Interactions on record — worth a quick check against your medications. Based on 4 of 8 ingredients. Check your meds →
Dietary supplement

Gut-to-Brain Hunger Control Ingredients & Drug Interactions

by Irwin Naturals

Gut-to-Brain Hunger Control label
See full label image
Softgel Capsule Category: Other Combinations
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Gut-to-Brain Hunger Control against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Gut-to-Brain Hunger Control is a dietary supplement by Irwin Naturals with 8 active ingredients. Its ingredients are commonly taken for morning sickness in pregnancy, premenstrual syndrome (pms), preventing or treating b6 deficiency.Based on those ingredients, 448 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Flaxseed Oil, Vitamin B6, Chromium. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against Gut-to-Brain Hunger Control by Irwin Naturals

Ask about any prescription or over-the-counter medication and we check it for interactions with Gut-to-Brain Hunger Control by Irwin Naturals — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of Gut-to-Brain Hunger Control by Irwin Naturals

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 7 of its 7 active ingredients.
  • No proprietary blends here — you can verify the dose of every single component.

Gut-to-Brain Hunger Control contains 7 active ingredients. The three most prominent are vitamins: B6 and B12 (essential nutrients your body uses for energy, nerve function, and metabolism) and chromium (a trace mineral that influences how your body handles blood sugar).

The product also includes flaxseed oil, a source of omega-3 fatty acids, plus three proprietary components—DNF-10 Yeast Hydrolysate, BioPerine Complex, and Aqtiv Medium Chain Triglyceride Oil—whose specific roles aren't detailed in the product information we have. The softgel capsules also contain inactive ingredients like gelatin, glycerin, and maltodextrin, which are standard fillers and binders.

Does it work?

Strong evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Strong

Clinical evidence supports at least one of this product's ingredients for its stated purpose.

Why this rating?
  • The label markets this product for: appetite control and weight management support.
  • We looked for evidence on: Binge eating disorder, Chromium deficiency, Impaired glucose tolerance (Prediabetes), Diabetes, Hyperlipidemia, Hypertriglyceridemia — and 4 related terms.
  • The strongest evidence on file: Chromium is rated "Likely Effective" for Chromium deficiency (Natural Medicines).
  • Also on file: Chromium is rated "Possibly Effective" for Diabetes.
  • Also on file: Chromium is rated "Possibly Ineffective" for Impaired glucose tolerance (Prediabetes).

The evidence supporting this product's ingredients varies. Vitamin B6 is effective for treating sideroblastic anemia and B6 deficiency, and possibly effective for pregnancy-related nausea and vomiting (though only under a doctor's guidance).

Vitamin B12 is effective for B12 deficiency and Imerslund-Grasbeck disease. Chromium is likely effective for chromium deficiency but only possibly effective for diabetes—and the evidence suggests it may not help prediabetes.

Flaxseed oil shows mostly negative findings: the evidence rates it possibly ineffective for obesity, rheumatoid arthritis, bipolar disorder, and high cholesterol. We hold no effectiveness data for the three proprietary ingredients in this formula.

The evidence, ingredient by ingredient Vitamin B6 Vitamin B12 Chromium Flaxseed Oil

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 4 of the 4 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 4 of 4.
  • General safety write-ups exist for 4 of 4.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Vitamin B6 is generally well tolerated at doses under 100 mg daily, but high doses over long periods can cause nerve damage (sensory neuropathy), especially at doses exceeding 1,000 mg daily. Common side effects at any dose are rare but may include headache, nausea, and abdominal pain.

Vitamin B12 is very safe with no established upper limit—excess is removed in urine—and is generally well tolerated; rare serious cases of severe low potassium have been linked to B12 correction of anemia. Chromium is usually well tolerated at typical supplement doses, though high or long-term use may pose risks; reported side effects include gastrointestinal irritation, headaches, mood changes, and rare cases of kidney or liver damage.

Flaxseed oil is generally well tolerated, though a small number of users report digestive changes, dry mouth, or indigestion at around 5 grams daily, and higher doses (30 grams or more daily) may cause loose stools. Rare severe allergic reactions have been reported.

We hold no pregnancy or breastfeeding safety data for any of these ingredients in the product facts on file.

