Interactions on record — worth a quick check against your medications. Based on 7 of 8 ingredients. Check your meds →
Dietary supplement

Flor-Essence Ingredients & Drug Interactions

by Flora

Flor-Essence label
See full label image
Other (e.g. Tea Bag) Category: Other Combinations
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Flor-Essence against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Flor-Essence is a dietary supplement by Flora with 8 active ingredients. Its ingredients are commonly taken for source of vitamins and minerals, antioxidant support, general nutrition.Based on those ingredients, 2,182 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are certified organic Slippery Elm, certified organic Red Clover, certified organic Rhubarb. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against Flor-Essence by Flora

Ask about any prescription or over-the-counter medication and we check it for interactions with Flor-Essence by Flora — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Flor-Essence by Flora

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 30, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 0 of its 8 active ingredients.
  • “Proprietary Blend” is a proprietary blend — the label gives one combined amount (1.30 Gram(s)) without saying how much of each component you get.

Flor-Essence contains 8 ingredients, most of which are certified organic herbs. The active components are watercress, burdock, sheep sorrel, kelp, blessed thistle, red clover, rhubarb, and slippery elm.

Each plays a traditional role in herbal wellness blends — watercress and sorrel contribute minerals and compounds, burdock and rhubarb are historically used for digestive support, blessed thistle and red clover have been used in women's health traditions, and slippery elm is known for its mucilage content. The product contains no listed inactive ingredients.

Does it work?

Couldn't assess
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not assessable

We hold no graded evidence for this product's ingredients for its stated purpose.

Why this rating?
  • The label markets this product for: gentle detox for the whole body.
  • Our graded evidence for these ingredients doesn't cover that particular purpose.

The herbs in this blend have not been rigorously studied for specific health claims. The product facts show insufficient reliable evidence for most of the conditions these ingredients are traditionally used for — including acne, skin aging, common cold, bronchitis, and menopausal symptoms.

Rhubarb alone carries ratings of possibly effective for pancreatitis and menopausal symptoms, but the evidence remains limited. In short, we don't yet have strong clinical data to confirm that Flor-Essence works for any particular condition.

The evidence, ingredient by ingredient Watercress Burdock Sorrel Blessed Thistle Red Clover Rhubarb Slippery Elm

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 7 of the 7 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 7 of 7.
  • General safety write-ups exist for 7 of 7.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Most of these herbs are generally well tolerated in food amounts, but several carry important cautions at medicinal doses. Watercress can cause gastrointestinal irritation at high doses and carries a risk of parasitic infection if consumed raw from the wild.

Burdock and rhubarb have been linked to rare cases of liver injury in case reports. Sorrel contains oxalates and high doses can damage the kidneys.

Red clover has estrogen-like activity, which may affect certain people. Blessed thistle can cause nausea and vomiting at doses above 5 grams per cup of tea.

Slippery elm and rhubarb may cause contact dermatitis in sensitive individuals.

Side effects, ingredient by ingredient Watercress Burdock Sorrel Blessed Thistle Red Clover Rhubarb Slippery Elm

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 7 of the 7 matched ingredients can interact with medications — Blessed Thistle, Burdock, Rhubarb, Red Clover, Watercress, among others.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; immunosuppressants / transplant drugs; heart-rhythm medications; lithium.
  • For scale: 2,183 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Check before taking Flor-Essence if you use blood thinners like warfarin, blood clot-preventing drugs, heart medications including digoxin, estrogen therapy, tamoxifen or other cancer drugs, liver or kidney medications, corticosteroids, diuretics, acid-reflux or heartburn medications, or allergy medications like fexofenadine. The severity ranges from Moderate (blood thinners, heart drugs, estrogen, cancer drugs) to Minor (enzyme-related interactions and antacids).

If you take any of these, confirm with your doctor or pharmacist that this product is safe for you.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with no assessable stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

Flor-Essence is a traditional herbal blend without strong clinical evidence supporting its effectiveness for specific health claims. Its main concern is the breadth of potential medication interactions — particularly with blood thinners, heart drugs, transplant medications, and acid-reflux treatments.

