Interactions on record — worth a quick check against your medications. Based on 5 of 9 ingredients. Check your meds →
Dietary supplement

DuoZyme Ingredients & Drug Interactions

by Karuna

DuoZyme label
See full label image
Capsule Category: Other Combinations
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 23, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking DuoZyme against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

DuoZyme is a dietary supplement by Karuna with 9 active ingredients. Its ingredients are commonly taken for digestive support for protein digestion, wound cleaning (debridement of dead tissue), sore throat and inflammation.Based on those ingredients, 39 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Betaine HCl, Papain, Pancreatin. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against DuoZyme by Karuna

Ask about any prescription or over-the-counter medication and we check it for interactions with DuoZyme by Karuna — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of DuoZyme by Karuna

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 23, 2026

What’s inside

Partial disclosure
Ingredient Transparency · database check
Partial

Most active ingredients list an amount, but at least one is hidden in a blend or missing.

Why this rating?
  • The label discloses an exact amount for 6 of its 9 active ingredients.
  • “Providing at least the following” is listed as a grouped ingredient — the label doesn't break down how much of each component you get.

DuoZyme is a blend of 9 digestive enzymes designed to help break down food. It contains amylase (for carbohydrates), papain (a protein-digesting enzyme from papaya), protease and pepsin (additional protein breakers), lipase (for fats), pancreatin (a mix of multiple enzymes from pancreas), and betaine HCl and glutamic acid hydrochloride (to support stomach acid).

It also includes ox bile extract to aid fat digestion. The inactive ingredients are silica, vegetable stearate, stearate, and maltodextrin — these are fillers and binders that make up the capsule.

Does it work?

Strong evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Strong

Clinical evidence supports at least one of this product's ingredients for its stated purpose.

Why this rating?
  • The label markets this product for: digestive enzymes for proper digestion.
  • We looked for evidence on: Dyspepsia, Pancreatic insufficiency, Exercise-induced muscle soreness, Indigestion, Bloating and gas, Enzyme insufficiency.
  • The strongest evidence on file: Pancreatic Enzyme Products is rated "Effective" for Pancreatic insufficiency (Natural Medicines).
  • Also on file: Papain is rated "Insufficient Reliable Evidence To Rate" for Exercise-induced muscle soreness.
  • Also on file: Lipase is rated "Insufficient Reliable Evidence To Rate" for Dyspepsia.

The evidence for most ingredients in DuoZyme is not established in our data. Pancreatin is rated as effective for pancreatic insufficiency — a condition where the pancreas doesn't produce enough digestive enzymes.

For the other ingredients and conditions (papain for muscle soreness or shingles, lipase for digestive upset, betaine HCl for indigestion or hay fever, and protease for general digestion), the evidence is insufficient to rate them reliably. That doesn't mean they don't work — it means we don't have strong studies to confirm it.

The evidence, ingredient by ingredient Papain Proteolytic Enzymes (proteases) Betaine Hydrochloride Pancreatic Enzyme Products Lipase

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 5 of the 5 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 5 of 5.
  • General safety write-ups exist for 5 of 5.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Papain is generally well tolerated when taken at normal doses short-term, though allergic reactions can occur in sensitive people — symptoms include itchy eyes, runny nose, sneezing, abdominal cramps, and diarrhea. At high doses, it may rarely cause severe stomach inflammation or even esophageal perforation.

Pancreatin and the other enzymes are generally well tolerated but may cause mild digestive upset, constipation, diarrhea, or allergic reactions in some people. Betaine HCl can irritate the stomach and shouldn't be used if you have ulcers, gastritis, or true acid reflux.

Pregnancy and breastfeeding: papain is possibly unsafe in pregnancy, especially concentrated forms or unripe papaya products — avoid it. Betaine HCl should be avoided in both pregnancy and breastfeeding due to insufficient safety data.

For protease, pepsin, pancreatin, and lipase, there isn't enough safety data for pregnancy and breastfeeding — talk with your doctor or pharmacist before using if you're pregnant or nursing.

