V, Rossi GP, Calò LA. Apparent mineralcorticoid excess syndrome, an often forgotten or unrecognized cause of hypokalemia and hypertension: case report and appraisal of the pathophysiology. Blood Press. 2014 Jun;23(3):189-92. PubMed
- Dehours E, Vallé B, Rougé-Bugat ME, Florent B, Bounes V, Franchitto N. Suspected hypokalaemia following liquorice ingestion on board ship. J Telemed Telecare. 2013 Jun;19(4):227-8. PubMed
- Kormann R, Languille E, Amiot HM, Hertig A. Dying for a cup of tea. BMJ Case Rep. 2012 Oct 19;2012. PubMed
- Panduranga P, Al-Rawahi N. Licorice-induced severe hypokalemia with recurrent torsade de pointes. Ann Noninvasive Electrocardiol. 2013 Nov;18(6):593-6. PubMed
- Räikkönen K, Seckl JR, Heinonen K, Pyhälä R, Feldt K, Jones A, Pesonen AK, Phillips DI, Lahti J, Järvenpää AL, Eriksson JG, Matthews KA, Strandberg TE, Kajantie E. Maternal prenatal licorice consumption alters hypothalamic-pituitary-adrenocortical axis fu
- Robles BJ, Sandoval AR, Dardon JD, Blas CA. Lethal liquorice lollies (liquorice abuse causing pseudohyperaldosteronism). BMJ Case Rep. 2013 Sep 19;2013. PubMed
- Chamberlain, J. J. and Abolnik, I. Z. Pulmonary edema following a licorice binge. West J Med 1997;167(3):184-185.
- Barrella, M., Lauria, G., Quatrale, R., and Paolino, E. Hypokaliemic rhabdomyolysis associated with liquorice ingestion: report of an atypical case. Ital.J Neurol.Sci 1997;18(4):217-220. PubMed
- Fugh-Berman, A. Herb-drug interactions. Lancet 2000;355(9198):134-138. PubMed
- Hasegawa, J., Suyama, Y., Kinugawa, T., Morisawa, T., and Kishimoto, Y. Echocardiographic findings of the heart resembling dilated cardiomyopathy during hypokalemic myopathy due to licorice-induced pseudoaldosteronism. Cardiovasc.Drugs Ther 1998;12(6):59 PubMed
- van Rossum, T. G., Vulto, A. G., Hop, W. C., Brouwer, J. T., Niesters, H. G., and Schalm, S. W. Intravenous glycyrrhizin for the treatment of chronic hepatitis C: a double-blind, randomized, placebo-controlled phase I/II trial. J Gastroenterol Hepatol 199 PubMed
- Lozano, P., Flores, D., Martinez, S., Artigues, I., Rimbau, E. M., and Gomez, F. Upper limb ischemia induced by chronic licorice ingestion. J Cardiovasc.Surg (Torino) 2000;41(4):631-632.
- Brouwers, A. J. and van der, Meulen J. ['Licorice hypertension' also caused by licorice tea]. Ned.Tijdschr Geneeskd. 4-14-2001;145(15):744-747.
- van Rossum, T. G., Vulto, A. G., Hop, W. C., and Schalm, S. W. Glycyrrhizin-induced reduction of ALT in European patients with chronic hepatitis C. Am J Gastroenterol 2001;96(8):2432-2437. PubMed
- Sigurjonsdottir, H. A., Manhem, K., Axelson, M., and Wallerstedt, S. Subjects with essential hypertension are more sensitive to the inhibition of 11 beta-HSD by liquorice. J Hum Hypertens 2003;17(2):125-131.