Side effects, ingredient by ingredient Vitamin B6 Vitamin B12 Chromium Flaxseed Oil

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 4 of the 4 matched ingredients can interact with medications — Vitamin B12, Chromium, Vitamin B6, Flaxseed Oil.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; diabetes medications; Parkinson's medications.
  • For scale: 448 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Check with your pharmacist before taking this product if you use seizure medications (phenytoin or phenobarbital), heart medications (amiodarone), diabetes medications (insulin or antidiabetic drugs), thyroid medications (levothyroxine/Synthroid), blood thinners (anticoagulants or antiplatelet drugs including aspirin), blood pressure medications (antihypertensives), the diabetes medication metformin (Glucophage), or the cholesterol medication ezetimibe (Zetia). Vitamin B6 at high doses can reduce how well seizure and some other medications work; chromium and flaxseed oil may increase bleeding risk and lower blood pressure further; and several ingredients may affect blood sugar control.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with clinical evidence supporting its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

This product may appeal to people interested in supporting digestion and metabolism with B vitamins and chromium, but it carries real interactions with blood pressure, diabetes, seizure, heart, thyroid, and blood-thinning medications. If you take any prescription drugs—especially for diabetes, thyroid disease, seizures, heart rhythm, or blood clotting—talk with your pharmacist before starting.

High-dose B6 use over time poses a nerve damage risk. Check your exact medications with the tool on this page.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 4 of 7 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Feb 23, 2025.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Gut-to-Brain Hunger Control, straight from the product label.

Brand Irwin Naturals
Barcode (UPC) 840081406038
Net contents 60 Liquid Soft-Gel(s)
Market status On market
Date entered into DSLD Feb 23, 2025
DSLD ID 323283
Product type Other Combinations
Supplement form Softgel Capsule
Dietary claims / uses Nutrient, All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Women (not pregnant or lactating)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Gut-to-Brain Hunger Control by Irwin Naturals, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
2 Liquid Softgel(s)
Maximum serving Sizes:
2 Liquid Softgel(s)
Servings per container
30
UPC/BARCODE
840081406038
IngredientAmount% DV
Calories10 Calorie(s)--
Vitamin B62.5 mg147%
Total Fat1 Gram(s)1%
Saturated Fat0.5 Gram(s)3%
Vitamin B1225 mcg1042%
Protein1 Gram(s)--
Chromium300 mcg857%
Flaxseed Oil500 mg--
DNF-10 Yeast Hydrolysate250 mg--
BioPerine Complex3 mg--
Aqtiv Medium Chain Triglyceride Oil500 mg--

Other ingredients: Gelatin, Water, Purified, Glycerin, Beeswax, Maltodextrin, Sunflower Lecithin, Titanium Dioxide, Mannitol, Silicon Dioxide, Caramel extract, Red Cabbage extract

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formulation

Balancing "calories in" with "calories out" is at the foundation of most weight management programs. In a world where we are surrounded by unhealthy, carbohydrate dense foods that look and taste amazing, this can be one of the hardest balancing acts to maintain and is often what causes weight loss efforts to lose momentum and disappear into the night... until now. Gut-to-brain hunger control is a unique weight management tool that addresses this core issue by helping you reduce calorie intake and carbohydrate cravings so that you can improved success in achieving your weight-loss goals. What makes us different: Liquid Soft-Gels - The nutrients in these easy-to-swallow liquid soft-gels are released fast. Other forms of delivery can contain binders and fillers that may cause stomach upset and offer no traditional value. Advanced Liquid Soft-Gels provide an optimum delivery system. Quality assurance - Irwin Naturals is committed to providing the highest quality products for your health. We employ compliance testing to ensure purity and potency.

Reduces hunger signals from the stomach to the brain, to help control carb cravings & calorie intake

No preservatives added.

General Statements

Global responsibility - Over the years we have donated to organizations that support the environment and the health of children.

