Interactions on record — worth a quick check against your medications. Based on 5 of 29 ingredients. Check your meds →
Dietary supplement

Even + Collagen Boost Lime Mint Ingredients & Drug Interactions

by zolt

Powder Category: Other Combinations
Most serious interaction: Moderate
The interaction bottom line Most serious interaction: Moderate

Even + Collagen Boost Lime Mint is a dietary supplement by zolt with 29 active ingredients. Its ingredients are commonly taken for constipation, diarrhea, high cholesterol.Based on those ingredients, 2,090 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Dietary Fiber, AstaReal natural Astaxanthin powder, D-Limonene. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

HelloPharmacist Scorecard of Even + Collagen Boost Lime Mint by zolt

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 5 of its 29 active ingredients.
  • “Natural Hybrid Terpene Complex Type” is a proprietary blend — the label gives one combined amount (75 mg) without saying how much of each component you get.

This powder contains 28 ingredients, of which the active components include D-limonene (a citrus extract), astaxanthin (a naturally derived pigment), alpha-GPC (a brain-supporting compound), hyaluronic acid (a skin hydration ingredient), and a blend of terpenes — plus organic Tremella fuciformis and several other botanical compounds. The inactive ingredients are organic agave inulin, citric acid, organic stevia, natural flavors, and spearmint oil powder.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: hair, skin and nail support.
  • We looked for evidence on: Aging skin, Wound healing, Burns, Sunburn, Diabetic foot ulcers, Venous leg ulcers — and 4 related terms.
  • The strongest evidence on file: Hyaluronic Acid is rated "Possibly Effective" for Dry eye (Natural Medicines).
  • Also on file: Hyaluronic Acid is rated "Possibly Effective" for Venous leg ulcers.
  • Also on file: Hyaluronic Acid is rated "Insufficient Reliable Evidence To Rate" for Aging skin, Burns, Wound healing, Diabetic foot ulcers.

The evidence for this product's ingredients is limited. D-limonene and astaxanthin both have insufficient reliable evidence to rate for their potential uses — the data we hold doesn't establish either one as effective for cancer, irritable bowel syndrome, age-related cognitive decline, macular degeneration, or skin aging.

Alpha-GPC is possibly effective for Alzheimer disease, though its use for other cognitive concerns (brain tumors, general cognitive function, stroke, vascular dementia) lacks sufficient evidence. Hyaluronic acid is possibly effective for dry eye and venous leg ulcers, but its use for aging skin, hay fever, and sexual dysfunction has insufficient evidence.

In short, while some ingredients have preliminary research, we don't have strong evidence that this combination works for any specific condition.

The evidence, ingredient by ingredient Black Psyllium Astaxanthin Alpha-gpc Hyaluronic Acid Limonene

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 5 of the 5 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 5 of 5.
  • General safety write-ups exist for 5 of 5.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

D-limonene is generally well tolerated in food amounts, but high-dose supplement safety data in humans is limited. It can cause nausea, vomiting, and diarrhea orally, and contact dermatitis if applied to skin.

Exposure to airborne limonene from fragrances and cleaning products has been linked to wheezing and asthma, especially in children. D-limonene should be avoided while breastfeeding due to insufficient safety data.

Astaxanthin appears well tolerated in studies, though long-term safety data are limited; it should be avoided in pregnancy and while breastfeeding. Common side effects include abdominal pain, diarrhea, and red-colored stools; at higher doses, severe stomach pain has been reported.

Alpha-GPC is generally well tolerated, but rarely causes dizziness, headache, insomnia, heartburn, nausea, and vomiting — and long-term use (2+ months) has been rarely associated with increased stroke risk. There's insufficient safety information for pregnancy and lactation.

Hyaluronic acid is generally well tolerated, though long-term supplement safety isn't fully studied; it should be avoided in pregnancy and lactation unless your doctor advises otherwise.

