Graviola Ingredients & Drug Interactions
by Vitabase
What is this page for?
First and foremost: checking Graviola against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
Graviola is a dietary supplement by Vitabase with 1 active ingredient. Its ingredients are commonly taken for cancer support (unproven), infections, inflammation.Based on those ingredients, 1 medication has a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Graviola. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.
Check Your Meds Against Graviola by Vitabase
Ask about any prescription or over-the-counter medication and we check it for interactions with Graviola by Vitabase — and tell you which ingredient is responsible.
AI summaries are generated from our interaction database for education only — always confirm with your pharmacist. How we use AI
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HelloPharmacist Scorecard of Graviola by Vitabase
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Full disclosure
This product contains one active ingredient: graviola, a tropical fruit extract. The capsule also holds inactive ingredients (gelatin, magnesium stearate, and stearic acid) that are standard binders and fillers.
Does it work?
Couldn't assess
The evidence for graviola isn't established yet. We don't have reliable data to say whether it works for human papillomavirus (HPV), headache, insect repellent, or male infertility — the conditions listed in our data all fall short of the evidence bar.
If you're considering it for one of these reasons, that's important context for your conversation with us.
How safe is it?
Well-documented data
Here's what you should know: regular use of graviola may not be safe. The most common side effects are stomach pain and nausea.
Rarely, people have reported movement disorders and nerve damage (myeloneuropathy) that resembles Parkinson's disease. One study even found that people with Parkinson's disease had worsening symptoms after consuming graviola.
Lab work also raises concerns about possible nerve toxicity with long-term use, though human safety data are limited. Graviola is rated possibly unsafe in pregnancy and should be avoided while breastfeeding — not enough reliable safety information exists for either.
Meds to double-check
Moderate interaction found
If you take carbamazepine (Tegretol), a seizure medication, check with us before using this product. Graviola may lower your carbamazepine levels enough to compromise seizure control.
The bottom line
Scorecard at a glanceFully disclosed formula with no assessable stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.
Graviola is a supplement with limited evidence of benefit and real safety concerns, especially with long-term use. If you take carbamazepine, it's a no-go.
If you're interested in it for another reason, talk to your pharmacist first — the risk profile matters here.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Mar 23, 2012.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about Graviola, straight from the product label.
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for Graviola by Vitabase, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| Graviola | 650 mg | -- |
Other ingredients: Gelatin, Magnesium Stearate, Stearic Acid
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Precautions
KEEP OUT OF REACH OF CHILDREN.
CAUTION: Do not exceed recommended dose.
This product is not intended for pregnant or nursing mothers, children under 18, or individuals with a known medical condition including any cardiovascular disorder and hypotension (low blood pressure).
If you have any questions about the advisability of taking this product, consult your physician prior to use.
DO NOT USE IF OUTER SEAL IS DAMAGED OR MISSING.
FDA Disclaimer Statement
These statements have not been evaluated by the Food and Drug Administration. This product is not intended to treat, cure, prevent or diagnose any disease.
Seals/Symbols
Vb
General Statements
Formulated to Promote a Healthy Immune System
Vitabase uses only high quality ingredients.
Suggested/Recommended/Usage/Directions
Suggested Use: As a dietary supplement, take two (2) capsules daily or as directed by a healthcare professional.
FDA Statement of Identity
DIETARY SUPPLEMENT
Formula
Each capsule contains 650 mg of 100% pure graviola leaf and stem ground to a fine powder. The Graviola found in this product was harvested in Brazil.
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
Graviola by Vitabase label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in Graviola by Vitabase
This is the 1 active ingredient this product is made of. Select it to open its full monograph.
Serving size2 Capsule(s) Dosage formCapsule Amounts shown are per serving.
Graviola
Interacts with1 drug
Graviola (soursop) is a tropical fruit tree whose leaves, fruit, and bark are used in traditional medicine, especially in parts of South America, Afri...
Graviola monograph & interactionsOther (inactive) ingredients: Gelatin, Magnesium Stearate, Stearic Acid. These complete the product’s ingredient list but are not active constituents.
Graviola by Vitabase Drug Interactions
HelloPharmacist Interaction Report
Graviola by Vitabase has one documented interaction we need to talk about.
It may decrease levels of carbamazepine (Tegretol), a seizure medication. A rat study showed that graviola extract reduced carbamazepine concentrations by about 46% — a moderately significant drop — which could make the seizure medication less effective at protecting you.
Read the full breakdown — every affected drug type, severity by severity
If you take carbamazepine, don't start graviola without checking with your pharmacist or doctor first. Your seizure control could be compromised.
Use the medication checker on this page to look up any other drugs you're on, just to be thorough.
Check your own medications below · Editorial policy · How we use AI
Want to check YOUR meds against Graviola?
Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.
Go to the checkerIngredients driving the most interactions
Individual Drug Interactions
The ingredients in Graviola interact with 1 drug. Click any drug to see the details.
1 of the 1 ingredient in Graviola interact with drugs. Each result below shows which ingredient is responsible. Graviola
CarbamazepineCarbatrol, Carnexiv, Equetro, Tegretol, Tegretol XR
How Carbamazepine interacts with Graviola — through 1 ingredient. Tap an ingredient for the detail:
GraviolaCarbamazepine (tegretol) Moderate
Interaction Summary
Theoretically, graviola might decrease concentrations of carbamazepine when used concomitantly.
Read the full Graviola + Carbamazepine interactionEach ingredient & the kinds of drugs it affects
For each ingredient in Graviola with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.
Graviola
Carbamazepine (Tegretol)
Theoretically, graviola might decrease concentrations of carbamazepine when used concomitantly.
A study in rats shows that graviola extract reduces the area under the curve of carbamazepine by 46% and maximum concentration by 35% when compared with carbamazepine alone.
Brand information
Manufacturer and brand details for Graviola, from the product label.
Graviola by Vitabase: Common Questions
Does Graviola by Vitabase interact with any medications?
How can one product interact with so many drugs?
Where does this information come from?
Can I take graviola while pregnant or breastfeeding?
What are the side effects of graviola?
Does graviola actually work for anything?
Is it safe to take graviola long-term?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Not sure if Graviola is safe with your meds?
Our pharmacists answer your medication & supplement questions — free.
Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.
The Full Monographs Behind Graviola’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Sources & How We Checked
Graviola's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 4 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Graviola 4 references
- Caparros-Lefebvre D, Elbaz A. Possible relation of atypical parkinsonism in the French West Indies with consumption of tropical plants: a case-control study. Caribbean Parkinsonism Study Group. Lancet 1999;354:281-6. PubMed
- Gavamukulya Y, Wamunyokoli F, El-Shemy HA. Annona muricata: Is the natural therapy to most disease conditions including cancer growing in our backyard? A systematic review of its research history and future prospects. Asian Pac J Trop Med. 2017;10(9):835- PubMed
- Abu Soukhon AA, Abu-Qatouseh L, Mansoor K, et al. Cytotoxicity Activity of Graviola Fruit Extract with Carbamazepine and Valproic Acid Show Antagonistic and Indifferent Effects. Asian Pac J Cancer Prev 2023;24(6):1869-1875. PubMed
- Cleret de Langavant L, Roze E, Petit A, et al. Annonaceae Consumption Worsens Disease Severity and Cognitive Deficits in Degenerative Parkinsonism. Mov Disord 2022;37(12):2355-2366. PubMed
Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC