Interactions on record — worth a quick check against your medications. Based on 2 of 4 ingredients. Check your meds →
Dietary supplement

Digestive Probiotic Ingredients & Drug Interactions

by CVS Health

Digestive Probiotic label
See full label image
Capsule Category: Non-nutrient/non-botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Digestive Probiotic against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Digestive Probiotic is a dietary supplement by CVS Health with 4 active ingredients. Its ingredients are commonly taken for digestive health and balance, diarrhea (including antibiotic-related), vaginal yeast and bacterial infections.Based on those ingredients, 182 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Lactobacillus acidophilus, Bifidobacterium longum. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against Digestive Probiotic by CVS Health

Ask about any prescription or over-the-counter medication and we check it for interactions with Digestive Probiotic by CVS Health — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Digestive Probiotic by CVS Health

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 23, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 0 of its 4 active ingredients.
  • “Proprietary Probiotic Blend” is a proprietary blend — the label doesn't break down how much of each component you get.

This product contains 4 active ingredients: three probiotic bacteria strains — Lactobacillus acidophilus, Bifidobacterium longum, and Bifidobacterium infantis NI313 — plus a proprietary probiotic blend that houses Lactobacillus rhamnosus. These are live, active organisms designed to support your gut bacteria balance.

You'll also find inactive ingredients like maltodextrin, inulin (a prebiotic fiber), and capsule materials; they're there to stabilize and deliver the probiotics.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: digestive health and balance.
  • We looked for evidence on: Antibiotic-associated diarrhea, Constipation, Diarrhea, Inflammatory bowel disease (IBD), Irritable bowel syndrome (IBS), Lactose intolerance — and 4 related terms.
  • The strongest evidence on file: Lactobacillus Acidophilus is rated "Possibly Effective" for Antibiotic-associated diarrhea (Natural Medicines).
  • Also on file: Lactobacillus Acidophilus is rated "Possibly Effective" for Irritable bowel syndrome (IBS).
  • Also on file: Lactobacillus Acidophilus is rated "Insufficient Reliable Evidence To Rate" for Constipation, Inflammatory bowel disease (IBD), Radiation-induced diarrhea, Lactose intolerance, and more.

The evidence for what this probiotic can do is mixed. Lactobacillus acidophilus shows possibly effective evidence for irritable bowel syndrome (IBS), Helicobacter pylori infection, antibiotic-associated diarrhea, and bacterial vaginosis.

Bifidobacterium longum, on the other hand, lacks enough reliable evidence to rate it for the conditions studied — cognitive decline, hay fever, anxiety, asthma, and athletic performance all came back with insufficient data. We don't hold effectiveness ratings for the other two ingredients in this product.

The evidence, ingredient by ingredient Lactobacillus Acidophilus Bifidobacterium Longum

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 2 of the 2 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 2 of 2.
  • General safety write-ups exist for 2 of 2.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Both Lactobacillus acidophilus and Bifidobacterium longum are generally well tolerated in healthy adults and children. That said, the data are limited in some areas, so check with your doctor before use — especially if you're seriously ill, immune-compromised, pregnant, or breastfeeding.

Rare gastrointestinal side effects have been reported with these probiotics when taken orally, including abdominal discomfort, bloating, flatulence, diarrhea, and burping. Even rarer are serious infections (bacteremia or sepsis), which have occurred almost entirely in critically ill or premature infants with other serious conditions, not in healthy adults.

Lactobacillus acidophilus is rated possibly safe in pregnancy; Bifidobacterium longum is rated possibly safe in both pregnancy and lactation, though limited data exist for breastfeeding.

Side effects, ingredient by ingredient Lactobacillus Acidophilus Bifidobacterium Longum

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 2 of the 2 matched ingredients can interact with medications — Lactobacillus Acidophilus, Bifidobacterium Longum.
  • The most serious interaction on file is rated Moderate.
  • For scale: 182 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before you take this product, double-check with your doctor or pharmacist if you're on antibiotic drugs (Moderate severity interaction). Antibiotics taken at the same time as this probiotic could reduce how well the beneficial bacteria work, so timing matters.

We hold no interaction data for the other two ingredients, so there may be additional interactions we haven't checked — running your full medication list through the search tool on this page will give you the complete picture.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

This probiotic may help with IBS, antibiotic-associated diarrhea, or a couple of other gut conditions if Lactobacillus acidophilus is the active ingredient doing the work — the evidence is there for those uses. If you take antibiotics, you'll need to time doses carefully with your doctor or pharmacist so the antibiotics don't kill off the live cultures.

