Interactions on record — worth a quick check against your medications. Based on 3 of 9 ingredients. Check your meds →
Dietary supplement

Gluten-Ade Ingredients & Drug Interactions

by CHK Nutrition

Capsule Category: Other Combinations
Most serious interaction: Moderate
The interaction bottom line Most serious interaction: Moderate

Gluten-Ade is a dietary supplement by CHK Nutrition with 9 active ingredients. Its ingredients are commonly taken for digestion and bloating, muscle soreness and exercise recovery, inflammation and swelling.Based on those ingredients, 302 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are FloraFit Lactobacillus acidophillus La-14, FiberAid Arabinogalactans. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

HelloPharmacist Scorecard of Gluten-Ade by CHK Nutrition

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 4 of its 11 active ingredients.
  • “Acid Protease” is listed as a grouped ingredient — the label doesn't break down how much of each component you get.
  • “DPPzyme IV Blend” is a proprietary blend — the label doesn't break down how much of each component you get.

Gluten-Ade contains 11 active ingredients, most of them digestive enzymes designed to break down different components of food. You get protease (which breaks down proteins) listed three times, amylase enzymes (which work on starches), cellulase (for fiber), glucoamylase, and a blend containing acid protease and other enzyme combinations.

The product also includes Lactobacillus acidophilus (a beneficial bacteria) and larch arabinogalactan (a type of fiber). The capsule itself and the other inactive ingredients are cellulose, magnesium stearate, and silica.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: Gluten digestive enzymes with acidophilus and prebiotics.
  • We looked for evidence on: Antibiotic-associated diarrhea, Lactose intolerance, Travelers' diarrhea, Rotaviral diarrhea, Radiation-induced diarrhea, Clostridioides difficile infection — and 4 related terms.
  • The strongest evidence on file: Lactobacillus Acidophilus is rated "Possibly Effective" for Antibiotic-associated diarrhea (Natural Medicines).
  • Also on file: Lactobacillus Acidophilus is rated "Possibly Effective" for Bacterial vaginosis.
  • Also on file: Lactobacillus Acidophilus is rated "Insufficient Reliable Evidence To Rate" for Respiratory tract infections, Radiation-induced diarrhea, Lactose intolerance, Rotaviral diarrhea, and more.

The data we hold doesn't establish that Gluten-Ade itself works for its stated purpose. However, Lactobacillus acidophilus — one of its ingredients — is rated as possibly effective for irritable bowel syndrome, Helicobacter pylori infection, antibiotic-associated diarrhea, and bacterial vaginosis.

Larch arabinogalactan has insufficient evidence to rate its effectiveness for common cold or high cholesterol. The enzyme components don't have established effectiveness ratings in our data.

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 3 of the 3 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 3 of 3.
  • General safety write-ups exist for 3 of 3.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Protease enzymes in this product are generally well tolerated for most adults but may cause digestive upset or allergic reactions — rarely, people with occupational exposure to proteolytic enzymes have developed allergic rhinitis or asthma. Lactobacillus acidophilus is generally well tolerated in healthy adults and children, though some people report minor gastrointestinal side effects like bloating, gas, or abdominal discomfort; very rarely, the live organisms have been linked to serious infections in immunocompromised patients.

Larch arabinogalactan is generally well tolerated as a fiber but may cause bloating and flatulence. During pregnancy, protease safety hasn't been established and is best avoided unless prescribed; Lactobacillus acidophilus is rated possibly safe in pregnancy; larch arabinogalactan lacks sufficient safety data.

For breastfeeding, protease and arabinogalactan have little data and aren't recommended without medical advice, while Lactobacillus acidophilus data during lactation is incomplete.

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 2 of the 3 matched ingredients can interact with medications — Lactobacillus Acidophilus, Larch Arabinogalactan.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: immunosuppressants / transplant drugs.
  • For scale: 302 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking Gluten-Ade, double-check your medications with your doctor or pharmacist if you're on immunosuppressant drugs (like cyclosporine or tacrolimus) — the arabinogalactan may reduce their effectiveness. Also flag any antibiotic use; you'll want to space out doses from this supplement.

For the other ingredients we couldn't check, use the search tool on this page to confirm your exact medications aren't affected.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

Gluten-Ade is an enzyme and probiotic blend mainly for digestive support, but effectiveness for gluten digestion specifically isn't established in our data. If you take immunosuppressant drugs or antibiotics, you need to check with your doctor or pharmacist before starting this product — the interactions could affect how those medications work.

