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Dietary supplement

Glutamine Ingredients & Drug Interactions

by Higher Nature

Glutamine label
See full label image
Capsule Category: Amino Acid/protein
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 9, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Glutamine against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Glutamine is a dietary supplement by Higher Nature with 1 active ingredient. Its ingredients are commonly taken for muscle recovery and sports performance, gut health and 'leaky gut', recovery from severe illness or injury.Based on those ingredients, 50 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are L-Glutamine. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Glutamine by Higher Nature

Ask about any prescription or over-the-counter medication and we check it for interactions with Glutamine by Higher Nature — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Glutamine by Higher Nature

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Aug 6, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains one active ingredient: L-glutamine, an amino acid your body makes naturally and uses for muscle, gut, and immune function. The capsule also holds inactive ingredients—hydroxypropyl methylcellulose, microcrystalline cellulose, and magnesium stearate—which are standard binders and fillers.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use — see Glutamine's own graded uses on its monograph.

Why this rating?
  • The label markets this product for: Digestive tract cell energy support.
  • We looked for evidence on: Diarrhea, Chemotherapy-induced diarrhea, Radiation-induced diarrhea, Antiretroviral-associated diarrhea, Crohn disease, Irritable bowel syndrome (IBS) — and 4 related terms.
  • The closest evidence on file: Glutamine is rated "Possibly Ineffective" for Crohn disease (Natural Medicines).
  • Also on file: Glutamine is rated "Possibly Ineffective" for Radiation-induced diarrhea.
  • Also on file: Glutamine is rated "Insufficient Reliable Evidence To Rate" for Chemotherapy-induced diarrhea, Diarrhea, Irritable bowel syndrome (IBS), Oral mucositis, and more.

L-glutamine is rated effective for sickle cell disease. For HIV/AIDS-related wasting, postoperative recovery, and critical illness from trauma, the evidence is possibly effective—meaning there's some research support but it's not yet as strong as the sickle cell data.

The evidence for other uses isn't established in our data.

The evidence, ingredient by ingredient Glutamine

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Glutamine is generally well tolerated by healthy adults. The most common side effects are mild digestive complaints—belching, bloating, constipation, diarrhea, flatulence, nausea, and vomiting—especially at higher doses.

Headache and musculoskeletal pain have also been reported. Two cases of mood symptoms (mania and hypomania) appeared in people with bipolar disorder taking up to 4 grams daily, though these are rare.

If you have kidney or liver disease, use glutamine only under medical supervision. During pregnancy, glutamine is rated likely safe.

During breastfeeding, there isn't enough safety data, so avoid supplement doses unless your doctor advises otherwise.

Side effects, ingredient by ingredient Glutamine

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Glutamine.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: seizure medications.
  • For scale: 50 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

If you take anticonvulsant (seizure) medication, check your exact drugs on this page and confirm with your doctor or pharmacist before starting glutamine. The risk is moderate and theoretical but important to rule out.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and safety information is well characterized.

Glutamine may help with sickle cell disease and possibly with recovery after surgery, trauma, or in HIV/AIDS wasting. If you take anticonvulsant medication, check with your doctor or pharmacist before starting—the interaction is theoretical but worth confirming it won't affect your seizure control.

Most people tolerate it well, though digestive upset and headache can happen. Talk it over with your healthcare provider to see if it's right for you.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Apr 23, 2024.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Glutamine, straight from the product label.

Brand Higher Nature
Barcode (UPC) 5031013109133
Net contents 90 Capsule(s)
Market status On market
Date entered into DSLD Apr 23, 2024
DSLD ID 304538
Product type Amino Acid/protein
Supplement form Capsule
Dietary claims / uses Nutrient, All Other, Structure/Function
Intended target group(s) Vegan, Vegetarian, Adult (18 - 50 Years), Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Glutamine by Higher Nature, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
2 Capsule(s)
Maximum serving Sizes:
10 Capsule(s)
Servings per container
9
UPC/BARCODE
5031013109133
IngredientAmount% DV
L-Glutamine1000 mg--

Other ingredients: Hydroxypropyl Methylcellulose, Microcrystalline Cellulose, Magnesium Stearate

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formulation

No artificial colours, flavours or preservatives. No yeast, added sugar or salt.

This product has not been tested on animals. Body Health

Advanced Formula Optimal Benefit

Vegetarian and vegan

Precautions

Warnings: If you are pregnant, breastfeeding, taking any medication or have a medical condition, please consult your healthcare professional before using this product.

Do not exceed recommended daily intake. Food supplements should not be used as a substitute for varied and balanced diet and healthy lifestyle.

Storage: Store in a cool, dry place out of reach of children.

Formula

Amino Acid

Glutamine provides cells in the digestive tract with a source of energy

Suggested/Recommended/Usage/Directions

Directions: Adults take 2-10 capsules with cold water 1-3 times a day at least 30 minutes before meals.

Storage

Storage: Store in a cool, dry place out of reach of children.

FDA Statement of Identity

Food Supplement

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Glutamine by Higher Nature label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Glutamine label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Glutamine by Higher Nature

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size2 Capsule(s) Dosage formCapsule Servings per container9 Amounts shown are per serving.

