Eurocel Ingredients & Drug Interactions
What is this page for?
First and foremost: checking Eurocel against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
Eurocel is a dietary supplement by Allergy Research Group with 4 active ingredients. Its ingredients are commonly taken for digestive complaints and diarrhea, inflammation and joint discomfort, stress and weight management (in combination products).Based on those ingredients, 1,228 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Phellodendron amurense (bark) extract, Schisandra (fruit) extract, Yin-Chen Wormwood (leaves) extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.
Check Your Meds Against Eurocel by Allergy Research Group
Ask about any prescription or over-the-counter medication and we check it for interactions with Eurocel by Allergy Research Group — and tell you which ingredient is responsible.
AI summaries are generated from our interaction database for education only — always confirm with your pharmacist. How we use AI
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HelloPharmacist Scorecard of Eurocel by Allergy Research Group
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Low disclosure
Eurocel contains four ingredients in a proprietary blend: Phellodendron amurense (bark) extract, Patrinia (entire plant) extract, Yin-Chen Wormwood (leaves) extract, and Schisandra (fruit) extract. The active ingredients work through traditional herbal mechanisms — phellodendron and yin chen are used in herbal medicine for liver and digestive support, schisandra traditionally supports energy and resilience, and patrinia rounds out the blend.
The capsule itself is made from gelatin and a few inactive ingredients (a fatty acid ester and a silicate compound) that help hold everything together.
Does it work?
Not established
The evidence we hold doesn't establish that Eurocel works for any of its traditional uses. Phellodendron shows insufficient reliable evidence for acne, benign prostate enlargement, diabetes, weight management, osteoarthritis, and peptic ulcers.
Yin Chen Wormwood similarly lacks established evidence for asthma, bile duct and liver conditions, irregular menstrual pain, and metabolic syndrome. Schisandra also shows insufficient evidence for asthma, athletic performance, cough, diabetes, diarrhea, and hepatitis.
If you're considering this product for a specific health concern, talk with your pharmacist about what the research actually shows.
How safe is it?
Well-documented data
Phellodendron and yin chen are used short-term in traditional medicine, but human safety data are limited for both. Yin chen in particular has been reported in higher doses (15–30 grams) to cause heart rhythm problems, fainting, numbness, and tremors, though it's generally well tolerated at typical doses.
Schisandra is generally well tolerated short-term, and the most common side effects reported in studies are decreased appetite, heartburn, stomach upset, and a skin rash (urticaria). A small number of trial participants using a combination product containing phellodendron and magnolia reported headache, fatigue, shaking hands, numbness around the mouth, sexual dysfunction, and heartburn, though it's unclear if phellodendron was responsible.
Berberine-containing herbs like phellodendron are not considered safe in pregnancy and should be avoided if you're pregnant. Do not use this product while breastfeeding — berberine can pass into breast milk and may harm infants, and yin chen and schisandra both lack reliable breastfeeding safety data.
Meds to double-check
Moderate interaction found
Before taking Eurocel, double-check these medication types with your pharmacist, starting with the most serious: blood thinners and antiplatelet drugs (such as warfarin or aspirin), blood pressure medications, sedatives and sleep aids, diabetes medications, the immunosuppressant tacrolimus, the antifungal voriconazole, the sedative midazolam, metformin, and any drugs your liver processes through the CYP2D6, CYP2C9, CYP2C19, or CYP3A4 enzymes. These are common enzyme systems, so many medications may be affected.
The bottom line
Scorecard at a glanceFormula with limited ingredient disclosure with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and safety information is well characterized.
Eurocel is a four-ingredient herbal blend used traditionally for liver and digestive support, but the evidence for its effectiveness isn't established in our data. The bigger concern is that it interacts with over 1,200 medications across many categories — blood thinners, blood pressure drugs, sedatives, diabetes medications, and dozens of others processed through your liver.
If you take any prescription medication or are pregnant or breastfeeding, talk with your pharmacist before starting it.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 3 of 4 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Nov 21, 2018.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about Eurocel, straight from the product label.
| Brand | Allergy Research Group |
|---|---|
| Barcode (UPC) | 713947740303 |
| Net contents | 180 Capsule(s) |
| Market status | On market |
| Date entered into DSLD | Nov 21, 2018 |
| DSLD ID | 183520 |
| Product type | Botanical |
| Supplement form | Capsule |
| Dietary claims / uses | All Other, Structure/Function |
| Intended target group(s) | Adult (18 - 50 Years) |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for Eurocel by Allergy Research Group, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| Proprietary Blend | 1 Gram(s) | -- |
| Phellodendron amurense (bark) extract | 0 NP | -- |
| Patrinia (entire plant) extract | 0 NP | -- |
| Yin-Chen Wormwood (leaves) extract | 0 NP | -- |
| Schisandra (fruit) extract | 0 NP | -- |
Other ingredients: Gelatin, Sucrose Fatty Acid Ester, Sodium Silicoaluminate
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements
Eurocel combines traditional Korean and Chinese herbal extracts which are known to support liver health.
Product of Korea
Traditional herbal liver support
Suggested/Recommended/Usage/Directions
Suggested use As a dietary supplement, 2 capsules three times daily between meals, or as directed by a healthcare practitioner.
Precautions
Warning: If GI symptoms (related to "die-off") i.e. gastrointestinal discomfort, nausea, or vomiting occur, reduce or discontinue usage. Caution: Do not use alcoholic beverages while taking Eurocel.
California Proposition 65 Warning: This product contains lead, a chemical known to the State of California to cause birth defects or other reproductive harm.
Storage
Keep in a cool, dry place, tightly capped.
FDA Statement of Identity
Dietary Supplement
FDA Disclaimer Statement
This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.
General
Rev. 005
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
Eurocel by Allergy Research Group label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in Eurocel by Allergy Research Group
These are the 4 active ingredients this product is made of. Select any to open its full monograph.
Serving size2 Capsule(s) Dosage formCapsule Servings per container90 Amounts shown are per serving.
Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.
Proprietary Blend
- › Phellodendron amurense (bark) extract
- › Patrinia (entire plant) extract
- › Yin-Chen Wormwood (leaves) extract
- › Schisandra (fruit) extract
Other (inactive) ingredients: Gelatin, Sucrose Fatty Acid Ester, Sodium Silicoaluminate. These complete the product’s ingredient list but are not active constituents.
Eurocel by Allergy Research Group Drug Interactions
HelloPharmacist Interaction Report
Eurocel by Allergy Research Group contains four ingredients, one of which we could not check for interactions.
The product has documented interactions with a substantial number of medications across multiple categories, with the most serious concern being its potential effects on blood thinners (anticoagulants) and antiplatelet drugs. Phellodendron, one of the main actives, contains berberine, which may reduce your blood's ability to clot and could increase bleeding risk if you're taking warfarin, aspirin, or similar medications.