Anyone with a history of allergic reactions to enzyme products should also talk it over first. Discuss this supplement with your own healthcare provider before you begin, especially if you're pregnant, breastfeeding, or have a weakened immune system.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 5 of 11 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Jun 24, 2020.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Gluten-Ade, straight from the product label.

Brand CHK Nutrition
Barcode (UPC) 787500067312
Net contents 60 Vegetarian Capsule(s)
Market status On market
Date entered into DSLD Jun 24, 2020
DSLD ID 228641
Product type Other Combinations
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Gluten Free, Sugar Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Gluten-Ade by CHK Nutrition, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
2 Vegetarian Capsule(s)
Maximum serving Sizes:
2 Vegetarian Capsule(s)
UPC/BARCODE
787500067312
IngredientAmount% DV
FOS10 mg--
Protease0 NP--
Glucoamylase0 NP--
Amylase I0 NP--
Cellulase0 NP--
Protease0 NP--
Gluten Enzyme Formula850 mg--
Acid Protease0 NP--
DPPzyme IV Blend0 NP--
Protease0 NP--
Amylase II0 NP--
FloraFit Lactobacillus acidophillus La-143 mg--
FiberAid Arabinogalactans10 mg--

Other ingredients: Vegetarian Capsule, Cellulose, Magnesium Stearate, Silica

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formulation

Contains no sugar, salt, yeast, wheat, gluten, soy, corn, preservatives, artificial colors or flavors.

Quality and potency guaranteed

Suggested/Recommended/Usage/Directions

Suggested use: As a dietary supplement, adults take two (2) vegetarian caps approximately 10-15 minutes prior to meal or as directed by a health care professional.

Storage

Store in a cool, dry place and away from direct light.

FDA Disclaimer Statement

This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Precautions

Keep out of reach of children.

General Statements

New day. Fresh start. Better health.

Formula

Gluten digestive enzymes with acidophilus & prebiotics

Gluten-ADE is a comprehensive gluten digestive enzyme formula with both pre- and probiotics. This formula is designed to support the digestion of gluten found in the protein of wheat, rye and other gluten containing grains. It has added acidophilus, FOS and arabinogalactans to support intestinal health.

FDA Statement of Identity

Dietary Supplement

See for yourself

Gluten-Ade by CHK Nutrition label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

What’s inside

The Ingredients in Gluten-Ade by CHK Nutrition

These are the 9 active ingredients this product is made of. Select any to open its full monograph.

Serving size2 Vegetarian Capsule(s) Dosage formCapsule Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

FOS

10 mg per serving

Glucoamylase

0 NP per serving Form: Aspergillus niger

Amylase I

0 NP per serving Form: Aspergillus oryzae

Cellulase

0 NP per serving Form: Trichoderma reesei

Gluten Enzyme Formula

850 mg per serving

Acid Protease

No known
interactions
0 NP per serving Form: Aspergillus niger, Aspergillus oryzae

Proteolytic enzymes are proteins that help break down other proteins, and common examples include bromelain (from pineapple), papain (from papaya), tr...

Acid Protease monograph & interactions
  • › DPPzyme IV Blend

Amylase II

0 NP per serving Form: Bacillus subtilis
3 mg per serving

Lactobacillus acidophilus is a 'friendly' bacterium used as a probiotic to support gut and vaginal health. It is generally well tolerated in healthy p...

FloraFit Lactobacillus acidophillus La-14 monograph & interactions

FiberAid Arabinogalactans

Interacts with
121 drugs
10 mg per serving

Larch arabinogalactan is a soluble fiber from larch trees that is mainly used as a prebiotic and for immune support. Early research is interesting but...

FiberAid Arabinogalactans monograph & interactions

Other (inactive) ingredients: Vegetarian Capsule, Cellulose, Magnesium Stearate, Silica. These complete the product’s ingredient list but are not active constituents.

Interaction report

Gluten-Ade by CHK Nutrition Drug Interactions

Want to check YOUR meds against Gluten-Ade?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

Go to the checker
302Drugs
302 Moderate

Ingredients driving the most interactions

Each ingredient & the kinds of drugs it affects

For each ingredient in Gluten-Ade with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

FloraFit Lactobacillus acidophillus La-141 drug type · 182 drugs

Antibiotic Drugs

Theoretically, taking Lactobacillus acidophilus with antibiotic drugs might decrease the effectiveness of L. acidophilus.
L. acidophilus preparations usually contain live and active organisms. Therefore, simultaneously taking antibiotics might kill a significant number of the organisms. Tell patients to separate administration of antibiotics and L. acidophilus preparations by at least two hours.

