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Dietary supplement

Guggulhills Ingredients & Drug Interactions

by Herbal Hills

Guggulhills label
See full label image
Tablet Or Pill Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 9, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Guggulhills against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Guggulhills is a dietary supplement by Herbal Hills with 1 active ingredient. Its ingredients are commonly taken for high cholesterol, joint pain and arthritis, weight management.Based on those ingredients, 757 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Guggul extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Guggulhills by Herbal Hills

Ask about any prescription or over-the-counter medication and we check it for interactions with Guggulhills by Herbal Hills — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Guggulhills by Herbal Hills

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

Guggulhills is a single-ingredient supplement containing guggul extract, a resin from the Commiphora mukul tree traditionally used in Ayurvedic medicine. The product also includes inactive ingredients (fillers and binders) such as xanthan gum, maize starch, silica, HPMC, and magnesium stearate to form the tablet.

Does it work?

Couldn't assess
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not assessable

This is a single-ingredient Guggul product and its label doesn't state a use — see Guggul's own graded uses on its monograph.

Why this rating?
  • We looked at the product name, claims, and label statements and couldn't find a stated purpose to grade.

The evidence for guggul's effectiveness is limited. For obesity — one of its traditional uses — research rates it as possibly ineffective.

For acne, hemorrhoids, and high cholesterol, there isn't enough reliable evidence in our data to rate whether it works. If you're considering it for any of these conditions, talk to your doctor or pharmacist about what the current evidence actually supports.

The evidence, ingredient by ingredient Guggul

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Guggul is generally well tolerated when taken by mouth, but it does carry some cautions. Common side effects include belching, bloating, diarrhea, headache, nausea, an unpleasant taste, and vomiting.

Skin reactions — both allergic and non-allergic — are fairly common; the risk appears to go up with higher doses (about 3% at 1,000 mg three times daily, rising to 15% at 2,000 mg three times daily). A rare but serious side effect is rhabdomyolysis (severe muscle breakdown).

Topically, guggul can cause allergic contact dermatitis in sensitive individuals. Guggul should be avoided during pregnancy because it may stimulate the uterus and its safety isn't established.

There isn't enough safety information to recommend it while breastfeeding either. Because digestive upset and skin reactions are possible, use it only under guidance from a healthcare provider.

Side effects, ingredient by ingredient Guggul

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Guggul.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs.
  • For scale: 758 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking Guggulhills, double-check with your pharmacist or doctor if you take blood thinners or antiplatelet drugs (like warfarin or aspirin); heart medications including beta-blockers (propranolol) or calcium channel blockers (diltiazem); birth control or hormone therapy; thyroid medication; tamoxifen or other cancer treatments; or any drugs metabolized by the liver enzyme CYP3A4 (a very common group). All of these have documented moderate interactions with guggul.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no assessable stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

Guggul extract has a lot of documented interactions — especially with blood thinners, heart medications, hormones, and cancer drugs — so it's not a "grab and go" supplement. If you take any prescription medication, check it against our tool before you start.

The evidence for what it's actually supposed to do (weight loss, acne, high cholesterol) is weak or missing, so talk with your pharmacist first about whether it makes sense for your situation.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Nov 21, 2012.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Guggulhills, straight from the product label.

Brand Herbal Hills
Barcode (UPC) 8906008260922
Net contents 60 Tablet(s)
Market status On market
Date entered into DSLD Nov 21, 2012
DSLD ID 15536
Product type Botanical
Supplement form Tablet Or Pill
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Guggulhills by Herbal Hills, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Tablet(s)
Maximum serving Sizes:
1 Tablet(s)
UPC/BARCODE
8906008260922
IngredientAmount% DV
Guggul extract500 mg--

Other ingredients: Xanthan Gum, Maize Starch, Silica, HPMC, Magnesium Stearate

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements

MULTIEFFECTIVE HERB

Batch No. : Exp. Date: Neutral Code # MH/PD/AYU/002/10

Supports Healthy Weight & Cholesterol

Pure – Natural – Effective Guggul is a very effective herb for maintaining healthy weight and healthy cholesterol levels. It is considered to posses purifying and rejuvenating properties. It is also useful in reducing symptoms associated with joint health, helpful improving blood circulation etc.