Read the full breakdown — every affected drug type, severity by severity
Phellodendron also interacts with drugs that lower blood pressure (antihypertensive drugs), sedatives and sleep aids (CNS depressants), diabetes medications, and several categories of drugs your liver processes through specific enzymes (CYP2D6, CYP2C9, and CYP3A4 substrates). It may also affect how your body handles metformin.
Yin Chen Wormwood similarly interacts with sedatives and has documented effects with the barbiturate pentobarbital. Schisandra has its own set of interactions with sedatives, blood thinner warfarin, the immunosuppressant tacrolimus, and antifungal and sedative medications processed through liver enzymes and a protein called P-glycoprotein.
We could not check Patrinia (entire plant) extract because we hold no data for it. Altogether, these interactions span 1,213 individual medications.
Before you start Eurocel, run your exact medications through the search tool on this page.
Check your own medications below · Editorial policy · How we use AI
Want to check YOUR meds against Eurocel?
Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.
Go to the checkerIngredients driving the most interactions
Individual Drug Interactions
The ingredients in Eurocel interact with 1,228 drugs. Click any drug to see the details.
3 of the 4 ingredients in Eurocel interact with drugs. Each result below shows which ingredient is responsible. Phellodendron amurense (bark) extract Schisandra (fruit) extract Yin-Chen Wormwood (leaves) extract
Ado-trastuzumab EmtansineKadcyla
How Ado-trastuzumab Emtansine interacts with Eurocel — through 2 ingredients. Tap an ingredient for the detail:
Phellodendron Amurense (bark) ExtractCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, phellodendron might increase serum levels of drugs metabolized by CYP3A4.
Read the full Phellodendron Amurense (bark) Extract + Ado-trastuzumab Emtansine interactionSchisandra (fruit) ExtractCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Schisandra can increase the levels and clinical effects of drugs metabolized by CYP3A4.
Read the full Schisandra (fruit) Extract + Ado-trastuzumab Emtansine interactionAbciximabReoPro
How Abciximab interacts with Eurocel — through 1 ingredient. Tap an ingredient for the detail:
Phellodendron Amurense (bark) ExtractAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, phellodendron might increase the risk of bleeding when used with anticoagulant or antiplatelet drugs.
Read the full Phellodendron Amurense (bark) Extract + Abciximab interactionAbemaciclibVerzenio
How Abemaciclib interacts with Eurocel — through 2 ingredients. Tap an ingredient for the detail:
Phellodendron Amurense (bark) ExtractCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, phellodendron might increase serum levels of drugs metabolized by CYP3A4.
Read the full Phellodendron Amurense (bark) Extract + Abemaciclib interactionSchisandra (fruit) ExtractCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Schisandra can increase the levels and clinical effects of drugs metabolized by CYP3A4.
Read the full Schisandra (fruit) Extract + Abemaciclib interactionAbiraterone
How Abiraterone interacts with Eurocel — through 2 ingredients. Tap an ingredient for the detail:
Schisandra (fruit) ExtractCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Schisandra can increase the levels and clinical effects of drugs metabolized by CYP3A4.
Read the full Schisandra (fruit) Extract + Abiraterone interactionPhellodendron Amurense (bark) ExtractCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, phellodendron might increase serum levels of drugs metabolized by CYP3A4.
Read the full Phellodendron Amurense (bark) Extract + Abiraterone interactionAbiraterone AcetateYonsa, Zytiga
How Abiraterone Acetate interacts with Eurocel — through 2 ingredients. Tap an ingredient for the detail:
Phellodendron Amurense (bark) ExtractCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, phellodendron might increase serum levels of drugs metabolized by CYP3A4.
Read the full Phellodendron Amurense (bark) Extract + Abiraterone Acetate interactionSchisandra (fruit) ExtractCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Schisandra can increase the levels and clinical effects of drugs metabolized by CYP3A4.
Read the full Schisandra (fruit) Extract + Abiraterone Acetate interactionAbrocitinibCibinqo
How Abrocitinib interacts with Eurocel — through 2 ingredients. Tap an ingredient for the detail:
Phellodendron Amurense (bark) ExtractCytochrome P450 2c9 (cyp2c9) Substrates, Anticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, phellodendron might increase serum levels of drugs metabolized by CYP2C9.
Read the full Phellodendron Amurense (bark) Extract + Abrocitinib interactionSchisandra (fruit) ExtractCytochrome P450 2c19 (cyp2c19) Substrates, Cytochrome P450 2c9 (cyp2c9) Substrates Moderate
Interaction Summary
Theoretically, schisandra might increase the levels and clinical effects of CYP2C19 substrates.
Read the full Schisandra (fruit) Extract + Abrocitinib interactionAcalabrutinibCalquence
How Acalabrutinib interacts with Eurocel — through 2 ingredients. Tap an ingredient for the detail:
Schisandra (fruit) ExtractCytochrome P450 3a4 (cyp3a4) Substrates, P-glycoprotein Substrates Moderate
Interaction Summary
Schisandra can increase the levels and clinical effects of drugs metabolized by CYP3A4.
Read the full Schisandra (fruit) Extract + Acalabrutinib interactionPhellodendron Amurense (bark) ExtractCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, phellodendron might increase serum levels of drugs metabolized by CYP3A4.
Read the full Phellodendron Amurense (bark) Extract + Acalabrutinib interactionAcarboseGlucobay, Prandase, Precose
How Acarbose interacts with Eurocel — through 1 ingredient. Tap an ingredient for the detail:
Phellodendron Amurense (bark) ExtractAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, phellodendron may increase the risk of hypoglycemia when taken with antidiabetes drugs.
Read the full Phellodendron Amurense (bark) Extract + Acarbose interactionAcebutololRhotral, Sectral
How Acebutolol interacts with Eurocel — through 1 ingredient. Tap an ingredient for the detail:
Phellodendron Amurense (bark) ExtractAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, phellodendron might have additive effects with antihypertensive drugs.
Read the full Phellodendron Amurense (bark) Extract + Acebutolol interactionAcenocoumarolSintrom
How Acenocoumarol interacts with Eurocel — through 1 ingredient. Tap an ingredient for the detail:
Phellodendron Amurense (bark) ExtractAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, phellodendron might increase the risk of bleeding when used with anticoagulant or antiplatelet drugs.
Read the full Phellodendron Amurense (bark) Extract + Acenocoumarol interactionAcepromazineAtravet
How Acepromazine interacts with Eurocel — through 2 ingredients. Tap an ingredient for the detail:
Phellodendron Amurense (bark) ExtractCns Depressants Moderate
Interaction Summary
Theoretically, phellodendron might increase the sedative effects of CNS depressants.