If you take any prescription medications or have kidney or liver concerns, talk with your doctor or pharmacist before using this product. Even if you're considering it as a general wellness tea, run your medications through the checker on this page first.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 7 of 8 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Feb 26, 2020.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Flor-Essence, straight from the product label.

Brand Flora
Barcode (UPC) 061998680902
Net contents 2.125 oz; 63 Gram(s)
Market status On market
Date entered into DSLD Feb 26, 2020
DSLD ID 213357
Product type Other Combinations
Supplement form Other (e.g. Tea Bag)
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Kosher, Women (not pregnant or lactating), Organic
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Flor-Essence by Flora, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
2 fl. Oz.
Maximum serving Sizes:
2 fl. Oz.
Servings per container
16
UPC/BARCODE
061998680902
IngredientAmount% DV
Proprietary Blend1.3 Gram(s)--
Watercress0 NP--
certified organic Burdock0 NP--
certified organic Sheep Sorrel0 NP--
certified organic Kelp0 NP--
certified organic Blessed Thistle0 NP--
certified organic Red Clover0 NP--
certified organic Rhubarb0 NP--
certified organic Slippery Elm0 NP--

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements

Elaine Alexander, the late Canadian health researcher and radio producer/broadcaster, collaborated exclusively with Flora to produce Flor-Essence. This purification tea was entrusted to Elaine by Dr. Charles Brusch, M.D., personal physician to the late President John F. Kennedy. Dr. Brusch was a partner in research and co-owner with the famous canadian nurse, Rene Caisse, in perfecting this formula at his Cambridge, Massachusetts, clinic. Flor-Essence is the only product on the market authorized to carry Elaine's signature on the packaging to vouch for its historical authenticity.

Premium Herbal Formula

Authorized by Elaine Alexander

Product of Canada

Not to be sold outside the USA

Seals/Symbols

Kosher Check

Quality Assurance International Certified Organic Non GMO Project Verified nongmoproject.org

Formula

Kosher Check

Made with organic burdock root, sheep sorrel, & slippery elm bark 97% organic ingredients

Formulation

Gentle detox for the whole body

Non GMO

Certified organic by QAI

Flor-Essence supports the whole body in its natural elimination process.

FDA Statement of Identity

Herbal Supplement

Suggested/Recommended/Usage/Directions

Directions: Caution: For complete directions and effective use of this product, see package insert. Each packet in this box makes 32 fl. oz. (1 quart) for a total of 3 quarts of tea when prepared as directed.

Suggested use: Adults: measure 2 fl. oz. (60 mL) of prepared tea and dilute with an equal or double amount of water twice daily. Take on an empty stomach approximately 1/2 hour before breakfast and 1/2 hour before bedtime. Sip slowly. For extra strength: take 3 times daily.

Precautions

Directions: Caution: For complete directions and effective use of this product, see package insert. Each packet in this box makes 32 fl. oz. (1 quart) for a total of 3 quarts of tea when prepared as directed.

Keep out of the reach of children.

Do not use during pregnancy or when nursing.

Storage

Please store this package in a dry place. Once prepared, keep refrigerated and use within 3 weeks.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Flor-Essence by Flora label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Flor-Essence label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Flor-Essence by Flora

These are the 8 active ingredients this product is made of. Select any to open its full monograph.

Serving size2 fl. Oz. Dosage formOther (e.g. Tea Bag) Servings per container16 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Interaction report

Flor-Essence by Flora Drug Interactions

Want to check YOUR meds against Flor-Essence?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
2,182Drugs
2,133 Moderate 49 Minor

Ingredients driving the most interactions

certified organic Slippery Elm 2,022
certified organic Red Clover 867
certified organic Rhubarb 658
certified organic Sheep Sorrel 169
certified organic Burdock 122

Individual Drug Interactions

The ingredients in Flor-Essence interact with 2,182 drugs. Click any drug to see the details.