Contents based on standard Raw Material as per Ayurvedic Text

FDA Statement of Identity

HERBAL SUPPLEMENT

Dietary Supplement

Seals/Symbols

HERBALHILLS

GMP Good Manufacturing Practice

ISO 22000:2005 CERTIFIED COMPANY

EXTRACT STANDARDIZED EXTRACT

Storage

Store in a cool dry place away from direct sunlight.

Precautions

Keep out of reach of children.

Do not use if inner seal is broken or missing.

Caution : Pregnant or lactating women are advised to consume herbal products under the advice of the Healthcare Practitioner.

Formula

1% Guggalsterones

Suggested/Recommended/Usage/Directions

Direction for use : As a dietary supplement take 1 capsule twice daily, preferably after meals or as recommended by a Healthcare Practitioner. For better results it should be taken with warm water

FDA Disclaimer Statement

These statements have not been evaluated by the Food & Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Guggulhills by Herbal Hills label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Guggulhills label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Guggulhills by Herbal Hills

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 Tablet(s) Dosage formTablet Or Pill Amounts shown are per serving.

Guggul extract

Interacts with
757 drugs
500 mg per serving Form: Gugglasterones

Guggul is a gum resin from the Commiphora wightii tree, long used in Ayurvedic medicine for cholesterol, joint, and skin problems. Modern studies are...

Guggul extract monograph & interactions

Other (inactive) ingredients: Xanthan Gum, Maize Starch, Silica, HPMC, Magnesium Stearate. These complete the product’s ingredient list but are not active constituents.

Interaction report

Guggulhills by Herbal Hills Drug Interactions

Want to check YOUR meds against Guggulhills?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
757Drugs
757 Moderate

Ingredients driving the most interactions

Guggul extract 757

Individual Drug Interactions

The ingredients in Guggulhills interact with 757 drugs. Click any drug to see the details.

1 of the 1 ingredient in Guggulhills interact with drugs. Each result below shows which ingredient is responsible. Guggul extract

Each ingredient & the kinds of drugs it affects

For each ingredient in Guggulhills with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Guggul extract9 drug types · 757 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, guggul might increase the risk of bleeding when taken with anticoagulant/antiplatelet drugs.
In vitro research and preliminary clinical studies suggest that guggul might have antiplatelet and anticoagulant effects.

Likelihood Possible Evidence B
Contraceptive Drugs

Theoretically, guggul might increase the risk of adverse effects when taken with contraceptive drugs.
In vitro research shows that guggul has estrogen-alpha receptor agonist activity.

Likelihood Possible Evidence D
Cytochrome P450 3A4 (Cyp3A4) Substrates

Theoretically, guggul might reduce the effects of CYP3A4 substrates.
In vitro research shows that guggul constituents known as guggulsterones can induce CYP3A4.

Likelihood Probable Evidence D
Diltiazem (Cardizem, Others)

Guggul might reduce the effects of diltiazem.
A small pharmacokinetic study shows that concomitant use of guggul with diltiazem reduces the bioavailability of diltiazem.

Likelihood Probable Evidence B
Estrogens

Theoretically, guggul might increase the risk of adverse effects when taken with estrogens.
In vitro research shows that guggul constituents known as guggulsterones have estrogen-alpha receptor agonist activity.

Likelihood Possible Evidence D
Propranolol (Inderal)

Guggul might reduce the effects of propranolol.
A small pharmacokinetic study shows that concomitant use of guggul with propranolol reduces the bioavailability of propranolol.

Likelihood Probable Evidence B
Rosuvastatin (Crestor)

Theoretically, guggul might increase the effects and adverse effects of rosuvastatin.
Animal research shows that guggul increases the bioavailability and hypolipidemic effects of rosuvastatin. The mechanism of this interaction is unclear.