Read the full Phellodendron Amurense (bark) Extract + Acepromazine interactionYin-chen Wormwood (leaves) ExtractCns Depressants Moderate
Interaction Summary
Theoretically, yin chen might enhance the therapeutic and adverse effects of other CNS depressants.
Read the full Yin-chen Wormwood (leaves) Extract + Acepromazine interactionAcetaminophen, AspirinGemnisyn
How Acetaminophen, Aspirin interacts with Eurocel — through 1 ingredient. Tap an ingredient for the detail:
Phellodendron Amurense (bark) ExtractAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, phellodendron might increase the risk of bleeding when used with anticoagulant or antiplatelet drugs.
Read the full Phellodendron Amurense (bark) Extract + Acetaminophen, Aspirin interactionAcetaminophen, Aspirin, CaffeineExcedrin, Excedrin Extra Strength, Excedrin Migraine
How Acetaminophen, Aspirin, Caffeine interacts with Eurocel — through 2 ingredients. Tap an ingredient for the detail:
Phellodendron Amurense (bark) ExtractAnticoagulant/antiplatelet Drugs, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, phellodendron might increase the risk of bleeding when used with anticoagulant or antiplatelet drugs.
Read the full Phellodendron Amurense (bark) Extract + Acetaminophen, Aspirin, Caffeine interactionSchisandra (fruit) ExtractCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Schisandra can increase the levels and clinical effects of drugs metabolized by CYP3A4.
Read the full Schisandra (fruit) Extract + Acetaminophen, Aspirin, Caffeine interactionAcetaminophen, Butalbital, CaffeineEsgic, Esgic Plus, Fiogesic, Fioricet, Repan, Tecnal +1 more
How Acetaminophen, Butalbital, Caffeine interacts with Eurocel — through 2 ingredients. Tap an ingredient for the detail:
Schisandra (fruit) ExtractCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Schisandra can increase the levels and clinical effects of drugs metabolized by CYP3A4.
Read the full Schisandra (fruit) Extract + Acetaminophen, Butalbital, Caffeine interactionPhellodendron Amurense (bark) ExtractCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, phellodendron might increase serum levels of drugs metabolized by CYP3A4.
Read the full Phellodendron Amurense (bark) Extract + Acetaminophen, Butalbital, Caffeine interactionAcetaminophen, Butalbital, Caffeine, CodeineEsgic with Codeine, Fioricet w/ Codeine
How Acetaminophen, Butalbital, Caffeine, Codeine interacts with Eurocel — through 3 ingredients. Tap an ingredient for the detail:
Phellodendron Amurense (bark) ExtractCytochrome P450 3a4 (cyp3a4) Substrates, Cytochrome P450 2d6 (cyp2d6) Substrates +1 Moderate
Interaction Summary
Theoretically, phellodendron might increase serum levels of drugs metabolized by CYP3A4.
Read the full Phellodendron Amurense (bark) Extract + Acetaminophen, Butalbital, Caffeine, Codeine interactionSchisandra (fruit) ExtractCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Schisandra can increase the levels and clinical effects of drugs metabolized by CYP3A4.
Read the full Schisandra (fruit) Extract + Acetaminophen, Butalbital, Caffeine, Codeine interactionYin-chen Wormwood (leaves) ExtractCns Depressants Moderate
Interaction Summary
Theoretically, yin chen might enhance the therapeutic and adverse effects of other CNS depressants.
Read the full Yin-chen Wormwood (leaves) Extract + Acetaminophen, Butalbital, Caffeine, Codeine interactionAcetaminophen, Butalbital, CodeineBancap w/ Codeine
How Acetaminophen, Butalbital, Codeine interacts with Eurocel — through 2 ingredients. Tap an ingredient for the detail:
Yin-chen Wormwood (leaves) ExtractCns Depressants Moderate
Interaction Summary
Theoretically, yin chen might enhance the therapeutic and adverse effects of other CNS depressants.
Read the full Yin-chen Wormwood (leaves) Extract + Acetaminophen, Butalbital, Codeine interactionPhellodendron Amurense (bark) ExtractCytochrome P450 2d6 (cyp2d6) Substrates, Cns Depressants Moderate
Interaction Summary
Theoretically, phellodendron might increase serum levels of drugs metabolized by CYP2D6.
Read the full Phellodendron Amurense (bark) Extract + Acetaminophen, Butalbital, Codeine interactionAcetaminophen, Butalbital, Codeine PhosphatePhrenilin #3
How Acetaminophen, Butalbital, Codeine Phosphate interacts with Eurocel — through 2 ingredients. Tap an ingredient for the detail:
Phellodendron Amurense (bark) ExtractCns Depressants, Cytochrome P450 2d6 (cyp2d6) Substrates Moderate
Interaction Summary
Theoretically, phellodendron might increase the sedative effects of CNS depressants.
Read the full Phellodendron Amurense (bark) Extract + Acetaminophen, Butalbital, Codeine Phosphate interactionYin-chen Wormwood (leaves) ExtractCns Depressants Moderate
Interaction Summary
Theoretically, yin chen might enhance the therapeutic and adverse effects of other CNS depressants.
Read the full Yin-chen Wormwood (leaves) Extract + Acetaminophen, Butalbital, Codeine Phosphate interactionAcetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, PhenylephrineHycomine Compound
How Acetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, Phenylephrine interacts with Eurocel — through 3 ingredients. Tap an ingredient for the detail:
Phellodendron Amurense (bark) ExtractCytochrome P450 2d6 (cyp2d6) Substrates, Cns Depressants +1 Moderate
Interaction Summary
Theoretically, phellodendron might increase serum levels of drugs metabolized by CYP2D6.
Read the full Phellodendron Amurense (bark) Extract + Acetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, Phenylephrine interactionYin-chen Wormwood (leaves) ExtractCns Depressants Moderate
Interaction Summary
Theoretically, yin chen might enhance the therapeutic and adverse effects of other CNS depressants.
Read the full Yin-chen Wormwood (leaves) Extract + Acetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, Phenylephrine interactionSchisandra (fruit) ExtractCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Schisandra can increase the levels and clinical effects of drugs metabolized by CYP3A4.
Read the full Schisandra (fruit) Extract + Acetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, Phenylephrine interactionAcetaminophen, Caffeine, CodeineGesic C15, Gesic C30, Gesic C8, Lenoltec 1, Lenoltec 2, Lenoltec 3 +1 more
How Acetaminophen, Caffeine, Codeine interacts with Eurocel — through 3 ingredients. Tap an ingredient for the detail:
Schisandra (fruit) ExtractCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Schisandra can increase the levels and clinical effects of drugs metabolized by CYP3A4.
Read the full Schisandra (fruit) Extract + Acetaminophen, Caffeine, Codeine interactionPhellodendron Amurense (bark) ExtractCns Depressants, Cytochrome P450 2d6 (cyp2d6) Substrates +1 Moderate
Interaction Summary
Theoretically, phellodendron might increase the sedative effects of CNS depressants.