Side effects, ingredient by ingredient Papain Proteolytic Enzymes (proteases) Betaine Hydrochloride Pancreatic Enzyme Products Lipase

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 3 of the 5 matched ingredients can interact with medications — Papain, Pancreatic Enzyme Products, Betaine Hydrochloride.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs.
  • For scale: 39 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Check with your doctor or pharmacist before taking DuoZyme if you're on warfarin (Coumadin) — papain may increase its effects. Also flag acarbose (Precose) for diabetes, as pancreatin may reduce how well it works.

If you take antacids, H2-blockers like famotidine, or proton pump inhibitors (PPIs like omeprazole), betaine HCl could make them less effective. Run your complete medication list through the interaction checker on this page.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glancePartially disclosed formula with clinical evidence supporting its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

DuoZyme is designed to help digest food if you have trouble with pancreatic enzymes or need digestive support, but it's not right for everyone. If you take warfarin, acarbose, antacids, H2-blockers, or PPIs, or if you have ulcers or acid reflux, check with your doctor or pharmacist before starting it.

Same goes if you're pregnant, breastfeeding, or have a serious digestive condition — get personalized advice from your healthcare provider first.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 6 of 9 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Aug 23, 2019.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about DuoZyme, straight from the product label.

Brand Karuna
Net contents 180 Capsule(s)
Market status On market
Date entered into DSLD Aug 23, 2019
DSLD ID 206144
Product type Other Combinations
Supplement form Capsule
Dietary claims / uses Nutrient, All Other
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for DuoZyme by Karuna, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
2 Capsule(s)
Maximum serving Sizes:
2 Capsule(s)
Servings per container
90
IngredientAmount% DV
Amylase0 NP--
Papain100 mg--
Protease0 NP--
Lipase0 NP--
Pepsin40 mg--
Glutamic Acid Hydrochloride300 mg--
Betaine HCl300 mg--
Pancreatin300 mg--
Ox Bile extract120 mg--
Providing at least the following0 NP--

Other ingredients: Silica, Vegetable Stearate, Stearate, Maltodextrin

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements

Fatty acids and botanicals for fungal control

Fast-acting, full range digestive enzymes

Responsible nutrition

DuoZyme utilizes the technologically superior enzyme-release system which was favorably evaluated by Dr. David Graham in an entric-coated pancreatic enzyme preparation that works (dig Dis Sci 1979;24:906-9).

FDA Statement of Identity

Dietary Supplement

Formula

Proper digestion requires both a gastric phase supplying hydrochloric acid and pepsin, and an alkaline duodenal phase supplying protease, amylase, and lipase enzymes. Duozyme provides all of these factors in a single, convenient, high potency capsule delivery system.

DuoZyme contains the acidulants betaine HCl and glutamic HCl, which help acidify gastric contents, creating a favorable environment for the proteolytic action of pepsin. Pancreatin and ox bile extract, contained in pH-sensitive microspheres, supplement the natural secretions of the pancreas and liver, and promote the intestinal phase of digestion. pH-sensitive microspheres typically provide a more effective means for delivering intact enzymes to the small intestine to reduce malabsorption of macronutrients (Dig Dis Sci 1979;24:906-9).

Suggested/Recommended/Usage/Directions

Suggested use for adults: Two or more capsules, taken with meals, or as directed.

Precautions

Warning: Patients with active peptic ulcer should use HCl product with caution.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

DuoZyme by Karuna label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

DuoZyme label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in DuoZyme by Karuna

These are the 9 active ingredients this product is made of. Select any to open its full monograph.

Serving size2 Capsule(s) Dosage formCapsule Servings per container90 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Papain

Interacts with
2 drugs
100 mg per serving

Papain is a protein-digesting enzyme from the papaya plant that is used in digestive supplements and some topical products. While it has clear food an...

Papain monograph & interactions

Pepsin

No known
interactions
40 mg per serving

Proteolytic enzymes are proteins that help break down other proteins, and common examples include bromelain (from pineapple), papain (from papaya), tr...

Pepsin monograph & interactions

Glutamic Acid Hydrochloride

300 mg per serving

Betaine HCl

Interacts with
36 drugs
300 mg per serving

Betaine hydrochloride is a supplement used to temporarily increase stomach acid in people who may have low acid levels. Evidence for its benefits is l...

Betaine HCl monograph & interactions

Pancreatin

Interacts with
1 drug
300 mg per serving

Pancreatic enzyme products supply the digestive enzymes (lipase, protease, and amylase) that some people cannot make enough of, helping them break dow...