Likelihood Possible Evidence D
Tamoxifen (Nolvadex)

Theoretically, guggul might interfere with tamoxifen therapy.
In vitro research shows that guggul has estrogen-alpha receptor agonist activity.

Likelihood Possible Evidence D
Thyroid Hormone

Theoretically, guggul might increase the risk for adverse effects when taken with thyroid hormone therapy.
Animal research suggests that guggul has thyroid-stimulating effects.

Likelihood Probable Evidence B
Guggul extract full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Guggulhills, from the product label.

Herbal Hills

See all Herbal Hills products
Name
Isha Agro Developers Pvt. Ltd. (An ISO 22000:2005 Certified Company)
Street Address
55-A/B, Lonavala Indl. Co-op. Est. Ltd.
City
Nangargaon
State
Lonavala
Phone Number
0091 22 2868 6868
Web Address
www.herbalhills.in
Pharmacist Counseling Corner

Guggulhills by Herbal Hills: Common Questions

Does Guggulhills by Herbal Hills interact with any medications?
Yes. Based on its ingredients, Guggulhills has a known interaction with 757 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Guggulhills contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take Guggulhills if I'm pregnant or breastfeeding?
No — guggul should be avoided during pregnancy because it may stimulate the uterus and safety isn't established. There also isn't enough safety information to recommend it while breastfeeding. Talk to your doctor or pharmacist about alternatives if you're pregnant or nursing.
What side effects might I experience?
The most common ones are digestive: belching, bloating, diarrhea, nausea, vomiting, and headache, plus an unpleasant taste. Skin reactions — rash, itching, and sometimes swelling — are also fairly common and happen more often at higher doses. Rarely, it can cause severe muscle breakdown (rhabdomyolysis).
Does guggul actually help with weight loss?
Research rates it as possibly ineffective for obesity. The evidence doesn't support that it works for weight loss, so it may not be worth the interaction risk or side effects.
Will this help my high cholesterol?
There isn't enough reliable evidence in our data to say whether guggul works for high cholesterol. Talk to your doctor about treatments that do have solid evidence behind them.
Can I use guggul on my skin for acne?
We don't have enough reliable evidence to rate whether it works for acne. Keep in mind that guggul can cause allergic contact dermatitis if you apply it topically, so a patch test would be wise if you're considering it.
Is guggul safe if I don't take any medications?
Even without medications, guggul is generally well tolerated but can cause digestive upset, skin reactions, and in rare cases serious muscle breakdown. Since the evidence for what it's supposed to do is weak, using it under guidance from a healthcare provider is the safest approach.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Guggulhills label
Go deeper

The Full Monographs Behind Guggulhills’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Guggul

Interacts with 757 drugs

Guggul is a gum resin from the Commiphora wightii tree, long used in Ayurvedic medicine for cholesterol, joint, and skin problems. Modern studies are mixed and often low-quality, and it can...