People who are seriously ill or have a weakened immune system should check with their doctor first. Talk it over with your own healthcare provider before starting, especially if you're on other medications or have any health concerns.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 2 of 4 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Aug 23, 2022.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Digestive Probiotic, straight from the product label.

Brand CVS Health
Net contents 28 One-a-day Vegetable Capsule(s)
Market status On market
Date entered into DSLD Aug 23, 2022
DSLD ID 276003
Product type Non-nutrient/non-botanical
Supplement form Capsule
Dietary claims / uses Nutrient, All Other, Structure/Function
Intended target group(s) Children 4 or More Years of Age, Adult (18 - 50 Years), Gluten Free, Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Digestive Probiotic by CVS Health, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Capsule(s)
Maximum serving Sizes:
1 Capsule(s)
Servings per container
28
IngredientAmount% DV
Lactobacillus rhamnosus0 NP--
Lactobacillus acidophilus0 NP--
Bifidobacterium longum0 NP--
Proprietary Probiotic Blend0 NP--
Bifidobacterium infantis NI3130 NP--

Other ingredients: Maltodextrin, Starch, Hypromellose, Inulin, Magnesium Stearate, Titanium Dioxide, Ascorbic Acid

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
FDA Statement of Identity

Dietary Supplement

Formula

Contains prebiotic fibers Formulated with 4 strains of healthy bacteria

2 billion live bacteria cells per capsule

About this product CVS Health Digestive Probiotic is a natural source of probiotic "friendly bacteria." It contains Bifidobacterium infantis NI313 and a blend of additional Lactobacillus and Bifidobacteria probiotic strains which help maintain healthy intestinal flora balance. It also contains inulin fibers, a prebiotic supporting friendly bacteria growth.

Formulation

Supports overall digestive health Contains probiotic strains resistant to stomach acids. Supports: Digestive balance Natural body defenses Healthy intestinal tract

Compare the differences of CVS Health Digestive Probiotic to Align CVS Health Digestive Probiotic Align Bifidobacterium Infantis per serving 12 mg 4 mg Bifidobacterium Infantis Strain NI313 35624 Lactobacillus Probiotic Blend L. acidophilus L. rhamnosus Bifidobacterium Probiotic Blend B. infantis B. longum B. infantis Total Live Probiotic Cells per capsule 2 billion 1 billion

Gluten, dairy and soy free

Why take probiotics? The human digestive tract is colonized by trillions of health-promoting "friendly probiotic bacteria" that ensure maintaining natural flora balance between all bacteria species living inside the intestinal tract. Maintaining a balanced flora is important not only for overall digestive health but also for supporting natural regularity.

Made in Canada

Contains 1 billion (4 mg) colony-forming units when manufactured and provides an effective level of bacteria until at least the "best by" date

Contains a minimum of 2 billion live bacteria cells when manufactured, and provides a minimum concentration of 500 million at expiration date.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Brand IP Statement(s)

Copyright 2015 CVS/pharmacy

General Statements

CVS Quality Money back guarantee

This product is not manufactured or distributed by The Procter & Gamble Company, owner of the registered trademark Align.

Suggested/Recommended/Usage/Directions

Directions: As a dietary supplement for intestinal microfiora balance. Children 12 years old and over and adults: Take one (1) capsule daily at mealtime. Capsule may be opened and sprinkled on cold food or cold drink.

Precautions

Keep out of reach of children.

Do not use if seal is broken.

Storage

Store at 72 degrees F or cooler. Do not expose to excessive heat or moisture.

No refrigeration needed.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Digestive Probiotic by CVS Health label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Digestive Probiotic label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Digestive Probiotic by CVS Health

These are the 4 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Capsule(s) Dosage formCapsule Servings per container28 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Proprietary Probiotic Blend

0 NP per serving

Other (inactive) ingredients: Maltodextrin, Starch, Hypromellose, Inulin, Magnesium Stearate, Titanium Dioxide, Ascorbic Acid. These complete the product’s ingredient list but are not active constituents.

Interaction report

Digestive Probiotic by CVS Health Drug Interactions

Want to check YOUR meds against Digestive Probiotic?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
182Drugs
182 Moderate

Ingredients driving the most interactions

Lactobacillus acidophilus 182
Bifidobacterium longum 182

Individual Drug Interactions

The ingredients in Digestive Probiotic interact with 182 drugs. Click any drug to see the details.

