Interactions on record — worth a quick check against your medications. Based on 2 of 4 ingredients. Check your meds →
Dietary supplement

Ds Digestive S Ingredients & Drug Interactions

by Systemic Formulas Bio Function

Ds Digestive S label
See full label image
Capsule Category: Other Combinations
Most serious interaction: Minor
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Ds Digestive S against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Minor

Ds Digestive S is a dietary supplement by Systemic Formulas Bio Function with 4 active ingredients. Its ingredients are commonly taken for testosterone support, athletic performance and muscle building, energy and endurance.Based on those ingredients, 36 medications have a known interaction with it, the most serious rated minor. The ingredients most likely to interact are Betaine HCl. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Ds Digestive S by Systemic Formulas Bio Function

Ask about any prescription or over-the-counter medication and we check it for interactions with Ds Digestive S by Systemic Formulas Bio Function — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of Ds Digestive S by Systemic Formulas Bio Function

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 4 of its 4 active ingredients.
  • No proprietary blends here — you can verify the dose of every single component.

Ds Digestive S has four active ingredients: Aspartic Acid, L-Glutamic Acid, Betaine HCl, and a Proprietary Blend. The first two are amino acids; Betaine HCl is a compound that raises stomach acid.

The product also contains gelatin, stearic acid, and lactose as inactive ingredients.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use.

Why this rating?
  • The label markets this product for: digestive health support with vegetable enzymes.
  • We looked for evidence on: Dyspepsia, Diarrhea, indigestion, bloating.
  • The closest evidence on file: Betaine Hydrochloride is rated "Insufficient Reliable Evidence To Rate" for Diarrhea (Natural Medicines).
  • Also on file: Betaine Hydrochloride is rated "Insufficient Reliable Evidence To Rate" for Dyspepsia.

The evidence on whether this product works isn't established in the data we hold. Aspartic Acid and Betaine HCl are both listed with insufficient reliable evidence for the conditions they're sometimes used for — we just don't have solid trial data showing they're effective.

That doesn't mean they don't work; it means the research isn't there yet or is too limited to draw conclusions.

The evidence, ingredient by ingredient Aspartic Acid Betaine Hydrochloride

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 2 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 2 of 2.
  • General safety write-ups exist for 2 of 2.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Betaine HCl isn't safe if you have ulcers, gastritis, or true acid reflux (the acid in this ingredient could irritate your stomach or prevent ulcers from healing). High-dose Aspartic Acid supplements haven't been studied long-term for safety — food amounts are likely fine, but supplement doses are less clear.

For pregnancy and breastfeeding, the safety data is limited. Aspartic Acid has conflicting safety ratings for pregnancy and should be avoided during both pregnancy and breastfeeding.

Betaine HCl also lacks safety data for pregnancy and breastfeeding, so it's best avoided during both.

Side effects, ingredient by ingredient Aspartic Acid Betaine Hydrochloride

Meds to double-check

Minor interactions only
Known Interaction Concern · database check
Minor only

Only Minor-severity interactions are documented for these ingredients.

Why this rating?
  • 1 of the 2 matched ingredients can interact with medications — Betaine Hydrochloride.
  • The most serious interaction on file is rated Minor.
  • For scale: 36 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Double-check with your pharmacist if you take H2-blockers, antacids, or proton pump inhibitors (PPIs). Betaine HCl in this product can reduce how well those medications work.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no established evidence rating for its marketed use. Only minor medication interactions are documented, and safety information is well characterized.

If your stomach is healthy and you're not pregnant or breastfeeding, this product may be worth trying — just check your medications first, especially any acid-reducing drugs. If you have any history of ulcers, gastritis, or reflux, or if you're pregnant or nursing, talk with your pharmacist or doctor before starting.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 2 of 4 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated May 24, 2013.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Ds Digestive S, straight from the product label.

Brand Systemic Formulas Bio Function
Barcode (UPC) 635585001816
Net contents 60 Capsule(s)
Market status On market
Date entered into DSLD May 24, 2013
DSLD ID 21850
Product type Other Combinations
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Ds Digestive S by Systemic Formulas Bio Function, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Capsule(s)
Maximum serving Sizes:
2 Capsule(s)
UPC/BARCODE
635585001816
IngredientAmount% DV
Aspartic Acid18 mg--
L-Glutamic Acid68 mg--
Betaine HCl68 mg--
Proprietary Blend720 mg--

Other ingredients: Gelatin, Stearic Acid, Lactose

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Storage

Keep away from Heat, Sunlight and Children.

Precautions

Keep away from Heat, Sunlight and Children.

General Statements

#18

Utilizes vegetable enzymes to provide support for good digestive health.

SOLD THROUGH PROFESSIONALS

MADE IN U.S.A.

D/10

FDA Disclaimer Statement

This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any diseases.

Suggested/Recommended/Usage/Directions

DIRECTIONS FOR NUTRITIONAL USE: 1-2 capsules up to twice a day for 1-3 months, or as directed. Then, take as needed for maintenance. Increase the amount of liquids you drink each day while taking this product.

FDA Statement of Identity

Dietary Supplement

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Ds Digestive S by Systemic Formulas Bio Function label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Ds Digestive S label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Ds Digestive S by Systemic Formulas Bio Function

These are the 4 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Capsule(s) Dosage formCapsule Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Aspartic Acid

No known
interactions
18 mg per serving

Aspartic acid is a common amino acid your body makes on its own and gets from protein-rich foods, so a true deficiency is rare. D-aspartic acid is hea...

Aspartic Acid monograph & interactions

L-Glutamic Acid

68 mg per serving

Betaine HCl

Interacts with
36 drugs
68 mg per serving

Betaine hydrochloride is a supplement used to temporarily increase stomach acid in people who may have low acid levels. Evidence for its benefits is l...