Side effects, ingredient by ingredient Black Psyllium Astaxanthin Alpha-gpc Hyaluronic Acid Limonene

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 4 of the 5 matched ingredients can interact with medications — Black Psyllium, Astaxanthin, Alpha-gpc, Limonene.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: heart-rhythm medications; lithium.
  • For scale: 2,091 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking this product, check with your doctor or pharmacist if you take any CYP2C19 inhibitors (like cimetidine or fluvoxamine), CYP2C9 inhibitors (like fluconazole or amiodarone), CYP3A4 substrates, CYP2B6 substrates, or CYP2C19 or CYP2C9 inducers (like carbamazepine, rifampin, or prednisone) — all Moderate-severity interactions. Also confirm if you use scopolamine patches (motion-sickness patches), as alpha-GPC may reduce their effectiveness.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

This is a multi-ingredient product with preliminary research at best and limited safety data for high-dose supplement use. If you take any medications — especially those that interact with liver enzymes, scopolamine patches, or other common drugs — talk with your doctor or pharmacist before starting.

Pregnant or breastfeeding individuals should check with their healthcare provider given the caution or avoidance flags on several ingredients.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 5 of 29 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Aug 23, 2021.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Even + Collagen Boost Lime Mint, straight from the product label.

Brand zolt
Barcode (UPC) 850009849335
Net contents 10 Packet(s); 1.8 Ounce(s); 51.8 Gram(s)
Market status On market
Date entered into DSLD Aug 23, 2021
DSLD ID 249550
Product type Other Combinations
Supplement form Powder
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Vegan, Vegetarian, Adult (18 - 50 Years), Kosher, Gluten Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Even + Collagen Boost Lime Mint by zolt, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
5.18 Gram(s)
Maximum serving Sizes:
5.18 Gram(s)
Servings per container
10
UPC/BARCODE
850009849335
IngredientAmount% DV
Calories10 Calorie(s)--
Total Carbohydrates2 Gram(s)1%
Dietary Fiber2 Gram(s)6%
D-Limonene0 NP--
Terpinolene0 NP--
Myrcene0 NP--
Beta-Pinene0 NP--
Beta-Caryophyllene0 NP--
Alpha-Pinene0 NP--
Geraniol0 NP--
Organic Tremella fuciformis2000 mg--
Alpha-Humulene0 NP--
Linalool Ex Ho Oil0 NP--
Nerolidol0 NP--
Alpha-Bisabolol0 NP--
Caryophyllene Oxide0 NP--
Citronellol0 NP--
Fenchol0 NP--
Phytol0 NP--
Borneol0 NP--
Valencene0 NP--
Guaiol0 NP--
Alpha-Cedrene0 NP--
AstaReal natural Astaxanthin powder1 mg--
Camphene0 NP--
AlphaSize Alpha GPC200 mg--
Hyaluronic Acid100 mg--
Natural Hybrid Terpene Complex Type75 mg--
Geranyl Acetate0 NP--
Ocimene0 NP--
Pulegone0 NP--
Sabinene0 NP--

Other ingredients: organic Agave Inulin, Citric Acid, organic Stevia, Natural Flavors, Spearmint oil powder

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formula

Vegan collagen Indica terpene complex

Terpenes Antioxidants Adaptogens

Rejuvenates hair, skin, and nails Hyaluronic acid and tremella mushroom Promotes calm and equilibrium Hybrid terpene complex Supports gut health Organic agave inulin

Kosher, vegan and gluten-free

All natural flavors and sweeteners

Formulation

No CBD Hemp free No THC

plant-powered superdrink mix

Your everyday equilibrium

Caffeine free

Balance + hair, skin & nail support

Hemp-free We're all about hemp-it's the inspiration behind all of our products. This Zolt superdrink is formulated with a poprietary indica terpene complex to replicate and amplify hemp's awesome benefits, without the hemp.

Kosher, vegan and gluten-free

Kosher, vegan and gluten-free No sugar.

General Statements

10 Mixie sticks

zolt. plant-powered performance

1% donated to National Yound Farmers Coalition

FDA Statement of Identity

Dietary Supplement

Dietary Supplement

Suggested/Recommended/Usage/Directions

Suggested Use Combine 1 mixie stick with 16 oz of water (any degrees F). Mix with gusto, as adaptogen may settle.

Precautions

Product intended for adult use only.