7 of the 8 ingredients in Flor-Essence interact with drugs. Each result below shows which ingredient is responsible. certified organic Slippery Elm certified organic Red Clover certified organic Rhubarb certified organic Sheep Sorrel certified organic Burdock certified organic Blessed Thistle Watercress

Each ingredient & the kinds of drugs it affects

For each ingredient in Flor-Essence with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

certified organic Slippery Elm1 drug type · 2,022 drugs

Oral Drugs

Theoretically, slippery elm may slow the absorption and reduce serum levels of oral drugs.
Slippery elm inner bark contains mucilage, which may interfere with the absorption of orally administered drugs.

Likelihood Possible Evidence D
certified organic Slippery Elm full monograph & interactions

certified organic Red Clover9 drug types · 867 drugs

Estrogens

Theoretically, concomitant use of large amounts of red clover might interfere with estrogen therapy.
Red clover contains phytoestrogens which might have estrogenic activity in some people. Theoretically, red clover might compete for estrogen receptors and interfere with estrogen-containing drug therapy.

Likelihood Probable Evidence D
Methotrexate (Trexall, Others)

Theoretically, red clover might increase the risk of methotrexate toxicity.
In a case report, a 52-year-old female receiving weekly methotrexate injections for psoriasis developed symptoms of methotrexate toxicity, including severe vomiting and epigastric pain, after three days of taking red clover 430 mg daily. Toxicity resolved after red clover was discontinued. However, no liver function tests or methotrexate levels were reported.

Likelihood Possible Evidence D
Tamoxifen (Nolvadex)

Theoretically, the phytoestrogens in red clover might interfere with tamoxifen.
In vitro and animal research suggests that genistein, a constituent of red clover, might antagonize the antitumor effects of tamoxifen. However, there is some evidence from an animal study that red clover does not reduce the efficacy of tamoxifen. Until more is known, tell patients taking tamoxifen to avoid red clover.

Likelihood Possible Evidence D
Anticoagulant/Antiplatelet Drugs

Although some laboratory research suggests that red clover may have anticoagulant and antiplatelet activity, clinical research has not shown this effect.
In vitro research suggests that genistein in red clover has antiplatelet effects, and historically, red clover was thought to have anticoagulant effects due to its coumarin content. However, some experts state that this is unlikely as most natural coumarins have not been shown to have anticoagulant effects, and their content in red clover is low. Additionally, some clinical research in postmenopausal patients found no effect on coagulation or prothrombin time with the use of red clover flowering tops 378 mg daily for 12 months or red clover isoflavone (Rimostil) 50 mg daily for 2 years.

Likelihood Unlikely Evidence B
Caffeine

Theoretically, soy might reduce the clearance of caffeine; however, a small clinical study found no effect.
Red clover contains genistein. Taking genistein 1 gram daily for 14 days seems to inhibit caffeine clearance and metabolism in healthy females. However, this effect does not seem to occur with the lower amounts of genistein found in red clover. A clinical study in healthy postmenopausal individuals shows that taking red clover capsules standardized to contain 60 mg isoflavones twice daily for 14 days does not affect the pharmacokinetics of caffeine.

Likelihood Unlikely Evidence D
Cytochrome P450 1A2 (Cyp1A2) Substrates

Theoretically, red clover might increase levels of drugs metabolized by CYP1A2; however, a small clinical study found no effect.
In vitro evidence shows that red clover inhibits CYP1A2. However, a clinical study in healthy postmenopausal individuals shows that taking red clover capsules standardized to contain 60 mg isoflavones twice daily for 14 days does not affect the pharmacokinetics of caffeine, a CYP1A2 probe substrate.

Likelihood Unlikely Evidence D
Cytochrome P450 2C19 (Cyp2C19) Substrates

Theoretically, red clover might increase the levels and clinical effects of drugs metabolized by CYP2C19.
In vitro evidence suggests that red clover weakly inhibits CYP2C19. This interaction has not been reported in humans.

Likelihood Unlikely Evidence D
Cytochrome P450 2C9 (Cyp2C9) Substrates

Theoretically, red clover might increase levels of drugs metabolized by CYP2C9; however, a small clinical study found no effect.
In vitro evidence suggests that red clover might inhibit CYP2C9. However, a clinical study in healthy postmenopausal individuals shows that taking red clover capsules standardized to contain 60 mg isoflavones twice daily for 14 days does not affect the pharmacokinetics of tolbutamide, a CYP2C9 probe substrate.