Questions: Contact consumer affairs Weekdays 8:00 AM to 5:00 PM (PST) 100+ highly specialized products: www.IrwinNaturals.com

Full Disclosure Ingredient Panel

Formula

DNF-10 satiety peptides This formula features DNF-10 satiety peptides, which has risen in popularity due to its potential to target the key hunger hormone Ghrelin. Preliminary research shows that DNF-10 can reduce the sensation of hunger and the impulse to eat carbohydrates helping to reduce fat mass and body mass index (BMI). Bonus features DNF-10 is complemented by the supportive effects of chromium, methylcobalamin (B12), Vitamin B6, and Medium Chain Triglycerides (MCTs), which combine to support cellular energy balance throughout the body. Patented BioPerine - Our special BioPerine Complex enhances the bioavailability, absorption and potency of many nutrients.

DNF-10 satiety peptides

Seals/Symbols

Pass Quality Tested Guaranteed

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Precautions

Usage warnings: Do not use if safety seal is broken. This product contains ingredient(s) that may affect blood sugar. Do not exceed recommended daily intake.

Check with your doctor before using this product if you are using medication or have any medical conditions. Do not use if you may become pregnant, are pregnant or nursing.

Not intended for use by persons under 18. Keep out of reach of children.

Contains: Tree nut (coconut, palm kernel)

Storage

Store in a cool, dry place.

FDA Statement of Identity

Dietary Supplement

Suggested/Recommended/Usage/Directions

Directions: (Adult) Take two (2) liquid soft-gels, two times per day with a full glass (8oz) of water, and 30-minutes prior to your two biggest meals.

Brand IP Statement(s)

BioPerine is a registered trademark of Sabinsa Corporation. Aqtiv is a trademark of ACME-HARDESTY Co. DNF-10 is marketed by Fytexia.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Gut-to-Brain Hunger Control by Irwin Naturals label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Gut-to-Brain Hunger Control label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Gut-to-Brain Hunger Control by Irwin Naturals

These are the 8 active ingredients this product is made of. Select any to open its full monograph.

Serving size2 Liquid Softgel(s) Dosage formSoftgel Capsule Servings per container30 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Vitamin B6

Interacts with
210 drugs
2.5 mg per serving Form: Pyridoxine Hydrochloride

Vitamin B6 (pyridoxine) is an essential water-soluble vitamin that your body needs for metabolism, brain function, and making red blood cells. It is b...

Vitamin B6 monograph & interactions

Vitamin B12

Interacts with
20 drugs
25 mcg per serving Form: Methylcobalamin

Vitamin B12 (cobalamin) is an essential nutrient your body needs to make red blood cells, keep nerves healthy, and support DNA. Supplements are very h...

Vitamin B12 monograph & interactions

Protein

1 Gram(s) per serving

Chromium

Interacts with
178 drugs
300 mcg per serving Form: Chromium Picolinate

Chromium is an essential trace mineral involved in how the body handles sugar and fat. Some studies suggest it may modestly help blood sugar control i...

Chromium monograph & interactions

Flaxseed Oil

Interacts with
293 drugs
500 mg per serving

Flaxseed oil is a plant-based source of the omega-3 fatty acid ALA, which the body can partly convert to the omega-3s found in fish oil. It may help s...

Flaxseed Oil monograph & interactions

DNF-10 Yeast Hydrolysate

250 mg per serving Form: Saccharomyces cerevisiae

BioPerine Complex

3 mg per serving Form: BioPerine, Ginger Rhizome Extract

Aqtiv Medium Chain Triglyceride Oil

500 mg per serving

Other (inactive) ingredients: Gelatin, Water, Purified, Glycerin, Beeswax, Maltodextrin, Sunflower Lecithin, Titanium Dioxide, Mannitol, Silicon Dioxide, Caramel extract, Red Cabbage extract. These complete the product’s ingredient list but are not active constituents.

Interaction report

Gut-to-Brain Hunger Control by Irwin Naturals Drug Interactions

Want to check YOUR meds against Gut-to-Brain Hunger Control?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
448Drugs
414 Moderate 34 Minor

Ingredients driving the most interactions

Flaxseed Oil 293
Vitamin B6 210
Chromium 178
Vitamin B12 20

Individual Drug Interactions

The ingredients in Gut-to-Brain Hunger Control interact with 448 drugs. Click any drug to see the details.

4 of the 8 ingredients in Gut-to-Brain Hunger Control interact with drugs. Each result below shows which ingredient is responsible. Flaxseed Oil Vitamin B6 Chromium Vitamin B12

Each ingredient & the kinds of drugs it affects

For each ingredient in Gut-to-Brain Hunger Control with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Flaxseed Oil3 drug types · 293 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, using flaxseed oil in combination with anticoagulant or antiplatelet drugs might have additive effects and increase the risk of bleeding.
Small clinical studies show that consuming flaxseed oil might decrease platelet aggregation and increase bleeding time.

Likelihood Possible Evidence D
Antihypertensive Drugs

Theoretically, combining flaxseed oil with other antihypertensive drugs might have additive effects and increase the risk of hypotension.
Some clinical evidence suggests that long-term consumption of flaxseed oil can modestly lower systolic and diastolic blood pressure, while other clinical research shows no effect.

Likelihood Possible Evidence D
Ezetimibe (Zetia)

Concomitant use of flaxseed oil and ezetimibe reduces the absorption of alpha-linolenic acid from flaxseed oil.
In one clinical study, concomitant consumption of ezetimibe 10 mg daily with flaxseed oil 2 grams providing 1 gram of alpha-linolenic acid daily blocked the absorption of alpha-linolenic acid, resulting in an overall reduction in alpha-linolenic plasma levels from baseline.

Likelihood Probable Evidence B
Flaxseed Oil full monograph & interactions

Vitamin B65 drug types · 210 drugs

Amiodarone (Cordarone)

Theoretically, vitamin B6 might increase the photosensitivity caused by amiodarone.
Despite initial case reports suggesting that pyridoxine may have a protective effect against amiodarone-induced photosensitivity, preliminary clinical research suggests that pyridoxine may actually exacerbate this adverse effect.

Likelihood Possible Evidence B
Antihypertensive Drugs

Theoretically, vitamin B6 may have additive effects when used with antihypertensive drugs.
Research in hypertensive rats shows that vitamin B6 can decrease systolic blood pressure. Similarly, clinical research in patients with hypertension shows that taking high doses of vitamin B6 may reduce systolic and diastolic blood pressure, possibly by reducing plasma levels of epinephrine and norepinephrine.

Likelihood Possible Evidence B
Phenobarbital (Luminal)

High doses of vitamin B6 may reduce the levels and clinical effects of phenobarbital.
Preliminary clinical evidence suggests that vitamin B6 200 mg daily can reduce plasma levels of phenobarbital, possibly by increasing metabolism. It is not known whether lower doses have any effect. Advise people taking phenobarbital to avoid high doses of vitamin B6.

Likelihood Possible Evidence D
Phenytoin (Dilantin)

High doses of vitamin B6 may reduce the levels and clinical effects of phenytoin.
Preliminary clinical evidence suggests that vitamin B6 200 mg daily can reduce plasma levels of phenytoin, possibly by increasing metabolism. It is not known whether lower doses have any effect. Advise people taking phenytoin to avoid high doses of vitamin B6.

Likelihood Possible Evidence D
Levodopa

Vitamin B6 may increase the metabolism of levodopa when taken alone, but not when taken in conjunction with carbidopa.
Vitamin B6 (pyridoxine) enhances the metabolism of levodopa, reducing its clinical effects. However, this interaction does not occur when carbidopa is used concurrently with levodopa (Sinemet). Therefore, it is not likely to be a problem in most people.

Likelihood Unlikely Evidence D
Vitamin B6 full monograph & interactions

Chromium5 drug types · 178 drugs

Antidiabetes Drugs

Theoretically, chromium may have additive effects with antidiabetic agents and increase the risk of hypoglycemia.
Some research shows that taking chromium might lower blood glucose levels, especially in patients with poorly controlled type 2 diabetes.

Likelihood Possible Evidence A
Insulin

Theoretically, concomitant use of chromium and insulin might increase the risk of hypoglycemia.
In clinical research, chromium has been shown to increase insulin sensitivity,

Likelihood Possible Evidence B
Levothyroxine (Synthroid, Others)

Chromium might bind levothyroxine in the intestinal tract and decrease levothyroxine absorption.
Clinical research in healthy volunteers shows that taking chromium picolinate 1000 mcg with levothyroxine 1 mg decreases serum levels of levothyroxine by 17% when compared to taking levothyroxine alone. Advise patients to take levothyroxine at least 30 minutes before or 3-4 hours after taking chromium.