Pancreatin monograph & interactions

Ox Bile extract

120 mg per serving

Providing at least the following

0 NP per serving

Other (inactive) ingredients: Silica, Vegetable Stearate, Stearate, Maltodextrin. These complete the product’s ingredient list but are not active constituents.

Interaction report

DuoZyme by Karuna Drug Interactions

Want to check YOUR meds against DuoZyme?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
39Drugs
3 Moderate 36 Minor

Ingredients driving the most interactions

Betaine HCl 36
Papain 2
Pancreatin 1

Individual Drug Interactions

The ingredients in DuoZyme interact with 39 drugs. Click any drug to see the details.

3 of the 9 ingredients in DuoZyme interact with drugs. Each result below shows which ingredient is responsible. Betaine HCl Papain Pancreatin

Each ingredient & the kinds of drugs it affects

For each ingredient in DuoZyme with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Betaine HCl3 drug types · 36 drugs

Antacids

Betaine hydrochloride increases stomach acidity and could decrease the effects of antacids.
In human research, betaine hydrochloride increases stomach acidity. Antacids are taken to decrease stomach acidity. Theoretically, taking betaine hydrochloride along with antacids might decrease the effects of the antacids.

Likelihood Possible Evidence D
H2-Blockers

Betaine hydrochloride increases stomach acidity and could decrease the effects of H2-blockers.
In human research, betaine hydrochloride increases stomach acidity. H2-blockers are used to decrease stomach acidity. Theoretically, taking betaine hydrochloride along with H2-blockers might decrease the effects of H2-blockers.

Likelihood Possible Evidence D
Proton Pump Inhibitors (Ppis)

Betaine hydrochloride increases stomach acidity and could decrease the effects of PPIs.
In human research, betaine hydrochloride increases stomach acidity. PPIs are used to decrease stomach acidity. Theoretically, taking betaine hydrochloride along with PPIs might decrease the effects of PPIs

Likelihood Possible Evidence D
Betaine HCl full monograph & interactions

Papain1 drug type · 2 drugs

Warfarin (Coumadin)

Theoretically, papain might increase the effects and side effects of warfarin.
In one case report, a patient previously stable on warfarin was found to have an international normalization ratio (INR) of 7.4, which was attributed to ingestion of a supplement containing papain from papaya extract.

Likelihood Possible Evidence D
Papain full monograph & interactions

Pancreatin1 drug type · 1 drug

Acarbose (Precose, Prandase)

Theoretically, pancreatic enzyme products may reduce the effects of acarbose.
The digestive enzymes present in pancreatic enzyme products may break down acarbose, reducing its effects.

Likelihood Possible Evidence D
Pancreatin full monograph & interactions
The maker

Brand information

Manufacturer and brand details for DuoZyme, from the product label.

Karuna

See all Karuna products
Name
Karuna Corp.
Pharmacist Counseling Corner

DuoZyme by Karuna: Common Questions

Does DuoZyme by Karuna interact with any medications?
Yes. Based on its ingredients, DuoZyme has a known interaction with 39 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
DuoZyme contains 9 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take DuoZyme if I'm pregnant or breastfeeding?
Papain in DuoZyme is possibly unsafe in pregnancy, so it's best avoided. Betaine HCl should also be avoided during both pregnancy and breastfeeding. For the other enzymes (pancreatin, protease, pepsin, lipase), there isn't enough safety data to know either way — talk with your doctor or pharmacist for personalized advice before taking it.
What is papain, and why is it in this product?
Papain is an enzyme that comes from papaya fruit and helps break down proteins during digestion. It's included in DuoZyme to support your body's ability to digest protein-rich foods.
Can I take DuoZyme if I have acid reflux or take antacids?
No. Betaine HCl in DuoZyme increases stomach acid, which can make acid reflux worse and can reduce how well antacids and acid-reducing drugs (like PPIs or H2-blockers) work. If you have reflux or take those medications, check with your doctor or pharmacist before starting DuoZyme.
What does pancreatin do?
Pancreatin is a blend of digestive enzymes from the pancreas that helps break down fats, proteins, and carbohydrates. It's effective for pancreatic insufficiency, when the pancreas doesn't make enough of its own enzymes.
What are the most common side effects of DuoZyme?
The enzymes in DuoZyme may cause mild digestive upset, constipation, diarrhea, or allergic reactions in some people. Allergic reactions to papain can include itchy eyes, runny nose, sneezing, abdominal cramps, and diarrhea. Serious side effects are rare but possible at high doses.
Does DuoZyme work for muscle soreness or other conditions besides digestion?
We don't have reliable evidence that papain or the other enzymes in DuoZyme work for muscle soreness, shingles, or other non-digestive conditions. The evidence is insufficient to rate them for those uses.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if DuoZyme is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