Likelihood Unlikely Evidence D
Cytochrome P450 3A4 (Cyp3A4) Substrates

Theoretically, red clover might increase levels of drugs metabolized by CYP3A4; however, a small clinical study found no effect.
In vitro evidence shows that red clover might inhibit CYP3A4 isoenzymes. However, a clinical study in healthy postmenopausal individuals shows that taking red clover capsules standardized to contain 60 mg isoflavones twice daily for 14 days does not affect the pharmacokinetics of alprazolam, a CYP3A4 probe substrate.

Likelihood Unlikely Evidence B
certified organic Red Clover full monograph & interactions

certified organic Rhubarb8 drug types · 658 drugs

Corticosteroids

Theoretically, frequent and high doses of rhubarb might increase the risk of hypokalemia when taken with corticosteroids.
Rhubarb has stimulant laxative effects. Overuse of rhubarb might compound corticosteroid-induced potassium loss.

Likelihood Possible Evidence D
Cyclosporine (Neoral, Sandimmune)

Theoretically, taking rhubarb with cyclosporine might reduce cyclosporine levels.
Animal research shows that co-administration of rhubarb decoction 0.25 or 1 gram/kg with cyclosporine 2.5 mg/kg, decreases cyclosporine maximum plasma concentration and overall exposure levels when compared with taking cyclosporine alone. The authors theorize that rhubarb might reduce cyclosporine bioavailability by inducing of P-glycoprotein and/or cytochrome P450 3A4. However, since rhubarb was administered as a single oral dose and enzyme induction usually occurs after multiple doses, it is possible that cyclosporine absorption was actually reduced via rhubarb's stimulant laxative effects. Also, the composition of the rhubarb decoction was not described.

Likelihood Possible Evidence D
Digoxin (Lanoxin)

Theoretically, overuse of rhubarb might increase the risk of adverse effects when taken with digoxin.
Rhubarb has stimulant laxative effects. Overuse of rhubarb might cause potassium depletion, increasing the risk of digoxin toxicity.

Likelihood Possible Evidence D
Diuretic Drugs

Theoretically, frequent and high doses of rhubarb might increase the risk of hypokalemia.
Rhubarb has stimulant laxative effects. Overuse of rhubarb might cause potassium depletion and compound diuretic-induced potassium loss.

Likelihood Possible Evidence D
Hepatotoxic Drugs

Theoretically, concomitant use of rhubarb with potentially hepatotoxic drugs might increase the risk of developing liver damage.
Some animal research suggests that anthraquinones in rhubarb might have hepatotoxic effects. Also, rhubarb use has been linked to at least 24 cases of liver injury, although details on the dose of rhubarb and duration of use in these cases is unclear.

Likelihood Possible Evidence D
Nephrotoxic Drugs

Theoretically, long-term use of anthraquinones from rhubarb might increase the risk of nephrotoxicity when used with nephrotoxic drugs.
The anthraquinone constituents of rhubarb have been shown to induce nephrotoxicity in animal research. Additionally, in a case report, a 23-year old female presented with kidney failure after taking 6 tablets of a proprietary slimming agent (found to contain the anthraquinones emodin and aloe-emodin from rhubarb) daily for 6 weeks and then adding diclofenac 25 mg 4 times daily for 2 days. The authors postulate that the anthraquinone constituents of rhubarb contributed to the renal dysfunction, and the addition of diclofenac, a nephrotoxic drug, led to renal failure. Until more is known, advise patients to avoid taking rhubarb if they are taking other potentially nephrotoxic drugs.

Likelihood Possible Evidence D
Stimulant Laxatives

Theoretically, rhubarb might increase the risk for fluid and electrolyte loss when taken with other stimulant laxatives.
Rhubarb has stimulant laxative effects. Concomitant use with stimulant laxatives might compound fluid and electrolyte loss.

Likelihood Possible Evidence D
Warfarin (Coumadin)

Theoretically, excessive use of rhubarb might increase the risk of bleeding when taken with warfarin.
Rhubarb has stimulant laxative effects and can cause diarrhea. Diarrhea can increase the effects of warfarin, increase international normalized ratio (INR), and increase the risk of bleeding. Advise patients who take warfarin not to take excessive amounts of rhubarb.