- Shintani, S., Murase, H., Tsukagoshi, H., and Shiigai, T. Glycyrrhizin (licorice)-induced hypokalemic myopathy. Report of 2 cases and review of the literature. Eur Neurol 1992;32(1):44-51. PubMed
- Chen, M. F., Shimada, F., Kato, H., Yano, S., and Kanaoka, M. Effect of oral administration of glycyrrhizin on the pharmacokinetics of prednisolone. Endocrinol Jpn 1991;38(2):167-174. PubMed
- Lee, C. K., Park, K. K., Lim, S. S., Park, J. H., and Chung, W. Y. Effects of the licorice extract against tumor growth and cisplatin-induced toxicity in a mouse xenograft model of colon cancer. Biol Pharm Bull 2007;30(11):2191-2195. PubMed
- Isaia, G. C., Pellissetto, C., Ravazzoli, M., and Tamone, C. Acute adrenal crisis and hypercalcemia in a patient assuming high liquorice doses. Minerva Med 2008;99(1):91-94.
- Bocker, D. and Breithardt, G. [Induction of arrhythmia by licorice abuse]. Z Kardiol 1991;80(6):389-391.
- Tacconi, P., Paribello, A., Cannas, A., and Marrosu, M. G. Carpal tunnel syndrome triggered by excessive licorice consumption. J Peripher.Nerv.Syst. 2009;14(1):64-65. PubMed
- Tu, J. H., He, Y. J., Chen, Y., Fan, L., Zhang, W., Tan, Z. R., Huang, Y. F., Guo, D., Hu, D. L., Wang, D., and Hong-Hao Zhou. Effect of glycyrrhizin on the activity of CYP3A enzyme in humans. Eur J Clin Pharmacol 2010;66(8):805-810. PubMed
- Goultschin, J., Palmon, S., Shapira, L., Brayer, L., and Gedalia, I. Effect of glycyrrhizin-containing toothpaste on dental plaque reduction and gingival health in humans. A pilot study. J Clin Periodontol 1991;18(3):210-212. PubMed
- Scali, M., Pratesi, C., Zennaro, M. C., Zampollo, V., and Armanini, D. Pseudohyperaldosteronism from liquorice-containing laxatives. J Endocrinol Invest 1990;13(10):847-848. PubMed
- Chatterjee, N., Domoto-Reilly, K., Fecci, P. E., Schwamm, L. H., and Singhal, A. B. Licorice-associated reversible cerebral vasoconstriction with PRES. Neurology 2010;75(21):1939-1941. PubMed
- Imtiaz, K. E. Sweet root, bitter pill: liquorice-induced hyperaldosteronism. QJM 2011;104(12):1093-1095. PubMed
- van Beers, E. J., Stam, J., and van den Bergh, W. M. Licorice consumption as a cause of posterior reversible encephalopathy syndrome: a case report. Crit Care 2011;15(1):R64. PubMed
- MacKenzie, M. A., Hoefnagels, W. H., Jansen, R. W., Benraad, T. J., and Kloppenborg, P. W. The influence of glycyrrhetinic acid on plasma cortisol and cortisone in healthy young volunteers. J Clin Endocrinol Metab 1990;70(6):1637-1643. PubMed
- Bardhan, K. D., Cumberland, D. C., Dixon, R. A., and Holdsworth, C. D. Clinical trial of deglycyrrhizinised liquorice in gastric ulcer. Gut 1978;19(9):779-782. PubMed
- Koster, M. and David, G. K. Reversible severe hypertension due to licorice ingestion. N Engl J Med 1968;278(25):1381-1383. PubMed
- Corse, F. M., Galgani, S., Gasparini, C., Giacanelli, M., and Piazza, G. Acute hypokalemic myopathy due to chronic licorice ingestion: report of a case. Ital J Neurol Sci 1983;4(4):493-497. PubMed
- Berlango Jimenez A., Jimenez Murillo L., Montero Perez F. J., Munoz Avila J. A., Torres Murillo J., and Calderon de la Barca Gazquez J. M. [Acute rhabdomyolysis and tetraparesis secondary to hypokalemia due to ingested licorice]. An Med Interna 1995;12(1)
- Bernardi, M., D'Intino, P. E., Trevisani, F., Cantelli-Forti, G., Raggi, M. A., Turchetto, E., and Gasbarrini, G. Effects of prolonged ingestion of graded doses of licorice by healthy volunteers. Life Sci 1994;55(11):863-872. PubMed
- van der Zwan A. Hypertension encephalopathy after liquorice ingestion. Clin Neurol Neurosurg 1993;95(1):35-37. PubMed
- Werner, S., Brismar, K., and Olsson, S. Hyperprolactinaemia and liquorice. Lancet 2-10-1979;1(8111):319.