Read the full Phellodendron Amurense (bark) Extract + Acetaminophen, Caffeine, Codeine interactionYin-chen Wormwood (leaves) ExtractCns Depressants Moderate
Interaction Summary
Theoretically, yin chen might enhance the therapeutic and adverse effects of other CNS depressants.
Read the full Yin-chen Wormwood (leaves) Extract + Acetaminophen, Caffeine, Codeine interactionAcetaminophen, Caffeine, Codeine, SalicylamideCodalan No.1, Codalan No.2, Codalan No.3
How Acetaminophen, Caffeine, Codeine, Salicylamide interacts with Eurocel — through 3 ingredients. Tap an ingredient for the detail:
Phellodendron Amurense (bark) ExtractCytochrome P450 3a4 (cyp3a4) Substrates, Cytochrome P450 2d6 (cyp2d6) Substrates +1 Moderate
Interaction Summary
Theoretically, phellodendron might increase serum levels of drugs metabolized by CYP3A4.
Read the full Phellodendron Amurense (bark) Extract + Acetaminophen, Caffeine, Codeine, Salicylamide interactionSchisandra (fruit) ExtractCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Schisandra can increase the levels and clinical effects of drugs metabolized by CYP3A4.
Read the full Schisandra (fruit) Extract + Acetaminophen, Caffeine, Codeine, Salicylamide interactionYin-chen Wormwood (leaves) ExtractCns Depressants Moderate
Interaction Summary
Theoretically, yin chen might enhance the therapeutic and adverse effects of other CNS depressants.
Read the full Yin-chen Wormwood (leaves) Extract + Acetaminophen, Caffeine, Codeine, Salicylamide interactionAcetaminophen, Caffeine, DihydrocodeineDHC Plus, Panlor DC, Panlor SS
How Acetaminophen, Caffeine, Dihydrocodeine interacts with Eurocel — through 3 ingredients. Tap an ingredient for the detail:
Phellodendron Amurense (bark) ExtractCytochrome P450 3a4 (cyp3a4) Substrates, Cns Depressants +1 Moderate
Interaction Summary
Theoretically, phellodendron might increase serum levels of drugs metabolized by CYP3A4.
Read the full Phellodendron Amurense (bark) Extract + Acetaminophen, Caffeine, Dihydrocodeine interactionSchisandra (fruit) ExtractCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Schisandra can increase the levels and clinical effects of drugs metabolized by CYP3A4.
Read the full Schisandra (fruit) Extract + Acetaminophen, Caffeine, Dihydrocodeine interactionYin-chen Wormwood (leaves) ExtractCns Depressants Moderate
Interaction Summary
Theoretically, yin chen might enhance the therapeutic and adverse effects of other CNS depressants.
Read the full Yin-chen Wormwood (leaves) Extract + Acetaminophen, Caffeine, Dihydrocodeine interactionAcetaminophen, Caffeine, IsomethepteneMigralam
How Acetaminophen, Caffeine, Isometheptene interacts with Eurocel — through 2 ingredients. Tap an ingredient for the detail:
Phellodendron Amurense (bark) ExtractCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, phellodendron might increase serum levels of drugs metabolized by CYP3A4.
Read the full Phellodendron Amurense (bark) Extract + Acetaminophen, Caffeine, Isometheptene interactionSchisandra (fruit) ExtractCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Schisandra can increase the levels and clinical effects of drugs metabolized by CYP3A4.
Read the full Schisandra (fruit) Extract + Acetaminophen, Caffeine, Isometheptene interactionAcetaminophen, Caffeine, PyrilamineMidol Max Strength Menstrual
How Acetaminophen, Caffeine, Pyrilamine interacts with Eurocel — through 2 ingredients. Tap an ingredient for the detail:
Schisandra (fruit) ExtractCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Schisandra can increase the levels and clinical effects of drugs metabolized by CYP3A4.
Read the full Schisandra (fruit) Extract + Acetaminophen, Caffeine, Pyrilamine interactionPhellodendron Amurense (bark) ExtractCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, phellodendron might increase serum levels of drugs metabolized by CYP3A4.
Read the full Phellodendron Amurense (bark) Extract + Acetaminophen, Caffeine, Pyrilamine interactionAcetaminophen, Chlorpheniramine Maleate, Dextromethorphan HbrVicks Formula 44M Cough, Cold & Flu Relief
How Acetaminophen, Chlorpheniramine Maleate, Dextromethorphan Hbr interacts with Eurocel — through 2 ingredients. Tap an ingredient for the detail:
Schisandra (fruit) ExtractCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Schisandra can increase the levels and clinical effects of drugs metabolized by CYP3A4.
Read the full Schisandra (fruit) Extract + Acetaminophen, Chlorpheniramine Maleate, Dextromethorphan Hbr interactionPhellodendron Amurense (bark) ExtractCytochrome P450 2d6 (cyp2d6) Substrates, Dextromethorphan (robitussin Dm, Others) +1 Moderate
Interaction Summary
Theoretically, phellodendron might increase serum levels of drugs metabolized by CYP2D6.
Read the full Phellodendron Amurense (bark) Extract + Acetaminophen, Chlorpheniramine Maleate, Dextromethorphan Hbr interactionAcetaminophen, Chlorpheniramine, Codeine, PhenylephrineColrex
How Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interacts with Eurocel — through 3 ingredients. Tap an ingredient for the detail:
Phellodendron Amurense (bark) ExtractCytochrome P450 3a4 (cyp3a4) Substrates, Cns Depressants +1 Moderate
Interaction Summary
Theoretically, phellodendron might increase serum levels of drugs metabolized by CYP3A4.
Read the full Phellodendron Amurense (bark) Extract + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interactionYin-chen Wormwood (leaves) ExtractCns Depressants Moderate
Interaction Summary
Theoretically, yin chen might enhance the therapeutic and adverse effects of other CNS depressants.
Read the full Yin-chen Wormwood (leaves) Extract + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interactionSchisandra (fruit) ExtractCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Schisandra can increase the levels and clinical effects of drugs metabolized by CYP3A4.
Read the full Schisandra (fruit) Extract + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interactionAcetaminophen, Chlorpheniramine, DextromethorphanCoricidin II Extra Strength Cold and Flu
How Acetaminophen, Chlorpheniramine, Dextromethorphan interacts with Eurocel — through 2 ingredients. Tap an ingredient for the detail:
Phellodendron Amurense (bark) ExtractCytochrome P450 3a4 (cyp3a4) Substrates, Dextromethorphan (robitussin Dm, Others) +1 Moderate
Interaction Summary
Theoretically, phellodendron might increase serum levels of drugs metabolized by CYP3A4.
Read the full Phellodendron Amurense (bark) Extract + Acetaminophen, Chlorpheniramine, Dextromethorphan interactionSchisandra (fruit) ExtractCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Schisandra can increase the levels and clinical effects of drugs metabolized by CYP3A4.
Read the full Schisandra (fruit) Extract + Acetaminophen, Chlorpheniramine, Dextromethorphan interactionAcetaminophen, Chlorpheniramine, Dextromethorphan HydrobromideCoricidin HBP Maximum Strength Flu
How Acetaminophen, Chlorpheniramine, Dextromethorphan Hydrobromide interacts with Eurocel — through 2 ingredients. Tap an ingredient for the detail:
Schisandra (fruit) ExtractCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Schisandra can increase the levels and clinical effects of drugs metabolized by CYP3A4.
Read the full Schisandra (fruit) Extract + Acetaminophen, Chlorpheniramine, Dextromethorphan Hydrobromide interactionPhellodendron Amurense (bark) ExtractCytochrome P450 2d6 (cyp2d6) Substrates, Dextromethorphan (robitussin Dm, Others) +1 Moderate
Interaction Summary
Theoretically, phellodendron might increase serum levels of drugs metabolized by CYP2D6.
Read the full Phellodendron Amurense (bark) Extract + Acetaminophen, Chlorpheniramine, Dextromethorphan Hydrobromide interactionAcetaminophen, Chlorpheniramine, Dextromethorphan, PhenylpropanolamineMulti Symptom Cold Relief
How Acetaminophen, Chlorpheniramine, Dextromethorphan, Phenylpropanolamine interacts with Eurocel — through 2 ingredients. Tap an ingredient for the detail:
Phellodendron Amurense (bark) ExtractDextromethorphan (robitussin Dm, Others), Cytochrome P450 2d6 (cyp2d6) Substrates +1 Moderate
Interaction Summary
Theoretically, phellodendron may increase serum levels of dextromethorphan.
Read the full Phellodendron Amurense (bark) Extract + Acetaminophen, Chlorpheniramine, Dextromethorphan, Phenylpropanolamine interactionSchisandra (fruit) ExtractCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Schisandra can increase the levels and clinical effects of drugs metabolized by CYP3A4.
Read the full Schisandra (fruit) Extract + Acetaminophen, Chlorpheniramine, Dextromethorphan, Phenylpropanolamine interactionAcetaminophen, Chlorpheniramine, Dextromethorphan, PseudoephedrineChildren's Tylenol Cold Plus Cough, Tylenol Cold Ex Strength
How Acetaminophen, Chlorpheniramine, Dextromethorphan, Pseudoephedrine interacts with Eurocel — through 2 ingredients. Tap an ingredient for the detail:
Schisandra (fruit) ExtractCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Schisandra can increase the levels and clinical effects of drugs metabolized by CYP3A4.
Read the full Schisandra (fruit) Extract + Acetaminophen, Chlorpheniramine, Dextromethorphan, Pseudoephedrine interactionPhellodendron Amurense (bark) ExtractCytochrome P450 2d6 (cyp2d6) Substrates, Dextromethorphan (robitussin Dm, Others) +1 Moderate
Interaction Summary
Theoretically, phellodendron might increase serum levels of drugs metabolized by CYP2D6.
Read the full Phellodendron Amurense (bark) Extract + Acetaminophen, Chlorpheniramine, Dextromethorphan, Pseudoephedrine interactionAcetaminophen, Chlorpheniramine, Guaifenesin, Phenylephrine, SalicylamideRhinogesic GG
How Acetaminophen, Chlorpheniramine, Guaifenesin, Phenylephrine, Salicylamide interacts with Eurocel — through 2 ingredients. Tap an ingredient for the detail:
Phellodendron Amurense (bark) ExtractCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, phellodendron might increase serum levels of drugs metabolized by CYP3A4.
Read the full Phellodendron Amurense (bark) Extract + Acetaminophen, Chlorpheniramine, Guaifenesin, Phenylephrine, Salicylamide interactionSchisandra (fruit) ExtractCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Schisandra can increase the levels and clinical effects of drugs metabolized by CYP3A4.
Read the full Schisandra (fruit) Extract + Acetaminophen, Chlorpheniramine, Guaifenesin, Phenylephrine, Salicylamide interactionEach ingredient & the kinds of drugs it affects
For each ingredient in Eurocel with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.
Phellodendron amurense (bark) extract
Anticoagulant/Antiplatelet Drugs
Theoretically, phellodendron might increase the risk of bleeding when used with anticoagulant or antiplatelet drugs.
Phellodendron contains berberine. In vitro and in vivo research suggest that berberine can inhibit platelet aggregation. Theoretically, phellodendron might also inhibit platelet aggregation.
Antidiabetes Drugs
Theoretically, phellodendron may increase the risk of hypoglycemia when taken with antidiabetes drugs.
Phellodendron contains berberine. Clinical research shows that berberine may lower blood glucose levels. Theoretically, phellodendron might also lower blood glucose levels.
Antihypertensive Drugs
Theoretically, phellodendron might have additive effects with antihypertensive drugs.
Phellodendron contains berberine. Animal research suggests that berberine can have hypotensive effects. Also, a clinical study suggests that taking berberine in combination with amlodipine can lower systolic and diastolic blood pressure when compared with amlodipine alone. Theoretically, phellodendron might also reduce blood pressure.
Cns Depressants
Theoretically, phellodendron might increase the sedative effects of CNS depressants.
Phellodendron contains berberine. Animal research suggests that berberine may have sedative effects. Theoretically, phellodendron might also have CNS depressants effects.
Cyclosporine (Neoral, Sandimmune)
Theoretically, phellodendron might increase blood levels of cyclosporine.
Phellodendron contains berberine. Preliminary clinical research shows that berberine can reduce metabolism of cyclosporine and increase serum levels, likely through inhibition of cytochrome P450 3A4 (CYP3A4), which metabolizes cyclosporine. Theoretically, phellodendron might also reduce the metabolism of cyclosporine.
Cytochrome P450 2C9 (Cyp2C9) Substrates
Theoretically, phellodendron might increase serum levels of drugs metabolized by CYP2C9.
Phellodendron contains berberine. Preliminary clinical research shows that berberine can inhibit CYP2C9. Theoretically, phellodendron might also inhibit CYP2C9.
Cytochrome P450 2D6 (Cyp2D6) Substrates
Theoretically, phellodendron might increase serum levels of drugs metabolized by CYP2D6.
Phellodendron contains berberine. In vitro research and preliminary clinical evidence show that berberine can inhibit CYP2D6. Theoretically, phellodendron might also inhibit CYP2D6.
Cytochrome P450 3A4 (Cyp3A4) Substrates
Theoretically, phellodendron might increase serum levels of drugs metabolized by CYP3A4.