Likelihood Probable Evidence B
Aspirin

Theoretically, aspirin might increase chromium absorption.
Animal research suggests that aspirin may increase chromium absorption and chromium levels in the blood.

Likelihood Possible Evidence D
Nonsteroidal Anti-Inflammatory Drugs (Nsaids)

NSAIDs might increase chromium levels in the body.
Drugs that are prostaglandin inhibitors, such as NSAIDs, seem to increase chromium absorption and retention.

Likelihood Possible Evidence D
Chromium full monograph & interactions

Vitamin B121 drug type · 20 drugs

Metformin (Glucophage)

Metformin, a common medication used to manage type 2 diabetes, has been associated with lower vitamin B12 levels in some individuals. Prolonged use of metformin can interfere with the absorption of B12 in the digestive system, potentially leading to a deficiency in this essential vitamin.

Likelihood Possible Evidence A
Vitamin B12 full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Gut-to-Brain Hunger Control, from the product label.

Irwin Naturals

See all Irwin Naturals products
Name
Irwin Naturals
Street Address
5310 Beethoven Street
City
Los Angeles
State
CA
ZipCode
90066
Phone Number
1-800-297-3273
Web Address
www.IrwinNaturals.com
Pharmacist Counseling Corner

Gut-to-Brain Hunger Control by Irwin Naturals: Common Questions

Does Gut-to-Brain Hunger Control by Irwin Naturals interact with any medications?
Yes. Based on its ingredients, Gut-to-Brain Hunger Control has a known interaction with 448 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Gut-to-Brain Hunger Control contains 8 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this if I'm on blood pressure medication?
Both vitamin B6 and flaxseed oil in this product may lower blood pressure, so taking them together with blood pressure medications could add up and potentially lower your pressure too much. Talk to your pharmacist or doctor first—they may need to monitor you or adjust your dose.
Is it safe to take this if I'm on metformin for diabetes?
Metformin can lower your vitamin B12 levels over time, and this product contains B12. That said, the documented interaction is minor. Your doctor or pharmacist should review whether this product is right for you alongside your diabetes regimen.
What's the risk of taking this with a blood thinner like warfarin?
Flaxseed oil in this product may thin the blood further and increase bleeding risk when combined with anticoagulants or antiplatelet drugs. This is a Moderate-severity concern, so check with your pharmacist before use.
Can I take this while pregnant or breastfeeding?
We don't hold pregnancy or breastfeeding safety data for these ingredients in our files. Talk with your doctor or pharmacist before use if you're pregnant or nursing—they can advise you based on your individual situation.
What are the most common side effects?
Vitamin B6 and chromium are generally well tolerated at normal doses. At higher doses, B6 can cause headaches, nausea, and nerve damage over time. Flaxseed oil may cause digestive upset, dry mouth, or indigestion in a small number of users.
Does this product actually help with hunger control?
The product facts we have don't include effectiveness data for hunger control specifically. The ingredients (B vitamins, chromium, and flaxseed oil) have evidence for other uses—like diabetes support and general nutrition—but we can't speak to whether they reduce appetite or hunger.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Gut-to-Brain Hunger Control label
Go deeper

The Full Monographs Behind Gut-to-Brain Hunger Control’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Vitamin B6

Interacts with 210 drugs

Vitamin B6 (pyridoxine) is an essential water-soluble vitamin that your body needs for metabolism, brain function, and making red blood cells. It is best known for helping with pregnancy-rel...

Read the full Vitamin B6 monograph → Herb & supplement monograph

Vitamin B12

Interacts with 20 drugs

Vitamin B12 (cobalamin) is an essential nutrient your body needs to make red blood cells, keep nerves healthy, and support DNA. Supplements are very helpful for people who are deficient — su...

Read the full Vitamin B12 monograph → Herb & supplement monograph

Chromium

Interacts with 178 drugs

Chromium is an essential trace mineral involved in how the body handles sugar and fat. Some studies suggest it may modestly help blood sugar control in certain people with type 2 diabetes, b...

Read the full Chromium monograph → Herb & supplement monograph

Flaxseed Oil

Interacts with 293 drugs

Flaxseed oil is a plant-based source of the omega-3 fatty acid ALA, which the body can partly convert to the omega-3s found in fish oil. It may help support heart health and provide healthy...