- Nishioka, K. and Seguchi, T. Contact allergy due to oil-soluble licorice extracts in cosmetic products. Contact Dermatitis 1999;40(1):56. PubMed
- Yoshino T, Yanagawa T, Watanabe K. Risk factors for pseudoaldosteronism with rhabdomyolysis caused by consumption of drugs containing licorice and differences between incidence of these conditions in Japan and other countries: case report and literature r
- Li G, Simmler C, Chen L, et al. Cytochrome P450 inhibition by three licorice species and fourteen licorice constituents. Eur J Pharm Sci. 2017;109:182-190. PubMed
- Li J, Fan X, Wang Q. Hypertensive crisis with 2 target organ impairment induced by glycyrrhizin: a case report. Medicine (Baltimore) 2018;97(11):e0073. PubMed
- Foster CA, Church KS, Poddar M, Van Uum SH, Spaic T. Licorice-induced hypertension: a case of pseudohyperaldosteronism due to jelly bean ingestion. Postgrad Med 2017;129(3):329-31. PubMed
- Gallacher SD, Tsokolas G, Dimitropoulos I. Liquorice-induced apparent mineralocorticoid excess presenting in the emergency department. Clin Med (Lond) 2017;17(1):43-5. PubMed
- Dai DW, Singh I, Hershman JM. Lozenge-induced hypermineralcorticoid state--a unique case of licorice lozenges resulting in hypertension and hypokalemia. J Clin Hypertens (Greenwich) 2016;18(2):159-60.
- O'Connell K, Kinsella J, McMahon C, Holian J, O'Riordan S. Posterior reversible encephalopathy syndrome (PRES) associated with liquorice consumption. Ir J Med Sci 2016;185(4):945-7. PubMed
- Hataya Y, Oba A, Yamashita T, Komatsu Y. Hyponatremia in an elderly patient due to isolated hypoaldosteronism occurring after licorice withdrawal. Intern Med 2017;56(2):175-9. PubMed
- Ha Y, Wang T, Li J, et al. Herb-Drug Interaction Potential of Licorice Extract and Paclitaxel: A Pharmacokinetic Study in Rats. Eur J Drug Metab Pharmacokinet. 2020;45(2):257-264. PubMed
- Edelman ER, Butala NM, Avery LL, Lundquist AL, Dighe AS. Case 30-2020: A 54-Year-Old Man with Sudden Cardiac Arrest. N Engl J Med. 2020;383(13):1263-1275. PubMed
- Wang H, Dong L, Qu F, et al. Effects of glycyrrhizin on the pharmacokinetics of nobiletin in rats and its potential mechanism. Pharm Biol. 2020 Dec;58(1):352-356. PubMed
- Attou R, Redant S, Honore PM, Preseau T, Hantson P, De Bels D. Liquorice intoxication can lead to cardiac arrest! Case Rep Emerg Med. 2020;2020:3727682. PubMed
- Benge E, Shah P, Yamaguchi L, Josef V. Trick or Treat? Licorice-Induced Hypokalemia: A Case Report. Cureus 2020;12(11):e11656. PubMed
- Abe K, Higurashi T, Takahashi M, et al. Concomitant Use of High-dose Methotrexate and Glycyrrhizin Affects Pharmacokinetics of Methotrexate, Resulting in Hepatic Toxicity. In Vivo 2021;35(4):2163-2169. PubMed
- Awad N, Makar G, Burroughs V, Ravi P, Burroughs SR. Licorice-induced apparent mineralocorticoid excess causing persistent hypertension and hypokalemia. Acta Endocrinol (Buchar) 2020;16(4):508-510. PubMed
- Patel P, Aknouk M, Dawson A, et al. How Much Is Too Much? Exploring Pseudohyperaldosteronism in Glycyrrhizic Acid Toxicity From Chronic Licorice Root Consumption. Cureus 2021;13(7):e16454. PubMed
- Fan ZJ, Liu JM, Li XX, et al. Glycyrrhizin-Induced Pseudohyperaldosteronism: A Case Report. Chin J Integr Med 2022. PubMed
- Gatica-Ortega ME, Pastor-Nieto MA. Allergic contact dermatitis to Glycyrrhiza inflata root extract in an anti-acne cosmetic product. Contact Dermatitis 2021;85(4):454-455.
