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Dietary supplement

Glutamine 500 Ingredients & Drug Interactions

by ProCaps

Glutamine 500 label
See full label image
Capsule Category: Amino Acid/protein
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 23, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Glutamine 500 against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Glutamine 500 is a dietary supplement by ProCaps with 1 active ingredient. Its ingredients are commonly taken for muscle recovery and sports performance, gut health and 'leaky gut', recovery from severe illness or injury.Based on those ingredients, 50 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are L-Glutamine. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Glutamine 500 by ProCaps

Ask about any prescription or over-the-counter medication and we check it for interactions with Glutamine 500 by ProCaps — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Glutamine 500 by ProCaps

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Aug 6, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains one active ingredient: L-glutamine, an amino acid your body naturally makes and uses. The capsule itself is made of gelatin.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: amino acid building blocks for protein tissues.
  • We looked for evidence on: Burns, Critical illness (trauma), Exercise-induced muscle damage, HIV/AIDS-related wasting, Low birth weight, Malnutrition — and 4 related terms.
  • The strongest evidence on file: Glutamine is rated "Possibly Effective" for HIV/AIDS-related wasting (Natural Medicines).
  • Also on file: Glutamine is rated "Possibly Effective" for Critical illness (trauma), Postoperative recovery.
  • Also on file: Glutamine is rated "Possibly Ineffective" for Burns, Low birth weight, Muscular dystrophy.

The evidence we hold shows L-glutamine is effective for sickle cell disease. For HIV/AIDS-related wasting, postoperative recovery, and critical illness from trauma, the data suggests it's possibly effective — meaning there's some promise, but the evidence isn't yet solid enough to say for sure.

The evidence, ingredient by ingredient Glutamine

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

L-glutamine is generally well tolerated in healthy adults. Common side effects when taken by mouth include belching, bloating, constipation, diarrhea, flatulence, stomach pain, headache, muscle and joint pain, nausea, and vomiting — most often seen at higher doses (10-30 grams daily).

A few uncommon cases of dizziness, mood changes (mania or hypomania in people with bipolar disorder), and neurological effects have been reported. If you have kidney or liver disease, you should only take this under medical supervision.

There isn't enough safety data to recommend supplemental doses during pregnancy or while breastfeeding unless your doctor advises it — talk with your doctor or pharmacist about whether it's right for you in either situation.

Side effects, ingredient by ingredient Glutamine

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Glutamine.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: seizure medications.
  • For scale: 50 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking this product, confirm with your doctor or pharmacist that you don't take anticonvulsant medications (drugs for seizures or nerve pain). Glutamine might theoretically reduce how well these medications work, and no interactions are documented for the other ingredients.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

L-glutamine is well-supported for sickle cell disease and shows promise for wasting illnesses and recovery from surgery or critical illness. It's generally well tolerated, though high doses can cause stomach upset.

The main caution is its theoretical interaction with anticonvulsant medications. Check your exact medications with your doctor or pharmacist before starting, especially if you take seizure or nerve pain drugs.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated May 22, 2021.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Glutamine 500, straight from the product label.

Brand ProCaps
Barcode (UPC) 691563
Net contents 240 Easy-To-Swallow Capsule(s)
Market status On market
Date entered into DSLD May 22, 2021
DSLD ID 248107
Product type Amino Acid/protein
Supplement form Capsule
Dietary claims / uses Nutrient, All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Gluten Free, Dairy Free, Sugar Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Glutamine 500 by ProCaps, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Capsule(s)
Maximum serving Sizes:
1 Capsule(s)
Servings per container
240
UPC/BARCODE
691563
IngredientAmount% DV
L-Glutamine500 mg--

Other ingredients: Gelatin Capsule

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions

Suggested use consume one or more capsules daily or as recommended by your physician. As with any dietary supplement, this product is most effective as part of a healthy diet and active lifestyle, along with a daily multi-vitamin-mineral formula. For questions about the use of this product call 800.332.7799.

Formulation

For over 40 years unsurpassed purity, quality and efficacy 100% solar production Zero carbon footprint

All solar

They are the essential building blocks of all protein-based tissues and are also required for the creation of digestive enzymes and key molecules, such as hemoglobin and the hormones insulin, thyroxin and epinephrine. Glutamine is perhaps the body's most versatile amino acid. It is the most abundant amino acid present in muscle tissue and thus essential for healthy skeletal and cardiac muscle function. Glutamine also plays a unique role in promoting the healthy mucosal lining and barrier function of the intestines and digestive system. Glutamine also plays a special role in the liver, kidneys and throughout our body by promoting nitrogen balance and acid-base balance. Glutamine also represents an important energy source for specialized cells of the nervous and immune systems. Most importantly, Glutamine is one of only three amino acid building blocks of Glutathione, our body's most powerful, internal, protective compound. In short, Glutamine's long list of critical functions has made it one of the most popular amino acids to supplement.

Contains no additives of any kind Contains no milk, soy, yeast, corn, wheat, gluten, sodium, salt, sugar, fat, cholesterol, color, preservative, common allergens or manufacturing additives.

General Statements

We remain uniquely committed to you and the planet. You have my unwavering promise. Andrew Lessman, founder Questions?/reorders? 800.800.1200 www.ProCapsLabs.com www.HSN.com 800.944.9999 www.QVC.com 800.345.1515

Formula

500mg Glutamine free form amino acid

Andrew Lessman's Glutamine 500 is a pure source of the conditionally essential amino acid Glutamine. Amino acids play a multitude of roles in the chemistry of our bodies.

