Interactions on record — worth a quick check against your medications. Based on 1 of 5 ingredients. Check your meds →
Dietary supplement

Genistein Soy Supplement Powder Ingredients & Drug Interactions

by Source Naturals

Powder Category: Non-nutrient/non-botanical
Most serious interaction: Moderate
The interaction bottom line Most serious interaction: Moderate

Genistein Soy Supplement Powder is a dietary supplement by Source Naturals with 5 active ingredients. Its ingredients are commonly taken for menopause symptoms (hot flashes), high cholesterol, bone health/osteoporosis.Based on those ingredients, 867 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Genistein. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

HelloPharmacist Scorecard of Genistein Soy Supplement Powder by Source Naturals

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 4 of its 4 active ingredients.
  • “SoyLife non-GMO Isoflavone Complex” is a proprietary blend — the label gives one combined amount (2.50 Gram(s)) without saying how much of each component you get.

This powder has 4 ingredients total. The active players are genistein and daidzein — both plant-derived compounds (phytoestrogens) that mimic estrogen in the body and come from soy and red clover.

The product also lists SoyLife non-GMO Isoflavone Complex as an ingredient; its breakdown is part of your overall dose. There are no inactive fillers listed in the label.

Does it work?

Insufficient evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Insufficient

There isn't enough reliable clinical evidence to rate this product's ingredients for its stated purpose.

Why this rating?
  • The label markets this product for: reduce hot flashes during menopause.
  • We looked for evidence on: Menopausal symptoms, Breast cancer-related hot flashes.
  • The closest evidence on file: Red Clover is rated "Insufficient Reliable Evidence To Rate" for Breast cancer-related hot flashes (Natural Medicines).
  • Also on file: Red Clover is rated "Insufficient Reliable Evidence To Rate" for Menopausal symptoms.

The evidence we have on file for genistein and daidzein doesn't establish that they work for androgenic alopecia (hair loss), menopausal symptoms, osteoarthritis, or osteoporosis — the ratings are all insufficient. This doesn't mean they don't work; it means the scientific evidence we're holding isn't solid enough to make a claim either way.

If you're considering this for a specific condition, talk with your pharmacist or doctor about what the current research actually shows.

The evidence, ingredient by ingredient Red Clover

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Both genistein and daidzein are generally well tolerated short-term in healthy adults, but their estrogen-like effects mean caution is warranted if you have hormone-sensitive conditions. The most common side effects reported are muscle pain, nausea, and vaginal spotting.

There's also a theoretical concern that increased isoflavone intake might modestly raise breast density in premenopausal women — something to discuss if you have a personal or family history of breast cancer. During pregnancy, the safety data advises against this product because of its estrogen-like effects and lack of safety studies.

While breastfeeding, there isn't enough safety information; best to avoid it and talk with your OB or pediatrician. We don't have pregnancy or breastfeeding data on file for the Total Isoflavones or Glycitein in this product.

Side effects, ingredient by ingredient Red Clover

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Red Clover.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs.
  • For scale: 868 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking this, double-check any estrogen-containing drugs (birth control, hormone therapy), methotrexate, and tamoxifen — these are Moderate risks. Also flag any medications your liver breaks down through CYP1A2, CYP2C19, CYP2C9, or CYP3A4 pathways, and blood thinners or antiplatelet drugs, though those last two are Minor concerns.

The search tool on this page will show you the full list of 857 affected medications.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with insufficient evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

This supplement interacts with estrogen therapy, methotrexate, tamoxifen, and potentially several other medications metabolized by your liver — plus a few others. If you take any prescription drugs, check each one against the tool on this page before adding this to your routine.

Pregnant or nursing? Skip it.

If you're on the fence about whether it's right for you, ask your pharmacist — they can look up your specific medications in seconds.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 2 of 4 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Feb 26, 2020.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Genistein Soy Supplement Powder, straight from the product label.

Brand Source Naturals
Barcode (UPC) 021078013075
Net contents 200 Gram(s); 7.05 Oz(s)
Market status On market
Date entered into DSLD Feb 26, 2020
DSLD ID 214153
Product type Non-nutrient/non-botanical
Supplement form Powder
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Vegetarian, Adult (18 - 50 Years), Gluten Free, Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Genistein Soy Supplement Powder by Source Naturals, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
2.5 Gram(s)
Maximum serving Sizes:
2.5 Gram(s)
Servings per container
80
UPC/BARCODE
021078013075
IngredientAmount% DV
Calories10 Calorie(s)--
Total Carbohydrates1 Gram(s)1%
Protein1 Gram(s)2%
Genistein2.5 mg--
Daidzein19 mg--
SoyLife non-GMO Isoflavone Complex2.5 Gram(s)--
Total Isoflavones50 mg--
Glycitein8.25 mg--

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
FDA Statement of Identity

Dietary Supplement

Seals/Symbols

Non GMO Validated

Precautions

Contains soy.