DuoZyme label
Go deeper

The Full Monographs Behind DuoZyme’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Papain

Interacts with 2 drugs

Papain is a protein-digesting enzyme from the papaya plant that is used in digestive supplements and some topical products. While it has clear food and laboratory uses, strong human evidence...

Read the full Papain monograph → Herb & supplement monograph

Proteolytic Enzymes (proteases)

Proteolytic enzymes are proteins that help break down other proteins, and common examples include bromelain (from pineapple), papain (from papaya), trypsin, chymotrypsin, and pancreatin. Peo...

Read the full Proteolytic Enzymes (proteases) monograph → Herb & supplement monograph

Betaine Hydrochloride

Interacts with 36 drugs

Betaine hydrochloride is a supplement used to temporarily increase stomach acid in people who may have low acid levels. Evidence for its benefits is limited and mostly based on tradition rat...

Read the full Betaine Hydrochloride monograph → Herb & supplement monograph

Pancreatic Enzyme Products

Interacts with 1 drug

Pancreatic enzyme products supply the digestive enzymes (lipase, protease, and amylase) that some people cannot make enough of, helping them break down and absorb food. Prescription versions...

Read the full Pancreatic Enzyme Products monograph → Herb & supplement monograph

Lipase

Lipase is a digestive enzyme that helps your body break down dietary fats. It is well established as part of prescription pancreatic enzyme therapy for people who cannot make enough of their...

Read the full Lipase monograph →
Sources

Sources & How We Checked

DuoZyme's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 57 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Papain 11 references
  1. The Review of Natural Products by Facts and Comparisons. St. Louis, MO: Wolters Kluwer Co., 1999.
  2. Shaw D, Leon C, Kolev S, Murray V. Traditional remedies and food supplements: a 5-year toxicological study (1991-1995). Drug Saf 1997;17:342-56.
  3. Shuttleworth D, Hill S, Marks R, Connelly DM. Relief of experimentally induced pruritus with a novel eutectic mixture of local anaesthetic agents. Br J Dermatol 1988;119:535-40.
  4. Mansfield LE, Ting S, Haverly RW, Yoo TJ. The incidence and clinical implications of hypersensitivity to papain in an allergic population, confirmed by blinded oral challenge. Ann Allergy 1985;55:541-3.
  5. Martin, T., Uhder, K., Kurek, R., Roeddiger, S., Schneider, L., Vogt, H. G., Heyd, R., and Zamboglou, N. Does prophylactic treatment with proteolytic enzymes reduce acute toxicity of adjuvant pelvic irradiation? Results of a double-blind randomized trial PubMed
  6. Walker-Renard, P. Update on the medicinal management of phytobezoars. Am J Gastroenterol. 1993;88(10):1663-1666.
  7. Tymoszuk D, Wiszniewska M, Walusiak-Skorupa J. Papain-induced occupational rhinoconjunctivitis and asthma - A case report. Med Pr 2016;67(1):109-12. PubMed
  8. Soto-Mera MT, López-Rico MR, Filgueira JF, et al. Occupational allergy to papain. Allergy 2000;55(10):983-4. PubMed
  9. Tarlo SM, Shaikh W, Bell B, et al. Papain-induced allergic reactions. Clin Allergy 1978;8(3):207-15. PubMed
  10. Baur X, König G, Bencze K, Fruhmann G. Clinical symptoms and results of skin test, RAST and bronchial provocation test in thirty-three papain workers: Evidence for strong immunogenic potency and clinically relevant proteolytic e?ects of airborne papain. C
  11. Novey HS, Keenan WJ, Fairshter RD, Wells ID, Wilson AF, Culver BD. Pulmonary disease in workers exposed to papain: clinico-physiological and immunological studies. Clin Allergy 1980;10(6):721-31. PubMed