Likelihood Possible Evidence D
certified organic Rhubarb full monograph & interactions

certified organic Sheep Sorrel3 drug types · 169 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, sorrel might cause additive effects and side effects when used with anticoagulant or antiplatelet drugs.
In vitro, sorrel has been shown to inhibit platelet aggregation. However, this effect has not been reported in humans.

Likelihood Possible Evidence D
Fexofenadine (Allegra)

Sorrel might reduce the effectiveness of fexofenadine by reducing its absorption from the gut.
In vitro research shows that an ethanol extract of sorrel inhibits organic anion-transporting polypeptide 1A2 (OATP1A2), which transports fexofenadine from the intestine into cells. In rats, concomitant administration of sorrel extract with fexofenadine reduces oral absorption of fexofenadine and the area under the plasma concentration-time curve (AUC).

Likelihood Likely Evidence D
Organic Anion-Transporting Polypeptide Substrates (Oatp)

Sorrel might reduce the effectiveness of OATP substrates by reducing their absorption from the gut.
In vitro research shows that sorrel inhibits OATP1A2. Theoretically it may inhibit other OATPs. The OATPs are expressed in the small intestine and liver and transport drugs into cells. Inhibition of OATP may reduce the bioavailability of oral drugs that are substrates of OATP.

Likelihood Possible Evidence D
certified organic Sheep Sorrel full monograph & interactions

certified organic Burdock1 drug type · 122 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, taking burdock with anticoagulant or antiplatelet drugs might increase the risk of bleeding.

In vitro research shows that lignans from burdock reduce rabbit platelet aggregation by inhibiting platelet activating factor. This interaction has not been reported in humans.

Likelihood Possible Evidence D
certified organic Burdock full monograph & interactions

certified organic Blessed Thistle3 drug types · 36 drugs

Antacids

Theoretically, blessed thistle might decrease the effectiveness of antacids.
There are reports that blessed thistle increases stomach acid.

Likelihood Possible Evidence D
H2-Blockers

Theoretically, blessed thistle might decrease the effectiveness of H2-blockers.
There are reports that blessed thistle increases stomach acid.

Likelihood Possible Evidence D
Proton Pump Inhibitors (Ppis)

Theoretically, blessed thistle might decrease the effectiveness of PPIs.
There are reports that blessed thistle increases stomach acid.

Likelihood Possible Evidence D
certified organic Blessed Thistle full monograph & interactions

Watercress3 drug types · 6 drugs

Chlorzoxazone (Parafon Forte, Paraflex)

Watercress might reduce the metabolism of chlorzoxazone and increase its effects and side effects. Clinical research in healthy volunteers shows that a single ingestion of watercress 50 grams increases the chlorzoxazone plasma concentration-time curve by about 56% and increases its half-life by about 53%.

Likelihood Probable Evidence B
Lithium

Watercress is thought to have diuretic properties. Theoretically, due to these potential diuretic effects, watercress might reduce excretion and increase levels of lithium.

Likelihood Probable Evidence D
Warfarin (Coumadin)

Watercress contains vitamin K. Consuming large amounts of watercress might antagonize the anticoagulant effects of warfarin.

Likelihood Possible Evidence B
Watercress full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Flor-Essence, from the product label.

Flora

See all Flora products
Name
FLORA INC.
Street Address
805 E. BADGER RD.
City
LYNDEN
State
WA
ZipCode
98264
Phone Number
1.800.446.2110
Web Address
www.florahealth.com
Pharmacist Counseling Corner