Note: If you are pregnant, may become pregnant, or breastfeeding, consult your health care professional before using this product.

Do not use if either tamper-evident seal is broken or missing.

Keep out of the reach of children.

Formula

Isoflavones are unique polyphenol compounds which are found in the soybean plant. Research suggests that soy protein and soy isoflavones may reduce the frequency and severity of hot flashes during menopause. Source Naturals genistein contains 50 mg of SoyLife isoflavones per serving which are naturally occurring and come from non-GMO soy. Convenient to mix with water or juice. One teaspoon provides slightly more isoflavones than two 1,000 mg tablets.

Isoflavones are unique polyphenol compounds which are found in the soybean plant. Research suggests that soy protein and soy isoflavones may reduce the frequency and severity of hot flashes during menopause.

Suggested/Recommended/Usage/Directions

Suggested Use: 1 teaspoon mixed with water or juice, twice daily with a meal.

Formulation

Suitable for vegetarians.

Contains no yeast, dairy, egg, gluten, corn or wheat. Contains no starch, preservatives, or artificial color, flavor or fragrance.

Non GMO Validated

Brand IP Statement(s)

SoyLife is a registered trademark of Frutarom USA, Inc.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

See for yourself

Genistein Soy Supplement Powder by Source Naturals label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

What’s inside

The Ingredients in Genistein Soy Supplement Powder by Source Naturals

These are the 5 active ingredients this product is made of. Select any to open its full monograph.

Serving size2.5 Gram(s) Dosage formPowder Servings per container80 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Protein

1 Gram(s) per serving

SoyLife non-GMO Isoflavone Complex

2.5 Gram(s) per serving Form: Soy
Interaction report

Genistein Soy Supplement Powder by Source Naturals Drug Interactions

Want to check YOUR meds against Genistein Soy Supplement Powder?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

Go to the checker
867Drugs
44 Moderate 823 Minor

Ingredients driving the most interactions

Genistein 867

Each ingredient & the kinds of drugs it affects

For each ingredient in Genistein Soy Supplement Powder with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Genistein9 drug types · 867 drugs

Estrogens

Theoretically, concomitant use of large amounts of red clover might interfere with estrogen therapy.
Red clover contains phytoestrogens which might have estrogenic activity in some people. Theoretically, red clover might compete for estrogen receptors and interfere with estrogen-containing drug therapy.

Likelihood Probable Evidence D
Methotrexate (Trexall, Others)

Theoretically, red clover might increase the risk of methotrexate toxicity.
In a case report, a 52-year-old female receiving weekly methotrexate injections for psoriasis developed symptoms of methotrexate toxicity, including severe vomiting and epigastric pain, after three days of taking red clover 430 mg daily. Toxicity resolved after red clover was discontinued. However, no liver function tests or methotrexate levels were reported.

Likelihood Possible Evidence D
Tamoxifen (Nolvadex)

Theoretically, the phytoestrogens in red clover might interfere with tamoxifen.
In vitro and animal research suggests that genistein, a constituent of red clover, might antagonize the antitumor effects of tamoxifen. However, there is some evidence from an animal study that red clover does not reduce the efficacy of tamoxifen. Until more is known, tell patients taking tamoxifen to avoid red clover.

Likelihood Possible Evidence D
Anticoagulant/Antiplatelet Drugs

Although some laboratory research suggests that red clover may have anticoagulant and antiplatelet activity, clinical research has not shown this effect.
In vitro research suggests that genistein in red clover has antiplatelet effects, and historically, red clover was thought to have anticoagulant effects due to its coumarin content. However, some experts state that this is unlikely as most natural coumarins have not been shown to have anticoagulant effects, and their content in red clover is low. Additionally, some clinical research in postmenopausal patients found no effect on coagulation or prothrombin time with the use of red clover flowering tops 378 mg daily for 12 months or red clover isoflavone (Rimostil) 50 mg daily for 2 years.

Likelihood Unlikely Evidence B
Caffeine

Theoretically, soy might reduce the clearance of caffeine; however, a small clinical study found no effect.
Red clover contains genistein. Taking genistein 1 gram daily for 14 days seems to inhibit caffeine clearance and metabolism in healthy females. However, this effect does not seem to occur with the lower amounts of genistein found in red clover. A clinical study in healthy postmenopausal individuals shows that taking red clover capsules standardized to contain 60 mg isoflavones twice daily for 14 days does not affect the pharmacokinetics of caffeine.