Read the full Guggul monograph →
Sources

Sources & How We Checked

Guggulhills's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 21 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Guggul 21 references
  1. McGuffin M, Hobbs C, Upton R, Goldberg A, eds. American Herbal Products Association's Botanical Safety Handbook. Boca Raton, FL: CRC Press, LLC 1997.
  2. Dalvi SS, Nayak VK, Pohujani SM, et al. Effect of gugulipid on bioavailability of diltiazem and propranolol. J Assoc Phys India 1994;42:454-5.
  3. Singh RB, Niaz MA, Ghosh S. Hypolipidemic and antioxidant effects of Commiphora mukul as an adjunct to dietary therapy in patients with hypercholesterolemia. Cardiovasc Drugs Ther 1994;8:659-64. PubMed
  4. Tripathi YB, Tripathi P, Malhotra OP, Tripathi SN. Thyroid stimulatory action of (Z)-guggulsterone: mechanism of action. Planta Med 1988;54:271-7.
  5. Agarwal RC, Singh SP, Saran RK, et al. Clinical trial of gugulipid – a new hypolipidemic agent of plant origin in primary hyperlipidemia. Ind J Med Res 1986;84:626-34.
  6. Malhotra SC, Ahuja MM, Sundaram KR. Long term clinical studies on the hypolipidaemic effect of Commiphora mukul (Guggulu) and clofibrate. Indian J Med Res 1977;65:390-5.
  7. Mester L, Mester M, Nityanand S. Inhibition of platelet aggregation by "guggulu" steroids. Planta Med 1979;37:367-9. PubMed
  8. Szapary PO, Wolfe ML, Bloedon LT, et al. Guggulipid for treatment of hypercholesterolemia: a randomized controlled trial. JAMA 2003;290:765-72.
  9. Brobst DE, Ding X, Creech KL, et al. Guggulsterone activates multiple nuclear receptors and induces CYP3A gene expression through the pregnane X receptor. J Pharmacol Exp Ther 2004;310:528-35. PubMed
  10. Bianchi A, Cantu P, Firenzuoli F, et al. Rhabdomyolysis caused by Commiphora mukul, a natural lipid-lowering agent. Ann Pharmacother 2004;38:1222-5.
  11. Gelfand JM, Crawford GH, Brod BA, Szazpary PO. Adverse cutaneous reactions to guggulipid. J Am Acad Dermatol 2005;52:533-4 PubMed
  12. Nohr, L. A., Rasmussen, L. B., and Straand, J. Resin from the mukul myrrh tree, guggul, can it be used for treating hypercholesterolemia? A randomized, controlled study. Complement Ther.Med. 2009;17(1):16-22. PubMed
  13. Gelfand, J. M., Crawford, G. H., Brod, B. A., and Szazpary, P. O. Adverse cutaneous reactions to guggulipid. J.Am.Acad.Dermatol. 2005;52(3 Pt 1):533-534. PubMed
  14. Kolonte, A., Guillot, B., and Raison-Peyron, N. Allergic contact dermatitis to guggul extract contained in an anticellulite gel-cream. Contact Dermatitis 2006;54(4):226-227. PubMed
  15. Salavert, M., Amarger, S., Le Bouedec, M. C., Roger, H., Souteyrand, P., and D'incan, M. Allergic contact dermatitis to guggul in a slimming cream. Contact Dermatitis 2007;56(5):286-287. PubMed
  16. Malhotra SC, Ahuja MM. Comparative hypolipidaemic effectiveness of gum guggulu (Commiphora mukul) fraction 'A', ethyl-P-chlorophenoxyisobutyrate and Ciba-13437-Su. Indian J Med Res 1971;59:1621-1632.
  17. Gaur SP, Garg RK, Kar AM, et al. Gugulipid, a new hypolipidaemic agent, in patients of acute ischaemic stroke: effect on clinical outcome, platelet function and serum lipids. Asia Pacif J Pharm 1997;12:65-69.
  18. Baldwa VS, Sharma RC, Ranka PC, et al. Effect of Commiphora mukul (guggul) on fibrinolytic activity and platelet aggregation in coronary artery disease. Rajas Med J 1980;19:84-86.
  19. Donato F, Raffetti E, Toninelli G, Festa A, Scarcella C, Castellano M; TRIGU Project Working Group. Guggulu and Triphala for the Treatment of Hypercholesterolaemia: A Placebo-Controlled, Double-Blind, Randomised Trial. Complement Med Res 2021;28(3):216-22 PubMed
  20. Mehdi Z, Fatemeh P, Roja R, et al. Efficacy and safety of Hemoheal cream in patients with hemorrhoids: a randomized double-blind placebo controlled clinical trial. J Tradit Chin Med 2021;41(2):301-307.
  21. Asad M, Asdaq SMB, Mohzari Y, et al. Pharmacokinetic and pharmacodynamic interaction of Rosuvastatin calcium with guggulipid extract in rats. Saudi J Biol Sci 2021;28(6):3490-3496. PubMed

See these in context on the Guggul monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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