Phellodendron contains berberine. In vitro research and preliminary clinical research show that berberine moderately inhibits CYP3A4. Theoretically, phellodendron might also inhibit CYP3A4.
Dextromethorphan (Robitussin Dm, Others)
Theoretically, phellodendron may increase serum levels of dextromethorphan.
Phellodendron contains berberine. Preliminary clinical research shows that berberine can inhibit cytochrome P450 2D6 (CYP2D6) activity and reduce the metabolism of dextromethorphan. Theoretically, phellodendron may also inhibit the metabolism of dextromethorphan.
Losartan (Cozaar)
Theoretically, phellodendron might reduce the therapeutic effects of losartan by decreasing its conversion to its active form.
Phellodendron contains berberine. Preliminary clinical research suggests that berberine can inhibit cytochrome P450 2C9 (CYP2C9) activity and reduce metabolism of losartan. Theoretically, phellodendron might also inhibit the metabolism of losartan.
Metformin (Glucophage)
Theoretically, phellodendron might increase the therapeutic and adverse effects of metformin.
Phellodendron contains berberine. In vitro and animal studies show that berberine can increase the systemic exposure and half-life of metformin, potentially increasing metformin's effects and side effects. This interaction seems to be most apparent when berberine is administered 2 hours prior to metformin. Taking berberine and metformin at the same time does not appear to increase systemic exposure to metformin. It is unclear if phellodendron might have this same effect.
Midazolam (Versed)
Theoretically, phellodendron might reduce metabolism of midazolam, which might increase the risk of severe adverse effects.
Phellodendron contains berberine. Preliminary clinical research shows that berberine can inhibit cytochrome P450 3A4 (CYP3A4) activity and reduce metabolism of midazolam. Theoretically, phellodendron might also inhibit the metabolism of midazolam.
Pentobarbital (Nembutal)
Theoretically, phellodendron might increase the sedative effect of pentobarbital.
Phellodendron contains berberine. Animal research shows that berberine can prolong pentobarbital-induced sleeping time. Theoretically, phellodendron might increase the sedative effects of pentobarbital.
Tacrolimus (Prograf)
Theoretically, phellodendron might increase blood levels of tacrolimus.
Phellodendron contains berberine. In a 16-year-old patient with idiopathic nephrotic syndrome who was being treated with tacrolimus 6.5 mg twice daily, intake of berberine 200 mg three times daily increased the blood concentration of tacrolimus from 8 to 22 ng/mL. Following a reduction of the tacrolimus dose to 3 mg daily, blood levels of tacrolimus decreased to 12 ng/mL. It is unclear if phellodendron might have this same effect.
Schisandra (fruit) extract
Cyclophosphamide
Theoretically, schisandra might increase the levels and clinical effects of cyclophosphamide.
In vitro research shows that schisandra increases the concentration of cyclophosphamide, likely through inhibition of cytochrome P450 3A4. After multiple doses of the schisandra constituents schisandrin A and schisantherin A, the maximum concentration of cyclophosphamide was increased by 7% and 75%, respectively, while the overall exposure to cyclophosphamide was increased by 29% and 301%, respectively.
Cyclosporine (Neoral, Sandimmune)
Schisandra can increase the levels and clinical effects of cyclosporine.
A small observational study in children with aplastic anemia found that taking schisandra with cyclosporine increased cyclosporine trough levels by 93% without increasing the risk of adverse events. However, the dose of cyclosporine was reduced in 9% of children to maintain appropriate cyclosporine blood concentrations.
Cytochrome P450 2C19 (Cyp2C19) Substrates
Theoretically, schisandra might increase the levels and clinical effects of CYP2C19 substrates.
In vitro research shows that schisandra inhibits CYP2C19, and animal research shows that schisandra increases the concentration of voriconazole, a CYP2C19 substrate. Theoretically, schisandra may also inhibit the metabolism of other CYP2C19 substrates. This effect has not been reported in humans.
Cytochrome P450 2C9 (Cyp2C9) Substrates
Theoretically, schisandra might decrease the levels and clinical effects of CYP2C9 substrates.
In vitro and animal research suggests that schisandra induces CYP2C9 enzymes. This effect has not been reported in humans.
Cytochrome P450 3A4 (Cyp3A4) Substrates
Schisandra can increase the levels and clinical effects of drugs metabolized by CYP3A4.
Most clinical and laboratory research shows that schisandra, administered either as a single dose or up to twice daily for 14 days, inhibits CYP3A4 and increases the concentration of CYP3A4 substrates such as cyclophosphamide, midazolam, tacrolimus, and talinolol. Although one in vitro and animal study shows that schisandra may induce CYP3A4 metabolism, this effect appears to be overpowered by schisandra's CYP3A4 inhibitory activity and has not been reported in humans.
Midazolam (Versed)
Schisandra can increase the levels and clinical effects of midazolam.
A small pharmacokinetic study in healthy adults shows that taking schisandra extract (Hezheng Pharmaceutical Co.) containing deoxyschizandrin 33.75 mg twice daily for 8 days and a single dose of midazolam 15 mg on day 8 increases the overall exposure to midazolam by about 119%, increases the peak plasma level of midazolam by 86%, and decreases midazolam clearance by about 52%. This effect has been attributed to inhibition of CYP3A4 by schisandra.
P-Glycoprotein Substrates
Schisandra might increase the levels and clinical effects of P-glycoprotein substrates.
In vitro research shows that schisandra extracts and constituents such as schisandrin B inhibit P-glycoprotein mediated efflux in intestinal cells and in P-glycoprotein over-expressing cell lines. Additionally, a small clinical study shows that schisandra increases the peak concentration and overall exposure to talinolol, a P-glycoprotein probe substrate. Theoretically, schisandra might inhibit the efflux of other P-glycoprotein substrates.
Sirolimus (Rapamune)
Schisandra can increase the levels and clinical effects of sirolimus.
A small pharmacokinetic study in healthy volunteers shows that taking 3 capsules of schisandra (Hezheng Pharmaceutical Company) containing a total of 33.75 mg deoxyschizandrin twice daily for 13 days and then taking a single dose of sirolimus 2 mg increases the overall exposure and peak level of sirolimus by two-fold. This effect is thought to be due to inhibition of cytochrome P450 3A4 by schisandra, as well as possible inhibition of the P-glycoprotein drug transporter.
Tacrolimus (Prograf)
Schisandra can increase the levels and clinical effects of tacrolimus.