See these in context on the Papain monograph →

Proteolytic Enzymes (proteases) 3 references
  1. Weeks JA, Harper RA, Simon RA, Burdick JD. Assessment of sensitization risk of a laundry pre-spotter containing protease. Cutan Ocul Toxicol. 2011;30(4):272-9. PubMed
  2. Marquès LI, Lara S, Abós T, Bartolomé B. Occupational rhinitis due to pepsin. J Investig Allergol Clin Immunol. 2006;16(2):136-7. DOI
  3. Cartier A, Malo JL, Pineau L, Dolovich J. Occupational asthma due to pepsin. J Allergy Clin Immunol. 1984;73(5 Pt 1):574-7. PubMed

See these in context on the Proteolytic Enzymes (proteases) monograph →

Lipase 1 reference
  1. Casper C, Hascoet JM, Ertl T, et al. Recombinant bile salt-stimulated lipase in preterm infant feeding: A randomized phase 3 study. PLoS One. 2016;11(5):e0156071. PubMed

See these in context on the Lipase monograph →

Betaine Hydrochloride 2 references
  1. Yago MR, Frymoyer A, Benet LZ, Smelick GS, Frassetto LA, Ding X, Dean B, Salphati L, Budha N, Jin JY, Dresser MJ, Ware JA. The use of betaine HCl to enhance dasatinib absorption in healthy volunteers with rabeprazole-induced hypochlorhydria. AAPS J. 2014 PubMed
  2. Yago MR, Frymoyer AR, Smelick GS, Frassetto LA, Budha NR, Dresser MJ, Ware JA, Benet LZ. Gastric reacidification with betaine HCl in healthy volunteers with rabeprazole-induced hypochlorhydria. Mol Pharm. 2013 Nov 4;10(11):4032-7. PubMed