Read the full Flaxseed Oil monograph →
Sources

Sources & How We Checked

Gut-to-Brain Hunger Control's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 136 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Vitamin B6 32 references
  1. Hansten PD, Horn JR. Drug Interactions Analysis and Management. Vancouver, WA: Applied Therapeutics Inc., 1997 and updates.
  2. Yates AA, Schlicker SA, Suitor CW. Dietary reference intakes: The new basis for recommendations for calcium and related nutrients, B vitamins, and choline. J Am Diet Assoc 1998;98:699-706. PubMed
  3. Geerling BJ, Dagnelie PC, Badart-Smook A, et al. Diet as a risk factor for the development of ulcerative colitis. Am J Gastroenterol 2000;95:1008-13. PubMed
  4. South M. Neonatal seizures after pyridoxine use -- reply. Lancet 1999;354:2083. PubMed
  5. Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Thiamin, Riboflavin, Niacin, Vitamin B6, Folate, Vitamin B12, Pantothenic Acid, Biotin, and Choline (2000). Washington, DC: National Academy Press, 2000. Available at: http://b
  6. Baxter P, Aicardi J. Neonatal seizures after pyridoxine use. Lancet 1999;354:2082-3. PubMed
  7. Bendich A, Cohen M. Vitamin B6 safety issues. Ann N Y Acad Sci 1990;585:321-30.
  8. Schaumburg H, Kaplan J, Windebank A. Sensory neuropathy from pyridoxine abuse. A new megavitamin syndrome. N Engl J Med 1983;309:445-8. PubMed
  9. Gordon N. Pyridoxine dependency: an update. Dev Med Child Neurol 1997;39:63-5. PubMed
  10. Lewis PJ. Pain in the hand and wrist. Pyridoxine supplements may help patients with carpal tunnel syndrome. BMJ 1995;310:1534. PubMed
  11. Kaufman G. Pyridoxine against amiodarone-induced photosensitivity (letter). Lancet 1984;1:51-2. PubMed
  12. Mulrow JP, Mulrow CD, McKenna WJ. Pyridoxine and amiodarone-induced photosensitivity. Ann Intern Med 1985;103:68-9. PubMed
  13. Kawada A, Kashima A, Shiraishi H, et al. Pyridoxine-induced photosensitivity and hypophosphatasia. Dermatology 2000;201:356-60.. PubMed
  14. Vasile A, Goldberg R, Kornberg B. Pyridoxine toxicity: report of a case. J Am Osteopath Assoc 1984;83:790-1. DOI
  15. Hansson O, Sillanpaa M. Pyridoxine and serum concentration of phenytoin and phenobarbitone. Lancet 1976;1:256. DOI
  16. Jansen T, Romiti R, Kreuter A, Altmeyer P. Rosacea fulminans triggered by high-dose vitamins B6 and B12. J Eur Acad Dermatol Venereol 2001;15:484-5..
  17. Chittumma P, Kaewkiattikun K, Wiriyasiriwach B. Comparison of the effectiveness of ginger and vitamin B6 for treatment of nausea and vomiting in early pregnancy: a randomized double-blind controlled trial. J Med Assoc Thai 2007;90:15-20.
  18. Hatzitolios, A., Iliadis, F., Katsiki, N., and Baltatzi, M. Is the anti-hypertensive effect of dietary supplements via aldehydes reduction evidence based? A systematic review. Clin Exp.Hypertens. 2008;30(7):628-639. PubMed
  19. Vasdev, S., Ford, C. A., Parai, S., Longerich, L., and Gadag, V. Dietary vitamin B6 supplementation attenuates hypertension in spontaneously hypertensive rats. Mol.Cell Biochem. 1999;200(1-2):155-162.
  20. de, Vogel S., Dindore, V., van, Engeland M., Goldbohm, R. A., van den Brandt, P. A., and Weijenberg, M. P. Dietary folate, methionine, riboflavin, and vitamin B-6 and risk of sporadic colorectal cancer. J Nutr 2008;138(12):2372-2378. PubMed
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Vitamin B12 30 references
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Chromium 53 references
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Flaxseed Oil 21 references
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