Consult with your physician before use.

Storage

Store at room temperature.

Seals/Symbols

Manufactured with care in the US in SOF, cGMP and FDA certified facilities

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

See for yourself

Even + Collagen Boost Lime Mint by zolt label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

What’s inside

The Ingredients in Even + Collagen Boost Lime Mint by zolt

These are the 29 active ingredients this product is made of. Select any to open its full monograph.

Serving size5.18 Gram(s) Dosage formPowder Servings per container10 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Dietary Fiber

Interacts with
2,025 drugs
2 Gram(s) per serving

Black psyllium is a soluble-fiber supplement made from the seeds of a Plantago plant, used mostly to ease constipation and support digestive health. I...

Dietary Fiber monograph & interactions

Organic Tremella fuciformis

2000 mg per serving

AstaReal natural Astaxanthin powder

Interacts with
671 drugs
1 mg per serving

Astaxanthin is a reddish carotenoid pigment with strong antioxidant activity in the lab, and it is widely promoted for skin, eye, heart, and exercise...

AstaReal natural Astaxanthin powder monograph & interactions

AlphaSize Alpha GPC

Interacts with
16 drugs
200 mg per serving

Alpha-GPC is a choline-containing compound used mainly for memory, brain health, and as a choline source. There is some evidence it may help cognition...

AlphaSize Alpha GPC monograph & interactions

Hyaluronic Acid

No known
interactions
100 mg per serving Form: Sodium Hyaluronate

Hyaluronic acid is a natural substance in the body that helps hold water in the skin, joints, and eyes. Oral and topical products are popular for skin...

Hyaluronic Acid monograph & interactions

Natural Hybrid Terpene Complex Type

75 mg per serving
  • D-Limonene
  • › Terpinolene
  • › Myrcene
  • › Beta-Pinene
  • › Beta-Caryophyllene
  • › Alpha-Pinene
  • › Geraniol
  • › Alpha-Humulene
  • › Linalool Ex Ho Oil
  • › Nerolidol
  • › Alpha-Bisabolol
  • › Caryophyllene Oxide
  • › Citronellol
  • › Fenchol
  • › Phytol
  • › Borneol
  • › Valencene
  • › Guaiol
  • › Alpha-Cedrene
  • › Camphene
  • › Geranyl Acetate
  • › Ocimene
  • › Pulegone
  • › Sabinene

Other (inactive) ingredients: Organic Agave Inulin, Citric Acid, Organic Stevia, Natural Flavors, Spearmint oil powder. These complete the product’s ingredient list but are not active constituents.

Interaction report

Even + Collagen Boost Lime Mint by zolt Drug Interactions

Want to check YOUR meds against Even + Collagen Boost Lime Mint?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

Go to the checker
2,090Drugs
800 Moderate 1,290 Minor

Ingredients driving the most interactions

Each ingredient & the kinds of drugs it affects

For each ingredient in Even + Collagen Boost Lime Mint with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Dietary Fiber7 drug types · 2,025 drugs

Carbamazepine (Tegretol)

Theoretically, black psyllium might reduce the effects of carbamazepine and increase the risk for convulsions.
Theoretically, black psyllium might reduce carbamazepine absorption. A preliminary study using blond psyllium reported decreased carbamazepine bioavailability due to binding of the drug to psyllium, as well as reduction of available fluid in the gut for dissolution of the drug. This interaction may also occur with black psyllium.

Likelihood Probable Evidence D
Lithium

Theoretically, taking black psyllium at the same time as lithium might reduce lithium absorption.
The fiber in black psyllium might reduce lithium absorption and plasma levels. Some case reports describe a reduction in plasma lithium levels with concomitant administration of blond psyllium. This was reversed when psyllium was stopped. This interaction may also occur with black psyllium.

Likelihood Probable Evidence D
Metformin (Glucophage)

Theoretically, black psyllium might increase the therapeutic and adverse effects of metformin.
Animal research shows that concurrent consumption of blond psyllium with metformin slows and increases the absorption of metformin. This interaction may also occur with black psyllium. To avoid changes in absorption, take psyllium 30-60 minutes after metformin.