2 of the 4 ingredients in Digestive Probiotic interact with drugs. Each result below shows which ingredient is responsible. Lactobacillus acidophilus Bifidobacterium longum

Each ingredient & the kinds of drugs it affects

For each ingredient in Digestive Probiotic with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Lactobacillus acidophilus1 drug type · 182 drugs

Antibiotic Drugs

Theoretically, taking Lactobacillus acidophilus with antibiotic drugs might decrease the effectiveness of L. acidophilus.
L. acidophilus preparations usually contain live and active organisms. Therefore, simultaneously taking antibiotics might kill a significant number of the organisms. Tell patients to separate administration of antibiotics and L. acidophilus preparations by at least two hours.

Likelihood Probable Evidence D
Lactobacillus acidophilus full monograph & interactions

Bifidobacterium longum1 drug type · 182 drugs

Antibiotic Drugs

Theoretically, taking Bifidobacterium longum with antibiotic drugs might decrease the effectiveness of B. longum.
Since B. longum preparations usually contain live and active organisms, simultaneously taking antibiotics might kill a significant number of the organisms. Tell patients to separate administration of antibiotics and B. longum preparations by at least 2 hours.

Likelihood Probable Evidence D
Bifidobacterium longum full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Digestive Probiotic, from the product label.

CVS Health

See all CVS Health products
Name
CVS Pharmacy, Inc.
Street Address
One CVS Drive
City
Woonsocket
State
RI
ZipCode
02895
Phone Number
1-800-746 7287
Web Address
CVS.com
Pharmacist Counseling Corner

Digestive Probiotic by CVS Health: Common Questions

Does Digestive Probiotic by CVS Health interact with any medications?
Yes. Based on its ingredients, Digestive Probiotic has a known interaction with 182 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Digestive Probiotic contains 4 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this probiotic while I'm on antibiotics?
Not at the same time — the antibiotic will kill the live bacteria in this product and make it less effective. You'll want to separate the doses, but the exact timing depends on which antibiotic you're taking. Talk to your pharmacist about the best schedule for your situation.
Is this safe to use while I'm pregnant?
Lactobacillus acidophilus in this product is rated possibly safe during pregnancy, and Bifidobacterium longum is rated possibly safe in both pregnancy and lactation. That said, data are limited, so check with your doctor before starting — they can give you personalized advice based on your health.
What side effects might I notice?
Most people tolerate it well, but some experience mild gastrointestinal side effects like bloating, flatulence, abdominal discomfort, or diarrhea — these are uncommon. Serious infections are very rare and have happened almost only in critically ill patients or premature infants, not healthy adults.
Will this help my IBS?
Lactobacillus acidophilus, one of the main ingredients here, has possibly effective evidence for IBS. That means there's some research supporting it, but it's not definitive — results vary by person, so talk with your doctor about whether it's worth trying for your situation.
What are the inactive ingredients?
The product contains maltodextrin, starch, inulin (a prebiotic fiber), hypromellose, magnesium stearate, titanium dioxide, and ascorbic acid — these are the capsule and stabilizing ingredients around the live bacteria.
Can I breastfeed while taking this?
Bifidobacterium longum is rated possibly safe during breastfeeding, though data are limited. Check with your doctor or pharmacist to make sure it's right for you and your baby.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Digestive Probiotic is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Digestive Probiotic label
Go deeper

The Full Monographs Behind Digestive Probiotic’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Lactobacillus Acidophilus

Interacts with 182 drugs

Lactobacillus acidophilus is a 'friendly' bacterium used as a probiotic to support gut and vaginal health. It is generally well tolerated in healthy people, and there is reasonable evidence...

Read the full Lactobacillus Acidophilus monograph → Herb & supplement monograph

Bifidobacterium Longum

Interacts with 182 drugs

Bifidobacterium longum is a 'friendly' bacterium found naturally in the human gut and used as a probiotic. It is generally well tolerated and is most studied for digestive issues, though evi...