Likelihood Probable Evidence D

FiberAid Arabinogalactans1 drug type · 121 drugs

Immunosuppressants

Theoretically, larch arabinogalactan might interfere with immunosuppression therapy due to immunostimulant effects. Immunosuppressant drugs include azathioprine (Imuran), basiliximab (Simulect), cyclosporine (Neoral, Sandimmune), daclizumab (Zenapax), muromonab-CD3 (OKT3, Orthoclone OKT3), mycophenolate (CellCept), tacrolimus (FK506, Prograf), sirolimus (Rapamune), prednisone (Deltasone, Orasone), corticosteroids (glucocorticoids), and other drugs.

Likelihood Possible Evidence D
The maker

Brand information

Manufacturer and brand details for Gluten-Ade, from the product label.

CHK Nutrition

See all CHK Nutrition products
Name
CHK Nutrition
Street Address
3930 E Calvary Rd
City
Duluth
State
MN
ZipCode
55803
Phone Number
877-538-8388
Pharmacist Counseling Corner

Gluten-Ade by CHK Nutrition: Common Questions

Does Gluten-Ade by CHK Nutrition interact with any medications?
Yes. Based on its ingredients, Gluten-Ade has a known interaction with 302 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Gluten-Ade contains 9 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Will this help me digest gluten?
The product is designed for that, but we don't have effectiveness data showing it works specifically for gluten digestion. If you have celiac disease or gluten sensitivity, talk with your doctor about whether this is right for you.
Can I take this while I'm on antibiotics?
You can, but you'll need to space out the doses. Antibiotics can kill the live bacteria in this supplement, which reduces its benefit. Ask your pharmacist for the best timing between them.
Is this safe during pregnancy?
The protease enzymes haven't been studied enough in pregnancy and are best avoided unless your doctor prescribes them. Lactobacillus acidophilus is rated possibly safe, but larch arabinogalactan lacks safety data. Talk with your doctor before taking this product if you're pregnant.
What side effects might I notice?
Most people tolerate it well, but some experience bloating, gas, or mild digestive upset. Allergic reactions to the enzymes are rare but possible, especially if you have a sensitivity to enzyme products used in detergents.
Can I take this if I take an immunosuppressant medication?
Not without checking with your doctor first. The arabinogalactan in this product may interfere with how immunosuppressant drugs work, so you need personalized advice from your healthcare provider.
What's the Lactobacillus acidophilus in here for?
It's a beneficial bacteria that may help with irritable bowel syndrome, antibiotic-associated diarrhea, and some other digestive or gut-related conditions. It works as a probiotic to support your gut flora.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Gluten-Ade is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Gluten-Ade label
Sources

Sources & How We Checked

Gluten-Ade's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 26 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Proteolytic Enzymes (proteases) 3 references
  1. Weeks JA, Harper RA, Simon RA, Burdick JD. Assessment of sensitization risk of a laundry pre-spotter containing protease. Cutan Ocul Toxicol. 2011;30(4):272-9. PubMed
  2. Marquès LI, Lara S, Abós T, Bartolomé B. Occupational rhinitis due to pepsin. J Investig Allergol Clin Immunol. 2006;16(2):136-7. DOI
  3. Cartier A, Malo JL, Pineau L, Dolovich J. Occupational asthma due to pepsin. J Allergy Clin Immunol. 1984;73(5 Pt 1):574-7. PubMed