Likelihood Possible Evidence D
Olanzapine (Zyprexa)

Theoretically, taking black psyllium at the same time as olanzapine might reduce olanzapine absorption.
The fiber in black psyllium might decrease the absorption of olanzapine. A single case report describes a reduction in the effectiveness of olanzapine when it was concomitantly administered with an unspecified type of psyllium 3 grams orally twice daily. This effect was reversed when psyllium was stopped.

Likelihood Possible Evidence D
Digoxin (Lanoxin)

Theoretically, taking black psyllium at the same time as digoxin might reduce digoxin absorption and decrease digoxin levels.
Psyllium might bind digoxin in the gut. However, some clinical evidence suggests that psyllium does not impact digoxin absorption.

Likelihood Unlikely Evidence B
Ethinyl Estradiol

Theoretically, taking black psyllium at the same time as ethinyl estradiol might alter levels of estradiol.
Concurrent use of blond psyllium with ethinyl estradiol results in a slight increase in the extent of ethinyl estradiol absorption and a slower rate of absorption. This is unlikely to be clinically significant.

Likelihood Unlikely Evidence D
Oral Drugs

Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.
Psyllium seems to have variable effects on drug absorption. To avoid changes in absorption, take psyllium 30-60 minutes after oral medications. Animal research shows that blond psyllium delays and increases the absorption of metformin and ethinyl estradiol. Case reports and animal research suggest that blond psyllium might reduce absorption of lithium, digoxin, olanzapine, and carbamazepine. Finally, some pharmacokinetic studies show that psyllium does not affect the absorption of levothyroxine or warfarin. Although many of these studies evaluated blond psyllium, the fiber content in black psyllium may have similar effects.

Likelihood Possible Evidence B

AstaReal natural Astaxanthin powder2 drug types · 671 drugs

Cytochrome P450 2B6 (Cyp2B6) Substrates

Theoretically, astaxanthin may decrease levels of drugs metabolized by CYP2B6.
In vitro research shows that astaxanthin induces cytochrome CYP2B6 enzyme activity in human hepatocytes. This effect has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 3A4 (Cyp3A4) Substrates

Theoretically, astaxanthin may decrease levels of drugs metabolized by CYP3A4.
In vitro research shows that astaxanthin induces CYP3A4 enzyme activity in human hepatocytes. This effect has not been reported in humans.

Likelihood Possible Evidence D

D-Limonene5 drug types · 229 drugs

Cytochrome P450 2C19 (Cyp2C19) Inducers

There's preliminary evidence that limonene might be a substrate for cytochrome P450 2C19 (CYP2C19). CYP2C19 inducers might decrease the effects of limonene. So far, this interaction has not been reported in humans. Inducers of CYP2C19 include carbamazepine (Tegretol), prednisone (Deltasone), and rifampin (Rifadin, Rimactane).

Likelihood Possible Evidence D
Cytochrome P450 2C19 (Cyp2C19) Inhibitors

There's preliminary evidence that limonene might be a substrate for cytochrome P450 2C19 (CYP2C19). So far, this interaction has not been reported in humans. However, watch for an increase in the limonene levels when it is taken with drugs that inhibit CYP2C19. Some drugs that inhibit CYP2C19 include cimetidine (Tagamet), fluvoxamine (Luvox), omeprazole (Prilosec); ticlopidine (Ticlid), topiramate (Topamax), and others.

Likelihood Possible Evidence D
Cytochrome P450 2C9 (Cyp2C9) Inducers

There's preliminary evidence that limonene might be a substrate for cytochrome P450 2C9 (CYP2C9). Inducers of CYP2C9 might decrease limonene levels. Inducers of CYP2C9 include rifampin (Rifadin, Rimactane) and secobarbital (Seconal).

Likelihood Possible Evidence D
Cytochrome P450 2C9 (Cyp2C9) Inhibitors

There's preliminary evidence that limonene might be a substrate for cytochrome P450 2C9 (CYP2C9). So far, this interaction has not been reported in humans. However, watch for side effects in patients taking limonene and CYP2C9 inhibitors. Some CYP2C9 inhibitors include amiodarone (Cordarone), fluconazole (Diflucan), lovastatin (Mevacor), paroxetine (Paxil), zafirlukast (Accolate), and many others.