Read the full Bifidobacterium Longum monograph →
Sources

Sources & How We Checked

Digestive Probiotic's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 36 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Lactobacillus Acidophilus 15 references
  1. Pierce A. The American Pharmaceutical Association Practical Guide to Natural Medicines. New York: The Stonesong Press, 1999:19.
  2. Begtrup LM, de Muckadell OB, Kjeldsen J, Christensen RD, Jarbøl DE. Long-term treatment with probiotics in primary care patients with irritable bowel syndrome--a randomised, double-blind, placebo controlled trial. Scand J Gastroenterol 2013;48(10):1127-35 PubMed
  3. Chatterjee S, Kar P, Das T, Ray S, Gangulyt S, Rajendiran C, Mitra M. Randomised placebo-controlled double blind multicentric trial on efficacy and safety of Lactobacillus acidophilus LA-5 and Bifidobacterium BB-12 for prevention of antibiotic-associated
  4. Shavakhi A, Tabesh E, Yaghoutkar A, Hashemi H, Tabesh F, Khodadoostan M,Minakari M, Shavakhi S, Gholamrezaei A. The effects of multistrain probiotic compound on bismuth-containing quadruple therapy for Helicobacter pylori infection: a randomized placebo-c
  5. Karamali M, Dadkhah F, Sadrkhanlou M, et al. Effects of probiotic supplementation on glycaemic control and lipid profiles in gestational diabetes: a randomized, double-blind, placebo-controlled trial. Diabetes Metab 2016;42(4):234-41. PubMed
  6. Badehnoosh B, Karamali M, Zarrati M, et al. The effects of probiotic supplementation on biomarkers of inflammation, oxidative stress and pregnancy outcomes in gestational diabetes. J Matern Fetal Neonatal Med. 2018 May;31(9):1128-1136.
  7. Kumar S, Kumar R, Rohilla L, Jacob N, Yadav J, Sachdeva N. A high potency multi-strain probiotic improves glycemic control in children with new-onset type 1 diabetes mellitus: A randomized, double-blind, and placebo-controlled pilot study. Pediatr Diabete
  8. Shahriari A, Karimi E, Shahriari M, Aslani N, Khooshideh M, Arab A. The effect of probiotic supplementation on the risk of gestational diabetes mellitus among high-risk pregnant women: A parallel double-blind, randomized, placebo-controlled clinical trial PubMed
  9. Xiao SD, Zhang DZ, Lu H, et al. Multicenter, randomized, controlled trial of heat-killed Lactobacillus acidophilus LB in patients with chronic diarrhea. Adv Ther. 2003;20(5):253-60.
  10. Rossi F, Amadoro C, Gasperi M, Colavita G. Lactobacilli infection case reports in the last three years and safety implications. Nutrients. 2022;14(6):1178. PubMed
  11. Ozer M, Goksu SY, Shahverdiani A, Mustafa M. Lactobacillus acidophilus-induced endocarditis and associated splenic abscess. Case Rep Infect Dis 2020;2020:1382709.
  12. Sadrin S, Sennoune S, Gout B, et al. A 2-strain mixture of Lactobacillus acidophilus in the treatment of irritable bowel syndrome: A placebo-controlled randomized clinical trial. Dig Liver Dis 2020;52(5):534-540. PubMed
  13. Stoffer JN, Slingsby TJ, Giuliari GP. Lactobacillus acidophilus endophthalmitis after intravitreal bevacizumab injection requiring intraocular lens explantation. Can J Ophthalmol 2022;57(1):e21-e22. PubMed
  14. Cukovic-Cavka S, Likic R, Francetic I, Rustemovic N, Opacic M, Vucelic B. Lactobacillus acidophilus as a cause of liver abscess in a NOD2/CARD15-positive patient with Crohn's disease. Digestion 2006;73(2-3):107-10.
  15. Hui J, Ren Y, Wang Y, Han Q. Lactobacillus acidophilus endophthalmitis postcataract operation: A case report with a literature review. Ocul Immunol Inflamm 2023.