- Wang JB, Huang A, Wang Y, et al. Corticosteroid plus glycyrrhizin therapy for chronic drug- or herb-induced liver injury achieves biochemical and histological improvements: a randomised open-label trial. Aliment Pharmacol Ther 2022;55(10):1297-1310. PubMed
- Puaratanaarunkon T, Washrawirul C, Chuenboonngarm N, Noppakun N, Asawanonda P, Kumtornrut C. Efficacy and safety of a facial serum containing snail secretion filtrate, Calendula officinalis, and Glycyrrhiza glaba root extract in the treatment of maskne: A
- Haron MH, Dale O, Martin K, et al. Evaluation of the Herb-Drug Interaction Potential of Commonly Used Botanicals on the US Market with Regard to PXR- and AhR-Mediated Influences on CYP3A4 and CYP1A2. J Diet Suppl 2022. PubMed
- Han EJ, Park JS. Lethal Arrhythmia Induced by Licorice. J Korean Med Sci 2023;38(12):e107. PubMed
Poria Mushroom 3 references
- McGuffin M, Hobbs C, Upton R, Goldberg A, eds. American Herbal Products Association's Botanical Safety Handbook. Boca Raton, FL: CRC Press, LLC 1997.
- Kim H, Park I, Park K, Park S, Kim YI, Park BG. The positive effects of Poria cocos extract on quality of sleep in insomnia rat models. Int J Environ Res Public Health 2022;19(11):6629. PubMed
- Lv Q, Di X, Bian B, Li K, Guo J. Neuroprotective effects of Poria cocos (Agaricomycetes) essential oil on Aß1-40-induced learning and memory deficit in rats. Int J Med Mushrooms 2022;24(10):73-82.
Lily-of-the-valley 7 references
- Blumenthal M, ed. The Complete German Commission E Monographs: Therapeutic Guide to Herbal Medicines. Trans. S. Klein. Boston, MA: American Botanical Council, 1998.
- McGuffin M, Hobbs C, Upton R, Goldberg A, eds. American Herbal Products Association's Botanical Safety Handbook. Boca Raton, FL: CRC Press, LLC 1997.
- Ellenhorn MJ, et al. Ellenhorn's Medical Toxicology: Diagnoses and Treatment of Human Poisoning. 2nd ed. Baltimore, MD: Williams & Wilkins, 1997.
- Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.
- Brinker F. Herb Contraindications and Drug Interactions. 2nd ed. Sandy, OR: Eclectic Medical Publications, 1998.
- Burnham TH, ed. Drug Facts and Comparisons, Updated Monthly. Facts and Comparisons, St. Louis, MO.
- Alexandre J, Foucault A, Coutance G, et al. Digitalis intoxication induced by an acute accidental poisoning by lily of the valley. Circulation 2012 Feb 28;125(8):1053-5. PubMed
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DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
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