See these in context on the Proteolytic Enzymes (proteases) monograph →

Lactobacillus Acidophilus 15 references
  1. Pierce A. The American Pharmaceutical Association Practical Guide to Natural Medicines. New York: The Stonesong Press, 1999:19.
  2. Begtrup LM, de Muckadell OB, Kjeldsen J, Christensen RD, Jarbøl DE. Long-term treatment with probiotics in primary care patients with irritable bowel syndrome--a randomised, double-blind, placebo controlled trial. Scand J Gastroenterol 2013;48(10):1127-35 PubMed
  3. Chatterjee S, Kar P, Das T, Ray S, Gangulyt S, Rajendiran C, Mitra M. Randomised placebo-controlled double blind multicentric trial on efficacy and safety of Lactobacillus acidophilus LA-5 and Bifidobacterium BB-12 for prevention of antibiotic-associated
  4. Shavakhi A, Tabesh E, Yaghoutkar A, Hashemi H, Tabesh F, Khodadoostan M,Minakari M, Shavakhi S, Gholamrezaei A. The effects of multistrain probiotic compound on bismuth-containing quadruple therapy for Helicobacter pylori infection: a randomized placebo-c
  5. Karamali M, Dadkhah F, Sadrkhanlou M, et al. Effects of probiotic supplementation on glycaemic control and lipid profiles in gestational diabetes: a randomized, double-blind, placebo-controlled trial. Diabetes Metab 2016;42(4):234-41. PubMed
  6. Badehnoosh B, Karamali M, Zarrati M, et al. The effects of probiotic supplementation on biomarkers of inflammation, oxidative stress and pregnancy outcomes in gestational diabetes. J Matern Fetal Neonatal Med. 2018 May;31(9):1128-1136.
  7. Kumar S, Kumar R, Rohilla L, Jacob N, Yadav J, Sachdeva N. A high potency multi-strain probiotic improves glycemic control in children with new-onset type 1 diabetes mellitus: A randomized, double-blind, and placebo-controlled pilot study. Pediatr Diabete
  8. Shahriari A, Karimi E, Shahriari M, Aslani N, Khooshideh M, Arab A. The effect of probiotic supplementation on the risk of gestational diabetes mellitus among high-risk pregnant women: A parallel double-blind, randomized, placebo-controlled clinical trial PubMed
  9. Xiao SD, Zhang DZ, Lu H, et al. Multicenter, randomized, controlled trial of heat-killed Lactobacillus acidophilus LB in patients with chronic diarrhea. Adv Ther. 2003;20(5):253-60.
  10. Rossi F, Amadoro C, Gasperi M, Colavita G. Lactobacilli infection case reports in the last three years and safety implications. Nutrients. 2022;14(6):1178. PubMed
  11. Ozer M, Goksu SY, Shahverdiani A, Mustafa M. Lactobacillus acidophilus-induced endocarditis and associated splenic abscess. Case Rep Infect Dis 2020;2020:1382709.
  12. Sadrin S, Sennoune S, Gout B, et al. A 2-strain mixture of Lactobacillus acidophilus in the treatment of irritable bowel syndrome: A placebo-controlled randomized clinical trial. Dig Liver Dis 2020;52(5):534-540. PubMed
  13. Stoffer JN, Slingsby TJ, Giuliari GP. Lactobacillus acidophilus endophthalmitis after intravitreal bevacizumab injection requiring intraocular lens explantation. Can J Ophthalmol 2022;57(1):e21-e22. PubMed
  14. Cukovic-Cavka S, Likic R, Francetic I, Rustemovic N, Opacic M, Vucelic B. Lactobacillus acidophilus as a cause of liver abscess in a NOD2/CARD15-positive patient with Crohn's disease. Digestion 2006;73(2-3):107-10.
  15. Hui J, Ren Y, Wang Y, Han Q. Lactobacillus acidophilus endophthalmitis postcataract operation: A case report with a literature review. Ocul Immunol Inflamm 2023.

See these in context on the Lactobacillus Acidophilus monograph →

Larch Arabinogalactan 8 references
  1. D'Adamo P. Larch arabinogalactan. J Naturopath Med 1996;6:33-7.
  2. Kelly GS. Larch arabinogalactan: Clinical relevance of a novel immune-enhancing polysaccharide. Alt Med Rev 1999;4:96-103.
  3. Marett R, Slavin JL. No long-term benefits of supplementation with arabinogalactan on serum lipids and glucose. J Am Diet Assoc 2004;104:636-9.
  4. Robinson RR, Feirtag J, Slavin JL. Effects of dietary arabinogalactan on gastrointestinal and blood parameters in healthy human subjects. J Am Coll Nutr 2001;20:279-85. PubMed
  5. Udani JK, Singh BB, Barrett ML, Singh VJ. Proprietary arabinogalactan extract increases antibody response to the pneumonia vaccine: a randomized, double-blind, placebo-controlled, pilot study in healthy volunteers. Nutr J 2010;9:32. PubMed
  6. Grube B, Stier H, Riede L, Gruenwald J. Tolerability of a proprietary larch arabinogalactan extract: a randomized, double-blind, placebo-controlled clinical trial in healthy subjects. Food Nutr Sci 2012;3:1533-8. DOI
  7. Dion C, Chappuis E, Ripoll C. Does larch arabinogalactan enhance immune function? A review of mechanistic and clinical trials. Nutr Metab (Lond) 2016;13:28. PubMed
  8. Riede L, Grube B, Gruenwald J. Larch arabinogalactan effects on reducing incidence of upper respiratory tract infections. Curr Med Res Opin 2013;29(3):251-8.

See these in context on the Larch Arabinogalactan monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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