Likelihood Possible Evidence D
Cytochrome P450 2C9 (Cyp2C9) Substrates

There's preliminary evidence that limonene might be a substrate for cytochrome P450 2C9 (CYP2C9), as well causing its induction. So far, this interaction has not been reported in humans. However, watch for a decrease in the levels of drugs metabolized by CYP2C9 in patients taking limonene. Some drugs metabolized by CYP2C9 include nonsteroidal anti-inflammatory drugs (NSAIDs) such as diclofenac (Cataflam, Voltaren), ibuprofen (Motrin), meloxicam (Mobic), and piroxicam (Feldene); celecoxib (Celebrex); amitriptyline (Elavil); warfarin (Coumadin); glipizide (Glucotrol); losartan (Cozaar); and others.

Likelihood Possible Evidence D

AlphaSize Alpha GPC1 drug type · 16 drugs

Scopolamine (Transderm Scop)

Theoretically, alpha-GPC might decrease the effects of scopolamine.
A small clinical study shows that alpha-GPC can partially counteract the attention and memory impairment effects caused by scopolamine given intramuscularly. Whether alpha-GPC can decrease the beneficial anti-motion sickness effects of the scopolamine patch (Transderm Scop) is unclear.

Likelihood Possible Evidence B
The maker

Brand information

Manufacturer and brand details for Even + Collagen Boost Lime Mint, from the product label.

zolt

Name
Cuboid, LLC
Street Address
PO Box 708
City
Short Hills
State
NJ
ZipCode
07078
Pharmacist Counseling Corner

Even + Collagen Boost Lime Mint by zolt: Common Questions

Does Even + Collagen Boost Lime Mint by zolt interact with any medications?
Yes. Based on its ingredients, Even + Collagen Boost Lime Mint has a known interaction with 2,090 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Even + Collagen Boost Lime Mint contains 29 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Is D-limonene safe to take while breastfeeding?
No — the safety data advises against using D-limonene supplements while breastfeeding. There isn't enough information to know it's safe at supplement doses during lactation. Talk with your doctor or pharmacist about alternatives.
What are the most common side effects of astaxanthin in this product?
Astaxanthin is generally well tolerated, but can cause abdominal pain, diarrhea, and red-colored stools. At higher doses (40 mg daily), severe stomach pain has been reported in a small number of cases.
Does this product work for anti-aging or skin health?
The evidence isn't established. Both astaxanthin and hyaluronic acid have insufficient reliable evidence to rate for aging skin. Hyaluronic acid is possibly effective for dry eye, but not for skin aging specifically based on the data we hold.
Is it safe to take this while pregnant?
The safety data advise against both D-limonene and astaxanthin during pregnancy because there isn't enough information. Hyaluronic acid and alpha-GPC also lack sufficient safety data in pregnancy. Talk with your doctor before using this product if you're pregnant or planning to become pregnant.
Does this product have any fillers?
Yes — the inactive ingredients include organic agave inulin, citric acid, organic stevia, natural flavors, and spearmint oil powder. These serve as binders, sweeteners, and flavoring agents in the powder.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Even + Collagen Boost Lime Mint label
Go deeper

The Full Monographs Behind Even + Collagen Boost Lime Mint’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Sources