FDA Statement of Identity

Dietary Supplement

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Glutamine 500 by ProCaps label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Glutamine 500 label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Glutamine 500 by ProCaps

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 Capsule(s) Dosage formCapsule Servings per container240 Amounts shown are per serving.

L-Glutamine

Interacts with
50 drugs
500 mg per serving

Glutamine is the most abundant amino acid in the body and is usually made in your muscles. A prescription form is FDA-approved to help reduce sickle c...

L-Glutamine monograph & interactions

Other (inactive) ingredients: Gelatin Capsule. These complete the product’s ingredient list but are not active constituents.

Interaction report

Glutamine 500 by ProCaps Drug Interactions

Want to check YOUR meds against Glutamine 500?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
50Drugs
50 Moderate

Ingredients driving the most interactions

L-Glutamine 50

Individual Drug Interactions

The ingredients in Glutamine 500 interact with 50 drugs. Click any drug to see the details.

1 of the 1 ingredient in Glutamine 500 interact with drugs. Each result below shows which ingredient is responsible. L-Glutamine

Each ingredient & the kinds of drugs it affects

For each ingredient in Glutamine 500 with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

L-Glutamine1 drug type · 50 drugs

Anticonvulsants

Theoretically, glutamine might antagonize the effects of anticonvulsant medications.
Glutamine is metabolized to the excitatory neurotransmitter glutamate. Glutamate might have antagonistic effects with anticonvulsant drugs. However, this interaction has not yet been reported in humans.

Likelihood Possible Evidence D
L-Glutamine full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Glutamine 500, from the product label.

ProCaps

See all ProCaps products
Name
ProCaps Labs
City
Henderson
State
NV
ZipCode
89011
Phone Number
800.800.1200
Web Address
www.ProCapsLabs.com
Pharmacist Counseling Corner

Glutamine 500 by ProCaps: Common Questions

Does Glutamine 500 by ProCaps interact with any medications?
Yes. Based on its ingredients, Glutamine 500 has a known interaction with 50 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Glutamine 500 contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Is glutamine safe to take during pregnancy or while breastfeeding?
There isn't enough safety data to know either way. The facts don't advise against it during pregnancy or lactation, but there's also not solid evidence of safety. Talk with your doctor or pharmacist about whether it's right for you in either situation.
What are the most common side effects?
Stomach-related effects are most typical: belching, bloating, constipation, diarrhea, gas, and nausea. These happen more often at higher doses. Headache and muscle pain have also been reported.
Does glutamine actually work?
The data shows it's effective for sickle cell disease. For HIV/AIDS wasting, recovery after surgery, and critical illness, the evidence suggests it possibly works, but the research isn't conclusive yet.
Who should not take this product?
If you have kidney or liver disease, take it only under medical supervision. If you take anticonvulsants (seizure or nerve pain medications), check with your doctor or pharmacist first. People with bipolar disorder should also talk with their doctor, since a couple of cases of mood changes have been reported.
Why does glutamine interact with anticonvulsants?
Your body breaks glutamine down into glutamate, a brain chemical that fires up nerve signals. Anticonvulsants are designed to calm those signals, so theoretically glutamate might work against them. This hasn't been seen in real patients, but it's a reason to double-check before combining them.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Glutamine 500 label
Go deeper

The Full Monographs Behind Glutamine 500’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Glutamine

Interacts with 50 drugs

Glutamine is the most abundant amino acid in the body and is usually made in your muscles. A prescription form is FDA-approved to help reduce sickle cell disease complications, but for most...

Read the full Glutamine monograph →
Sources

Sources & How We Checked

Glutamine 500's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 11 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Glutamine 11 references
  1. Miller AL. Therapeutic considerations of L-glutamine: a review of the literature. Altern Med Rev 1999;4:239-48..
  2. Bozzetti F, Biganzoli L, Gavazzi C, et al. Glutamine supplementation in cancer patients receiving chemotherapy: a double-blind randomized study. Nutrition 1997;13:748-51.. PubMed
  3. Mebane AH. L-Glutamine and mania. Am J Psychiatry 984;141:1302-3.
  4. Meldrum BS. Glutamate as a neurotransmitter in the brain: review of physiology and pathology. J Nutr 2000;130:1007S-15S.. PubMed
  5. Garlick PJ. Assessment of the safety of glutamine and other amino acids. J Nutr 2001;131:2556S-61S.. PubMed
  6. Chapman AG. Glutamate and epilepsy. J Nutr 2000;130:1043S-5S.. PubMed
  7. Ziegler TR. Glutamine supplementation in cancer patients receiving bone marrow transplantation and high dose chemotherapy. J Nutr 2001;131:2578S-84S.. PubMed
  8. Laviano A, Molfino A, Lacaria MT, Canelli A, De Leo S, Preziosa I, Rossi Fanelli F. Glutamine supplementation favors weight loss in nondieting obese female patients. A pilot study. Eur J Clin Nutr. 2014 Nov;68(11):1264-6. PubMed
  9. Endari (l-glutamine) [package insert]. Torrance, CA: Emmaus Medical,Inc; 2017.
  10. Niihara Y, Miller ST, Kanter J, et al. A Phase 3 Trial of l-Glutamine in Sickle Cell Disease. N Engl J Med 2018;379(3):226-35. doi: 10.1056/NEJMoa1715971.
  11. Ogden HB, Child RB, Fallowfield JL, et al. Gastrointestinal Tolerance of Low, Medium and High Dose Acute Oral l-Glutamine Supplementation in Healthy Adults: A Pilot Study. Nutrients. 2020;12(10):2953. PubMed

See these in context on the Glutamine monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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