See these in context on the Betaine Hydrochloride monograph →

Pancreatic Enzyme Products 40 references
  1. Martindale W. Martindale the Extra Pharmacopoeia. Pharmaceutical Press, 1999.
  2. McEvoy GK, ed. AHFS Drug Information. Bethesda, MD: American Society of Health-System Pharmacists, 1998.
  3. Smyth RL, van Velzen D, Smyth AR, et al. Strictures of ascending colon in cystic fibrosis and high-strength pancreatic enzymes. Lancet 1994;343:85-6. PubMed
  4. Bergner A, Bergner RK. Pulmonary hypersensitivity associated with pancreatin powder exposure. Pediatrics 1975;55:814-7. DOI
  5. Wiessmann KJ, Baur X. Occupational lung disease following long-term inhalation of pancreatic extracts. Eur J Respir Dis 1985;66:13-20.
  6. Bragelmann, R., Armbrecht, U., Rosemeyer, D., Schneider, B., Zilly, W., and Stockbrugger, R. W. The effect of pancreatic enzyme supplementation in patients with steatorrhoea after total gastrectomy. Eur.J Gastroenterol.Hepatol. 1999;11(3):231-237. PubMed
  7. Halm, U., Loser, C., Lohr, M., Katschinski, M., and Mossner, J. A double-blind, randomized, multicentre, crossover study to prove equivalence of pancreatin minimicrospheres versus microspheres in exocrine pancreatic insufficiency. Aliment.Pharmacol.Ther. PubMed
  8. O'Keefe, S. J., Cariem, A. K., and Levy, M. The exacerbation of pancreatic endocrine dysfunction by potent pancreatic exocrine supplements in patients with chronic pancreatitis. J Clin Gastroenterol. 2001;32(4):319-323. PubMed
  9. Shin, S. Y., Hur, G. Y., Ye, Y. M., and Park, H. S. A case of occupational rhinitis caused by porcine pancreatic extract developing into occupational asthma. J Korean Med Sci. 2008;23(2):347-349. PubMed
  10. Andersen, H. O., Hjelt, K., Waever, E., and Overgaard, K. The age-related incidence of meconium ileus equivalent in a cystic fibrosis population: the impact of high-energy intake. J Pediatr Gastroenterol.Nutr 1990;11(3):356-360. DOI
  11. Ramo, O. J., Puolakkainen, P. A., Seppala, K., and Schroder, T. M. Self-administration of enzyme substitution in the treatment of exocrine pancreatic insufficiency. Scand.J Gastroenterol. 1989;24(6):688-692. PubMed
  12. Aparisi, L., Rodrigo, J. M., Serra, M. A., Del Olmo, J., Bisquert, M., and Raga, F. [Efficacy of a new microencapsulated pancreatin versus a conventional preparation, in the treatment of steatorrhea of pancreatic origin]. Rev.Esp.Enferm.Apar.Dig. 1989;76
  13. Ansaldi-Balocco, N., Santini, B., and Sarchi, C. Efficacy of pancreatic enzyme supplementation in children with cystic fibrosis: comparison of two preparations by random crossover study and a retrospective study of the same patients at two different ages DOI
  14. Beverley, D. W., Kelleher, J., Macdonald, A., Littlewood, J. M., Robinson, T., and Walters, M. P. Comparison of four pancreatic extracts in cystic fibrosis. Arch Dis.Child 1987;62(6):564-568. PubMed
  15. Silber, W. Pankreoflat in benign diseases of the oesophagus: a blind therapeutic trial. S.Afr.Med J 7-7-1973;47(26):1137-1138.
  16. Sack, J., Blau, H., Goldfarb, D., Ben-Zaray, S., and Katznelson, D. Hyperuricosuria in cystic fibrosis patients treated with pancreatic enzyme supplements. A study of 16 patients in Israel. Isr.J Med Sci. 1980;16(6):417-419.
  17. Oades, P. J., Bush, A., Ong, P. S., and Brereton, R. J. High-strength pancreatic enzyme supplements and large-bowel stricture in cystic fibrosis. Lancet 1-8-1994;343(8889):109. DOI
  18. Mac Sweeney, E. J., Oades, P. J., Buchdahl, R., Rosenthal, M., and Bush, A. Relation of thickening of colon wall to pancreatic-enzyme treatment in cystic fibrosis. Lancet 3-25-1995;345(8952):752-756. PubMed
  19. Jones, R., Franklin, K., Spicer, R., and Berry, J. Colonic strictures in children with cystic fibrosis on low-strength pancreatic enzymes. Lancet 8-19-1995;346(8973):499. DOI
  20. Taylor, C. J. and Steiner, G. M. Fibrosing colonopathy in a child on low-dose pancreatin. Lancet 10-21-1995;346(8982):1106-1107. PubMed
  21. Ong, P. S., Oades, P. J., Bush, A., and Brereton, R. J. Colonic stricture in a boy with cystic fibrosis. Postgrad.Med J 1995;71(835):309-312. PubMed
  22. Milla, C. E., Wielinski, C. L., and Warwick, W. J. High-strength pancreatic enzymes. Lancet 3-5-1994;343(8897):599. DOI
  23. McHugh, K., Thomson, A., and Tam, P. Case report: colonic stricture and fibrosis associated with high-strength pancreatic enzymes in a child with cystic fibrosis. Br.J Radiol. 1994;67(801):900-901. PubMed
  24. Nouisa-Arvanitakis, S., Stapleton, F. B., Linshaw, M. A., and Kennedy, J. Therapeutic approach to pancreatic extract-induced hyperuricosuria in cystic fibrosis. J Pediatr 1977;90(2):302-305. PubMed
  25. Lancellotti, L., Cabrini, G., Zanolla, L., and Mastella, G. High- versus low-lipase acid-resistant enzyme preparations in cystic fibrosis: a crossover randomized clinical trial. J Pediatr.Gastroenterol.Nutr. 1996;22(1):73-78. DOI
  26. FitzSimmons, S. C., Burkhart, G. A., Borowitz, D., Grand, R. J., Hammerstrom, T., Durie, P. R., Lloyd-Still, J. D., and Lowenfels, A. B. High-dose pancreatic-enzyme supplements and fibrosing colonopathy in children with cystic fibrosis. N.Engl.J Med 5-1- PubMed
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See these in context on the Pancreatic Enzyme Products monograph →

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DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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