Likelihood Unlikely Evidence D
Cytochrome P450 1A2 (Cyp1A2) Substrates

Theoretically, red clover might increase levels of drugs metabolized by CYP1A2; however, a small clinical study found no effect.
In vitro evidence shows that red clover inhibits CYP1A2. However, a clinical study in healthy postmenopausal individuals shows that taking red clover capsules standardized to contain 60 mg isoflavones twice daily for 14 days does not affect the pharmacokinetics of caffeine, a CYP1A2 probe substrate.

Likelihood Unlikely Evidence D
Cytochrome P450 2C19 (Cyp2C19) Substrates

Theoretically, red clover might increase the levels and clinical effects of drugs metabolized by CYP2C19.
In vitro evidence suggests that red clover weakly inhibits CYP2C19. This interaction has not been reported in humans.

Likelihood Unlikely Evidence D
Cytochrome P450 2C9 (Cyp2C9) Substrates

Theoretically, red clover might increase levels of drugs metabolized by CYP2C9; however, a small clinical study found no effect.
In vitro evidence suggests that red clover might inhibit CYP2C9. However, a clinical study in healthy postmenopausal individuals shows that taking red clover capsules standardized to contain 60 mg isoflavones twice daily for 14 days does not affect the pharmacokinetics of tolbutamide, a CYP2C9 probe substrate.

Likelihood Unlikely Evidence D
Cytochrome P450 3A4 (Cyp3A4) Substrates

Theoretically, red clover might increase levels of drugs metabolized by CYP3A4; however, a small clinical study found no effect.
In vitro evidence shows that red clover might inhibit CYP3A4 isoenzymes. However, a clinical study in healthy postmenopausal individuals shows that taking red clover capsules standardized to contain 60 mg isoflavones twice daily for 14 days does not affect the pharmacokinetics of alprazolam, a CYP3A4 probe substrate.

Likelihood Unlikely Evidence B
The maker

Brand information

Manufacturer and brand details for Genistein Soy Supplement Powder, from the product label.

Source Naturals

Name
Source Naturals, Inc.
Street Address
P. O. Box 2118
City
Santa Cruz
State
CA
ZipCode
95062
Web Address
www.sourcenaturals.com
Pharmacist Counseling Corner

Genistein Soy Supplement Powder by Source Naturals: Common Questions

Does Genistein Soy Supplement Powder by Source Naturals interact with any medications?
Yes. Based on its ingredients, Genistein Soy Supplement Powder has a known interaction with 867 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Genistein Soy Supplement Powder contains 5 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
What exactly is genistein, and why is it in a soy supplement?
Genistein is a phytoestrogen — a plant compound that acts like estrogen in your body. It's naturally found in soy and red clover, so it's included here as the active ingredient meant to deliver those effects.
Can I take this if I'm on birth control or hormone therapy?
Not without checking with your pharmacist first. The phytoestrogens in this powder theoretically compete with estrogen receptors and could make your hormone therapy less effective. This is a Moderate-severity interaction, so it matters.
Is it safe to take while pregnant?
No. The safety data advises against it during pregnancy because of its estrogen-like effects and the lack of safety studies. Talk with your OB before considering any soy or red clover supplement while pregnant.
What are the most common side effects?
Muscle pain, nausea, and vaginal spotting were reported in studies. A specific isoflavone product also showed headache, though no more often than placebo.
Does this actually work for hot flashes or bone health?
We don't have reliable evidence on file to say yes — the effectiveness ratings are all insufficient. You'd need to talk with your doctor about what the broader research shows and whether it's worth trying.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Genistein Soy Supplement Powder is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Genistein Soy Supplement Powder label
Go deeper

The Full Monographs Behind Genistein Soy Supplement Powder’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Sources