See these in context on the Lactobacillus Acidophilus monograph →

Bifidobacterium Longum 21 references
  1. Ha GY, Yang CH, Kim H, Chong Y. Case of sepsis caused by Bifidobacterium longum. J Clin Microbiol 1999;37:1227-8.
  2. Pierce A. The American Pharmaceutical Association Practical Guide to Natural Medicines. New York: The Stonesong Press, 1999:19.
  3. Xiao JZ, Takahashi S, Odamaki T, et al. Antibiotic susceptibility of bifidobacterial strains distributed in the Japanese market. Biosci Biotechnol Biochem. 2010;74(2):336-42. PubMed
  4. Rautava S, Kainonen E, Salminen S, Isolauri E. Maternal probiotic supplementation during pregnancy and breast-feeding reduces the risk of eczema in the infant. J Allergy Clin Immunol. 2012;130(6):1355-60. PubMed
  5. Pruccoli G, Silvestro E, Pace Napoleone C, Aidala E, Garazzino S, Scolfaro C. Are probiotics safe? Bifidobacterium bacteremia in a child with severe heart failure. Infez Med. 2019;27(2):175-178.
  6. Pellonperä O, Vahlberg T, Mokkala K, et al. Weight gain and body composition during pregnancy: a randomised pilot trial with probiotics and/or fish oil. Br J Nutr. 2020 Nov 4:1-11. PubMed
  7. Pellonperä O, Mokkala K, Houttu N, et al. Efficacy of fish oil and/or probiotic intervention on the incidence of gestational diabetes mellitus in an at-risk group of overweight and obese women: A randomized, placebo-controlled, double-blind clinical trial PubMed
  8. Shahriari A, Karimi E, Shahriari M, Aslani N, Khooshideh M, Arab A. The effect of probiotic supplementation on the risk of gestational diabetes mellitus among high-risk pregnant women: A parallel double-blind, randomized, placebo-controlled clinical trial PubMed
  9. Esaiassen E, Hjerde E, Cavanagh JP, Simonsen GS, Klingenberg C; Norwegian Study Group on Invasive Bifidobacterial Infections. Bifidobacterium bacteremia: Clinical characteristics and a genomic approach to assess pathogenicity. J Clin Microbiol. 2017;55(7) PubMed
  10. Enomoto T, Sowa M, Nishimori K, et al. Effects of bifidobacterial supplementation to pregnant women and infants in the prevention of allergy development in infants and on fecal microbiota. Allergol Int 2014;63(4):575-85. PubMed
  11. US Food and Drug Administration (FDA). Dear Healthcare Provider Letter: Warning Regarding Use of Probiotics in Preterm Infants. September 2023. Available at: https://www.fda.gov/media/172606/download?attachment. Accessed November 1, 2023.
  12. Pillai A, Tan J, Paquette V, Panczuk J. Does probiotic bacteremia in premature infants impact clinically relevant outcomes? A case report and updated review of literature. Clin Nutr ESPEN. 2020;39:255-259. PubMed
  13. Sabaté JM, Iglicki F. Effect of Bifidobacterium longum 35624 on disease severity and quality of life in patients with irritable bowel syndrome. World J Gastroenterol 2022;28(7):732-744.
  14. Malaguarnera M, Greco F, Barone G, Gargante MP, Malaguarnera M, Toscano MA. Bifidobacterium longum with fructo-oligosaccharide (FOS) treatment in minimal hepatic encephalopathy: a randomized, double-blind, placebo-controlled study. Dig Dis Sci 2007;52(11) PubMed
  15. Zbinden A, Zbinden R, Berger C, Arlettaz R. Case series of Bifidobacterium longum bacteremia in three preterm infants on probiotic therapy. Neonatology 2015;107(1):56-9.
  16. Tamaki H, Nakase H, Inoue S, et al. Efficacy of probiotic treatment with Bifidobacterium longum 536 for induction of remission in active ulcerative colitis: A randomized, double-blinded, placebo-controlled multicenter trial. Dig Endosc 2016;28(1):67-74.
  17. Bertelli C, Pillonel T, Torregrossa A, et al. Bifidobacterium longum bacteremia in preterm infants receiving probiotics. Clin Infect Dis 2015;60(6):924-7. PubMed
  18. Esaiassen E, Cavanagh P, Hjerde E, Simonsen GS, Støen R, Klingenberg C. Bifidobacterium longum subspecies infantis bacteremia in 3 extremely preterm infants receiving probiotics. Emerg Infect Dis 2016;22(9):1664-6.
  19. Tena D, Losa C, Medina MJ, Sáez-Nieto JA. Peritonitis caused by Bifidobacterium longum: case report and literature review. Anaerobe 2014;27:27-30. PubMed
  20. Sangkanjanavanich S, Pradubpongsa P, Mitthamsiri W, Sangasapaviliya A, Boonpiyathad T. Bifidobacterium infantis 35624 efficacy in patients with uncontrolled asthma: A randomized placebo-controlled trial. Ann Allergy Asthma Immunol 2022;129(6):790-792. PubMed
  21. Wilson HL, Ong CW. Bifidobacterium longum vertebrodiscitis in a patient with cirrhosis and prostate cancer. Anaerobe 2017;47:47-50. PubMed

See these in context on the Bifidobacterium Longum monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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