Flor-Essence by Flora: Common Questions

Does Flor-Essence by Flora interact with any medications?
Yes. Based on its ingredients, Flor-Essence has a known interaction with 2,182 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Flor-Essence contains 8 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Is Flor-Essence safe during pregnancy?
Several ingredients carry cautions or warnings in pregnancy. Watercress is rated Likely Unsafe; blessed thistle and rhubarb are rated Possibly Unsafe. Red clover and sorrel have insufficient safety data or are rated Possibly Safe. Because the combination and individual doses aren't clear, talk with your doctor or pharmacist before using this product if you're pregnant.
Can I take this while breastfeeding?
Safety data while nursing are limited for most ingredients in this blend. Blessed thistle has traditional use for milk supply but lacks well-studied safety; rhubarb's laxative compounds may pass into breast milk. Talk with your doctor or pharmacist before using Flor-Essence while breastfeeding.
What does slippery elm do in this product?
Slippery elm is included for its mucilage — a gel-like compound traditionally used to soothe the digestive tract. However, this mucilage may also slow how your body absorbs other oral medications you take, so it's important to time doses carefully if you use other drugs.
Does Flor-Essence contain any fillers or additives?
No inactive ingredients are listed for this product — it contains only the 8 active herbal ingredients.
Can I take this if I have kidney or liver problems?
Several ingredients carry specific concerns for kidney and liver health. Sorrel's high oxalate content may stress the kidneys; rhubarb has been linked to cases of kidney and liver injury. Talk with your doctor before using this product if you have kidney or liver disease.
Why does watercress interact with blood thinners?
Watercress contains vitamin K, which your body uses to form blood clots. If you take warfarin (a blood thinner), high amounts of vitamin K can work against the drug and reduce its ability to prevent clots. This is why it's important to keep watercress intake consistent and to check with your doctor if you're on a blood thinner.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Flor-Essence label
Go deeper

The Full Monographs Behind Flor-Essence’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Watercress

Interacts with 6 drugs

Watercress is a nutrient-rich leafy green that provides vitamins A, C, and K plus minerals and antioxidant plant compounds. Eaten as a food it is generally safe and healthy for most people,...

Read the full Watercress monograph → Herb & supplement monograph

Burdock

Interacts with 122 drugs

Burdock is a traditional herb most often used for skin problems and as a so-called 'blood purifier,' but high-quality human studies are lacking and most claims are not well proven. It is wid...

Read the full Burdock monograph → Herb & supplement monograph

Sorrel

Interacts with 169 drugs

Sorrel is a tangy, leafy herb used in cooking and traditional medicine, often for congestion, digestion, and inflammation. Solid human evidence for any health benefit is limited, and its hig...

Read the full Sorrel monograph → Herb & supplement monograph

Blessed Thistle

Interacts with 36 drugs

Blessed thistle is a bitter herb traditionally used to stimulate appetite and ease mild digestive complaints. High-quality human studies are lacking, so its benefits are not well proven. It...

Read the full Blessed Thistle monograph → Herb & supplement monograph

Red Clover

Interacts with 867 drugs

Red clover is a plant rich in isoflavones (plant compounds with weak estrogen-like activity) that is most often used for menopause symptoms like hot flashes. The evidence is mixed and genera...

Read the full Red Clover monograph → Herb & supplement monograph

Rhubarb

Interacts with 658 drugs

Rhubarb root has a long history of use as a laxative and in traditional Chinese medicine, and its edible stalks are a common food. Most medicinal claims are backed by limited or low-quality...

Read the full Rhubarb monograph → Herb & supplement monograph

Slippery Elm

Interacts with 2,022 drugs

Slippery elm is a traditional herbal remedy made from the inner bark of a North American elm tree, used mainly to soothe sore throats and irritated digestive tracts. Its mucilage can coat an...

Read the full Slippery Elm monograph →
Sources

Sources & How We Checked

Flor-Essence's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 102 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Watercress 34 references
  1. Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.
  2. Brinker F. Herb Contraindications and Drug Interactions. 2nd ed. Sandy, OR: Eclectic Medical Publications, 1998.
  3. Leclercq I, Desager JP, Horsmans Y. Inhibition of chlorzoxazone metabolism, a clinical probe for CYP2E1, by a single ingestion of watercress. Clin Pharmacol Ther 1998;64:144-9. PubMed
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Sorrel 8 references
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Blessed Thistle 2 references
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Rhubarb 20 references
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Slippery Elm 3 references
  1. The Review of Natural Products by Facts and Comparisons. St. Louis, MO: Wolters Kluwer Co., 1999.
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