Sources & How We Checked

Genistein Soy Supplement Powder's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 24 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Red Clover 24 references
  1. Kurzer MS, Xu X. Dietary phytoestrogens. Annu Rev Nutr 1997;17:353-81. PubMed
  2. Electronic Code of Federal Regulations. Title 21. Part 182 -- Substances Generally Recognized As Safe. Available at: https://www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfcfr/CFRSearch.cfm?CFRPart=182
  3. Budzinski JW, Foster BC, Vandenhoek S, Arnason JT. An in vitro evaluation of human cytochrome P450 3A4 inhibition by selected commercial herbal extracts and tinctures. Phytomedicine 2000;7:273-82. PubMed
  4. This P, De La Rochefordiere A, Clough K, et al. Phytoestrogens after breast cancer. Endocr Relat Cancer 2001;8:129-34. PubMed
  5. Tice J, Cummings SR, Ettinger B, et al. Few adverse effects of two red clover extracts rich in phytoestrogens: a multicenter, placebo-controlled trial. Alt Ther 2001;7:S33.
  6. Ingram DM, Hickling C, West L, et al. A double-blind randomized controlled trial of isoflavones in the treatment of cyclical mastalgia. The Breast 2002;11:170-4. PubMed
  7. Unger M, Frank A. Simultaneous determination of the inhibitory potency of herbal extracts on the activity of six major cytochrome P450 enzymes using liquid chromatography/mass spectrometry and automated online extraction. Rapid Commun Mass Spectrom 2004;1 PubMed
  8. Cheong JL, Bucknall R. Retinal vein thrombosis associated with a herbal phytoestrogen preparation in a susceptible patient. Postgrad Med J 2005;81:266-7.. PubMed
  9. Geller SE, Shulman LP, van Breemen RB, et al. Safety and efficacy of black cohosh and red clover for the management of vasomotor symptoms: a randomized controlled trial. Menopause 2009;16:1156-66. PubMed
  10. Hidalgo LA, Chedraui PA, Morocho N, et al. The effect of red clover isoflavones on menopausal symptoms, lipids and vaginal cytology in menopausal women: a randomized, double-blind, placebo-controlled study. Gynecol Endocrinol 2005;21(5):257-264. PubMed
  11. Campbell MJ, Woodside JV, Honour JW, et al. Effect of red clover-derived isoflavone supplementation on insulin-like growth factor, lipid and antioxidant status in healthy female volunteers: a pilot study. Eur J Clin Nutr 2004;58(1):173-179. PubMed
  12. Guerrero JA, Lozano ML, Castillo J, et al. Flavonoids inhibit platelet function through binding to the thromboxane A2 receptor. J Thromb Haemost 2005;3(2):369-376. PubMed
  13. Kondo K, Suzuki Y, Ikeda Y, Umemura K. Genistein, an isoflavone included in soy, inhibits thrombotic vessel occlusion in the mouse femoral artery and in vitro platelet aggregation. Eur J Pharmacol 2002;455(1):53-57. PubMed
  14. Polini N, Rauschemberger MB, Mendiberri J, et al. Effect of genistein and raloxifene on vascular dependent platelet aggregation. Mol Cell Endocrinol 2007;267(1-2):55-62. PubMed
  15. Wuttke W, Jarry H, Seidlova-Wuttke D. Plant-derived alternative treatments for the aging male: facts and myths. Aging Male 2010;13(2):75-81. PubMed
  16. Villaseca P. Non-estrogen conventional and phytochemical treatments for vasomotor symptoms: what needs to be known for practice. Climacteric 2012;15(2):115-124. PubMed
  17. Chen, Y., Xiao, C. Q., He, Y. J., Chen, B. L., Wang, G., Zhou, G., Zhang, W., Tan, Z. R., Cao, S., Wang, L. P., and Zhou, H. H. Genistein alters caffeine exposure in healthy female volunteers. Eur.J Clin.Pharmacol. 2011;67(4):347-353. PubMed
  18. Friedman, J. A., Taylor, S. A., McDermott, W., and Alikhani, P. Multifocal and recurrent subarachnoid hemorrhage due to an herbal supplement containing natural coumarins. Neurocrit.Care 2007;7(1):76-80. PubMed
  19. Hooper, L., Madhavan, G., Tice, J. A., Leinster, S. J., and Cassidy, A. Effects of isoflavones on breast density in pre- and post-menopausal women: a systematic review and meta-analysis of randomized controlled trials. Hum.Reprod.Update. 2010;16(6):745-7 PubMed
  20. Orr A and Parker R. Red clover causing symptoms suggestive of methotrexate toxicity in a patient on high-dose methotrexate. Menopause Int. 2013;19(3):133-134. PubMed
  21. Clifton-Bligh PB, et al. Red cover isoflavones enriched with formononetin lower serum LDL cholesterol- a randomized, double-blind, placebo-controlled trial. Eur J Clin Nutr. 2015;69(1):134-142.
  22. Risk assessment for peri- and post-menopausal women taking food supplements containing isolated isoflavones. EFSA Panel on Food Additives and Nutrient Sources added to Food (ANS). 2015. DOI
  23. Ferraris C, Ballestra B, Listorti C, et al. Red clover and lifestyle changes to contrast menopausal symptoms in premenopausal patients with hormone-sensitive breast cancer receiving tamoxifen. Breast Cancer Res Treat 2020;180(1):157-65. doi: 10.1007/s1054 PubMed
  24. Chen L, Choi J, Leonard SW, et al. No Clinically Relevant Pharmacokinetic Interactions of a Red Clover Dietary Supplement with Cytochrome P450 Enzymes in Women. J Agric Food Chem. 2020;68(47):13929-13939. PubMed

See these in context on the Red Clover monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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