Sources & How We Checked

Even + Collagen Boost Lime Mint's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 39 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Black Psyllium 18 references
  1. McGuffin M, Hobbs C, Upton R, Goldberg A, eds. American Herbal Products Association's Botanical Safety Handbook. Boca Raton, FL: CRC Press, LLC 1997.
  2. Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.
  3. Covington TR, et al. Handbook of Nonprescription Drugs. 11th ed. Washington, DC: American Pharmaceutical Association, 1996.
  4. Etman M. Effect of a bulk forming laxative on the bioavailablility of carbamazepine in man. Drug Dev Ind Pharm 1995;21:1901-6.
  5. Perlman BB. Interaction between lithium salts and ispaghula husk. Lancet 1990;335:416.
  6. Vaswani SK, Hamilton RG, Valentine MD, Adkinson NF. Psyllium laxative-induced anaphylaxis, asthma, and rhinitis. Allergy 1996;51:266-8. PubMed
  7. Lantner RR, Espiritu BR, Zumerchik P, Tobin MC. Anaphylaxis following ingestion of a psyllium-containing cereal. JAMA 1990;264:2534-6. DOI
  8. Kaplan MJ. Anaphylactic reaction to "Heartwise." N Engl J Med 1990;323:1072-3. DOI
  9. Nordstrom M, Melander A, Robertsson E, Steen B. Influence of wheat bran and of a bulk-forming ispaghula cathartic on the bioavailability of digoxin in geriatric in-patients. Drug Nutr Interact 1987;5:67-9..
  10. Robinson DS, Benjamin DM, McCormack JJ. Interaction of warfarin and nonsystemic gastrointestinal drugs. Clin Pharmacol Ther 1971;12:491-5. PubMed
  11. Garcia JJ, Fernandez N, Diez MJ, et al. Influence of two dietary fibers in the oral bioavailability and other pharmacokinetic parameters of ethinyloestradiol. Contraception 2000;62:253-7. PubMed
  12. Fernandez N, Lopez C, Díez R, et al. Drug interactions with the dietary fiber Plantago ovata husk. Expert Opin Drug Metab Toxicol 2012;8(11):1377-86.
  13. Semen plantaginis in: WHO Monographs on Selected Medicinal Plants, volume 1. World Health Organization, Geneva, 1999. Available at http://apps.who.int/medicinedocs/en/d/Js2200e/. Accessed November 26, 1026.
  14. Code of Federal Regulations, Title 21 (21CFR 101.17). Food labeling warning, notice, and safe handling statements. Available at www.ecfr.gov/cgi-bin/text-idx?SID=20f647d3b74161501f46564b915b4048&mc=true&node=se21.2.101_117&rgn=div8. Accessed December 3, 2
  15. Code of Federal Regulations, Title 21 (21CFR 201.319). Specific labeling requirements - water-soluble gums, hydrophilic gums, and hydrophilic mucilloids. Available at www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfcfr/CFRSearch.cfm?fr=201.319. Accessed Dece
  16. Diez R, Garcia JJ, Diez MJ, Sierra M, Sahagun AM, Fernandez N. Influence of Plantago ovata husk (dietary fiber) on the bioavailability and other pharmacokinetic parameters of metformin in diabetic rabbits. BMC Complement Altern Med. 2017 Jun 7;17(1):298. PubMed
  17. Chiu AC, Sherman SI. Effects of pharmacological fiber supplements on levothyroxine absorption. Thyroid. 1998;8(8):667-71. PubMed
  18. Merrick C, Madden CA, Capurso NA. A Case of Blunted Orally Disintegrating Olanzapine Effect Due to Coadministered Psyllium. J Clin Psychiatry 2021;82(2):20cr13633. PubMed