L-Glutamine

Interacts with
50 drugs
1000 mg per serving

Glutamine is the most abundant amino acid in the body and is usually made in your muscles. A prescription form is FDA-approved to help reduce sickle c...

L-Glutamine monograph & interactions

Other (inactive) ingredients: Hydroxypropyl Methylcellulose, Microcrystalline Cellulose, Magnesium Stearate. These complete the product’s ingredient list but are not active constituents.

Interaction report

Glutamine by Higher Nature Drug Interactions

Want to check YOUR meds against Glutamine?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
50Drugs
50 Moderate

Ingredients driving the most interactions

L-Glutamine 50

Individual Drug Interactions

The ingredients in Glutamine interact with 50 drugs. Click any drug to see the details.

1 of the 1 ingredient in Glutamine interact with drugs. Each result below shows which ingredient is responsible. L-Glutamine

Each ingredient & the kinds of drugs it affects

For each ingredient in Glutamine with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

L-Glutamine1 drug type · 50 drugs

Anticonvulsants

Theoretically, glutamine might antagonize the effects of anticonvulsant medications.
Glutamine is metabolized to the excitatory neurotransmitter glutamate. Glutamate might have antagonistic effects with anticonvulsant drugs. However, this interaction has not yet been reported in humans.

Likelihood Possible Evidence D
L-Glutamine full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Glutamine, from the product label.

Higher Nature

See all Higher Nature products
Name
Higher Nature Ltd (EU)
Street Address
Block 1, Blanchardstown Corporate Park, Ballycoolen Road
City
Dublin
ZipCode
D15 AKK1
Web Address
highernature.com
Pharmacist Counseling Corner

Glutamine by Higher Nature: Common Questions

Does Glutamine by Higher Nature interact with any medications?
Yes. Based on its ingredients, Glutamine has a known interaction with 50 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Glutamine contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Will glutamine upset my stomach?
Possibly. Belching, bloating, constipation, diarrhea, flatulence, nausea, and vomiting are the most common side effects, especially at higher doses. These are usually mild, but if they bother you, a dose adjustment may help.
Is glutamine safe during pregnancy?
Yes—it's rated likely safe in pregnancy. There's no reason to avoid it if your doctor recommends it.
Can I take glutamine while breastfeeding?
There isn't enough safety data to know. Avoid supplement doses unless your doctor or lactation consultant advises otherwise.
Does glutamine really work for sickle cell disease?
It's rated effective for sickle cell disease based on the research we have. For other uses like postoperative recovery or HIV wasting, the evidence is possibly effective—there's some support but it's not yet conclusive.
What if I have kidney or liver problems?
Use glutamine only under medical supervision if you have kidney or liver disease. Talk to your doctor first to make sure it's safe for you.
Can glutamine affect my mood?
In rare cases, glutamine has been linked to mood changes (mania and hypomania) in people with bipolar disorder. If you have bipolar disorder or a mood disorder, mention glutamine to your doctor before starting.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Glutamine is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Glutamine label
Go deeper

The Full Monographs Behind Glutamine’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Glutamine

Interacts with 50 drugs

Glutamine is the most abundant amino acid in the body and is usually made in your muscles. A prescription form is FDA-approved to help reduce sickle cell disease complications, but for most...

Read the full Glutamine monograph →
Sources

Sources & How We Checked

Glutamine's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 11 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Glutamine 11 references
  1. Miller AL. Therapeutic considerations of L-glutamine: a review of the literature. Altern Med Rev 1999;4:239-48..
  2. Bozzetti F, Biganzoli L, Gavazzi C, et al. Glutamine supplementation in cancer patients receiving chemotherapy: a double-blind randomized study. Nutrition 1997;13:748-51.. PubMed
  3. Mebane AH. L-Glutamine and mania. Am J Psychiatry 984;141:1302-3.
  4. Meldrum BS. Glutamate as a neurotransmitter in the brain: review of physiology and pathology. J Nutr 2000;130:1007S-15S.. PubMed
  5. Garlick PJ. Assessment of the safety of glutamine and other amino acids. J Nutr 2001;131:2556S-61S.. PubMed
  6. Chapman AG. Glutamate and epilepsy. J Nutr 2000;130:1043S-5S.. PubMed
  7. Ziegler TR. Glutamine supplementation in cancer patients receiving bone marrow transplantation and high dose chemotherapy. J Nutr 2001;131:2578S-84S.. PubMed
  8. Laviano A, Molfino A, Lacaria MT, Canelli A, De Leo S, Preziosa I, Rossi Fanelli F. Glutamine supplementation favors weight loss in nondieting obese female patients. A pilot study. Eur J Clin Nutr. 2014 Nov;68(11):1264-6. PubMed
  9. Endari (l-glutamine) [package insert]. Torrance, CA: Emmaus Medical,Inc; 2017.
  10. Niihara Y, Miller ST, Kanter J, et al. A Phase 3 Trial of l-Glutamine in Sickle Cell Disease. N Engl J Med 2018;379(3):226-35. doi: 10.1056/NEJMoa1715971.
  11. Ogden HB, Child RB, Fallowfield JL, et al. Gastrointestinal Tolerance of Low, Medium and High Dose Acute Oral l-Glutamine Supplementation in Healthy Adults: A Pilot Study. Nutrients. 2020;12(10):2953. PubMed

See these in context on the Glutamine monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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