Clinical research in healthy children and adults, transplant patients, and patients with nephrotic syndrome and various rheumatic immunologic disorders shows that taking schisandra with tacrolimus increases tacrolimus peak levels by 183% to 268%, prolongs or delays time to peak tacrolimus concentrations, increases overall exposure to tacrolimus by 126% to 343%, and decreases tacrolimus clearance by 19% to 73%. This effect is thought to be due to inhibition of P-glycoprotein drug transporter and CYP3A4 and CYP3A5 by schisandra. Some clinical and observational studies suggest that schisandra increases tacrolimus levels similarly in both expressors and non-expressors of CYP3A5, while other studies suggest it does so to a greater degree in CYP3A5 expressors than non-expressors. Animal research suggests that the greatest increase in tacrolimus levels occurs when schisandra is taken either concomitantly or up to 2 hours before tacrolimus, and clinical and observational research in humans suggests that schisandra may increase whole blood levels of tacrolimus and decrease clearance of tacrolimus in a dose-dependent manner.
Talinolol
Schisandra can increase the levels and clinical effects of talinolol.
A small pharmacokinetic study in healthy volunteers shows that taking schisandra extract 300 mg twice daily for 14 days with a single dose of talinolol 100 mg on day 14 increases the peak talinolol level by 51% and the overall exposure to talinolol by 47%. This effect is thought to be due to the possible inhibition of cytochrome P450 3A4 and P-glycoprotein by schisandra.
tly.
Voriconazole (Vfend)
Theoretically, schisandra might increase the levels and clinical effects of voriconazole.
Animal research shows that oral schisandra given daily for 1 or 14 days increases levels of intravenously administered voriconazole, a cytochrome P450 (CYP) 2C19 substrate. This effect is thought to be due to inhibition of CYP2C19 by schisandra. However, this interaction has not been reported in humans.
Warfarin (Coumadin)
Theoretically, schisandra might decrease the levels and clinical effects of warfarin.
Animal research suggests that oral schisandra extract, given daily for 6 days, reduces levels of intravenously administered warfarin. This effect might be due to the induction of cytochrome P450 (CYP) 2C9 metabolism by schisandra. However, this interaction has not been reported in humans.
Yin-Chen Wormwood (leaves) extract
Cns Depressants
Theoretically, yin chen might enhance the therapeutic and adverse effects of other CNS depressants.
Animal research shows that yin chen has sedative effects and can reduce motor activity and impair balance and coordination. When used in combination with pentobarbital, yin chen increases sleeping time when compared to pentobarbital alone.
Pentobarbital (Nembutal)
Theoretically, yin chen might enhance the therapeutic and adverse effects of pentobarbital.
Animal research shows that yin chen, given orally in combination with pentobarbital, can increase sleeping time compared to pentobarbital alone.
Brand information
Manufacturer and brand details for Eurocel, from the product label.
Allergy Research Group
See all Allergy Research Group products- Name
- Allergy Research Group
- City
- Alameda
- State
- CA
- ZipCode
- 94502
- Phone Number
- 510-263-2000
- Web Address
- www.allergyresearchgroup.com
Eurocel by Allergy Research Group: Common Questions
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The Full Monographs Behind Eurocel’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Phellodendron
Interacts with 1,160 drugsPhellodendron is a traditional Chinese medicine bark (Huang Bai) that contains berberine and other plant compounds with antimicrobial and anti-inflammatory activity in lab studies. Human evi...
Read the full Phellodendron monograph → Herb & supplement monographYin Chen
Interacts with 248 drugsYin Chen is a traditional Chinese medicine herb used mainly for liver and gallbladder complaints and jaundice. Most of the evidence comes from laboratory and animal studies, so its benefits...
Read the full Yin Chen monograph → Herb & supplement monographSchisandra
Interacts with 803 drugsSchisandra is a traditional Chinese medicine berry used as an adaptogen for stress, fatigue, and liver support. Human evidence is limited and most claims are not well proven, but it appears...
Read the full Schisandra monograph →Sources & How We Checked
Eurocel's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 52 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Phellodendron 22 references
- Chan E. Displacement of bilirubin from albumin by berberine. Biol Neonate 1993;63:201-8. PubMed
- Janbaz KH, Gilani AH. Studies on preventive and curative effects of berberine on chemical-induced hepatotoxicity in rodents. Fitoterapia 2000;71:25-33.. PubMed
- Wu X, Li Q, Xin H, Yu A, Zhong M. Effects of berberine on the blood concentration of cyclosporin A in renal transplanted recipients: clinical and pharmacokinetic study. Eur J Clin Pharmacol 2005;61:567-72. PubMed
- Garrison R, Chambliss WG. Effect of a proprietary Magnolia and Phellodendron extract on weight management: a pilot, double-blind, placebo-controlled clinical trial. Altern Ther Health Med 2006;12:50-4.
- Zhang Y, Li X, Zou D, et al. Treatment of type 2 diabetes and dyslipidemia with the natural plant alkaloid berberine. J Clin Endocrinol Metab 2008;93:2559-65. PubMed
- Budzinski JW, Foster BC, Vandenhoek S, Arnason JT. An in vitro evaluation of human cytochrome P450 3A4 inhibition by selected commercial herbal extracts and tinctures. Phytomedicine 2000;7:273-82. PubMed
- Chatterjee P, Franklin MR. Human cytochrome p450 inhibition and metabolic-intermediate complex formation by goldenseal extract and its methylenedioxyphenyl components. Drug Metab Dispos 2003;31:1391-7. PubMed
- Shanbhag, S. M., Kulkarni, H. J., and Gaitonde, B. B. Pharmacological actions of berberine on the central nervous system. Jpn.J Pharmacol 1970;20(4):482-487. PubMed
- Wu, J. F. and Liu, T. P. [Effects of berberine on platelet aggregation and plasma levels of TXB2 and 6-keto-PGF1 alpha in rats with reversible middle cerebral artery occlusion]. Yao Xue.Xue.Bao. 1995;30(2):98-102.
- Peng, W. H., Hsieh, M. T., and Wu, C. R. Effect of long-term administration of berberine on scopolamine-induced amnesia in rats. Jpn J Pharmacol 1997;74(3):261-266. DOI
- Sabir M and Bhide NK. Study of some pharmacological actions of berberine. Ind J Physiol & Pharmac 1971;15(3):111-132.
- Tripathi YB and Shukla SD. Berberis artistata inhibits PAF induced aggregation of rabbit platelets. Phytotherapy Research 1996;10:628-630.