Betaine HCl monograph & interactions

Proprietary Blend

720 mg per serving Form: Ammonium Chloride, Bromelain, Calcium, Echinacea, Gentian, Goldenseal, Kola, Pancrealipase, Pancreatin, Papaya, Pepsin, RNA/DNA Liver Substance, RNA/DNA OX Bile Substance, RNA/DNA Stomach Substance, Spearmint

Other (inactive) ingredients: Gelatin, Stearic Acid, Lactose. These complete the product’s ingredient list but are not active constituents.

Interaction report

Ds Digestive S by Systemic Formulas Bio Function Drug Interactions

Want to check YOUR meds against Ds Digestive S?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
36Drugs
36 Minor

Ingredients driving the most interactions

Betaine HCl 36

Individual Drug Interactions

The ingredients in Ds Digestive S interact with 36 drugs. Click any drug to see the details.

1 of the 4 ingredients in Ds Digestive S interact with drugs. Each result below shows which ingredient is responsible. Betaine HCl

Each ingredient & the kinds of drugs it affects

For each ingredient in Ds Digestive S with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Betaine HCl3 drug types · 36 drugs

Antacids

Betaine hydrochloride increases stomach acidity and could decrease the effects of antacids.
In human research, betaine hydrochloride increases stomach acidity. Antacids are taken to decrease stomach acidity. Theoretically, taking betaine hydrochloride along with antacids might decrease the effects of the antacids.

Likelihood Possible Evidence D
H2-Blockers

Betaine hydrochloride increases stomach acidity and could decrease the effects of H2-blockers.
In human research, betaine hydrochloride increases stomach acidity. H2-blockers are used to decrease stomach acidity. Theoretically, taking betaine hydrochloride along with H2-blockers might decrease the effects of H2-blockers.

Likelihood Possible Evidence D
Proton Pump Inhibitors (Ppis)

Betaine hydrochloride increases stomach acidity and could decrease the effects of PPIs.
In human research, betaine hydrochloride increases stomach acidity. PPIs are used to decrease stomach acidity. Theoretically, taking betaine hydrochloride along with PPIs might decrease the effects of PPIs

Likelihood Possible Evidence D
Betaine HCl full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Ds Digestive S, from the product label.

Systemic Formulas Bio Function

See all Systemic Formulas Bio Function products
Name
Systemic Formulas Inc.
Street Address
P.O.Box 1516
City
Ogden
State
UT
ZipCode
84402
Web Address
www.systemicformulas.com
Pharmacist Counseling Corner

Ds Digestive S by Systemic Formulas Bio Function: Common Questions

Does Ds Digestive S by Systemic Formulas Bio Function interact with any medications?
Yes. Based on its ingredients, Ds Digestive S has a known interaction with 36 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Ds Digestive S contains 4 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this if I'm pregnant?
The safety data isn't there for either Aspartic Acid or Betaine HCl during pregnancy. The facts advise avoiding both during pregnancy. Talk with your doctor or pharmacist about whether it's right for you.
Can I take this while breastfeeding?
Safety data for both Aspartic Acid and Betaine HCl during breastfeeding is insufficient or lacking. Both are listed as best avoided. Check with your pharmacist or doctor for personalized advice.
What does Betaine HCl actually do?
It increases stomach acid. That's why it can interfere with acid-reducing medications and may irritate your stomach if you have ulcers or reflux. It's sometimes used to support digestion in people with low stomach acid.
Is there any evidence this actually works?
The research data we hold shows insufficient evidence for the conditions Aspartic Acid and Betaine HCl are used for. That means the studies aren't robust enough yet to say yes or no confidently.
Does this have fillers?
Yes — it contains gelatin, stearic acid, and lactose as inactive ingredients. Let us know if you need to avoid any of those.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Ds Digestive S is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Ds Digestive S label
Go deeper

The Full Monographs Behind Ds Digestive S’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Aspartic Acid

Aspartic acid is a common amino acid your body makes on its own and gets from protein-rich foods, so a true deficiency is rare. D-aspartic acid is heavily marketed for boosting testosterone...

Read the full Aspartic Acid monograph → Herb & supplement monograph

Betaine Hydrochloride

Interacts with 36 drugs

Betaine hydrochloride is a supplement used to temporarily increase stomach acid in people who may have low acid levels. Evidence for its benefits is limited and mostly based on tradition rat...

Read the full Betaine Hydrochloride monograph →
Sources

Sources & How We Checked

Ds Digestive S's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 3 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Aspartic Acid 1 reference
  1. Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Energy, Carbohydrate, Fiber, Fat, Fatty Acids, Cholesterol, Protein, and Amino Acids. Washington, DC: The National Academies Press, 2005. Available at: https://doi.org/10.17226 DOI

See these in context on the Aspartic Acid monograph →

Betaine Hydrochloride 2 references
  1. Yago MR, Frymoyer A, Benet LZ, Smelick GS, Frassetto LA, Ding X, Dean B, Salphati L, Budha N, Jin JY, Dresser MJ, Ware JA. The use of betaine HCl to enhance dasatinib absorption in healthy volunteers with rabeprazole-induced hypochlorhydria. AAPS J. 2014 PubMed
  2. Yago MR, Frymoyer AR, Smelick GS, Frassetto LA, Budha NR, Dresser MJ, Ware JA, Benet LZ. Gastric reacidification with betaine HCl in healthy volunteers with rabeprazole-induced hypochlorhydria. Mol Pharm. 2013 Nov 4;10(11):4032-7. PubMed

See these in context on the Betaine Hydrochloride monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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