See these in context on the Black Psyllium monograph →

Limonene 10 references
  1. Electronic Code of Federal Regulations. Title 21. Part 182 -- Substances Generally Recognized As Safe. Available at: https://www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfcfr/CFRSearch.cfm?CFRPart=182
  2. Vigushin DM, Poon GK, Boddy A, et al. Phase I and pharmacokinetic study of D-limonene in patients with advanced cancer. Cancer Research Campaign Phase I/II Clinical Trials Committee. Cancer Chemother Pharmacol 1998;42:111-7. PubMed
  3. Crowell PL. Prevention and therapy of cancer by dietary monoterpenes. J Nutr 1999;129:775S-778S. PubMed
  4. Matura M, Goossens A, Bordalo O, et al. Oxidized citrus oil (R-limonene): a frequent skin sensitizer in Europe. J Am Acad Dermatol 2002;47:709-14. PubMed
  5. Topham EJ, Wakelin SH. D-Limonene contact dermatitis from hand cleansers. Contact Dermatitis 2003;49:108-9.
  6. Miyazawa M, Shindo M, Shimada T. Metabolism of (+)- and (-)-limonenes to respective carveols and perillyl alcohols by CYP2C9 and CYP2C19 in human liver microsomes. Drug Metab Dispos 2002;30:602-7. PubMed
  7. Dales RE, Cakmak S. Is residential ambient air limonene associated with asthma? Findings from the Canadian Health Measures Survey. Environ Pollut 2019;244:966-70. PubMed
  8. Dittmar D, Schuttelaar MLA. Contact sensitization to hydroperoxides of limonene and linalool: results of consecutive patch testing and clinical relevance. Contact Dermatitis 2019;80(2):101-9. PubMed
  9. Gatica-Ortega ME, Pastor-Nieto MA, Schoendorff-Ortega C, Mollejo-Villanueva M, Giménez-Arnau A. Lymphomatoid contact dermatitis caused by limonene hydroperoxides confirmed by an exposure provocation test with the involved personal hygiene products. Contac PubMed
  10. Nath NS, Liu B, Green C, Atwater AR. Contact allergy to hydroperoxides of linalool and D-limonene in a US population. Dermatitis 2017;28(5):313-6. PubMed

See these in context on the Limonene monograph →

Astaxanthin 3 references
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  2. Kistler, A., Liechti, H., Pichard, L., Wolz, E., Oesterhelt, G., Hayes, A., and Maurel, P. Metabolism and CYP-inducer properties of astaxanthin in man and primary human hepatocytes. Arch.Toxicol. 2002;75(11-12):665-675. PubMed
  3. Choi HD, Youn YK, Shin WG. Positive effects of astaxanthin on lipid profiles and oxidative stress in overweight subjects. Plant Foods Hum Nutr. 2011;66:363-369. PubMed

See these in context on the Astaxanthin monograph →

Alpha-gpc 4 references
  1. Di Perri R, Coppola G, Ambrosio LA, et al. A multicentre trial to the evaluate the efficacy and tolerability of alpha-glycerylphosphorylcholine versus cytosine diphosphocholine in patients with vascular dementia. J Int Med Res 1991;19:330-41.
  2. Barbagallo Sangiorgi G, Barbagallo M, Giordano M, et al. Alpha-glycerophosphocholine in the mental recovery of cerebral ischemic attacks: An Italian multicenter clinical trial. Ann N Y Acad Sci 1994;717:253-69. PubMed
  3. Canal N, Franceschi M, Alberoni M, et al. Effect of L-alpha-glyceryl-phosphorylcholine on amnesia caused by scopolamine. Int J Clin Pharmacol Ther Toxicol 1991;29:103-7.
  4. Lee G, Choi S, Chang J, et al. Association of L-a glycerylphosphorylcholine with subsequent stroke risk after 10 Years. JAMA Netw Open 2021;4(11):e2136008.

See these in context on the Alpha-gpc monograph →

Hyaluronic Acid 4 references
  1. Park Y, Song JS, Choi CY, Yoon KC, Lee HK, Kim HS. A randomized multicenter study comparing 0.1%, 0.15%, and 0.3% sodium hyaluronate with 0.05% cyclosporine in the treatment of dry eye. J Ocul Pharmacol Ther. 2017;33(2):66-72. PubMed
  2. U.S. Food and Drug Administration. Do Not Use Needle-Free Devices for Injection of Dermal Fillers - FDA Safety Communication. October 8, 2021. Available at: https://www.fda.gov/medical-devices/safety-communications/do-not-use-needle-free-devices-injection
  3. Disphanurat W, Srisantithum B. Efficacy and safety of 0.15% isobutylamido thiazolyl resorcinol combined with hyaluronic acid vs 0.15% isobutylamido thiazolyl resorcinol or hyaluronic acid alone in melasma treatment: A randomized evaluator-blind trial. J C PubMed
  4. Humbert P, Mikosinki J, Benchikhi H, Allaert FA. Efficacy and safety of a gauze pad containing hyaluronic acid in treatment of leg ulcers of venous or mixed origin: a double-blind, randomised, controlled trial. Int Wound J 2013;10(2):159-66. PubMed

See these in context on the Hyaluronic Acid monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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