- Yin, J., Xing, H., and Ye, J. Efficacy of berberine in patients with type 2 diabetes mellitus. Metabolism 2008;57(5):712-717. PubMed
- Zhang, H., Wei, J., Xue, R., Wu, J. D., Zhao, W., Wang, Z. Z., Wang, S. K., Zhou, Z. X., Song, D. Q., Wang, Y. M., Pan, H. N., Kong, W. J., and Jiang, J. D. Berberine lowers blood glucose in type 2 diabetes mellitus patients through increasing insulin re
- Guo, Y., Chen, Y., Tan, Z. R., Klaassen, C. D., and Zhou, H. H. Repeated administration of berberine inhibits cytochromes P450 in humans. Eur J Clin Pharmacol 2012;68(2):213-217. PubMed
- Wei, W., Zhao, H., Wang, A., Sui, M., Liang, K., Deng, H., Ma, Y., Zhang, Y., Zhang, H., and Guan, Y. A clinical study on the short-term effect of berberine in comparison to metformin on the metabolic characteristics of women with polycystic ovary syndro
- Hermann, R. and von, Richter O. Clinical evidence of herbal drugs as perpetrators of pharmacokinetic drug interactions. Planta Med 2012;78(13):1458-1477. PubMed
- Chun YT, Yip TT, Lau KL, and et al. A biochemical study on the hypotensive effect of berberine in rats. Gen Pharmac 1979;10:177-182. PubMed
- Hou Q, Han W, Fu X. Pharmacokinetic interaction between tacrolimus and berberine in a child with idiopathic nephrotic syndrome. Eur J Clin Pharmacol 2013;69(10):1861-2. PubMed
- Lan J, Zhao Y, Dong F, et al. Meta-analysis of the effect and safety of berberine in the treatment of type 2 diabetes mellitus, hyperlipemia and hypertension. J Ethnopharmacol. 2015;161:69-81. PubMed
- Kalman DS, Feldman S, Feldman R, et al. Effect of a proprietary magnolia and phellodendron extract on stress levels in healthy women: a pilot, double-blind, placebo-controlled clinical trial. Nutr J 2008;7:11.
- Lyu Y, Zhang Y, Yang M, et al. Pharmacokinetic interactions between metformin and berberine in rats: Role of oral administration sequences and microbiota. Life Sci. 2019;235:116818. PubMed
Yin Chen 4 references
- McGuffin M, Hobbs C, Upton R, Goldberg A, eds. American Herbal Products Association's Botanical Safety Handbook. Boca Raton, FL: CRC Press, LLC 1997.
- Bensky D, Gamble A, Kaptchuk T. Chinese Herbal Medicine Materia Medica. Seattle, WA: Eastland Press, 1996:214-6.
- Huang KC. The Pharmacology of Chinese Herbs. 2nd ed. Boca Raton, FL: CRC Press, LLC, 1999:258.
- dela Peña IJ, Hong E, Kim HJ, et al. Artemisia capillaris thunberg produces sedative-hypnotic effects in mice, which are probably mediated through potentiation of the GABAA receptor. Am J Chin Med. 2015;43(4):667-79.
Schisandra 26 references
- Leung AY, Foster S. Encyclopedia of Common Natural Ingredients Used in Food, Drugs and Cosmetics. 2nd ed. New York, NY: John Wiley & Sons, 1996.
- Iwata H, Tezuka Y, Kadota S, et al. Identification and characterization of potent CYP3A4 inhibitors in Schisandra fruit extract. Drug Metab Dispos 2004;32:1351-8. PubMed
- Mu Y, Zhang J, Zhang S, et al. Traditional Chinese medicines Wu Wei Zi (Schisandra chinensis Baill) and Gan Cao (Glycyrrhiza uralensis Fisch) activate pregnane X receptor and increase warfarin clearance in rats. J Pharmacol Exp Ther 2006;316:1369-77. PubMed
- Xin HW, Wu XC, Li Q, et al. Effects of Schisandra sphenanthera extract on the pharmacokinetics of tacrolimus in healthy volunteers. Br J Clin Pharmacol 2007;64:469-75.
- Qin XL, Bi HC, Wang XD, et al. Mechanistic understanding of the different effects of Wuhzi Tablet (Schisandra sphenanthera extract) on the absorption and first-pass intestinal and hepatic metabolism of tacrolimus (FK506). Int J Pharm 2010;389:114-21.
- Makino, T., Mizuno, F., and Mizukami, H. Does a kampo medicine containing schisandra fruit affect pharmacokinetics of nifedipine like grapefruit juice? Biol.Pharm.Bull. 2006;29(10):2065-2069. PubMed
- Fan L, Mao XQ, Tao GY, Wang G, Jiang F, Chen Y, Li Q, Zhang W, Lei HP, Hu DL, Huang YF, Wang D, Zhou HH. Effect of Schisandra chinensis extract and Ginkgo biloba extract on the pharmacokinetics of talinolol in healthy volunteers. Xenobiotica. 2009 Mar;39(
- Jiang W, Wang X, Xu X, Kong L. Effect of Schisandra sphenanthera extract on the concentration of tacrolimus in the blood of liver transplant patients. Int J Clin Pharmacol Ther. 2010 Mar;48(3):224-9. PubMed
- Xin HW, Wu XC, Li Q, Yu AR, Xiong L. Effects of Schisandra sphenanthera extract on the pharmacokinetics of midazolam in healthy volunteers. Br J Clin Pharmacol. 2009 May;67(5):541-6.
- Li J, Chen S, Qin X, et at. Wuzhi Tablet (<i>Schisandra sphenanthera</i> Extract) is a Promising Tacrolimus-Sparing Agent for Renal Transplant Recipients Who are CYP3A5 Expressers: a Two-Phase Prospective Study. Drug Metab Dispos. 2017;45(11):1114-1119.
- Qin XL, Li JL, Wang SH, Chen X, Huang M, Bi HC. Co-administration of Wuzhi tablet (Schisandra sphenanthera extract) alters tacrolimus pharmacokinetics in a dose- and time-dependent manner in rats. J Ethnopharmacol. 2020;263:113233. PubMed
- Yuan F, Liang X, Chen X, Qin X, Tan C, Wang L. CYP2C19 is involved in the effect of Wuzhi tablet (Schisandra sphenanthera extract) and its constituents on the pharmacokinetics of intravenous voriconazole. Pharmazie. 2020;75(11):559-564. DOI
- Zhang Z, Lu X, Dong L, Ma J, Fan X. Clinical observation on the effect of Wuzhi soft capsule on FK506 concentration in membranous nephropathy patients. Medicine (Baltimore). 2019;98(48):e18150. PubMed
- Yoo HH, Lee M, Lee MW, Lim SY, Shin J, Kim DH. Effects of Schisandra lignans on P-glycoprotein-mediated drug efflux in human intestinal Caco-2. Planta Med. 2007;73(5):444-50.
- Qiangrong P, Wang T, Lu Q, Hu X. Schisandrin B--a novel inhibitor of P-glycoprotein. Biochem Biophys Res Commun. 2005;335(2):406-11. PubMed
- Chen L, Ji N, Zhang M, Chen W. The influence of Wuzhi capsule on the pharmacokinetics of cyclophosphamide. Recent Pat Anticancer Drug Discov 2021. PubMed
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DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
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